Vaccine-induced antibodies inhibit CETP activity in vivo and reduce aortic lesions in a rabbit model of atherosclerosis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 20, Issue 9, 2000, Pages 2106-2112

  Rittershaus, Charles W ^a   Miller, David P ^a   Thomas, Lawrence J ^a   Picard, Michele D ^a   Honan, Christopher M ^a   Emmett, Constance D ^a   Pettey, Carolyn L ^a   Adari, Hedy ^a   Hammond, Russell A ^a   Beattie, David T ^a   Callow, Allan D ^b   Marsh, Henry C ^a   Ryan, Una S ^a  

^a AVANT Immunotherapeutics Inc   (United States)

^b BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Atherosclerosis; CETP; Lipoproteins; Vaccine

Indexed keywords

CHOLESTEROL; CHOLESTEROL ESTER TRANSFER PROTEIN; HIGH DENSITY LIPOPROTEIN; TETANUS TOXIN; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIBODY TITER; AORTA INJURY; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE MODEL; LIPOPROTEIN BLOOD LEVEL; NONHUMAN; PRIORITY JOURNAL; RABBIT; VACCINATION;

EID: 0033822810     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.20.9.2106     Document Type: Article

References (51)

1. High-density lipoprotein: The clinical implications of recent studies
2. High density lipoproteins and coronary heart disease
3. Effects of diet and exercise m men and postmenopausal women with low levels of HDL cholesterol and high levels of LDL cholesterol
4. Role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors ('statins') in familial combined hyperlipidemia
5. Evaluation of effects of unmodified niacin on fasting and postprandial plasma lipids in normolipidemic men with hypoalphalipoproteinemia
6. Molecular basis of lipid transfer protein deficiency in a family with increased high-density lipoproteins
7. Plasma cholesteryl ester transfer protein
8. Cholesteryl ester transfer protein: Its role in plasma lipid transport
9. Plasma cholesteryl ester transfer protein and high-density lipoproteins: New insights from molecular genetic studies
10. Transfers and exchanges of esterified cholesterol between plasma lipoproteins
11. Monoclonal antibody inhibition of cholesteryl ester transfer protein activity in the rabbit: Effects on lipoprotein composition and high density lipoprotein cholesteryl ester metabolism
12. Inhibition of cholesteryl ester transfer protein activity in hamsters alters HDL lipid composition
13. Inhibition of cholesteryl ester transfer protein by CGS 25159 and changes in lipoproteins in hamsters
14. Changes in plasma lipoprotein cholesterol levels by antisense oligodeoxynucleotides against cholesteryl ester transfer protein in cholesterol-fed rabbits
15. Effect of antisense oligonucleotides against cholesteryl ester transfer protein on the development of atherosclerosis in cholesterol-fed rabbits
16. Reduced high density lipoprotein cholesterol in human cholesteryl ester transfer protein transgenic mice
17. Spontaneous combined hyperlipidemia, coronary heart disease and decreased survival in Dahl salt-sensitive hypertensive rats transgenic for human cholesteryl ester transfer protein
18. Deficiency of serum cholesteryl-ester transfer activity in patients with familial hyperalphalipoproteinaemia
19. Universally immunogenic T cell epitopes promiscuous binding to human MHC class II and promiscuous recognition by T cells
20. Mechanism of cholesteryl ester transfer protein inhibition by a neutralizing monoclonal antibody and mapping of the monoclonal antibody epitope
21. Inhibition of cholesteryl ester transfer protein activity by monoclonal antibody: Effects on cholesteryl ester formation and neutral lipid mass transfer in human plasma
22. Cholesteryl ester transfer protein inhibition in hypercholesterolemic hamsters: Kinetics of apoprotein changes
23. Structure-function studies of human cholesteryl ester transfer protein by linker insertion scanning mutagenesis
24. Monoclonal antibodies to the Mr 74,000 cholesteryl ester transfer protein neutralize all of the cholesteryl ester and triglyceride transfer activities in human plasma
25. Modification of the N-terminal cysteine of plasma cholesteryl ester transfer protein selectively inhibits triglyceride transfer activity
26. Interfacial properties of recombinant human cholesterol ester transfer protein
27. Identification of a sequence within the C-terminal 26 amino acids of cholesteryl ester transfer protein responsible for binding a neutralizing monoclonal antibody and necessary for neutral lipid transfer activity
28. Mammalian adipose tissue and muscle are major sources of lipid transfer protein mRNA
29. Genetic cholesteryl ester transfer protein deficiency caused by two prevalent mutations as a major determinant of increased levels of high density lipoprotein cholesterol
30. Plasma lipid transfer proteins, high-density lipoproteins, and reverse cholesterol transport
31. Cholesteryl ester transfer protein: Friend or foe?
32. Cholesteryl ester transfer protein: An enigmatic protein
33. Exon 10 skipping caused by intron 10 splice donor site mutation in cholesteryl ester transfer protein gene results in abnormal downstream splice site selection
34. Cholesteryl ester transfer protein deficiency caused by a nonsense mutation detected in the patient's macrophage mRNA
35. A novel nonsense mutation (G181X) in the human cholesteryl ester transfer protein gene in Japanese hyperalphalipoproteinemic subjects
36. Mutations in cholesteryl ester transfer protein and hepatic lipase in a North American population
37. Human plasma CETP deficiency: Identification of a novel mutation in exon 9 of the CETP gene in a Caucasian subject from North America
38. A low prevalence of coronary heart disease among subjects with increased high-density lipoprotein cholesterol levels, including those with plasma cholesteryl ester transfer protein deficiency
39. Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels
40. Genetic cholesteryl ester transfer protein deficiency is extremely frequent in the Omagari area of Japan: Marked hyperalphalipoproteinemia caused by CETP gene mutation is not associated with longevity
41. Relation of polymorphisms in the cholesteryl ester transfer protein gene to transfer protein activity and plasma lipoprotein levels in alcohol drinkers
42. Heterogeneity at the CETP gene locus: Influence on plasma CETP concentrations and HDL cholesterol levels
43. Regulation of plasma HDL cholesterol and subfraction distribution by genetic and environmental factors: Associations between the TaqI B RFLP in the CETP gene and smoking and obesity
44. Linkage analysis of the genetic determinants of high density lipoprotein concentrations and composition: Evidence for involvement of the apolipoprotein A-II and cholesteryl ester transfer protein loci
45. Relationship of HDL and coronary heart disease to a common amino acid polymorphism in the cholesteryl ester transfer protein in men with and without hypertriglyceridemia
46. Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacin
47. Drug treatment of lipid disorders
48. Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol. N Engl J Med
49. Hypercholesterolemia in the rabbit induced by feeding graded amounts of low-level cholesterol: Methodological considerations regarding individual variability in response to dietary cholesterol and development of lesion type
50. Action of atorvastatin in combined hyperlipidemia: Preferential reduction of cholesteryl ester transfer from HDL to VLDL1 particles
51. Apparent discontinuation rates in patients prescribed lipid-lowering drugs