Protective effect of rofecoxib and nimesulide against intra-striatal quinolinic acid-induced behavioral, oxidative stress and mitochondrial dysfunctions in rats

NeuroToxicology

Volumn 31, Issue 2, 2010, Pages 195-203

  Kalonia, Harikesh ^a   Kumar, Puneet ^a   Kumar, Anil ^a   Nehru, Bimla ^b  

^a PANJAB UNIVERSITY   (India)

^b PANJAB UNIVERSITY   (India)

Author keywords

Cyclooxygenase; Mitochondria; Nimesulide; Oxidative stress; Quinolinic acid; Rofecoxib

Indexed keywords

CATALASE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYTOCHROME C OXIDASE; GLUTATHIONE; MALONALDEHYDE; NIMESULIDE; NITRITE; QUINOLINIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROFECOXIB; SUCCINATE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE DISMUTASE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; COORDINATION DISORDER; CORPUS STRIATUM; DEGENERATIVE DISEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; INFLAMMATORY DISEASE; LIPID PEROXIDATION; MALE; MORNING DOSAGE; MOTOR COORDINATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; WEIGHT REDUCTION;

ANIMALS; ATAXIA; BODY WEIGHT; CELL SURVIVAL; CORPUS STRIATUM; CYCLOOXYGENASE 2 INHIBITORS; LACTONES; MALE; MICROINJECTIONS; MITOCHONDRIA; MITOCHONDRIAL DISEASES; NEUROTOXICITY SYNDROMES; OXIDATIVE STRESS; QUINOLINIC ACID; RATS; RATS, WISTAR; SULFONAMIDES; SULFONES;

ANIMALIA; RATTUS;

EID: 77649270021     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2009.12.008     Document Type: Article

References (57)

1. Aguilera P., Chanez-Cardenas M.E., Floriano-Sanchez E., Barrera D., Santamaria A., Sanchez-Gonzalez D.J., et al. Time-related changes in constitutive and inducible nitric oxide synthases in the rat striatum in a model of Huntington's disease. Neurotoxicology 28 (2007) 1200-1207
2. Asanuma M., Nishibayashi-Asanuma S., Miyazaki I., Kohno M., and Ogawa N. Neuroprotective effects of non-steroidal anti-inflammatory drugs by direct scavenging of nitric oxide radicals. J Neurochem 76 (2001) 1895-1904
3. Asanuma M., Miyazaki I., Diaz-Corrales F.J., and Ogawa N. Quinone formation as dopaminergic neuron-specific oxidative stress in the pathogenesis of sporadic Parkinson's disease and neurotoxin-induced parkinsonism. Acta Med Okayama 58 (2004) 221-233
4. Berman S.B., and Hastings T.G. Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease. J Neurochem 73 (1999) 1127-1137
5. Borlongan C.V., Randall T.S., Cahill D.W., and Sanberg P.R. Asymmetrical motor behavior in rats with unilateral striatal excitotoxic lesions as revealed by the elevated body swing test. Brain Res 676 (1995) 231-234
6. Boyd J.D., Jang H., Shepherd K.R., Faherty C., Slack S., Jiao Y., et al. Response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) differs in mouse strains and reveals a divergence in JNK signaling and COX-2 induction prior to loss of neurons in the substantia nigra pars compacta. Brain Res 1175 (2007) 107-116
7. Breder C.D., Dewitt D., and Kraig R.P. Characterization of inducible cyclooxygenase in rat brain. J Comp Neurol 355 (1995) 296-315
8. Bruyn R.P., and Stoof J.C. The quinolinic acid hypothesis in Huntington's chorea. J Neurol Sci 95 (1990) 29-38
9. Bywood P.T., and Johnson S.M. Mitochondrial complex inhibitors preferentially damage substantia nigra dopamine neurons in rat brain slices. Exp Neurol 179 (2003) 47-59
10. Ellman G.L. Tissue sulfhydryl groups. Arch Biochem Biophys 82 (1959) 70-77
11. 2+ entry resulting in apoptosis. J Neurochem 104 (2008) 1177-1189
12. Foster A.C., Gill R., Kemp J.A., and Woodruff G.N. Systemic administration of MK-801 prevents N-methyl-d-aspartate-induced neuronal degeneration in rat brain. Neurosci Lett 76 (1987) 307-311
13. Gendron T.F., Brunette E., Tauskela J.S., and Morley P. The dual role of prostaglandin E(2) in excitotoxicity and preconditioning-induced neuroprotection. Eur J Pharmacol 517 (2005) 17-27
14. Gornall A.G., Bardawill C.J., and David M.M. Determination of serum proteins by means of the biuret reaction. J Biol Chem 177 (1949) 751-766
15. Green L.C., Wagner D.A., Glogowski J., Skipper P.L., Wishnok J.S., and Tannenbaum S.R. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal Biochem 126 (1982) 131-138
16. Guidetti P., and Schwarcz R. 3-Hydroxykynurenine and quinolinate: pathogenic synergism in early grade Huntington's disease?. Adv Exp Med Biol 527 (2003) 137-145
17. Gupta S., Kass G.E., Szegezdi E., and Joseph B. The mitochondrial death pathway: a promising therapeutic target in diseases. J Cell Mol Med 13 (2009) 1004-1033
18. Heyes M.P., Saito K., Crowley J.S., Davis L.E., Demitrack M.A., Der M., et al. Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease. Brain 115 (1992) 1249-1273
19. Huntjens D.R., Spalding D.J., Danhof M., and Della Pasqua O.E. Differences in the sensitivity of behavioral measures of pain to the selectivity of cyclo-oxygenase inhibitors. Eur J Pain 13 (2009) 448-457
20. Kalonia H., Kumar P., Kumar A., and Nehru B. Effect of caffeic acid and rofecoxib and their combination against intrastriatal quinolinic acid induced oxidative damage, mitochondrial and histological alterations in rats. Inflammopharmacology 17 (2009) 211-219
21. King T.E. Preparation of succinate dehydrogenase and reconstitution of succinate oxidase. Methods Enzymol 10 (1967) 322-331
22. King T.E., and Howard R.L. Preparations and properties of soluble NADH dehydrogenases from cardiac muscle. Methods Enzymol 10 (1967) 275-284
23. Kono Y. Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys 186 (1978) 189-195
24. Kulkarni S.K. Hand book of experimental pharmacology. 3rd ed. (1999), Vallabh prakashan, Delhi
25. Kumar P., and Kumar A. Possible role of sertraline against 3-nitropropionic acid induced behavioral, oxidative stress and mitochondrial dysfunctions in rat brain. Prog Neuropsychopharmacol Biol Psychiatry 33 (2009) 100-108
26. Kumar A., Seghal N., Padi S.V., and Naidu P.S. Differential effects of cyclooxygenase inhibitors on intracerebroventricular colchicine-induced dysfunction and oxidative stress in rats. Eur J Pharmacol 551 (2006) 58-66
27. Kumar P., Padi S.S., Naidu P.S., and Kumar A. Cyclooxygenase inhibition attenuates 3-nitropropionic acid-induced neurotoxicity in rats: possible antioxidant mechanisms. Fundam Clin Pharmacol 21 (2007) 297-306
28. Liang X., Wu L., Wang Q., Hand T., Bilak M., McCullough L., et al. Function of COX-2 and prostaglandins in neurological disease. J Mol Neurosci 33 (2007) 94-99
29. Liu Y., Peterson D.A., Kimura H., and Schubert D. Mechanisms of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolinium bromide (MTT) reduction. J Neurochem 69 (1997) 581-593
30. Lleo A., Galea E., and Sastre M. Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases. Cell Mol Life Sci 64 (2007) 1403-1418
31. Luck H. Catalase. In: Bergmeyer H.U. (Ed). Methods of enzyme analysis (1971), Academic press, New York 885
32. Maharaj H., Maharaj D.S., and Daya S. Acetylsalicylic acid and acetaminophen protect against oxidative neurotoxicity. Metab Brain Dis 21 (2006) 189-199
33. Nanji A.A., Miao L., Thomas P., Rahemtulla A., Khwaja S., Zhao S., et al. Enhanced cyclooxygenase-2 gene expression in alcoholic liver disease in the rat. Gastroenterology 112 (1997) 943-951
34. Ndengele M.M., Cuzzocrea S., Esposito E., Mazzon E., Di Paola R., Matuschak G.M., et al. Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity. FASEB J 22 (2008) 3154-3164
35. O'Connor Cernak C., and Vink R. Inhibition of cyclooxygenase 2 by nimesulide improves cognitive outcome more than motor outcome following diffuse traumatic brain injury in rats. Exp Brain Res 147 (2002) 193-199
36. Olds M.E., Jacques D.B., and Kopyov O. Behavioral and anatomical effects of quinolinic acid in the striatum of the hemiparkinsonian rat. Synapse 55 (2005) 26-36
37. Padi S.S., and Kulkarni S.K. Differential effects of naproxen and rofecoxib on the development of hypersensitivity following nerve injury in rats. Pharmacol Biochem Behav 79 (2004) 349-358
38. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates. 6th ed. (2007), Academic Press, San Diego
39. Pepicelli O., Fedele E., Bonanno G., Raiteri M., Ajmone-Cat M.A., Greco A., et al. In vivo activation of N-methyl-d-aspartate receptors in the rat hippocampus increases prostaglandin E (2) extracellular levels and triggers lipid peroxidation through cyclooxygenase-mediated mechanisms. J Neurochem 81 (2002) 1028-1034
40. Perez-De La Cruz V., Elinos-Calderon D., Robledo-Arratia Y., Medina-Campos O.N., Pedraza-Chaverri J., Ali S.F., et al. Targeting oxidative/nitrergic stress ameliorates motor impairment, and attenuates synaptic mitochondrial dysfunction and lipid peroxidation in two models of Huntington's disease. Behav Brain Res 199 (2009) 210-217
41. Porcelli A.M., Angelin A., Ghelli A., Mariani E., Martinuzzi A., Carelli V., et al. Respiratory complex I dysfunction due to mitochondrial DNA mutations shifts the voltage threshold for opening of the permeability transition pore toward resting levels. J Biol Chem 284 (2009) 2045-2052
42. Reddy P.V., Rao K.V., and Norenberg M.D. The mitochondrial permeability transition, and oxidative and nitrosative stress in the mechanism of copper toxicity in cultured neurons and astrocytes. Lab Invest 88 (2008) 816-830
43. Ribeiro C.A., Grando V., Dutra Filho C.S., Wannmacher C.M., and Wajner M. Evidence that quinolinic acid severely impairs energy metabolism through activation of NMDA receptors in striatum from developing rats. J Neurochem 99 (2006) 1531-1542
44. Saldana M., Pujols L., Roca-Ferrer J., Cardozo A., Aguilar E., et al. Relevance of COX-2 gene expression in dementia with lewy bodies associated with Alzheimer pathology. Mov Disord 23 (2008) 804-810
45. Salzberg-Brenhouse H.C., Chen E.Y., Emerich D.F., Baldwin S., Hogeland K., Ranelli S., et al. Inhibitors of cyclooxygenase-2, but not cyclooxygenase-1 provide structural and functional protection against quinolinic acid-induced neurodegeneration. J Pharmacol Exp Ther 306 (2003) 218-228
46. Sas K., Robotka H., Toldi J., and Vecsei L. Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders. J Neurol Sci 257 (2007) 221-239
47. Silakova J.M., Hewett J.A., and Hewett S.J. Naproxen reduces excitotoxic neurodegeneration in vivo with an extended therapeutic window. J Pharmacol Exp Ther 309 (2004) 1060-1066
48. Sottocasa G.L., Kuylenstierna B., Ernster L., and Bergstrand A. An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study. J Cell Biol 32 (1967) 415-438
49. Spitzer J.A., Zheng M., Kolls J.K., Vande Stouwe C., and Spitzer J.J. Ethanol and LPS modulate NF-kappaB activation, inducible NO synthase and COX-2 gene expression in rat liver cells in vivo. Front Biosci 7 (2002) 99-108
50. Stone T.W., and Perkins M.N. Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS. Eur J Pharmacol 72 (1981) 411-412
51. Stowe D.F. Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function. Antioxid Redox Signal 11 (2009) 1373-1414
52. Takemiya T., Matsumura K., and Yamagata K. Roles of prostaglandin synthesis in excitotoxic brain diseases. Neurochem Int 51 (2007) 112-120
53. Vandresen-Filho S., de Araujo Herculano B., Franco J.L., Boeck C.R., Dafre A.L., and Tasca C.I. Evaluation of glutathione metabolism in NMDA preconditioning against quinolinic acid-induced seizures in mice cerebral cortex and hippocampus. Brain Res 1184 (2007) 38-45
54. Velloso N.A., Dalmolin G.D., Fonini G., Gindri Sinhorin V.D., Ferreira da Silveira A., Rubin M.A., et al. Spermine attenuates behavioral and biochemical alterations induced by quinolinic acid in the striatum of rats. Brain Res 1198 (2008) 107-114
55. Warner T.D., and Mitchell J.A. Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic. FASEB J 18 (2004) 790-804
56. Wills E.D. Mechanisms of lipid peroxide formation in animal tissues. Biochem J 99 (1966) 667-676
57. Zahler W.L., and Cleland W.W. A specific and sensitive assay for disulfides. J Biol Chem 243 (1968) 716-719