메뉴 건너뛰기




Volumn 2, Issue 10, 2010, Pages 742-747

EAK proteins: Novel conserved regulators of C. elegans lifespan

Author keywords

Aging; Akt; C. elegans; Cancer; Diabetes; Eak; FoxO; Insulin signaling; Lifespan; Longevity; Osteoporosis

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; AKT 1 PROTEIN, C ELEGANS; AKT-1 PROTEIN, C ELEGANS; CAENORHABDITIS ELEGANS PROTEIN; CYTOCHROME P450; DAF 16 PROTEIN, C ELEGANS; DAF 36 PROTEIN, C ELEGANS; DAF 9 PROTEIN, C ELEGANS; DAF-16 PROTEIN, C ELEGANS; DAF-36 PROTEIN, C ELEGANS; DAF-9 PROTEIN, C ELEGANS; FORKHEAD TRANSCRIPTION FACTOR; OXYGENASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR;

EID: 79954565717     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100214     Document Type: Article
Times cited : (11)

References (44)
  • 1
    • 0027771804 scopus 로고
    • A C. elegans mutant that lives twice as long as wild type
    • Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R. A C. elegans mutant that lives twice as long as wild type. Nature. 1993; 366:461-464.
    • (1993) Nature , vol.366 , pp. 461-464
    • Kenyon, C.1    Chang, J.2    Gensch, E.3    Rudner, A.4    Tabtiang, R.5
  • 2
    • 0033609291 scopus 로고    scopus 로고
    • Signals from the reproductive system regulate the lifespan of C. elegans
    • Hsin H, Kenyon C. Signals from the reproductive system regulate the lifespan of C. elegans. Nature. 1999; 399:362-366.
    • (1999) Nature , vol.399 , pp. 362-366
    • Hsin, H.1    Kenyon, C.2
  • 4
    • 2942563805 scopus 로고    scopus 로고
    • Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
    • Hwangbo DS, Gershman B, Tu MP, Palmer M, Tatar M. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature. 2004; 429:562-566.
    • (2004) Nature , vol.429 , pp. 562-566
    • Hwangbo, D.S.1    Gershman, B.2    Tu, M.P.3    Palmer, M.4    Tatar, M.5
  • 5
    • 0037942739 scopus 로고    scopus 로고
    • Extended longevity in mice lacking the insulin receptor in adipose tissue
    • Bluher M, Kahn BB, Kahn CR. Extended longevity in mice lacking the insulin receptor in adipose tissue. Science. 2003; 299:572-574.
    • (2003) Science , vol.299 , pp. 572-574
    • Bluher, M.1    Kahn, B.B.2    Kahn, C.R.3
  • 7
    • 34547097247 scopus 로고    scopus 로고
    • Brain IRS2 signaling coordinates life span and nutrient homeostasis
    • Taguchi A, Wartschow LM, White MF. Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science. 2007; 317:369-372.
    • (2007) Science , vol.317 , pp. 369-372
    • Taguchi, A.1    Wartschow, L.M.2    White, M.F.3
  • 11
    • 67651151249 scopus 로고    scopus 로고
    • Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity
    • Pawlikowska L, et al. Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell. 2009; 8:460-472.
    • (2009) Aging Cell , vol.8 , pp. 460-472
    • Pawlikowska, L.1
  • 12
    • 70350359126 scopus 로고    scopus 로고
    • Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations
    • Li Y, et al. Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. Hum Mol Genet. 2009; 18:4897-4904.
    • (2009) Hum Mol Genet , vol.18 , pp. 4897-4904
    • Li, Y.1
  • 14
    • 33846295218 scopus 로고    scopus 로고
    • FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis
    • Paik JH, et al. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell. 2007; 128:309-323.
    • (2007) Cell , vol.128 , pp. 309-323
    • Paik, J.H.1
  • 16
    • 75149115329 scopus 로고    scopus 로고
    • FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts
    • Rached MT, Kode A, Xu L, Yoshikawa Y, Paik JH, Depinho RA, Kousteni S. FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts. Cell Metab. 2010; 11:147-160.
    • (2010) Cell Metab , vol.11 , pp. 147-160
    • Rached, M.T.1    Kode, A.2    Xu, L.3    Yoshikawa, Y.4    Paik, J.H.5    Depinho, R.A.6    Kousteni, S.7
  • 19
    • 34548349302 scopus 로고    scopus 로고
    • Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver
    • Matsumoto M, Pocai A, Rossetti L, Depinho RA, Accili D. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab. 2007; 6:208-216.
    • (2007) Cell Metab , vol.6 , pp. 208-216
    • Matsumoto, M.1    Pocai, A.2    Rossetti, L.3    Depinho, R.A.4    Accili, D.5
  • 20
    • 45549090182 scopus 로고    scopus 로고
    • Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation
    • Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA, White MF. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab. 2008; 8:65-76.
    • (2008) Cell Metab , vol.8 , pp. 65-76
    • Dong, X.C.1    Copps, K.D.2    Guo, S.3    Li, Y.4    Kollipara, R.5    DePinho, R.A.6    White, M.F.7
  • 21
    • 63549108476 scopus 로고    scopus 로고
    • Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans
    • Greer EL, Brunet A. Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell. 2009; 8:113-127.
    • (2009) Aging Cell , vol.8 , pp. 113-127
    • Greer, E.L.1    Brunet, A.2
  • 22
    • 0035846604 scopus 로고    scopus 로고
    • daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
    • Henderson ST, Johnson TE. daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol. 2001; 11:1975-1980.
    • (2001) Curr Biol , vol.11 , pp. 1975-1980
    • Henderson, S.T.1    Johnson, T.E.2
  • 23
    • 0035846601 scopus 로고    scopus 로고
    • Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway
    • Lee RY, Hench J, Ruvkun G. Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr Biol. 2001; 11: 1950-1957.
    • (2001) Curr Biol , vol.11 , pp. 1950-1957
    • Lee, R.Y.1    Hench, J.2    Ruvkun, G.3
  • 24
    • 0034967720 scopus 로고    scopus 로고
    • Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF- 1 and germline signaling
    • Lin K, Hsin H, Libina N, Kenyon C. Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF- 1 and germline signaling. Nat Genet. 2001; 28:139-145.
    • (2001) Nat Genet , vol.28 , pp. 139-145
    • Lin, K.1    Hsin, H.2    Libina, N.3    Kenyon, C.4
  • 25
    • 33744976074 scopus 로고    scopus 로고
    • C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span
    • Berdichevsky A, Viswanathan M, Horvitz HR, Guarente L. C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell. 2006; 125:1165-1177.
    • (2006) Cell , vol.125 , pp. 1165-1177
    • Berdichevsky, A.1    Viswanathan, M.2    Horvitz, H.R.3    Guarente, L.4
  • 26
    • 33845736825 scopus 로고    scopus 로고
    • The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans
    • Li J, Tewari M, Vidal M, Lee SS. The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans. Dev Biol. 2007; 301:82-91.
    • (2007) Dev Biol , vol.301 , pp. 82-91
    • Li, J.1    Tewari, M.2    Vidal, M.3    Lee, S.S.4
  • 27
    • 15444371989 scopus 로고    scopus 로고
    • JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16
    • Oh SW, Mukhopadhyay A, Svrzikapa N, Jiang F, Davis RJ, Tissenbaum HA. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci U S A. 2005; 102:4494-4499.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 4494-4499
    • Oh, S.W.1    Mukhopadhyay, A.2    Svrzikapa, N.3    Jiang, F.4    Davis, R.J.5    Tissenbaum, H.A.6
  • 29
    • 33644772542 scopus 로고    scopus 로고
    • Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilichormone signaling
    • Berman JR, Kenyon C. Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilichormone signaling. Cell. 2006; 124:1055-1068.
    • (2006) Cell , vol.124 , pp. 1055-1068
    • Berman, J.R.1    Kenyon, C.2
  • 34
    • 77951208475 scopus 로고    scopus 로고
    • Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan
    • Dumas KJ, Guo C, Wang X, Burkhart KB, Adams EJ, Alam H, Hu PJ. Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan. Dev Biol. 2010; 340:605-612.
    • (2010) Dev Biol , vol.340 , pp. 605-612
    • Dumas, K.J.1    Guo, C.2    Wang, X.3    Burkhart, K.B.4    Adams, E.J.5    Alam, H.6    Hu, P.J.7
  • 35
    • 39949084871 scopus 로고    scopus 로고
    • Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity
    • Zhang Y, Xu J, Puscau C, Kim Y, Wang X, Alam H, Hu PJ. Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity. Dev Biol. 2008; 315:290-302.
    • (2008) Dev Biol , vol.315 , pp. 290-302
    • Zhang, Y.1    Xu, J.2    Puscau, C.3    Kim, Y.4    Wang, X.5    Alam, H.6    Hu, P.J.7
  • 36
    • 33746649803 scopus 로고    scopus 로고
    • Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling
    • Hu PJ, Xu J, Ruvkun G. Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet. 2006; 2:e99.
    • (2006) PLoS Genet , vol.2
    • Hu, P.J.1    Xu, J.2    Ruvkun, G.3
  • 37
    • 48249142372 scopus 로고    scopus 로고
    • Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans
    • Patel DS, Fang LL, Svy DK, Ruvkun G, Li W. Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans. Development. 2008; 135:2239-2249.
    • (2008) Development , vol.135 , pp. 2239-2249
    • Patel, D.S.1    Fang, L.L.2    Svy, D.K.3    Ruvkun, G.4    Li, W.5
  • 39
    • 0042170293 scopus 로고    scopus 로고
    • SDF-9, a protein tyrosine phosphatase-like molecule, regulates the L3/dauer developmental decision through hormonal signaling in C. elegans
    • Ohkura K, Suzuki N, Ishihara T, Katsura I. SDF-9, a protein tyrosine phosphatase-like molecule, regulates the L3/dauer developmental decision through hormonal signaling in C. elegans. Development. 2003; 130:3237-3248.
    • (2003) Development , vol.130 , pp. 3237-3248
    • Ohkura, K.1    Suzuki, N.2    Ishihara, T.3    Katsura, I.4
  • 41
    • 0344530503 scopus 로고    scopus 로고
    • Insulin inhibition of transcription stimulated by the forkhead protein Foxo1 is not solely due to nuclear exclusion
    • Tsai WC, Bhattacharyya N, Han LY, Hanover JA, Rechler MM. Insulin inhibition of transcription stimulated by the forkhead protein Foxo1 is not solely due to nuclear exclusion. Endocrinology. 2003; 144:5615-5622.
    • (2003) Endocrinology , vol.144 , pp. 5615-5622
    • Tsai, W.C.1    Bhattacharyya, N.2    Han, L.Y.3    Hanover, J.A.4    Rechler, M.M.5
  • 44
    • 33750588944 scopus 로고    scopus 로고
    • Nutrient control of phosphorylation and translocation of Foxo1 in C57BL/6 and db/db mice
    • Aoyama H, Daitoku H, Fukamizu A. Nutrient control of phosphorylation and translocation of Foxo1 in C57BL/6 and db/db mice. Int J Mol Med. 2006; 18:433-439.
    • (2006) Int J Mol Med , vol.18 , pp. 433-439
    • Aoyama, H.1    Daitoku, H.2    Fukamizu, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.