Cholesteryl ester transfer protein: The controversial relation to atherosclerosis and emerging new biological roles

IUBMB Life

Volumn 63, Issue 4, 2011, Pages 248-257

  Oliveira, Helena C F ^a   De Faria, Eliana C ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Alzheimer disease; atherosclerosis; CETP; inflammation; obesity

Indexed keywords

ALDOSTERONE; ANACETRAPIB; ATORVASTATIN; CHOLESTEROL; CHOLESTEROL ESTER; CHOLESTEROL ESTER TRANSFER PROTEIN; CHOLESTEROL ESTER TRANSFER PROTEIN INHIBITOR; DALCETRAPIB; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OXIDIZED LOW DENSITY LIPOPROTEIN; TORCETRAPIB;

ADIPOGENESIS; ALZHEIMER DISEASE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ATHEROGENESIS; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; CORONARY ARTERY ATHEROSCLEROSIS; DRUG RESEARCH; DRUG TREATMENT FAILURE; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC RISK; HUMAN; HYPERTENSION; LIPID PEROXIDATION; LIPOPROTEIN BLOOD LEVEL; LIVER METABOLISM; LONGEVITY; MACROPHAGE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIDE EFFECT; SINGLE NUCLEOTIDE POLYMORPHISM;

ADIPOGENESIS; ALZHEIMER DISEASE; ANIMALS; ATHEROSCLEROSIS; CHOLESTEROL; CHOLESTEROL ESTER TRANSFER PROTEINS; CLINICAL TRIALS AS TOPIC; HUMANS; INFLAMMATION; LIPOPROTEINS; MUTATION; OBESITY; OXIDATION-REDUCTION;

EID: 79954515931     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.448     Document Type: Review

References (85)

1. Nichols, A. V., and, Smith, L., (1965) Effect of very low-density lipoproteins on lipid transfer in incubated serum. J. Lipid Res. 6, 206-210.
2. Pattnaik, N. M., Montes, A., Hughes, L. B., and, Zilversmit, D. B., (1978) Cholesteryl ester exchange protein in human plasma isolation and characterization. Biochim. Biophys. Acta. 530, 428-438. (Pubitemid 9016119)
3. Ha, Y. C., and, Barter, P. J., (1982) Differences in plasma cholesteryl ester transfer activity in sixteen vertebrate species. Comp. Biochem. Physiol. B. 71, 265-269.
4. Hesler, C. B., Swenson, T. L., and, Tall, A. R., (1987) Purification and characterization of a human plasma cholesteryl ester transfer protein. J. Biol. Chem. 262, 2275-2282. (Pubitemid 17102658)
5. Drayna, D., Jarnagin, A. S., McLean, J., Henzel, W., Kohr, W., Fielding, C., and, Lawn, R., (1987) Cloning and sequencing of human cholesteryl ester transfer protein cDNA. Nature 327, 632-634. (Pubitemid 17086900)
6. Brown, M. L., Inazu, A., Hesler, C. B., Agellon, L. B., Mann, M. E., Marcel, Y. L., Milne, R. W., Koizumi, J., Mabuchi, H., Takeda, R., and, Tall, A. R., (1989) Molecular basis of lipid transfer protein deficiency in a family with increased high-density lipoproteins. Nature 342, 448-451. (Pubitemid 19277523)
7. Inazu, A., Brown, M. L., Hesler, C. B., Agellon, L. B., Koizumi, J., Takata, K., Maruhama, Y., Mabuchi, H., and, Tall, A. R., (1990) Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation. N. Engl. J. Med. 323, 1234-1238. (Pubitemid 20366528)
8. Swenson, T. L., Hesler, C. B., Brown, M. L., Quinet, E., Trotta, P. P., Haslanger, M. F., Gaeta, F. C. A., Marcels, Y. L., Milne, R. W., and, Tall, A. R., (1989) Mechanism of cholesteryl ester transfer protein inhibition by a neutralizing monoclonal antibody and mapping of the monoclonal antibody epitope. J. Biol. Chem. 264, 14318-14326. (Pubitemid 19214261)
9. Wang, S., Wang, X., Deng, L., Rassart, E., Milne, R. W., and, Tall, A. R., (1993) Point mutagenesis of carboxyl-terminal amino acids of cholesteryl ester transfer protein. Opposite faces of an amphipathic helix important for cholesteryl ester transfer or for binding neutralizing antibody. J. Biol. Chem. 268, 1955-1959. (Pubitemid 23033599)
10. Roy, P., MacKenzie, R., Hirama, T., Jiang, X.-C., Kussie, P., Tall, A. R., Rassart, E., and, Milne, R., (1996) Structure-function relationships of human cholesteryl ester transfer protein: analysis using monoclonal antibodies. J. Lipid Res. 37, 22-34. (Pubitemid 26052616)
11. Agellon, L. B., Quinet, E. M., Gillette, T. G., Drayna, D. T., Brown, M. L., and, Tall, A. R., (1990) Organization of the human cholesteryl ester transfer protein gene. Biochemistry 29, 1372-1376. (Pubitemid 20063363)
12. Jiang, X.-C., Agellon, L. B., Walsh, A., Breslow, J. L., and, Tall, A. R., (1992) Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequences. J. Clin. Invest. 90, 1290-1295.
13. Oliveira, H. C. F., Chouinard, R. A., Agellon, L. B., Bruce, C., Ma, L., Walsh, A., Breslow, J. L., and, Tall, A. R., (1996) Human cholesteryl ester transfer protein gene proximal promoter contains dietary cholesterol positive responsive elements and mediates expression in small intestine and periphery while predominant liver and spleen expression is controlled by 5′-distal sequences. Cis-acting sequences mapped in transgenic mice. J. Biol. Chem. 271, 31831-31838. (Pubitemid 26422203)
14. Luo, Y., and, Tall, A. R., (2000) Sterol upregulation of human CETP expressio in vitro and in transgenic mice by an LXR element. J. Clin. Invest. 105, 513-520. (Pubitemid 30127252)
15. Brousseau, M. E., Schaefer, E. J., Wolfe, M. L., Bloedon, L. T., Digenio, A. G., Clark, R. W., Mancuso, J. P., and, Rader, D. J., (2004) Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol. N. Engl. J. Med. 350, 1505-1515. (Pubitemid 38477775)
16. Barter, P. J., Caulfield, M., Eriksson, M., Grundy, S. M., Kastelein, J. J., Komajda, M., Lopez-Sendon, J., Mosca, L., Tardif, J. C., Waters, D. D., Shear, C. L., Revkin, J. H., Buhr, K. A., Fisher, M. R., and, Tall, A. R., Brewer, B,; ILLUMINATE Investigators. (2007) Effects of torcetrapib in patients at high risk for coronary events. N. Engl. J. Med. 357, 2109-2122. (Pubitemid 350146106)
17. Qiu, X., Mistry, A., Ammirati, M. J., Chrunyk, B. A., Clark, R. W., Cong Y., Culp J. S., Danley D. E., Freeman T. B., Geoghegan K. F., Griffor M. C., Hawrylik S. J., Hayward C. M., Hensley P., Hoth L. R., Karam G. A., Lira M. E., Lloyd D. B., McGrath K. M., Stutzman-Engwall K. J., Subashi A. K., Subashi T. A., Thompson J. F., Wang I. K., Zhao H., and, Seddon A. P., (2007) Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules. Nat. Struct. Mol. Biol. 14, 106-113.
18. Glomset, J. A., (1968) The plasma lecithins: cholesterol acyltransferase reaction. J. Lipid Res. 9, 155-167.
19. Rader, D. J., Alexander, E. T., Weibel, G. L., Billheimer, J., and, Rothblat, G. H., (2009) The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis. J. Lipid Res. 50 Suppl, S189-S194.
20. Hayek, T., Masucci-Magoulas, L., Jiang, X., Walsh, A., Rubin, E., Breslow, J. L., and, Tall, A. R., (1995) Decreased early atherosclerotic lesions in hypertriglyceridemic mice expressing cholesteryl ester transfer protein transgene. J. Clin. Invest. 96, 2071-2074.
21. Föger, B., Chase, M., Amar, M. J., Vaisman, B. L., Shamburek, R. D., Paigen B., Fruchart-Najib J., Paiz J. A., Koch C. A., Hoyt R. F., Brewer H. B. Jr., and, Santamarina-Fojo S., (1999) Cholesteryl ester transfer protein corrects dysfunctional high density lipoproteins and reduces aortic atherosclerosis in lecithin cholesterol acyltransferase transgenic mice. J. Biol. Chem. 274, 36912-36920.
22. Berti, J. A., de Faria, E. C., and, Oliveira, H. C., F. (2005) Atherosclerosis in aged mice over-expressing the reverse cholesterol transport genes. Braz. J. Med. Biol. Res. 38, 391-398. (Pubitemid 40485179)
23. Kako, Y., Massé, M., Huang, L. S., Tall, A. R., and, Goldberg, I. J., (2002) Lipoprotein lipase deficiency and CETP in streptozotocin-treated apoB-expressing mice. J. Lipid Res. 43, 872-877. (Pubitemid 34602608)
24. MacLean, P. S., Bower, J. F., Vadlamudi, S., Osborne, J. N., Bradfield, J. F., Burden H. W., Bensch W. H., Kauffman R. F., and, Barakat H. A., (2003) Cholesteryl ester transfer protein expression prevents diet-induced atherosclerotic lesions in male db/db mice. Arterioscler. Thromb. Vasc. Biol. 23, 1412-1415. (Pubitemid 36994530)
25. Cazita, P. M., Berti, J. A., Aoki, C., Gidlund, M., Harada, L. M., Nunes V. S., Quintão E. C. R., and, Oliveira H. C. F., (2003) Cholesteryl ester transfer protein expression attenuates atherosclerosis in ovariectomized mice. J. Lipid Res. 44, 33-40. (Pubitemid 36114767)
26. Casquero, A. C., Berti, J. A., Salerno, A. G., Bighetti, E. J., Cazita, P. M., Ketelhuth D. F., Gidlund M., and, Oliveira H. C. F., (2006) Atherosclerosis is enhanced by testosterone deficiency and attenuated by CETP expression in transgenic mice. J. Lipid Res. 47, 1526-1534. (Pubitemid 44079907)
27. Harder, C., Lau, P., Meng, A., Whitman, S. C., and, McPherson, R., (2007) Cholesteryl ester transfer protein (CETP) expression protects against diet induced atherosclerosis in SR-BI deficient mice. Arterioscler. Thromb. Vasc. Biol. 27, 858-864. (Pubitemid 46606717)
28. Marotti, K. R., Castle, C. K., Boyle, T. P., Lin, A. H., Murray, R. W., and, Melchior, G. W., (1993) Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein. Nature 364, 73-75. (Pubitemid 23233459)
29. Plump, A. S., Masucci-Magoulas, L., Bruce, C., Bisgaier, C. L., Breslow, J. L., and, Tall, A. R., (1999) Increased atherosclerosis in ApoE and LDL receptor gene knock-out mice as a result of human cholesteryl ester transfer protein transgene expression. Arterioscler. Thromb. Vasc. Biol. 19, 1105-1110. (Pubitemid 29177362)
30. Herrera, V. L., Makrides, S. C., Xie, H. X., Adari, H., Krauss, R. M., Ryan, U. S., and, Ruiz-Opazo, N., (1999) Spontaneous combined hyperlipidemia, coronary heart disease and decreased survival in Dahl salt-sensitive hypertensive rats transgenic for human cholesteryl ester transfer protein. Nat. Med. 5, 1383-1389.
31. Rittershaus, C. W., Miller, D. P., Thomas, L. J., Picard, M. D., Honan, C. M., Emmett C. D., Pettey C. L., Adari H, Hammond R. A., Beattie D. T., Callow A. D., Marsh H. C., and, Ryan U. S., (2000) Vaccine-induced antibodies inhibit CETP activit in vivo and reduce aortic lesions in a rabbit model of atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 20, 2106-2112.
32. Sugano, M., Makino, N., Sawada, S., Otsuka, S., Watanabe, M., Okamoto, H., Kamada, M., and, Mizushima, A., (1998) Effect of antisense oligonucleotides against cholesteryl ester transfer protein on the development of atherosclerosis in cholesterol-fed rabbits. J. Biol. Chem. 273, 5033-5036. (Pubitemid 28108660)
33. Okamoto, H., Yonemori, F., Wakitani, K., Minowa, T., Maeda, K., and, Shinkai, H., (2000) A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits. Nature 406, 203-207. (Pubitemid 30469005)
34. Morton, R. E., (1988) Interaction of plasma-derived lipid transfer protein with macrophages in culture. J. Lipid Res. 29, 1367-1377. (Pubitemid 18261059)
35. Stein, Y., Stein, O., Olivecrona, T., and, Halperin, G., (1985) Putative role of cholesteryl ester transfer protein in removal of cholesteryl ester from vascular interstitium, studied in a model system in cell culture. Biochim. Biophys. Acta. 834, 336-345. (Pubitemid 15025242)
36. Miwa, K., Inazu, A., Kawashiri, M., Nohara, A., Higashikata, T., Kobayashi J., Koizumi J., Nakajima K., Nakano T., Niimi M., Mabuchi H., and, Yamagishi M., (2009) Cholesterol efflux from J774 macrophages and Fu5AH hepatoma cells to serum is preserved in CETP-deficient patients. Clin. Chim. Acta. 402, 19-24.
37. Harada, L. M., Amigo, L., Cazita, P. M., Salerno, A. G., Rigotti, A. A., Quintão, E. C. R., and, Oliveira, H. C. F., (2007) CETP expression enhances liver HDL-cholesteryl ester uptake but does not alter VLDL and biliary lipid secretion. Atherosclerosis 191, 313-318. (Pubitemid 46400715)
38. Tanigawa, H., Billheimer, J. T., Tohyama, J., Zhang, Y., Rothblat, G., and, Rader, D. J., (2007) Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport. Circulation 116, 1267-1273. (Pubitemid 47517538)
39. Van Eck, M., Ye, D., Hildebrand, R. B., Kar Kruijt, J., de Haan, W., oekstra M., Rensen P. C., Ehnholm C., Jauhiainen M., and Van, Berkel T. J., (2007) Important role for bone marrow-derived cholesteryl ester transfer protein in lipoprotein cholesterol redistribution and atherosclerotic lesion development in LDL receptor knockout mice. Circ. Res. 100, 678-685. (Pubitemid 46594882)
40. Hirano, K., Yamashita, S., Nakajima, N., Arai, T., Maruyama, T., Yoshida Y., Ishigami M., Sakai N., Kameda-Takemura K., and, Matsuzawa Y., (1997) Genetic cholesteryl ester transfer protein deficiency is extremely frequent in the Omagari area of Japan: marked hyperalphalipoproteinemia caused by CETP gene mutation is not associated with longevity. Arterioscler. Thromb. Vasc. Biol. 17, 1053-1059. (Pubitemid 27260323)
41. Zhong, S., Sharp, D. S., Grove, J. S., Bruce, C., Yano, K., Curb, J. D., and, Tall, A. R., (1996) Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels. J. Clin. Invest. 97, 2917-2923. (Pubitemid 26197108)
42. Curb, J. D., Abbott, R. D., Rodriguez, B. L., Masaki, K., Chen, R., Sharp, D. S., and, Tall, A. R., (2004) A prospective study of HDL-C and cholesteryl ester transfer protein gene mutations and the risk of coronary heart disease in the elderly. J. Lipid Res. 45, 948-953. (Pubitemid 38552866)
43. Ordovas, J. M., Cupples, L. A., Corella, D., Otvos, J. D., Osgood, D., Martinez A., Lahoz C., Coltell O., Wilson P. W., and, Schaefer E. J., (2000) Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study. Arterioscler. Thromb. Vasc. Biol. 20, 1323-1329. (Pubitemid 30262934)
44. Vasan, R. S., Pencina, M. J., Robins, S. J., Zachariah, J. P., Kaur, G., D'Agostino, R. B., and, Ordovas, J. M., (2009) Association of circulating cholesteryl ester transfer protein activity with incidence of cardiovascular disease in the community. Circulation 120, 2414-2420.
45. Thompson, A., Di Angelantonio, E., Sarwar, N., Erqou, S., Saleheen, D., Dullaart R. P., Keavney B., Ye Z., and, Danesh J., (2008) Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk. JAMA 299, 2777-2788. (Pubitemid 351846853)
46. Tsai, M. Y., Johnson, C., Kao, W. H., Sharrett, A. R., Arends, V. L., Kronmal R., Jenny N. S., Jacobs D. R. Jr., Arnett D., O'Leary D., and, Post W., (2008) Cholesteryl ester transfer protein genetic polymorphisms, HDL cholesterol, and subclinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 200, 359-367.
47. Hiura, Y., Shen, C. S., Kokubo, Y., Okamura, T., Morisaki, T., Tomoike H., Yoshida T., Sakamoto H., Goto Y., Nonogi H., and, Iwai N., (2009) Identification of genetic markers associated with high-density lipoprotein-cholesterol by genome-wide screening in a Japanese population: the Suita study. Circ. J. 73, 1119-1126.
48. Forrest, M. J., Bloomfield, D., Briscoe, R. J., Brown, P. N., Cumiskey A. M., Ehrhart J., Hershey J. C., Keller W. J., Ma X., McPherson H. E., Messina E., Peterson L. B., Sharif-Rodriguez W., Siegl P. K., Sinclair P. J., Sparrow C. P., Stevenson A. S., Sun S. Y., Tsai C., Vargas H., Walker M 3rd, West S. H., White V., and, Woltmann R. F., (2008) Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone. Br. J. Pharmacol. 154, 1465-1473.
49. Duriez, P., Bordet, R., and, Berthelot, P., (2007) The strange case of Dr HDL and Mr HDL: does a NO's story illuminate the mystery of HDL's dark side uncovered by Dr HDL's drug targeting CETP. Med. Hypotheses. 69, 752-757. (Pubitemid 47260662)
50. Yuhanna, I. S., Zhu, Y., Cox, B. E., Hahner, L. D., Osborne-Lawrence, S., Lu, P., Marcel Y. L., Anderson R. G., Mendelsohn M. E., Hobbs H. H., and, Shaul P. W., (2001) High-density lipoprotein binding to scavenger receptor-BI activates endothelial nitric oxide synthase. Nat. Med. 7, 853-857. (Pubitemid 32691642)
51. Nissen, S. E., Tardif, J. C., Nicholls, S. J., Revkin, J. H., Shear C. L., Duggan W. T., Ruzyllo W., Bachinsky W. B., Lasala G. P., and, Tuzcu E. M.,; ILLUSTRATE Investigators. (2007) Effect of torcetrapib on the progression of coronary atherosclerosis. N. Engl. J. Med. 356, 1304-1316. (Pubitemid 46513296)
52. Nicholls, S. J., Tuzcu, E. M., Brennan, D. M., Tardif, J. C., and, Nissen, S. E., (2008) CETP inhibition, HDL raising and progression of coronary atherosclerosis: insights from ILLUSTRATE. Circulation 118, 2506-2514.
53. deGoma, E. M., deGoma, R. L., and, Rader, D. J., (2008) Beyond high-density lipoprotein cholesterol levels evaluating high-density lipoprotein function as influenced by novel therapeutic approaches. J. Am. Coll. Cardiol. 51, 2199-2211. (Pubitemid 351754991)
54. Parthasarathy, S., Barnett, J., and, Fong, L. G., (1990) High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein. Biochim. Biophys. Acta. 1044, 275-283. (Pubitemid 20151285)
55. Castilho, L. N., Oliveira, H. C. F., Cazita, P. M., de Oliveira, A. C., Sesso, A., and, Quintão, E. C. R., (2001) Oxidation of LDL enhances the cholesteryl ester transfer protein (CETP)-mediated cholesteryl ester transfer rate to HDL, bringing on a diminished net transfer of cholesteryl ester from HDL to oxidized LDL. Clin. Chim. Acta. 304, 99-106. (Pubitemid 32124744)
56. Chiba, H., Akita, H., Kotani, K., Kanno, T., and, Manabe, M., (1997) Complete cholesteryl ester transfer protein deficiency increases oxidized-LDL in plasma. Rinsho Byori. 45, 55-57.
57. Sack, M. N., Rader, D. J., and, Cannon, R.O., III., (1994) Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women. Lancet 343, 269-270. (Pubitemid 24039631)
58. Helisten, H., Höckerstedt, A., Wähälä, K., Tiitinen, A., Adlercreutz, H., Jauhiainen, M., and, Tikkanen, M. J., (2001) Accumulation of high-density lipoprotein-derived estradiol-17beta fatty acid esters in low-density lipoprotein particles. J. Clin. Endocrinol. Metab. 86, 1294-1300. (Pubitemid 32323019)
59. Cazita, P. M., Barbeiro, D. F., Moretti, A. I., Quintão, E. C., and, Soriano, F. G., (2008) Human cholesteryl ester transfer protein expression enhances the mouse survival rate in an experimental systemic inflammation model: a novel role for CETP. Shock 30, 590-595.
60. Hardardottir, I., Moser, A. H., Fuller, J., Fielding, C., Feingold, K., and, Grunfeld, C., (1996) Endotoxin and cytokines decrease serum levels and extra hepatic protein and mRNA levels of cholesteryl ester transfer protein in syrian hamsters. J. Clin. Invest. 97, 2585-2592. (Pubitemid 26187346)
61. Masucci-Magoulas, L., Moulin, P., Jiang, X. C., Richardson, H., Walsh, A., Breslow, J. L., and, Tall, A. R., (1995) Decreased cholesteryl ester transfer protein (CETP) mRNA and protein and increased high-density lipoprotein following lipopolysaccharide administration in human CETP transgenic mice. J. Clin. Invest. 95, 1587-1594.
62. Jahangiri, A., de Beer, M. C., Noffsinger, V., Tannock, L. R., Ramaiah, C., Webb N. R., van der Westhuyzen D. R., and, de Beer F. C., (2009) HDL remodeling during the acute phase response. Arterioscler. Thromb. Vasc. Biol. 29, 261-267.
63. Grion, C. M., Cardoso, L. T., Perazolo, T. F., Garcia, A. S., Barbosa, D. S., Morimoto H. K., Matsuo T., and, Carrilho A. J., (2010) Lipoproteins and CETP levels as risk factors for severe sepsis in hospitalized patients. Eur. J. Clin Invest. 40, 330-338.
64. Clark, R. W., Cunningham, D., Cong, Y., Subashi, T. A., Tkalcevic, G. T., Lloyd D. B., Boyd J. G., Chrunyk B. A., Karam G. A., Qiu X., Wang I. K., and, Francone O. L., (2010) Assessment of cholesteryl ester transfer protein inhibitors for interaction with proteins involved in the immune response to infection. J. Lipid Res. 51, 967-974.
65. Yamada, T., Kawata, M., Arai, H., Fukasawa, M., Inoue, K., and, Sato, T., (1995) Astroglial localization of cholesteryl ester transfer protein in normal and Alzheimer's disease brain tissues. Acta. Neuropathol. 90, 633-636.
66. Chen, D. W., Yang, J. F., Tang, Z., Dong, X. M., Feng, X. L., Yu, S., and, Chan, P., (2008) Cholesteryl ester transfer protein polymorphism D442G associated with a potential decreased risk for Alzheimer's disease as a modifier for APOE epsilon4 in Chinese. Brain Res. 1187, 52-57. (Pubitemid 350191809)
67. Arias-Vásquez, A., Isaacs, A., Aulchenko, Y. S., Hofman, A., Oostra, B. A., Breteler M., and van Duijn C. M. (2007) The cholesteryl ester transfer protein (CETP) gene and the risk of Alzheimer's disease. Neurogenetics 8, 189-193. (Pubitemid 47051013)
68. Sanders, A. E., Wang, C., Katz, M., Derby, C. A., Barzilai, N., Ozelius, L., and, Lipton, R. B., (2010) Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia. JAMA 303, 150-158.
69. Rodríguez, E., Mateo, I., Infante, J., Llorca, J., Berciano, J., and, Combarros, O., (2006) Cholesteryl ester transfer protein (CETP) polymorphism modifies the Alzheimer's disease risk associated with APOE epsilon4 allele. J. Neurol. 253, 181-185. (Pubitemid 43255888)
70. Fidani, L., Goulas, A., Crook, R., Petersen, R. C., Tangalos, E., Kotsis, A., and, Hardy, J., (2004) An association study of the cholesteryl ester transfer protein TaqI B polymorphism with late onset Alzheimer's disease. Neurosci. Lett. 357, 152-154. (Pubitemid 38230953)
71. Zhu, H., Gopalraj, R. K., Kelly, J. F., Bennett, D. A., and, Estus, S., (2005) Lack of genetic association of cholesteryl ester transfer protein polymorphisms with late onset Alzheimers disease. Neurosci. Lett. 381, 36-41. (Pubitemid 40693139)
72. Gauthier, B., Robb, M., and, McPherson, R., (1999) Cholesteryl ester transfer protein gene expression during differentiation of human preadipocytes to adipocytes in primary culture. Atherosclerosis 142, 301-307. (Pubitemid 29059488)
73. Qureischie, H., Heun, R., Lütjohann, D., Popp, J., Jessen, F., et al. (2008) CETP polymorphisms influence cholesterol metabolism but not Alzheimer's disease risk. Brain Res 1232, 1-6.
74. Radeau, T., Lau, P., Robb, M., McDonnell, M., Ailhaud, G., and, McPherson, R., (1995) Cholesteryl ester transfer protein (CETP) mRNA abundance in human adipose tissue: relationship to cell size and membrane cholesterol content. J. Lipid Res. 36, 2552-2561. (Pubitemid 26028792)
75. Radeau, T., Robb, M., Lau, P., Borthwick, J., and, McPherson, R., (1998) Relationship of adipose tissue cholesteryl ester transfer protein (CETP) mRNA to plasma concentrations of CETP in man. Atherosclerosis 139, 369-376. (Pubitemid 28361822)
76. Angel, A., and, Bray, G. A., (1979) Synthesis of fatty acids and cholesterol by liver, adipose tissue and intestinal mucosa from obese and control patients. Eur. J. Clin. Invest. 9, 355-362.
77. Vassiliou, G., and, McPherson, R., (2004) Role of cholesteryl ester transfer protein in selective uptake of high density lipoprotein cholesteryl esters by adipocytes. J. Lipid Res. 45, 1683-1693. (Pubitemid 39296208)
78. Gauthier, A., Lau, P., Zha, X., Milne, R., and, McPherson, R., (2005) Cholesteryl ester transfer protein directly mediates selective uptake of high density lipoprotein cholesteryl esters by the liver. Arterioscler. Thromb. Vasc. Biol. 25, 2177-2184. (Pubitemid 41416318)
79. Zhou, H., Li, Z., Silver, D. L., and, Jiang, X.-C., (2006) Cholesteryl ester transfer protein (CETP) expression enhances HDL cholesteryl ester liver delivery, which is independent of scavenger receptor BI, LDL receptor related protein and possibly LDL receptor. Biochim. Biophys. Acta. 1761, 1482-1488. (Pubitemid 44821908)
80. Laimer, M. W., Engl, J., Tschoner, A., Kaser, S., Ritsch, A., Tatarczyk T., Rauchenzauner M., Weiss H., Aigner F., Patsch J. R., and, Ebenbichler C. F.,. (2009) Effects of weight loss on lipid transfer proteins in morbidly obese women. Lipids 44, 1125-1130.
81. Berti, J. A., Casquero, A. C., Patricio, P. R., Bighetti, E. J. B., Carneiro, E. M., Boschero, A. C., and, Oliveira, H. C. F., (2003) Cholesteryl ester transfer protein expression is down-regulated in hyperinsulinemic transgenic mice. J. Lipid. Res. 44, 1870-1876. (Pubitemid 37356659)
82. Terán-García, M., Després, J. P., Tremblay, A., and, Bouchard, C., (2008) Effects of cholesterol ester transfer protein (CETP) gene on adiposity in response to long-term overfeeding. Atherosclerosis 196, 455-460.
83. Salerno, A. G., Silva, T. R., Amaral, M. E., Alberici, L. C., Bonfleur, M. L., Patrício P. R., Francesconi E. P., Grassi-Kassisse D. M., Vercesi A. E., Boschero A. C., and, Oliveira H. C. F., (2007) Overexpression of apolipoprotein CIII increases and CETP reverses diet-induced obesity in transgenic mice. Int. J. Obes. 31, 1586-1595. (Pubitemid 47482661)
84. Zhou, H., Li, Z., Hojjati, M. R., Jang, D., Beyer, T. P., Cao, G., Tall, A. R., and, Jiang, X.-C., (2006) Adipose tissue specific CETP expression in mice: impact on lipoprotein metabolism. J. Lipid Res. 47, 2011-2019. (Pubitemid 44401989)
85. Salerno, A. G., Patrício, P. R., Berti, J. A., and, Oliveira, H. C. F., (2009) Cholesteryl ester transfer protein (CETP) increases postprandial triglyceridaemia and delays triacylglycerol plasma clearance in transgenic mice. Biochem. J. 419, 629-634.