The farnesyltransferase inhibitor manumycin A is a novel trypanocide with a complex mode of action including major effects on mitochondria

Molecular and Biochemical Parasitology

Volumn 104, Issue 1, 1999, Pages 67-80

  Ali, Bassam R S ^a   Pal, Arun ^a   Croft, Simon L ^b   Taylor, Richard J K ^c   Field, Mark C ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c UNIVERSITY OF YORK   (United Kingdom)

Author keywords

Chemotherapy; Farnesyltransferase; Small GTPases; Trypanosomiasis

Indexed keywords

ANTITRYPANOSOMAL AGENT; LIMONENE; MANUMYCIN A; PERILLYL ALCOHOL; PHOSPHONIC ACID DERIVATIVE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL KILLING; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MAMMAL CELL; MITOCHONDRION; MOUSE; NONHUMAN; PRENYLATION; PRIORITY JOURNAL; TRYPANOSOMIASIS;

ALKYL AND ARYL TRANSFERASES; ANIMALS; MICE; MITOCHONDRIA; POLYENES; POLYUNSATURATED ALKAMIDES; PROTEIN ISOPRENYLATION; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS; TSETSE FLIES;

EID: 0032746383     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(99)00131-0     Document Type: Article

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