Bone grafting alternatives in spinal surgery

Spine Journal

Volumn 2, Issue 3, 2002, Pages 206-215

  Vaccaro, Alexander R ^a,j   Chiba, Kazuhiro ^b   Heller, John G ^c   Patel, Tushar Ch ^d   Thalgott, John S ^e   Truumees, Eeric ^f,g   Fischgrund, Jeffrey S ^g   Craig, Matthew R ^h   Berta, Scott C ^a   Wang, Jeffrey C ⁱ  

^a THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

^b KEIO UNIVERSITY   (Japan)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e International Spinal Development and Research Foundation   (United States)

^f WILLIAM BEAUMONT HOSPITAL   (United States)

^g Wayne State University   (United States)

^h VETERANS AFFAIRS MEDICAL CENTER   (United States)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j ROTHMAN INSTITUTE   (United States)

more..

Author keywords

Autologous bone; Bone graft; Bone morphogenetic proteins; Gene therapy; Spinal diseases; Spinal fusion

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN RECEPTOR; CARBOXYMETHYLCELLULOSE; CARRIER PROTEIN; COLLAGEN; GROWTH DIFFERENTIATION FACTOR 5; GROWTH FACTOR; MACROGOL; NICOTINE; OSTEOGENIC PROTEIN 1; POLYGLYCOLIC ACID; POLYLACTIC ACID; POLYMER; RECOMBINANT GROWTH FACTOR;

ADULT; ALLOGRAFT; ALLOTRANSPLANTATION; ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOGRAFT; AUTOLOGOUS BONE MARROW TRANSPLANTATION; AUTOTRANSPLANTATION; BONE CONDUCTION; BONE DEMINERALIZATION; BONE DEVELOPMENT; BONE MATRIX; BONE TRANSPLANTATION; CONTROLLED STUDY; DONOR SITE; DOSE RESPONSE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; FRACTURE HEALING; GENE THERAPY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMPLANTATION; INTERVERTEBRAL DISK DEGENERATION; MALE; METHODOLOGY; MORBIDITY; NONHUMAN; OPERATION DURATION; PROSTHESES AND ORTHOSES; SPINE; SPINE FUSION; SPINE STABILIZATION; SPINE SURGERY; SPONDYLOLISTHESIS; SURGICAL TECHNIQUE; TISSUE INDUCTION; TRANSPLANTATION;

ANIMALS; BONE MATRIX; BONE MORPHOGENETIC PROTEINS; BONE TRANSPLANTATION; GENE THERAPY; HUMANS; MALE; MIDDLE AGED; PROSTHESES AND IMPLANTS; SPINAL FUSION; SPINE; TRANSPLANTATION, HOMOLOGOUS;

EID: 6444245808     PISSN: 15299430     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1529-9430(02)00180-8     Document Type: Article

References (83)

1. Fusion. Biology of lumbar spine fusion and bone graft materials
2. The tension-stress effect on the genesis and growth of tissues. The influence of the rate and frequency of distraction
3. The biology of bone graft repair
4. Physical and biological aspects of repair in dog cortical-bone transplants
5. Autogenous cortical bone grafts in the reconstruction of segmental skeletal defects
6. Complications of iliac crest bone graft harvesting
7. Iliac crest bone graft harvest donor site morbidity. A statistical evaluation
8. Morbidity at bone graft donor sites
9. The function of bone marrow in the incorporation of bone graft
10. The clinical use of combined xenografts of bone and autologous red marrow. A preliminary report
11. The culture of human osteoblasts upon bone graft substitutes
12. Autologous marrow injection as a substitute for operative grafting of tibial nonunions
13. Bone transplantation and the human immunodeficiency virus. An estimate of the risk of acquired immunodeficiency syndrome (AIDS)
14. Use of allografts following resection of tumors of the musculoskeletal system
15. Alternatives to autologous bone graft. Efficacy and indications
16. A prospective analysis of autograft vs. allograft in posterolateral fusion in the same patient. A minimum one year follow-up in 144 patients
17. Bone allografts in spine surgery
18. Exploration of the spine for pseudoarthrosis following spinal fusion in the treatment of scoliosis
19. Experimental spinal fusion with decalcified bone matrix and deep frozen allogenic bone in rabbits
20. Giant cell tumor treated by curettage, cementation, and bone grafting
21. Experimental posterolateral spinal fusion with a demineralized bone matrix gel (Grafton)
22. New formulations of demineralized bone matrix as a more effective graft alternative in experimental posterolateral lumbar spine arthrodesis
23. Feasibility study of Novian SRS in the treatment of unstable distal radius fractures
24. Bone grafting and new composite biosynthetic graft materials
25. Interporous hydroxyapatite as a bone graft substitute in tibial plateau fractures
26. Calcium phosphate ceramics as hard tissue prosthetics
27. Hydroxyapatite and tricalcium phosphate bone graft substitutes
28. Porous hydroxyapatite as a bone graft substitute in diaphyseal defects. A histometric study
29. Skeletal repair by in situ formation of the mineral phase of bone
30. The possible use of coralline hydroxyapatite as a bone implant
31. The evaluation of biphasic calcium phosphate ceramics for use in grafting long bone diaphyseal defects
32. Anterior interbody fusion of the cervical spine with coralline hydroxyapatite
33. The use of coralline hydroxyapatite for interbody spinal fusions
34. Multicenter trial of Collagraft as bone graft substitute
35. Evaluation of bone-grafting materials in a new canine segmental spinal fusion model
36. Regulation of differentiation pathway of skeletal mesenchymal cells in cell lines by transforming growth factor-beta superfamily
37. Transient and localized expression of bone morphogenetic protein 4 messenger RNA during fracture healing
38. Enhanced expression of type I receptors for bone morphogenetic protein during bone formation
39. Distinct and overlapping patterns of localization of bone morphogenetic protein (BMP) family members and a BMP type II receptor during fracture healing in rats
40. Immunohistochemical localization of bone morphogenetic proteins and the receptors in epiphyseal growth plate
41. Bone morphogenetic protein: From basic studies to clinical approaches
42. Cartilage-derived morphogenetic proteins: New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development
43. CDMP-1/GDF-5 and chondrogenesis
44. Role of CDMP-1 in skeletal morphogenesis: Promotion of mesenchymal cell recruitment and chondrocyte differentiation
45. Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily
46. A human chondrodysplasia due to a mutation in a TGF-beta superfamily member
47. Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1
48. Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva
49. Immunohistochemical demonstration of bone morphogenetic protein-2 and transforming growth factor-beta in the ossification of the posterior longitudinal ligament of the cervical spine
50. Bone morphogenetic protein-2 stimulates differentiation of cultured spinal ligament cells from patients with ossification of the posterior longitudinal ligament
51. Bone morphogenetic protein receptors and activin receptors are highly expressed in ossified ligament tissues of patients with ossification of the posterior longitudinal ligament
52. Expression and localization of bone morphogenetic protein (BMPs) and BMP receptors in ossification of the ligamentum flavum
53. Fibroblasts of spinal ligaments pathologically differentiate into chondrocytes induced by recombinant human bone morphogenetic protein-2: Morphological examinations for ossification of spinal ligaments
54. Smad 6 inhibits TGF-beta superfamily signaling
55. Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects
56. Posterolateral intertransverse process spinal arthrodesis with rhBMP2 in a nonhuman primate: Important lessons learned regarding dose, carrier, and safety
57. Induction of dentine in amputated pulp of dogs by recombinant human bone morphogenetic protein-2 and -4 with collagen matrix
58. Ectopic bone induction on and in porous hydroxyapatite combined with collagen and bone morphogenetic protein
59. Telopeptide-depleted bovine skin collagen as a carrier for bone morphogenetic protein
60. Bone morphogenetic protein encapsulated with a biodegradeable and biocompatible polymer
61. Evaluation of polylactic acid homopolymers as carriers for bone morphogenetic protein
62. Polylactic acid-polyethylene glycol block copolymer. A new biodegradable synthetic carrier for bone morphogenetic protein
63. New synthetic absorbable polymers as BMP carriers: Plastic properties of poly-D,L-lactic acid-polyethylene glycol block copolymers
64. Evaluation of carriers of bone morphogenetic protein for spinal fusion
65. Augmentation of autograft using rhBMP-2 and different carrier media in the canine spinal fusion model
66. The use of recombinant human bone morphogenetic protein 2 (rhBMP-2) to promote spinal fusion in a nonhuman primate anterior interbody fusion model
67. The 1995 Volvo award in basic sciences. The use of an osteoconductive growth factor for lumbar spine fusion. Part II: Study of dose, carrier, and species
68. Experimental spinal fusion with recombinant human bone morphogenetic protein 2 (rhBMP-2)
69. Spinal fusion with recombinant human growth and differentiation factor-5 combined with a mineralized collagen matrix
70. 2000 Young Investigator Research Award winner. Evaluation of OP-1 as a graft substitute for intertransverse process lumbar fusion
71. Posterolateral spinal arthrodesis using osteogenic protein-1: An in-vivo time-course study using a canine model
72. OP-1 overcomes the inhibitory effect of nicotine on posterolateral lumbar fusion
73. Improved lumbar vertebral interbody fusion using rhOP-1 a comparison of autogenous bone graft, govine hydroxylapatite (Bio-Oss), and BMP-7 (rhOP-1) in sheep
74. The safety of OP-1 for lumbar fusion with decompression-a canine study
75. The use of rhBMP-2 in interbody fusion cages: Definitive evidence of osteoconduction in humans
76. Posterolateral lumbar fusion using OP-1: Preliminary results
77. A safety and efficacy study of OP-1 (rhBMP-7) as an adjunct to posterolateral lumbar fusion
78. 1998 Volvo award winner in basic science studies. Lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoconductive protein (LMP-1)
79. LMP-1, a LIM-domain protein, mediates BMP-6 effects on bone formation
80. Adenoviral delivery of LIM mineralization protein-1 induces new bone formation in vitro and in vivo
81. The use of biologic materials in spinal fusion
82. Nonautologous interbody fusion materials in cervical spine surgery: How strong is the evidence to justify their use?