Modulation of doxorubicin activity in cancer cells by conjugation with fatty acyl and terpenyl hydrazones

European Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2010, Pages 1947-1954

  Effenberger, K ^a   Breyer, S ^a   Schobert, R ^a  

^a UNIVERSITY OF BAYREUTH   (Germany)

Author keywords

Apoptosis; Doxorubicin; Fatty acids; Menthol; Multidrug resistance

Indexed keywords

CASPASE 8; CASPASE 9; DOXORUBICIN; DOXORUBICIN MENTHOXYCARBONYL UNDECANOYL HYDRAZONE; DOXORUBICIN N ACYLHYDRAZONE; DOXORUBICIN N HEPTADECANOYL HYDRAZONE; HYDRAZONE DERIVATIVE; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER RESISTANCE; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOTOXICITY; DESENSITIZATION; DRUG CONJUGATION; DRUG EFFICACY; DRUG SPECIFICITY; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA; MELANOMA; MEMBRANE DAMAGE; MITOCHONDRIAL MEMBRANE; MULTIDRUG RESISTANCE; UTERINE CERVIX CARCINOMA;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL PROLIFERATION; DNA; DOXORUBICIN; DRUG SCREENING ASSAYS, ANTITUMOR; FATTY ACIDS; HL-60 CELLS; HUMANS; HYDRAZONES; MITOCHONDRIAL MEMBRANES; MOLECULAR CONFORMATION; PLASMIDS; REACTIVE OXYGEN SPECIES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 77949485534     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.01.037     Document Type: Article

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