Symptomatic ectopic bone formation after off-label use of recombinant human bone morphogenetic protein-2 in transforaminal lumbar interbody fusion: Report of 4 cases

Journal of Neurosurgery: Spine

Volumn 12, Issue 1, 2010, Pages 40-46

  Chen, Nan Fu ^a,b   Smith, Zachary A ^b   Stiner, Eric ^b   Armin, Sean ^b,c   Sheikh, Hormoz ^b   Khoo, Larry T ^b  

^a Kaohsiung Armed Force General Hospital   (Taiwan)

^b UCLA MEDICAL CENTER   (United States)

^c LOMA LINDA UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Absorbable collagen sponge; Ectopic bone; Recombinant human bone morphogenetic protein; Transforaminal lumbar interbody fusion

Indexed keywords

NONSTEROID ANTIINFLAMMATORY AGENT; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; STEROID;

ADULT; AGED; ARTICLE; BONE DISEASE; BONE RADIOGRAPHY; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISKOGRAPHY; ECTOPIC BONE; FEMALE; HUMAN; MALE; MYELOGRAPHY; NUCLEAR MAGNETIC RESONANCE IMAGING; OFF LABEL DRUG USE; RADICULOPATHY; RECURRENT DISEASE; REOPERATION; SPINE FUSION; SPONDYLOLISTHESIS; STENOSIS; TRANSFORAMINAL LUMBAR INTERBODY FUSION;

ADMINISTRATION, TOPICAL; ADULT; AGED; BONE MORPHOGENETIC PROTEIN 2; DISKECTOMY; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTERVERTEBRAL DISK DEGENERATION; LAMINECTOMY; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; MYELOGRAPHY; NERVE COMPRESSION SYNDROMES; OFF-LABEL USE; OSSIFICATION, HETEROTOPIC; POSTOPERATIVE COMPLICATIONS; PROSTHESIS IMPLANTATION; RECOMBINANT PROTEINS; REOPERATION; SPINAL FUSION; SPINAL NERVE ROOTS; SPONDYLOLISTHESIS; SURGICAL PROCEDURES, MINIMALLY INVASIVE; TOMOGRAPHY, X-RAY COMPUTED;

EID: 74549207562     PISSN: 15475654     EISSN: 15475646     Source Type: Journal    
DOI: 10.3171/2009.4.SPINE0876     Document Type: Article

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