Sleeping sickness pathogen (Trypanosoma brucei) and natural products: Therapeutic targets and screening systems

Planta Medica

Volumn 77, Issue 6, 2011, Pages 586-597

  Hannaert, Véronique ^a  

^a DE DUVE INSTITUTE   (Belgium)

Author keywords

drug targets; natural products; sleeping sickness; Trypanosoma brucei; Trypanosomatidae

Indexed keywords

DNA TOPOISOMERASE; EFLORNITHINE; FEXINIDAZOLE; KINETOPLAST DNA; MELARSOPROL; NATURAL PRODUCT; NIFURTIMOX; OXIDOREDUCTASE; PAFURAMIDINE; PENTAMIDINE; PROTEIN FARNESYLTRANSFERASE; SURAMIN; THIOL; TUBULIN;

ABDOMINAL PAIN; AFRICAN TRYPANOSOMIASIS; ALLERGIC REACTION; ANEMIA; ANTIPROTOZOAL ACTIVITY; BONE MARROW SUPPRESSION; BRAIN DISEASE; CARBOHYDRATE METABOLISM; CARDIOTOXICITY; DRUG MECHANISM; DRUG SCREENING; EXFOLIATIVE DERMATITIS; GASTROINTESTINAL SYMPTOM; HUMAN; HYPOGLYCEMIA; INJECTION SITE PAIN; INJECTION SITE SWELLING; LEUKOPENIA; MYRISTYLATION; NEPHROTOXICITY; NONHUMAN; REVIEW; THROMBOCYTOPENIA; TRYPANOSOMA BRUCEI; URINARY TRACT DISEASE;

AFRICA; ANIMALS; BIOLOGICAL AGENTS; CARBOHYDRATE METABOLISM; DNA TOPOISOMERASES; DNA, KINETOPLAST; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE; FARNESYLTRANSTRANSFERASE; HUMANS; OXIDOREDUCTASES; PROTOZOAN PROTEINS; SULFHYDRYL COMPOUNDS; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN; TUBULIN;

TRYPANOSOMA BRUCEI; TRYPANOSOMATIDAE;

EID: 79954576292     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0030-1250411     Document Type: Review

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