Building better vaccines: How apoptotic cell death can induce inflammation and activate innate and adaptive immunity

Current Opinion in Immunology

Volumn 12, Issue 5, 2000, Pages 597-603

  Restifo, Nicholas P ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA VACCINE; FAS LIGAND; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA; PROTEIN KINASE; RIBONUCLEASE; RNA; TUMOR NECROSIS FACTOR RECEPTOR; VACCINE;

APOPTOSIS; DENDRITIC CELL; HUMAN; IMMUNE SYSTEM; IMMUNITY; INFLAMMATION; NONHUMAN; REVIEW;

EID: 0033812475     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(00)00148-5     Document Type: Review

References (79)

1. Consequences of cell death. Exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells
2. Natural adjuvants: Endogenous activators of dendritic cells
3. Dendritic cell maturation is induced by mycoplasma infection but not by necrotic cells
4. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
5. Cell death: The significance of apoptosis
6. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
7. Human melanoma cells do not express Fas (Apo-1/CD95) ligand
8. Fas-mediated suicide of tumor-reactive T cells following activation by specific tumor: Selective rescue by caspase inhibition
9. Not so fas: Re-evaluating the role of FasL in autoimmunity and tumor escape
10. Apoptotic death of CD8+ T lymphocytes after immunization: Induction of a suppressive population of Mac l+/Gr-1+ cells
11. Unopposed production of granulocyte-macrophage colony-stimulating factor by tumors inhibits CD8-1+ T cell responses by dysregulating antigen-presenting cell maturation
12. Fas counter-attack - The best form of tumor defense?
13. The central effectors of cell death in the immune system
14. Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies
15. Apoptosis: Definition, mechanisms, and relevance to disease
16. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE
17. Identification and characterization of Ich-3, a member of the interleukin-1 -beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE
18. ERICE, a novel FLICE-activatable caspase
19. Caspase-1 activation of IL-1 beta and IL-18 are essential for Shigella flexneri-induced inflammation
20. Caspase 1-independent IL-1 beta release and inflammation induced by the apoptosis inducer Fas ligand
21. Interleukin-18 (IFN-gamma-inducing factor) induces IL-8 and IL-1 beta via TNF alpha production from non-CD14+ human blood mononuclear cells
22. Generation of mature dendritic cells from a CD14+ cell line (XS52) by IL-4, TNF-alpha, IL-1 beta, and agonistic anti-CD40 monoclonal antibody
23. Migration of Langerhans cells and dermal dendritic cells in skin organ cultures: Augmentation by TNF-alpha and IL-1 beta
24. Signal transduction pathways activated by the IL-1 receptor family: Ancient signaling machinery in mammals, insects, and plants
25. Biologic activities of IL-1 and its role in human disease
26. The IL-1 receptor/toll-like receptor superfamily: Crucial receptors for inflammation and host defense
27. Cytokines as endogenous pyrogens
28. The interleukin-1 system: Receptors, ligands, and ICE in the brain, and their involvement in the fever response
29. The role of IL-18 in innate immunity
30. IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor
31. Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-l-beta-converting enzyme (caspase-1)-deficient mice
32. Interleukln-18
33. Two CD95 (APO-1/Fas) signaling pathways
34. A receptor for phosphatidylserine-specific clearance of apoptotic cells
35. The human 2',5'-oligoadenylate synthetase family: Interferon-induced proteins with unique enzymatic properties
36. The role of 2'-5' oligoadenylate- activated ribonuclease L in apoptosis
37. PKR; a sentinel kinase for cellular stress
38. A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis
39. Structure of the double-stranded RNA-binding domain of the protein kinase PKR reveals the molecular basis of its dSRNA-mediated activation
40. The elF-2 alpha kinases and the control of protein synthesis
41. Cancer therapy using a self-replicating RNA vaccine
42. The apoptosis pathway triggered by the interferon-induced protein kinase PKR requires the third basic domain, initiates upstream of Bcl-2, and involves ICE-like proteases
43. NF-kappa-B activation by double-stranded-RNA-activated protein kinase (PKR) is mediated through NF-kappa-B-inducing kinase and I-kappa-B kinase
44. The role of c-FLIP in modulation of CD95-induced apoptosis
45. Anti-apoptotic strategies of lymphotropic viruses
46. The fight of viruses against apoptosis
47. Viral interference with apoptosis
48. Interaction of the adenovirus 14.7-kDa protein with FLICE inhibits Fas ligand-induced apoptosis
49. HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms
50. The antiviral enzymes PKR and RNase L suppress gene expression from viral and non-viral based vectors
51. Expression of the myxoma virus tumor necrosis factor receptor homologue and M11L genes is required to prevent virus-induced apoptosis in infected rabbit T lymphocytes
52. Myxoma virus M11L ORF encodes a protein for which cell surface localization is critical in manifestation of viral virulence
53. M11L. A novel mitochondria-localized protein of myxoma virus that blocks apoptosis of infected leukocytes
54. Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme
55. Developing recombinant and synthetic vaccines for the treatment of melanoma
56. Predominant role for directly transfected dendritic cells in antigen presentation to CD8+ T cells after gene gun immunization
57. Antigen expression by dendritic cells correlates with the therapeutic effectiveness of a model recombinant poxvirus tumor vaccine
58. Route of immunization and the therapeutic impact of recombinant anticancer vaccines
59. Cutting edge: CD4+ T Cell control of CD8+ T cell reactivity to a model tumor antigen
60. The future of interleukin-2: Enhancing therapeutic anticancer vaccines
61. Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade
62. Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy
63. Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
64. Genetic vaccination with 'self' tyrosinase-related protein 2 causes melanoma eradication but not vitiligo
65. Identification of a MHC class II-restricted human gp100 epitope using DR4-1E transgenic mice
66. gp100/pmel 17 is a murine tumor rejection antigen: Induction of 'self'-reactive, tumoricidal T cells using high-affinity, altered peptide ligand
67. Recombinant virus vaccination against 'self' antigens using anchor-fixed immunogens
68. Generation of polyclonal rabbit antisera to mouse melanoma associated antigens using gene gun immunization
69. Self-tolerance to the murine homologue of a tyrosinase-derived melanoma antigen. Implications for tumor immunotherapy
70. An autologous oral DNA vaccine protects against murine melanoma
71. Vaccination with a recombinant vaccinia virus encoding a 'self' antigen induces autoimmune vitiligo and tumor cell destruction in mice: Requirement for CD4(+) T lymphocytes
72. Enhancement of tumor-specific immune response with plasmid DNA replicon vectors
73. DNA and RNA-based vaccines: Principles, progress and prospects
74. The promise of nucleic acid vaccines
75. CCR6 mediates dendritic cell localization, lymphocyte homeostasis, and immune responses in mucosal tissue
76. Type I interferon as a powerful adjuvant for monocyte-derived dendritic cell development and activity in vitro and in Hu-PBL-SCID mice
77. Alpha/beta interferons potentiate virus-induced apoptosis through activation of the FADD/Caspase-8 death signaling pathway
78. The emerging role of the interferon-induced PKR protein kinase as an apoptotic effector: A new face of death?
79. Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinase