Osteogenic protein-1: A review of its utility in spinal applications

BioDrugs

Volumn 20, Issue 4, 2006, Pages 243-251

  Brown, Andrew ^a   Stock, Gordon ^a   Patel, Alpesh A ^a   Okafor, Chukwuka ^a   Vaccaro, Alexander ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; INFUSE; RECOMBINANT OSTEOGENIC PROTEIN 1; RHBMP; RHBMP7; SYNAPSIN I; UNCLASSIFIED DRUG;

BONE DEVELOPMENT; BONE TRANSPLANTATION; CLINICAL TRIAL; DRUG CLEARANCE; HUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; BONE MORPHOGENETIC PROTEIN 7; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; CLINICAL TRIALS; CLINICAL TRIALS AS TOPIC; DRUG DELIVERY SYSTEMS; HUMANS; RECOMBINANT PROTEINS; SPONDYLARTHRITIS; TRANSPLANTATION, AUTOLOGOUS;

EID: 33745925594     PISSN: 11738804     EISSN: 11738804     Source Type: Journal    
DOI: 10.2165/00063030-200620040-00005     Document Type: Review

References (39)

1. Urist MR. Bone: formation by autoinduction. Science 1965; 150: 893-9
2. Einhorn T. Clinical applications of rhBMPs: early experience and future development. J Bone Joint Surg 2003; 85-A Suppl. 3: 82-8
3. Arrington ED, Smith WJ, Chambers HG, et al. Complications of iliac crest bone graft harvesting. Clin Orthop Relat Res 1996 Aug; (329): 300-9
4. Sasso RC, Williams JI, Dimasi N, et al. Posteoperative drains at the donor sites of iliac-crest bone grafts: a prospective, randomized study of morbidity at the donor site in patients who had a traumatic injury of the spine. J Bone Joint Surg Am 1998; 80: 631-5
5. Carlisle E, Fischgrund JS. Bone morphogenetic proteins for spinal fusion. Spine J 2005 Nov-Dec; 5 Suppl. 6: 240-9S
6. Muschler GF, Nakamoto C, Grauer JN. Bone healing and grafting. In: Vaccaro AR, editor. Orthopaedic knowledge update 8. Rosemont (IL): American Academy of Orthopaedic Surgeons, 2005: 29-37
7. Termaat MF, Den Boer FC, Bakker FC, et al. Current concepts review: bone morphogenic proteins. J Bone Joint Surg 2005 Jun; 87A (6): 1367-78
8. Wozney JM, Rosen V, Celeste AJ, et al. Novel regulators of bone formation: molecular clones and activities. Science 1988; 242: 1528-34
9. Alden T, Varady P, Kallmes DF, et al. Bone morphogenic protein gene therapy. Spine 2002; 27 (16S): S87-93
10. ten Dijke P, Korchynskyi O, Valdimarsdottir G, et al. Controlling cell fate by bone morphogenic protein receptors. Mol Cell Endocrinol 2003 Dec 15; 211 (1-2): 105-13
11. ten Dijke P, Fu J, Schaap P, et al. Signal transduction of bone morphogenic proteins in osteoblast differentiation. J Bone Joint Surg 2003; 85-A Suppl. 3: 34-8
12. Ebara S, Nakayama K. Mechanism for the action of bone morphogenic proteins and regulation of their activity. Spine 2002; 27 (16S): S10-5
13. Valentin-Opran A, Wozney J, Csimma C, et al. Clinical evaluation of rhBMP-2. Clin Orthop Relat Res 2002; 3: 79-83
14. Seeherman H, Wozney J, Li R. BMP delivery systems. Spine 2002; 27: S16-23
15. Bruder SP, Fox BS. Tissue engineering of bone: cell based strategies. Clin Orthop Relat Res 1999; 367: S68-83
16. Johnson EE, Urist MR, Finerman GA. Bone morphogenetic protein augmentation grafting of resistant femoral nonunions: a preliminary report. Clin Orthop Relat Res 1988 May; (230): 257-65
17. Johnson EE, Urist MR, Finerman GA. Repair of segmental defects of the tibia with cancellous bone grafts augmented with human bone morphogenetic protein: a preliminary report. Clin Orthop Relat Res 1988 Nov; (236): 249-57
18. Johnson EE, Urist MR, Finerman GA. Distal metaphyseal tibial nonunion: deformity and bone loss treated by open reduction, internal fixation, and human bone morphogenetic protein (hBMP). Clin Orthop Relat Res 1990 Jan; (250): 234-40
19. Johnson EE, Urist MR, Finerman GA. Resistant nonunions and partial or complete segmental defects of long bones: treatment with implants of a composite of human bone morphogenetic protein (BMP) and autolyzed, antigen-extracted, allogeneic (AAA) bone. Clin Orthop Relat Res 1992 Apr; (277): 229-37
20. Harvinder S. Bone morphogenic proteins and spine surgery. Spine 2003; 28 (15S): S64-73
21. Geesink RG, Hoefnagels NH, Bulstra SK. Osteogenic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect. J Bone Joint Surg Br 1999 Jul; 81 (4): 710-8
22. Friedlaender GE, Perry CR, Cole JD, et al. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg Am 2001; 83-A Suppl. 1 (Pt 2): S151-8
23. Vaccaro AR, Patel T, Fischgrund J, et al. A pilot study evaluating the safety and efficacy of OP-1 Putty (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis for degenerative spondylolisthesis. Spine 2004 Sep 1; 29 (17): 1885-92
24. Cook SD, Dalton JE, Tan EH, et al. In vivo evaluation of recombinant human osteogenic protein (rhOP-1) implants as a bone graft substitute for spinal fusions. Spine 1994 Aug 1; 19 (15): 1655-63
25. Paramore CG, Lauryssen C, Rauzzino MJ, et al. The safety of OP-1 for lumbar fusion with decompression: a canine study. Neurosurgery 1999 May; 44 (5): 1151-5
26. Patel TC, Erulkar JS, Grauer JN, et al. Osteogenic protein-1 overcomes the inhibitory effect of nicotine on posterolateral lumbar fusion. Spine 2001 Aug 1; 26 (15): 1656-61
27. Grauer JN, Patel TC, Erulkar JS, et al. 2000 Young Investigator Research Award winner. Evaluation of OP-1 as a graft substitute for intertransverse process lumbar fusion. Spine 2001 Jan 15; 26 (2): 127-33
28. Boden SD, Schimandle JH, Hutton WC. An experimental lumbar intertransverse process spinal fusion model: radiographic, histologic, and biomechanical healing characteristics. Spine 1995 Feb 15; 20 (4): 412-20
29. Magin MN, Delling G. Improved lumbar vertebral interbody fusion using rhOP-1: a comparison of autogenous bone graft, bovine hydroxylapatite (Bio-Oss), and BMP-7 (rhOP-1) in sheep. Spine 2001 Mar 1; 26 (5): 469-78
30. Cunningham BW, Shimamoto N, Sefter JC, et al. Osseointegration of autograft versus osteogenic protein-1 in posterolateral spinal arthrodesis: emphasis on the comparative mechanisms of bone induction. Spine J 2002 Jan-Feb; 2 (1): 11-24
31. Jenis LG, Wheeler D, Parazin SJ, et al. The effect of osteogenic protein-1 in instrumented and noninstrumented posterolateral fusion in rabbits. Spine J 2002 May-Jun; 2 (3): 173-8
32. Grauer JN, Vaccaro AR, Kato M, et al. Development of a New Zealand white rabbit model of spinal pseudarthrosis repair and evaluation of the potential role of OP-1 to overcome pseudarthrosis. Spine 2004 Jul 1; 29 (13): 1405-12
33. Sandhu HS, Khan SN. Animal models for preclinical assessment of bone morphogenetic proteins in the spine. Spine 2002 Aug 15; 27 (16 Suppl. 1): S32-8
34. Vaccaro AR, Anderson DG, Toth CA. Recombinant human osteogenic protein-1 (bone morphogenetic protein-7) as an osteoinductive agent in spinal fusion. Spine 2002 Aug 15; 27 (16 Suppl. 1): S59-65
35. Poynton AR, Lane JM. Safety profile for the clinical use of bone morphogenetic proteins in the spine. Spine 2002 Aug 15; 27 (16 Suppl. 1): S40-8
36. Laursen M, Hoy K, Hansen ES, et al. Related articles, links recombinant bone morphogenetic protein-7 as an intracorporal bone growth stimulator in unstable thoracolumbar burst fractures in humans: preliminary results. Eur Spine J 1999; 8 (6): 485-90
37. Johnsson R, Stromqvist B, Aspenberg P. Randomized radiostereometric study comparing osteogenic protein-1 (BMP-7) and autograft bone in human noninstrumented posterolateral lumbar fusion: 2002 Volvo Award in clinical studies. Spine 2002 Dec 1; 27 (23): 2654-61
38. Vaccaro AR, Patel T, Fischgrund J, et al. A pilot safety and efficacy study of OP-1 putty (rhBMP-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. Eur Spine J 2003 Oct; 12 (5): 495-500. Epub 2003 Aug 8
39. Vaccaro AR, Patel T, Fischgrund J, et al. A 2-year follow-up pilot study evaluating the safety and efficacy of op-1 putty (rhbmp-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions. Eur Spine J 2005 Sep; 14 (7): 623-9. Epub 2005 Jan 26