Modulation of plasmid DNA vaccine antigen clearance by caspase 12 RNA interference potentiates vaccination

Clinical and Vaccine Immunology

Volumn 18, Issue 4, 2011, Pages 533-538

  Geiben Lynn, Ralf ^a   Frimpong Boateng, Kwesi ^a   Letvin, Norman L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 12; CASPASE 8; CASPASE 9; DNA VACCINE; PLASMID DNA; PROTEIN BCL 2; PROTEIN BCL XL; SHORT HAIRPIN RNA; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DNA IMMUNIZATION; DRUG EFFICACY; GENE EXPRESSION; IMMUNOGENICITY; MOUSE; MUSCLE CELL; NONHUMAN; PRIORITY JOURNAL; RNA INTERFERENCE; UPREGULATION;

ANIMALS; ANTIBODIES; ANTIGENS; APOPTOSIS; CASPASE 12; CD8-POSITIVE T-LYMPHOCYTES; INJECTIONS, INTRAMUSCULAR; MICE; MICE, INBRED C57BL; MUSCLE CELLS; PLASMIDS; RNA INTERFERENCE; VACCINATION; VACCINES, DNA;

EID: 79954492561     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00390-10     Document Type: Article

References (42)

1. Baglioni, C., and T. W. Nilsen. 1983. Mechanisms of antiviral action of interferon. Interferon 5:23-42.
2. Barouch, D. H., et al. 2004. Immunogenicity of recombinant adenovirus serotype 35 vaccine in the presence of pre-existing anti-Ad5 immunity. J. Immunol. 172:6290-6297. (Pubitemid 38621236)
3. Billy, E., V. Brondani, H. Zhang, U. Muller, and W. Filipowicz. 2001. Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines. Proc. Natl. Acad. Sci. U. S. A. 98:14428-14433.
4. Caplen, N. J. 2004. Gene therapy progress and prospects. Downregulating gene expression: the impact of RNA interference. Gene Ther. 11:1241-1248.
5. Chattergoon, M. A., et al. 2000. Targeted antigen delivery to antigen-presenting cells including dendritic cells by engineered Fas-mediated apoptosis. Nat. Biotechnol. 18:974-979.
6. Condon, C., S. C. Watkins, C. M. Celluzzi, K. Thompson, and L. D. Falo, Jr. 1996. DNA-based immunization by in vivo transfection of dendritic cells. Nat. Med. 2:1122-1128.
7. Elbashir, S. M., J. Martinez, A. Patkaniowska, W. Lendeckel, and T. Tuschl. 2001. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J. 20:6877-6888. (Pubitemid 33134217)
8. Geiben-Lynn, R., et al. 2008. CD4+ T lymphocytes mediate in vivo clearance of plasmid DNA vaccine antigen expression and potentiate CD8+ T-cell immune responses. Blood 112:4585-4590.
9. Goebels, N., D. Michaelis, H. Wekerle, and R. Hohlfeld. 1992. Human myoblasts as antigen-presenting cells. J. Immunol. 149:661-667.
10. Greenland, J. R., R. Geiben, S. Ghosh, W. A. Pastor, and N. L. Letvin. 2007. Plasmid DNA vaccine-elicited cellular immune responses limit in vivo vaccine antigen expression through Fas-mediated apoptosis. J. Immunol. 178:5652-5658.
11. Hovav, A. H., et al. 2007. Duration of antigen expression in vivo following DNA immunization modifies the magnitude, contraction, and secondary responses of CD8+ T lymphocytes. J. Immunol. 179:6725-6733.
12. Kim, T. W., et al. 2003. Enhancing DNA vaccine potency by combining a strategy to prolong dendritic cell life with intracellular targeting strategies. J. Immunol. 171:2970-2976. (Pubitemid 37093519)
13. Kim, T. W., et al. 2004. Enhancement of suicidal DNA vaccine potency by delaying suicidal DNA-induced cell death. Gene Ther. 11:336-342. (Pubitemid 38220086)
14. Kim, T. W., et al. 2003. Enhancing DNA vaccine potency by coadministration of DNA encoding antiapoptotic proteins. J. Clin. Invest. 112:109-117.
15. Kim, T. W., et al. 2005. Modification of professional antigen-presenting cells with small interfering RNA in vivo to enhance cancer vaccine potency. Cancer Res. 65:309-316. (Pubitemid 40070823)
16. Leitner, W. W., and N. P. Restifo. 2003. DNA vaccines and apoptosis: to kill or not to kill? J. Clin. Invest. 112:22-24.
17. Leitner, W. W., H. Ying, D. A. Driver, T. W. Dubensky, and N. P. Restifo. 2000. Enhancement of tumor-specific immune response with plasmid DNA replicon vectors. Cancer Res. 60:51-55.
18. Leung, R. K., and P. A. Whittaker. 2005. RNA interference: from gene silencing to gene-specific therapeutics. Pharmacol. Ther. 107:222-239.
19. Liu, M. A. 2003. DNA vaccines: a review. J. Intern. Med. 253:402-410.
20. Liu, M. A., B. Wahren, and G. B. Karlsson Hedestam. 2006. DNA vaccines: recent developments and future possibilities. Hum. Gene Ther. 17:1051-1061.
21. Mantegazza, R., et al. 1991. Modulation of MHC class II antigen expression in human myoblasts after treatment with IFN-gamma. Neurology 41:1128-1132.
22. Nakagawa, T., et al. 2000. Caspase-12 mediates endoplasmic-reticulum- specific apoptosis and cytotoxicity by amyloid-beta. Nature 403:98-103. (Pubitemid 30038529)
23. National Researach Council. 1996. Guide for the care and use of laboratory animals. National Academy Press, Washington, DC.
24. Nkolola, J. P., et al. 2010. Breadth of neutralizing antibodies elicited by stable, homogeneous clade A and clade C HIV-1 gp140 envelope trimers in guinea pigs. J. Virol. 84:3270-3279.
25. Orlans, F. B. 1997. Ethical decision making about animal experiments. Ethics Behav. 7:163-171.
26. Paddison, P. J., A. A. Caudy, and G. J. Hannon. 2002. Stable suppression of gene expression by RNAi in mammalian cells. Proc. Natl. Acad. Sci. U. S. A. 99:1443-1448.
27. Pietersz, G. A., C. K. Tang, and V. Apostolopoulos. 2006. Structure and design of polycationic carriers for gene delivery. Mini Rev. Med. Chem. 6:1285-1298.
28. Restifo, N. P. 2000. Building better vaccines: how apoptotic cell death can induce inflammation and activate innate and adaptive immunity. Curr. Opin. Immunol. 12:597-603.
29. Roberts, D. M., et al. 2006. Hexon-chimaeric adenovirus serotype 5 vectors circumvent pre-existing anti-vector immunity. Nature 441:239-243.
30. Ruiz-Vela, A., J. T. Opferman, E. H. Cheng, and S. J. Korsmeyer. 2005. Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep. 6:379-385.
31. Saleh, M., et al. 2006. Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature 440:1064-1068.
32. Sasaki, S., R. R. Amara, A. E. Oran, J. M. Smith, and H. L. Robinson. 2001. Apoptosis-mediated enhancement of DNA-raised immune responses by mutant caspases. Nat. Biotechnol. 19:543-547.
33. Shankar, P., N. Manjunath, and J. Lieberman. 2005. The prospect of silencing disease using RNA interference. JAMA 293:1367-1373. (Pubitemid 40381489)
34. Shata, M. T., L. Stevceva, S. Agwale, G. K. Lewis, and D. M. Hone. 2000. Recent advances with recombinant bacterial vaccine vectors. Mol. Med. Today 6:66-71.
35. Sledz, C. A., M. Holko, M. J. de Veer, R. H. Silverman, and B. R. Williams. 2003. Activation of the interferon system by short-interfering RNAs. Nat. Cell Biol. 5:834-839.
36. Stan, A. C., S. Casares, T. D. Brumeanu, D. M. Klinman, and C. A. Bona. 2001. CpG motifs of DNA vaccines induce the expression of chemokines and MHC class II molecules on myocytes. Eur. J. Immunol. 31:301-310.
37. Terabe, M., et al. 2000. NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat. Immunol. 1:515-520.
38. Whitmire, J. K., J. T. Tan, and J. L. Whitton. 2005. Interferon-gamma acts directly on CD8+ T cells to increase their abundance during virus infection. J. Exp. Med. 201:1053-1059.
39. Williams, B. R. 1997. Role of the double-stranded RNA-activated protein kinase (PKR) in cell regulation. Biochem. Soc. Trans. 25:509-513.
40. Wootz, H., I. Hansson, L. Korhonen, U. Napankangas, and D. Lindholm. 2004. Caspase-12 cleavage and increased oxidative stress during motoneuron degeneration in transgenic mouse model of ALS. Biochem. Biophys. Res. Commun. 322:281-286.
41. Xu, L., and T. Anchordoquy. 2011. Drug delivery trends in clinical trials and translational medicine: challenges and opportunities in the delivery of nucleic acid-based therapeutics. J. Pharm. Sci. 100:38-52.
42. Zong, W. X., et al. 2003. Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J. Cell Biol. 162:59-69.