CD4+ T lymphocytes mediate in vivo clearance of plasmid DNA vaccine antigen expression and potentiate CD8 + T-cell immune responses

Blood

Volumn 112, Issue 12, 2008, Pages 4585-4590

  Geiben Lynn, Ralf ^a   Greenland, John R ^a   Frimpong Boateng, Kwesi ^a   Van Rooijen, Nico ^b   Hovav, Avi Hai ^a   Letvin, Norman L ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; FAS ANTIGEN; FAS LIGAND; GAG PROTEIN; LIPOSOME; LUCIFERASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PLASMID DNA; ANTIGEN; BETA 2 MICROGLOBULIN; EPITOPE;

ADOPTIVE TRANSFER; ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXICITY; DNA IMMUNIZATION; IMMUNOGENICITY; IN VIVO STUDY; INNATE IMMUNITY; INOCULATION; KNOCKOUT MOUSE; MACROPHAGE; MOUSE; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; T CELL DEPLETION; ANIMAL; C57BL MOUSE; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; PLASMID;

ANIMALS; ANTIGENS; ANTIGENS, CD95; BETA 2-MICROGLOBULIN; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; EPITOPES, T-LYMPHOCYTE; FAS LIGAND PROTEIN; IMMUNITY, CELLULAR; LUCIFERASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PLASMIDS; VACCINES, DNA;

EID: 58149380862     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-06-165803     Document Type: Article

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