In vivo activation of N-methyl-D-aspartate receptors in the rat hippocampus increases prostaglandin E2 extracellular levels and triggers lipid peroxidation through cyclooxygenase-mediated mechanisms

Journal of Neurochemistry

Volumn 81, Issue 5, 2002, Pages 1028-1034

  Pepicelli, O ^a   Fedele, E ^a   Bonanno, G ^a   Raiteri, M ^a   Ajmone Cat, M A ^b   Greco, A ^b   Levi, G ^b   Minghetti, L ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Cyclooxygenase; Excitotoxicity; Isoprostane; Neurodegeneration; Prostaglandin

Indexed keywords

8 ISOPROSTAGLANDIN F2 ALPHA; ARACHIDONYL TRIFLUOROMETHYL KETONE; CYCLOOXYGENASE 2; DIZOCILPINE; EXCITOTOXIN; FLURBIPROFEN; INDOMETACIN; ISOPROSTANE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHOLIPASE A2; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; RADICAL; REACTIVE OXYGEN METABOLITE; THROMBOXANE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVITY; HIPPOCAMPUS; LIPID PEROXIDATION; MALE; MICRODIALYSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; SEIZURE;

ANIMALS; DINOPROST; DINOPROSTONE; DIZOCILPINE MALEATE; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; EXTRACELLULAR SPACE; F2-ISOPROSTANES; HIPPOCAMPUS; LIPID PEROXIDATION; MALE; MICRODIALYSIS; N-METHYLASPARTATE; PHOSPHOLIPASES A; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

ANIMALIA; HIPPOCAMPUS HIPPOCAMPUS;

EID: 0036319108     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.00897.x     Document Type: Article

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