CETP expression enhances liver HDL-cholesteryl ester uptake but does not alter VLDL and biliary lipid secretion

Atherosclerosis

Volumn 191, Issue 2, 2007, Pages 313-318

  Harada, Lila M ^a   Amigo, Ludwig ^b   Cazita, Patrícia M ^a   Salerno, Alessandro G ^c   Rigotti, Attilio A ^b   Quintão, Eder C R ^a   Oliveira, Helena C F ^c  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^c UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Bile acid metabolism; CETP transgenic mice; Cholesterol metabolism; Hepatic HDL uptake; Reverse cholesterol transport; VLDL metabolism

Indexed keywords

BILE ACID; CHOLESTEROL ESTER; CHOLESTEROL ESTER TRANSFER PROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LIVER PROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADIPOSE TISSUE; ADRENAL GLAND; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BILE SECRETION; CATABOLISM; CONTROLLED STUDY; DIETARY INTAKE; DOWN REGULATION; FEMALE; HOMEOSTASIS; HUMAN; LIPID BILE LEVEL; LIPID TRANSPORT; LIVER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN; STEADY STATE; TRANSGENIC MOUSE;

ANIMALS; BILE; BILE ACIDS AND SALTS; CHOLESTEROL; CHOLESTEROL ESTER TRANSFER PROTEINS; CHOLESTEROL ESTERS; CHOLESTEROL, VLDL; FECES; FEMALE; HUMANS; LIPOPROTEINS, HDL; LIPOPROTEINS, VLDL; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; TIME FACTORS; TRIGLYCERIDES;

EID: 33947180987     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2006.05.036     Document Type: Article

References (38)

1. Attie A.D., Kastelein J.P., and Hayden M.R. Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis. J Lipid Res 42 (2001) 1717-1726
2. Glomset J.A. The plasma lecithins: cholesterol acyltransferase reaction. J Lipid Res 9 (1968) 155-167
3. Santamarina-Fojo S., Lambert G., Hoeg J.M., and Brewer Jr. H.B. Lecithin-cholesterol acyltransferase: role in lipoprotein metabolism, reverse cholesterol transport and atherosclerosis. Curr Opin Lipidol 11 (2000) 267-275
4. Klucken J., Buchler C., Orso E., et al. ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport. Proc Natl Acad Sci USA 97 (2000) 817-822
5. Ji Y., Jian B., Wang N., et al. Scavenger receptor BI promotes high density lipoprotein-mediated cellular cholesterol efflux. J Biol Chem 272 (1997) 20982-20985
6. Rigotti A., Miettinen H.E., and Krieger M. The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues. Endocr Rev 24 (2003) 357-387
7. Kinoshita M., Fujita M., Usui S., et al. Scavenger receptor type BI potentiates reverse cholesterol transport system by removing cholesterol ester from HDL. Atherosclerosis 173 (2004) 197-202
8. Ji Y., Wang N., Ramakrishnan R., et al. Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile. J Biol Chem 274 (1999) 33398-33402
9. Oliveira H.C., Ma L., Milne R., et al. Cholesteryl ester transfer protein activity enhances plasma cholesteryl ester formation Studies in CETP transgenic mice and human genetic CETP deficiency. Arterioscler Thromb Vasc Biol 17 (1997) 1045-1052
10. Morton R.E. Interaction of plasma-derived lipid transfer protein with macrophages in culture. J Lipid Res 29 (1988) 1367-1377
11. Cazita P.M., Berti J.A., Aoki C., et al. Cholesteryl ester transfer protein expression attenuates atherosclerosis in ovariectomized mice. J Lipid Res 44 (2003) 33-40
12. Collet X., Tall A.R., Serajuddin H., et al. Remodeling of HDL by CETP in vivo and by CETP and hepatic lipase in vitro results in enhanced uptake of HDL CE by cells expressing scavenger receptor B-I. J Lipid Res 40 (1999) 1185-1193
13. Granot E., Tabas I., and Tall A.R. Human plasma cholesteryl ester transfer protein enhances the transfer of cholesteryl ester from high density lipoproteins into cultured HepG2 cells. J Biol Chem 262 (1987) 3482-3487
14. Vassiliou G., and McPherson R. Role of cholesteryl ester transfer protein in selective uptake of high density lipoprotein cholesteryl esters by adipocytes. J Lipid Res 45 (2004) 1683-1693
15. Benoist F., Lau P., McDonnell M., et al. Cholesteryl ester transfer protein mediates selective uptake of high density lipoprotein cholesteryl esters by human adipose tissue. J Biol Chem 272 (1997) 23572-23577
16. Dietschy J.M., and Turley S.D. Control of cholesterol turnover in the mouse. J Biol Chem 277 (2002) 3801-3804
17. Ouguerram K., Krempf M., Maugeais C., et al. A new labeling approach using stable isotopes to study in vivo plasma cholesterol metabolism in humans. Metabolism 51 (2002) 5-11
18. Osono Y., Woollett L.A., Marotti K.R., Melchior G.W., and Dietschy J.M. Centripetal cholesterol flux from extrahepatic organs to the liver is independent of the concentration of high density lipoprotein-cholesterol in plasma. Proc Natl Acad Sci USA 93 (1996) 4114-4119
19. Jiang X.C., Agellon L.B., Walsh A., Breslow J.L., and Tall A. Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequences. J Clin Invest 90 (1992) 1290-1295
20. Oliveira H.C., and Quintao E.C. 'In vitro' cholesteryl ester bidirectional flow between high-density lipoproteins and triglyceride-rich emulsions: effects of particle concentration and composition, cholesteryl ester transfer activity and oleic acid. J Biochem Biophys Meth 32 (1996) 45-57
21. Tai M.M. A mathematical model for the determination of total area under glucose tolerance and other metabolic curves. Diabetes Care 17 (1994) 152-154
22. Jiao S., Cole T.G., Kitchens R.T., Pfleger B., and Schonfeld G. Genetic heterogeneity of plasma lipoproteins in the mouse: control of low density lipoprotein particle sizes by genetic factors. J Lipid Res 31 (1990) 467-477
23. Escola-Gil J.C., Julve J., Marzal-Casacuberta A., et al. ApoA-II expression in CETP transgenic mice increases VLDL production and impairs VLDL clearance. J Lipid Res 42 (2001) 241-248
24. Mardones P., Quinones V., Amigo L., et al. Hepatic cholesterol and bile acid metabolism and intestinal cholesterol absorption in scavenger receptor class B type I-deficient mice. J Lipid Res 42 (2001) 170-180
25. Botham K.M., Avella M., Cantafora A., and Bravo E. The hepatic uptake of rat high-density lipoprotein cholesteryl ester is delayed after treatment with cholesteryl ester transfer protein. Proc Soc Exp Biol Med 220 (1999) 31-38
26. Hayek T., Chajek-Shaul T., Walsh A., et al. An interaction between the human cholesteryl ester transfer protein (CETP) and apolipoprotein A-I genes in transgenic mice results in a profound CETP-mediated depression of high density lipoprotein cholesterol levels. J Clin Invest 90 (1992) 505-510
27. Stein O., Dabach Y., Hollander G., et al. Reverse cholesterol transport in mice expressing simian cholesteryl ester transfer protein. Atherosclerosis 164 (2002) 73-78
28. Gauthier A., Lau P., Zha X., Milne R., and McPherson R. Cholesteryl ester transfer protein directly mediates selective uptake of high density lipoprotein cholesteryl esters by the liver. Arterioscler Thromb Vasc Biol 25 (2005) 2177-2184
29. Brousseau M.E., Diffenderfer M.R., Millar J.S., et al. Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion. Arterioscler Thromb Vasc Biol 25 (2005) 1057-1064
30. Masson D., Staels B., Gautier T., et al. Cholesteryl ester transfer protein modulates the effect of liver X receptor agonists on cholesterol transport and excretion in the mouse. J Lipid Res 45 (2004) 543-550
31. Oliveira H.C., Chouinard R.A., Agellon L.B., et al. Human cholesteryl ester transfer protein gene proximal promoter contains dietary cholesterol positive responsive elements and mediates expression in small intestine and periphery while predominant liver and spleen expression is controlled by 5′-distal sequences. Cis-acting sequences mapped in transgenic mice. J Biol Chem 271 (1996) 31831-31838
32. Luo Y., Liang C.P., and Tall A.R. The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor. J Biol Chem 276 (2001) 24767-24773
33. Chiang J.Y., Kimmel R., and Stroup D. Regulation of cholesterol 7 alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). Gene 262 (2001) 257-265
34. Agellon L.B., Drover V.A., Cheema S.K., Gbaguidi G.F., and Walsh A. Dietary cholesterol fails to stimulate the human cholesterol 7 alpha-hydroxylase gene (CYP7A1) in transgenic mice. J Biol Chem 277 (2002) 20131-20134
35. Chen J.Y., Levy-Wilson B., Goodart S., and Cooper A.D. Mice expressing the human CYP7A1 gene in the mouse CYP7A1 knock-out background lack induction of CYP7A1 expression by cholesterol feeding and have increased hypercholesterolemia when fed a high fat diet. J Biol Chem 277 (2002) 42588-42595
36. Rudel L., Deckelman C., Wilson M., Scobey M., and Anderson R. Dietary cholesterol and downregulation of cholesterol 7 alpha-hydroxylase and cholesterol absorption in African green monkeys. J Clin Invest 93 (1994) 2463-2472
37. Nguyen L.B., Xu G., Shefer S., et al. Comparative regulation of hepatic sterol 27-hydroxylase and cholesterol 7alpha-hydroxylase activities in the rat, guinea pig, and rabbit: effects of cholesterol and bile acids. Metabolism 48 (1999) 1542-1548
38. Jiang X.C., Masucci-Magoulas L., Mar J., et al. Down-regulation of mRNA for the low density lipoprotein receptor in transgenic mice containing the gene for human cholesteryl ester transfer protein. Mechanism to explain accumulation of lipoprotein B particles. J Biol Chem 268 (1993) 27406-27412