Iron deposits in multiple sclerosis and Alzheimer's disease brains

Brain Research

Volumn 760, Issue 1-2, 1997, Pages 298-303

  Levine, Steven M ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

Demyelination; Iron histochemistry; Macrophage; Microglia; Oxidative damage; Plaque

Indexed keywords

AMYLOID; DIAMINOBENZIDINE; IRON; LIPOFUSCIN; PROTEINASE K; REAGENT; SODIUM BOROHYDRIDE; TRITON X 100; XYLENE;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DEMYELINATING DISEASE; HISTOCHEMISTRY; HUMAN; HUMAN TISSUE; IRON STORAGE; MACROPHAGE; MICROGLIA; MULTIPLE SCLEROSIS; OLIGODENDROGLIA; OXIDATIVE STRESS; PRIORITY JOURNAL; SENILE PLAQUE;

ALZHEIMER DISEASE; BRAIN; HUMANS; IRON; MULTIPLE SCLEROSIS;

EID: 0030788672     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00470-8     Document Type: Article

References (19)

1. Adams C.W.M. Perivascular iron deposition and other vascular damage in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry. 51:1988;260-265.
2. Ben-Shachar D., Youdim M.B.H. Intranigral iron injection induces behavioral and biochemical 'Parkinsonism' in rats. J. Neurochem. 57:1991;2133-2135.
3. Ben-Shachar D., Youdim M.B.H. Iron, melanin and dopamine interaction: relevance to Parkinson's disease. Prog. Neuropsychopharmacol. Biol. Psychiatry. 17:1993;139-150.
4. D.C. Borg, Oxygen free radicals and tissue injury. A reference outline, in: M. Tarr, F. Samson (Eds.), Oxygen Free Radicals in Tissue Damage, Birkhauser, Boston, 1993, pp. 12-53.
5. D.C. Borg, K.M. Schaich, Iron and iron-derived radicals, in: B. Halliwell (Ed.), Oxygen Radicals and Tissue Injury, Federation of American Societies for Experimental Biology, Bethesda, MD, 1988, pp. 20-26.
6. Connor J.R., Menzies S.L., St. Martin S.M., Mufson E.J. A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains. J. Neurosci. Res. 31:1992;75-83.
7. Connor J.R., Pavlick G., Karli D., Menzies S.L., Palmer C. A histochemical study of iron-positive cells in the developing rat brain. J. Comp. Neurol. 355:1995;111-123.
8. Craelius W., Migdal M.W., Luessenhop C.P., Sugar A., Mihalakis I. Iron deposits surrounding multiple sclerosis plaques. Arch. Pathol. Lab. Med. 106:1982;397-399.
9. Erb G., Osterbur D.L., LeVine S.M. The distribution of iron in the brain: a phylogenetic analysis using iron histochemistry. Dev. Brain Res. 93:1996;120-128.
10. Gutteridge J.M.C. Iron and oxygen radicals in brain. Ann. Neurol. 32:1992;S16-S21.
11. Halliwell B., Gutteridge J.M.C. Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem. J. 219:1984;1-14.
12. LeVine S.M., Goldman J.E. Spatial and temporal patterns of oligodendrocyte differentiation in rat cerebrum and cerebellum. J. Comp. Neurol. 277:1988;441-455.
13. LeVine S.M., Macklin W.B. Iron-enriched oligodendrocytes: a reexamination of their spatial distribution. J. Neurosci. Res. 26:1990;508-512.
14. LeVine S.M. Oligodendrocytes and myelin sheaths in normal, quaking and shiverer brains are enriched in iron. J. Neurosci. Res. 29:1991;413-419.
15. LeVine S.M., Torres M.V. Morphological features of degenerating oligodendrocytes in twitcher mice. Brain Res. 587:1992;348-352.
16. Nguyen-Legros J., Bizot J., Bolesse M., Publicani J.P. Noir de diaminobenzidine: une nouvelle méthode histochimique de révélation du fer exogène. Histochemistry. 66:1980;239-244.
17. Riederer P., Sofic E., Rausch W.-D., Schmidt B., Reynolds G.P., Jellinger K., Youdim M.B.H. Transition metals, ferritin, glutathione, and ascorbic acid in Parkinsonian brains. J. Neurochem. 52:1989;515-520.
18. Sengstock G.J., Olanow C.W., Dunn A.J., Arendash G.W. Iron induces degeneration of nigrostriatal neurons. Brain Res. Bull. 28:1992;645-649.
19. Walton J.C., Kaufmann J.C.E. Iron deposits and multiple sclerosis. Arch. Pathol. Lab. Med. 108:1984;755-756.