Suppressing inflammatory cascade by cyclo-oxygenase inhibitors attenuates quinolinic acid induced Huntington's disease-like alterations in rats

Life Sciences

Volumn 88, Issue 17-18, 2011, Pages 784-791

  Kalonia, Harikesh ^a   Kumar, Anil ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Excitotoxicity; Huntington's disease; Mitochondrial dysfunction; Oxidative stress; Quinolinic acid

Indexed keywords

CASPASE 3; CELECOXIB; CYTOKINE; INTERLEUKIN 6; MELOXICAM; MITOCHONDRIAL ENZYME; QUINOLINIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR DISORDER; BODY WEIGHT; CELL DEATH; CONTROLLED STUDY; CORPUS STRIATUM; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG MEGADOSE; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; HUNTINGTON DISEASE LIKE SYNDROME; LOCOMOTION; MALE; MOTOR COORDINATION; NONHUMAN; OXIDATIVE STRESS; RAT; ROTAROD TEST; WALKING;

ANIMALS; BRAIN; CASPASE 3; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUNTINGTON DISEASE; INFLAMMATION; INTERLEUKIN-6; LIPID PEROXIDATION; LOCOMOTION; MALE; MITOCHONDRIA; OXIDATIVE STRESS; PYRAZOLES; QUINOLINIC ACID; RATS; RATS, WISTAR; SULFONAMIDES; THIAZINES; THIAZOLES; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 79954575048     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2011.02.020     Document Type: Article

References (73)

1. T. Azarashvili, R. Stricker, and G. Reiser The mitochondria permeability transition pore complex in the brain with interacting proteins - promising targets for protection in neurodegenerative diseases Biol Chem 391 2010 619 629
2. M.F. Beal, N.W. Kowall, K.J. Swartz, R.J. Ferrante, and J.B. Martin Systemic approaches to modifying quinolinic acid striatal lesions in rats J Neurosci 8 1988 3901 3908
3. M.F. Beal, R.J. Ferrante, K.J. Swartz, and N.W. Kowall Chronic quinolinic acid lesions in rats closely resemble Huntington's disease J Neurosci 11 1991 1649 1659
4. J.E. Belizário, J. Alves, J.M. Occhiucci, M. Garay-Malpartida, and A. Sesso A mechanistic view of mitochondrial death decision pores Braz J Med Biol Res 40 2007 1011 1024 (Pubitemid 47232855)
5. S.B. Berman, and T.G. Hastings Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease J Neurochem 73 1999 1127 1137 (Pubitemid 29395471)
6. C.V. Borlongan, T.S. Randall, D.W. Cahill, and P.R. Sanberg Asymmetrical motor behavior in rats with unilateral striatal excitotoxic lesions as revealed by the elevated body swing test Brain Res 676 1995 231 234
7. R.P. Bruyn, and J.C. Stoof The quinolinic acid hypothesis in Huntington's chorea J Neurol Sci 95 1990 29 38 (Pubitemid 20034383)
8. P.T. Bywood, and S.M. Johnson Mitochondrial complex inhibitors preferentially damage substantia nigra dopamine neurons in rat brain slices Exp Neurol 179 2003 47 59 (Pubitemid 36062618)
9. J. Cabrera, R.J. Reiter, D.X. Tan, W. Qi, R.M. Sainz, and J.C. Mayo Melatonin reduces oxidative neurotoxicity due to quinolinic acid: in vitro and in vivo findings Neuropharmacology 39 2000 507 514 (Pubitemid 30052939)
10. D.W. Choi Excitotoxic cell death J Neurobiol 23 1992 1261 1276
11. J. Croitoru-Lamoury, G.J. Guillemin, D. Dormont, and B.J. Brew Quinolinic acid up-regulates chemokine production and chemokine receptor expression in astrocytes Adv Exp Med Biol 527 2003 37 45 (Pubitemid 38197626)
12. A. Dhir, P.S. Naidu, and S.K. Kulkarni Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action Prog Neuropsychopharmacol Biol Psychiatry 30 2006 1478 1485 (Pubitemid 44634957)
13. R.J. Ferrante, N.W. Kowall, P.B. Cipolloni, E. Storey, and M.F. Beal Excitotoxin lesions in primates as a model for Huntington's disease: histopathologic and neurochemical characterisation Exp Neurol 119 1993 46 71 (Pubitemid 23074242)
14. Ferreira, I.L., Nascimento, M.V., Ribeiro, M., Almeida, S., Cardoso, S.M., Grazina, M., et al. Mitochondrial-dependent apoptosis in Huntington's disease human cybrids. Exp Neurol 222:243-55.
15. A.C. Foster, A. Vezzani, E.D. French, and R. Schwarcz Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid Neurosci Lett 48 1984 273 278 (Pubitemid 14054435)
16. T.F. Gendron, E. Brunette, J.S. Tauskela, and P. Morley The dual role of prostaglandin E(2) in excitotoxicity and preconditioning-induced neuroprotection Eur J Pharmacol 517 2005 17 27 (Pubitemid 40910248)
17. M. Giordano, L.M. Ford, J.L. Brauckmann, A.B. Norman, and P.R. Sanberg MK801 prevents quinolinic acid-induced behavioral deficits and neurotoxicity in the striatum Brain Res Bull 24 1990 313 319 (Pubitemid 20119421)
18. A.G. Gornall, C.J. Bardawill, and M.M. David Determination of serum proteins by means of the biuret reaction J Biol Chem 177 1949 751 766
19. L.C. Green, D.A. Wagner, J. Glgowski, P.L. Skipper, J.S. Wishnok, and S.R. Tannebaum Analysis of nitrate, nitrite, and [15 N] nitrate in biological fluids Annu Rev Biochem 126 1982 131 138 (Pubitemid 13203451)
20. A. Gupta, A. Dhir, A. Kumar, and S.K. Kulkarni Protective effect of cyclooxygenase (COX)-inhibitors against drug-induced catatonia and MPTP-induced striatal lesions in rats Pharmacol Biochem Behav 94 2009 219 226
21. B. Halliwell Oxidative stress and neurodegeneration: where are we now? J Neurochem 97 2006 1634 1658 (Pubitemid 43873658)
22. M.P. Heyes, K. Saito, J.S. Crowley, L.E. Davis, M.A. Demitrack, and M. Der Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease Brain 115 1992 1249 1273
23. J.J. Hoozemans, E.S. van Haastert, R. Veerhuis, T. Arendt, W. Scheper, and P. Eikelenboom Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer's disease J Neuroinflammation 2 2005 27
24. S.D. Hurley, J.A. Olschowka, and M.K. O'Banion Cyclooxygenase inhibition as a strategy to ameliorate brain injury J Neurotrauma 19 2002 1 15 (Pubitemid 34117092)
25. J. Jordán, V. Ceña, and J.H. Prehn Mitochondrial control of neuron death and its role in neurodegenerative disorders J Physiol Biochem 59 2003 129 141
26. H. Kalonia, P. Kumar, B. Nehru, and A. Kumar Neuroprotective effect of MK-801 against intra-striatal quinolinic acid induced behavioral, oxidative stress and cellular alterations in rats Indian J Exp Biol 47 2009 880 892
27. H. Kalonia, P. Kumar, A. Kumar, and B. Nehru Protective effect of rofecoxib and nimesulide against intra-striatal quinolinic acid-induced behavioral, oxidative stress and mitochondrial dysfunctions in rats Neurotoxicology 31 2010 195 203
28. T.E. King Preparation of succinate dehydrogenase and reconstitution of succinate oxidase Meth Enzymol 10 1967 322
29. T.E. King, and R.L. Howard Preparations and properties of soluble NADH dehydrogenases from cardiac muscle Meth Enzymol 10 1967 275
30. G.R. Kinsey, J. McHowat, K.S. Patrick, and R.G. Schnellmann Role of Ca2+- independent phospholipase A2gamma in Ca2+-induced mitochondrial permeability transition J Pharmacol Exp Ther 321 2007 707 715 (Pubitemid 46624527)
31. Y. Kono Generation of superoxide radical during auto-oxidation of hydroxylamine and an assay of superoxide dismutase Arch Biochem Biophys 186 1978 189 195 (Pubitemid 8290500)
32. R.C. Kukreja, H.A. Kontos, M.L. Hess, and E.F. Ellis PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH Circ Res 59 1986 612 619 (Pubitemid 17035305)
33. P. Kumar, S.S. Padi, P.S. Naidu, and A. Kumar Cyclooxygenase inhibition attenuates 3-nitropropionic acid-induced neurotoxicity in rats: possible antioxidant mechanisms Fundam Clin Pharmacol 21 2007 297 306 (Pubitemid 46800477)
34. P.A. Lapchak, D.M. Araujo, D. Song, and J.A. Zivin Neuroprotection by the selective cyclooxygenase-2 inhibitor SC-236 results in improvements in behavioral deficits induced by reversible spinal cord ischemia Stroke 32 2001 1220 1225 (Pubitemid 32825814)
35. S. Layé Polyunsaturated fatty acids, neuroinflammation and well being Prostaglandins Leukot Essent Fatty Acids 82 2010 295 303
36. F. Leblhuber, J. Walli, K. Jellinger, G.P. Tilz, B. Widner, and F. Laccone Activated immune system in patients with Huntington's disease Clin Chem Lab Med 36 1998 747 750 (Pubitemid 28521525)
37. J. Lee, S.L. Chan, C. Lu, M.A. Lane, and M.P. Mattson Phenformin suppresses calcium responses to glutamate and protects hippocampal neurons against excitotoxicity Exp Neurol 175 2002 161 167 (Pubitemid 34507918)
38. Y. Liu, D.A. Peterson, H. Kimura, and D. Schubert Mechanisms of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolinium bromide (MTT) reduction J Neurochem 69 1997 581 593 (Pubitemid 27327958)
39. A. Lleo, E. Galea, and M. Sastre Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases Cell Mol Life Sci 64 2007 1403 1418 (Pubitemid 46889230)
40. H. Luck Catalase H.U. Bergmeyer, Methods of enzyme analysis 1971 New York Academic press
41. R.C. Maia, C.A. Culver, and S.M. Laster Evidence against calcium as a mediator of mitochondrial dysfunction during apoptosis induced by arachidonic acid and other free fatty acids J Immunol 177 2006 6398 6404 (Pubitemid 44628858)
42. H. Manev, T. Uz, K. Sugaya, and T. Qu Putative role of neuronal 5-lipoxygenase in an aging brain FASEB J 14 2000 1464 1469 (Pubitemid 30439756)
43. V.L. Marcheselli, and N.G. Bazan Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Inhibition by a platelet-activating factor antagonist J Biol Chem 271 1996 24794 24799 (Pubitemid 26333227)
44. L. Minghetti Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases J Neuropathol Exp Neurol 63 2004 901 910 (Pubitemid 39202493)
45. L. Minghetti Role of COX-2 in inflammatory and degenerative brain diseases Subcell Biochem 42 2007 127 141
46. L. Minghetti, A. Greco, R.L. Potenza, A. Pezzola, D. Blum, and K. Bantubungi Effects of the adenosine A2A receptor antagonist SCH 58621 on cyclooxygenase-2 expression, glial activation, and brain-derived neurotrophic factor availability in a rat model of striatal neurodegeneration J Neuropathol Exp Neurol 66 2007 363 371 (Pubitemid 46701318)
47. S. Narumiya Prostanoids and inflammation: a new concept arising from receptor knockout mice J Mol Med 87 2009 1015 1022
48. J.S. Nie, J. Zhao, H.J. Liu, H.M. Zhang, Q.L. Zhang, and Q. Niu Changes of mitochondria membrane potential and cytoplasmic cytochrome C in neuron apoptosis induced by benzo(a)pyrene Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 28 2010 8 11
49. G. Paxinos, and C. Watson The rat brain in stereotaxic coordinates 6th edition 2007 Academic Press San Diego
50. L.A. Pemberton, S.J. Kerr, G. Smythe, and B.J. Brew Quinolinic acid production by macrophages stimulated with IFN-gamma, TNF-α, and IFN-α J Interferon Cytokine Res 17 1997 589 595 (Pubitemid 27451155)
51. O. Pepicelli, E. Fedele, G. Bonanno, M. Raiteri, M.A. Ajmone-Cat, and A. Greco In vivo activation of N-methyl-D-aspartate receptors in the rat hippocampus increases prostaglandin E(2) extracellular levels and triggers lipid peroxidation through cyclooxygenase-mediated mechanisms J Neurochem 81 2002 1028 1034 (Pubitemid 34809285)
52. F. Pérez-Severiano, M. Rodríguez-Pérez, J. Pedraza-Chaverrí, P.D. Maldonado, O.N. Medina-Campos, and A. Ortíz-Plata S-allylcysteine, a garlic-derived antioxidant, ameliorates quinolinic acid-induced neurotoxicity and oxidative damage in rats Neurochem Int 45 2004 1175 1183 (Pubitemid 39222059)
53. P.H. Reddy Mitochondrial medicine for aging and neurodegenerative diseases Neuromolecular Med 10 2008 291 315
54. P.H. Reddy, and M.F. Beal Amyloid beta, mitochondrial dysfunction, and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease Trends Mol Med 14 2008 45 53
55. P.H. Reddy, P. Mao, and M. Manczak Mitochondrial structural and functional dynamics in Huntington's disease Brain Res Rev 61 2009 33 48
56. C.A. Ribeiro, V. Grando, C.S. Dutra Filho, C.M. Wannmacher, and M. Wajner Evidence that quinolinic acid severely impairs energy metabolism through activation of NMDA receptors in striatum from developing rats J Neurochem 99 2006 1531 1542 (Pubitemid 44924231)
57. P.R. Sanberg, S.F. Calderon, M. Giordano, J.M. Tew, and A.B. Norman The quinolinic acid model of Huntington's disease: locomotor abnormalities Exp Neurol 105 1989 45 53 (Pubitemid 19198876)
58. A. Santamaría, and C. Ríos MK-801, an N-methyl-D-aspartate receptor antagonist, blocks quinolinic acid-induced lipid peroxidation in rat corpus striatum Neurosci Lett 159 1993 51 54 (Pubitemid 23283236)
59. M.L. Scattoni, A. Valanzano, A. Pezzola, Z.D. March, F.R. Fusco, and P. Popoli Adenosine A2A receptor blockade before striatal excitotoxic lesions prevents long term behavioural disturbances in the quinolinic rat model of Huntington's disease Behav Brain Res 176 2007 216 221 (Pubitemid 44880086)
60. R. Schwarcz, W.O. Whetsell Jr., and R.M. Mangano Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain Science 219 1983 316 318 (Pubitemid 13222319)
61. R. Schwarcz, A.C. Foster, E.D. French, W.O. Whetsell Jr., and C. Kohler Excitotoxic models for neurodegenerative disorders Life Sci 35 1984 19 32
62. A.I. Scovassi, C. Soldani, P. Veneroni, M.G. Bottone, and C. Pellicciari Changes of mitochondria and relocation of the apoptosis-inducing factor during apoptosis Ann NY Acad Sci 1171 2009 12 17
63. D.A. Shear, J. Dong, C.D. Gundy, K.L. Haik-Creguer, and G.L. Dunbar Comparison of intrastriatal injections of quinolinic acid and 3-nitropropionic acid for use in animal models of Huntington's disease Prog Neuropsychopharmacol Biol Psychiatry 22 1998 1217 1240 (Pubitemid 28511596)
64. G.L. Sottocasa, B. Kuylenstierna, L. Ernster, and A. Bergstrand An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study J Cell Biol 32 1967 415 438
65. T.W. Stone Neuropharmacology of quinolinic and kynurenic acids Pharmacol Rev 45 1993 309 379 (Pubitemid 23292874)
66. T.W. Stone, and M.N. Perkins Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS Eur J Pharmacol 72 1981 411 412 (Pubitemid 11081065)
67. S.F. Tzeng, H.Y. Hsiao, and O.T. Mak Prostaglandins and cyclooxygenases in glial cells during brain inflammation Curr Drug Targets Inflamm Allergy 4 2005 335 340
68. E.M. Vazey, K. Chen, S.M. Hughes, and B. Connor Transplanted adult neural progenitor cells survive, differentiate and reduce motor function impairment in a rodent model of Huntington's disease Exp Neurol 199 2006 384 396 (Pubitemid 43928967)
69. X. Wang, S. Zhu, M. Drozda, W. Zhang, I.G. Stavrovskaya, and E. Cattaneo Minocycline inhibits caspase-independent and -dependent mitochondrial cell death pathways in models of Huntington's disease Proc Natl Acad Sci USA 100 2003 10483 10487 (Pubitemid 37071904)
70. X. Wang, X. Gao, X. Zhang, Y. Tu, M. Jin, and G.P. Zhao The negative cell cycle regulator, Tob (transducer of ErbB-2), is involved in motor skill learning Biochem Biophys Res Commun 340 2006 1023 1027 (Pubitemid 43083381)
71. E.D. Wills Mechanism of lipid peroxide formation in animal tissue Biochem J 99 1966 667 676
72. T. Yamazaki, M. Muramoto, T. Oe, N. Morikawa, O. Okitsu, and T. Nagashima Diclofenac, a non-steroidal anti-inflammatory drug, suppresses apoptosis induced by endoplasmic reticulum stresses by inhibiting caspase signaling Neuropharmacology 50 2006 558 567
73. X. Zhang, F. Dong, G.E. Mayer, D.C. Bruch, J. Ren, and B. Culver Selective inhibition of cyclooxygenase-2 exacerbates methamphetamine-induced dopamine depletion in the striatum in rats Neuroscience 150 2007 950 958 (Pubitemid 350235789)