Cholesteryl ester transfer protein directly mediates selective uptake of high density lipoprotein cholesteryl esters by the liver

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 25, Issue 10, 2005, Pages 2177-2184

  Gauthier, Andre ^a   Lau, Paulina ^a   Zha, Xiaohui ^a   Milne, Ross ^a   McPherson, Ruth ^a  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

Author keywords

CETP; HDL; Lipoproteins; Selective uptake; Torcetrapib

Indexed keywords

CHOLESTEROL ESTER TRANSFER PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; TORCETRAPIB;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DRUG MECHANISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS;

ADENOVIRIDAE; ANIMALS; ANTIGENS, CD36; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELLS, CULTURED; CHOLESTEROL ESTER TRANSFER PROTEINS; CHOLESTEROL ESTERS; GENE TRANSFER TECHNIQUES; GLYCOPROTEINS; HEPATOCYTES; HUMANS; LIPOPROTEINS, HDL; LIVER; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; QUINOLINES; RECEPTORS, LDL;

EID: 26244455164     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000183613.13929.13     Document Type: Article

References (31)

1. Tall A. Plasma lipid transfer proteins. Annu Rev Biochem. 1995;64: 235-257.
2. Bruce C, Sharp DS, Tall AR. Relationship of HDL and coronary heart disease to a common amino acid polymorphism in the cholesteryl ester transfer protein in men with and without hypertriglyceridemia. J Lipid Res. 1998;39:1071-1078.
3. van der Steeg WA, Kuivenhoven JA, Klerkx AH, Boekholdt SM, Hovingh GK, Kastelein JJ. Role of CETP inhibitors in the treatment of dyslipidemia. Curr Opin Lipidol. 2004;15:631-636.
4. Forrester JS, Makkar R, Shah PK. Increasing high-density lipoprotein cholesterol in dyslipidemia by cholesteryl ester transfer protein inhibition: an update for clinicians. Circulation. 2005;111:1847-1854.
5. Rinninger F, Pittman RC. Regulation of the selective uptake of high density lipoprotein- associated cholesteryl esters. J Lipid Res. 1987;28: 1313-1325.
6. Krieger M. Scavenger receptor class B type I is a multiligand HDL receptor that influences diverse physiologic systems. J Clin Invest. 2001; 108:793-797.
7. Brundert M, Ewert A, Heeren J, Behrendt B, Ramakrishnan R, Greten H, Merkel M, Rinninger F. Scavenger receptor class B type I mediates the selective uptake of high-density lipoprotein-associated cholesteryl ester by the liver in mice. Arterioscler Thromb Vasc Biol. 2005;25:143-148.
8. Hogarth CA, Roy A, Ebert DL. Genomic evidence for the absence of a functional cholesteryl ester transfer protein gene in mice and rats. Comp Biochem Physiol B Biochem Mol Biol. 2003;135:219-229.
9. Calvo D, Vega MA. Identification, primary structure, and distribution of CLA-1, a novel member of the CD36/LIMPII gene family. J Biol Chem. 1993;268:18929-18935.
10. Inazu A, Jiang X-C, Haraki T, Yagi K, Kamon N, Koizumi J, Mabuchi H, Takeda R, Takata K, Moriyama Y, Doi M, Tall A. Genetic cholesteryl ester transfer protein deficiency caused by two prevalent mutations as a major determinant of increased levels of high density lipoprotein cholesterol. J Clin Invest. 1994;94:1872-1882.
11. Vassiliou G, McPherson R. Role of cholesteryl ester transfer protein in selective uptake of high density lipoprotein cholesteryl esters by adipocytes. J Lipid Res. 2004;45:1683-1693.
12. Benoist F, Lau P, McDonnell M, Doelle H, Milne R, McPherson R. Cholesteryl ester transfer protein mediates selective uptake of high density lipoprotein cholesteryl esters by human adipose tissue. J Biol Chem. 1997;272:23572-23577.
13. Collet X, Tall AR, Serajuddin H, Guendouzi K, Royer L, Oliveira H, Barbaras R, Jiang XC, Francone OL. Remodeling of HDL by CETP in vivo and by CETP and hepatic lipase in vitro results in enhanced uptake of HDL CE by cells expressing scavenger receptor B-I. J Lipid Res. 1999;40:1185-1193.
14. Granot E, Tabas I, Tall AR. Human plasma cholesteryl ester transfer protein enhances the transfer of cholesteryl ester from high density lipoproteins into cultured HepG2 cells. J Biol Chem. 1987;262:3482-3487.
15. Rinninger F, Pittman RC. Mechanism of the cholesteryl ester transfer protein-mediated uptake of high density lipoprotein cholesteryl esters by Hep G2 cells. J Biol Chem. 1989;264:6111-6118.
16. Subrahmanyan L, Kisilevsky R. Effects of culture substrates and normal hepatic sinusoidal cells on in vitro hepatocyte synthesis of Apo-SAA. Scand J Immunol. 1988;27:251-260.
17. Thomas SS, Plenkiewicz J, Ison ER, Bols M, Zou W, Szarek WA, Kisilevsky R. Influence of monosaccharide derivatives on liver cell glycosaminoglycan synthesis: 3-deoxy-D-xylo-hexose (3-deoxy-D-galactose) and methyl (methyl 4-chloro-4-deoxy-beta-D-galactopyranosid) uronate. Biochim Biophys Acta. 1995;1272:37-48.
18. Sattler W, Mohr D, Stocker R. Rapid isolation of lipoproteins and assessment of their peroxidation by high-performance liquid chromatography postcolumn chemiluminescence. Methods Enzymol. 1994;233:469-489.
19. Reaven E, Tsai L, Azhar S. Intracellular events in the "selective" transport of lipoprotein- derived cholesteryl esters. J Biol Chem. 1996; 271:16208-16217.
20. Vassiliou G, Benoist F, Lau P, Kavaslar GN, McPherson R. The low density lipoprotein receptor-related protein contributes to selective uptake of high density lipoprotein cholesteryl esters by SW872 liposarcoma cells and primary human adipocytes. J Biol Chem. 2001;276:48823-48830.
21. Clark RW, Sutfin TA, Ruggeri RB, Willauer AT, Sugarman ED, Magnus-Aryitey G, Cosgrove PG, Sand TM, Wester RT, Williams JA, Perlman ME, Bamberger MJ. Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: an initial multidose study of torcetrapib. Arterioscler Thromb Vasc Biol. 2004;24:490-497.
22. Seo T, Al Haideri M, Treskova E, Worgall TS, Kako Y, Goldberg IJ, Deckelbaum RJ. Lipoprotein lipase-mediated selective uptake from low density lipoprotein requires cell surface proteoglycans and is independent of scavenger receptor class B type 1. J Biol Chem. 2000;275: 30355-30362.
23. Stein O, Stein Y. Lipid transfer proteins (LTP) and atherosclerosis. Atherosclerosis. 2005;178:217-230.
24. Marcel YL, McPherson R, Hogue M, Czarnecka H, Zawadzki Z, Weech PK, Whitlock ME, Tall AR, Milne RW. Distribution and concentration of cholesteryl ester transfer protein in plasma of normolipemic subjects. J Clin Invest. 1990;85:10-17.
25. Knecht TP, Pittman RC. A plasma membrane pool of cholesteryl esters that may mediate the selective uptake of cholesteryl esters from high-density lipoproteins. Biochim Biophys Acta. 1989;1002:365-375.
26. Drobnik W, Borsukova H, Bottcher A, Pfeiffer A, Liebisch G, Schutz GJ, Schindler H, Schmitz G. Apo AI/ABCA1-dependent and HDL3-mediated lipid efflux from compositionally distinct cholesterol-based microdomains. Traffic. 2002;3:268-278.
27. Brasseur R, Pillot T, Lins L, Vandekerckhove J, Rosseneu M. Peptides in membranes: tipping the balance of membrane stability. Trends Biochem Sci. 1997;22:167-171.
28. Rye KA, Hime NJ, Barter PJ. Evidence that cholesteryl ester transfer protein-mediated reductions in reconstituted high density lipoprotein size involve particle fusion. J Biol Chem. 1997;272:3953-3960.
29. Linsel-Nitschke P, Tall AR. HDL as a target in the treatment of atherosclerotic cardiovascular disease. Nat Rev Drug Discov. 2005;4:193-205.
30. Brousseau ME, Schaefer EJ, Wolfe ML, Bloedon LT, Digenio AG, Clark RW, Mancuso JP, Rader DJ. Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol. N Engl J Med. 2004;350:1505-1515.
31. Lloyd DB, Lira ME, Wood LS, Durham LK, Freeman TB, Preston G, Qiu X, Sugarman E, Bonnette P, Lanzetti A, Milos PM, Thompson JF. Cholesteryl ester transfer protein variants have differential stability but uniform inhibition by torcetrapib. J Biol Chem. 2005;280:14918-14922.