Induction of DNA strand breaks by dental composite components compared to x-ray exposure in human gingival fibroblasts

Archives of Toxicology

Volumn 85, Issue 2, 2011, Pages 143-148

  Durner, Jürgen ^a   Dȩbiak, Małgorzata ^b   Bürkle, Alexander ^b   Hickel, Reinhard ^a   Reichl, Franz Xaver ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

DNA strand breaks; Genotoxic potential; HEMA; TEGDMA; X ray

Indexed keywords

BISPHENOL A BIS(2 HYDROXYPROPYL) ETHER DIMETHACRYLATE; DNA; METHACRYLIC ACID METHYL ESTER; TRIETHYLENE GLYCOL DIMETHACRYLATE;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; ELUTION; FIBROBLAST; GENOTOXICITY; GINGIVA; HUMAN; HUMAN CELL; INCUBATION TIME; IONIZING RADIATION; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INJURY; TOOTH RADIOGRAPHY; X RAY;

BISPHENOL A-GLYCIDYL METHACRYLATE; CELL LINE; COMPOSITE RESINS; DNA BREAKS; FIBROBLASTS; GINGIVA; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; METHACRYLATES; METHYLMETHACRYLATE; MUTAGENICITY TESTS; OSMOLAR CONCENTRATION; POLYETHYLENE GLYCOLS; POLYMETHACRYLIC ACIDS; X-RAY THERAPY; X-RAYS;

EID: 79954427384     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-010-0558-0     Document Type: Article

References (39)

1. Anand AK, Jain J, Negi PS et al (2006) Can dose reduction to one parotid gland prevent xerostomia?-A feasibility study for locally advanced head and neck cancer patients treated with intensitymodulated radiotherapy. Clin Oncol 18:497-504 (Pubitemid 43964472)
2. Arossi GA, Lehmann M, Dihl RR, Reguly ML, de Andrade HH (2010) Induced DNA damage by dental resin monomers in somatic cells. Basic Clin Pharmacol Toxicol 106:124-129
3. Birnboim HC, Jevcak JJ (1981) Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation. Cancer Res 41:1889-1892 (Pubitemid 11114591)
4. Brenner DJ, Hall EJ (2007) Computed tomography-an increasing source of radiation exposure. N Engl J Med 357:2277-2284 (Pubitemid 350190758)
5. Burdak-Rothkamm S, Short SC, Folkard M, Rothkamm K, Prise KM (2007) ATR-dependent radiation-induced gamma H2AX foci in bystander primary human astrocytes and glioma cells. Oncogene 26:993-1002
6. Chang MC, Lin LD, Chan CP et al (2009) The effect of BisGMA on cyclooxygenase-2 expression, PGE2 production and cytotoxicity via reactive oxygen species-and MEK/ERK-dependent and-independent pathways. Biomaterials 30:4070-4077
7. Di Pietro A, Visalli G, La Maestra S et al (2008) Biomonitoring of DNA damage in peripheral blood lymphocytes of subjects with dental restorative fillings. Mutat Res 650:115-122
8. Dickey JS, Baird BJ, Redon CE, Sokolov MV, Sedelnikova OA, Bonner WM (2009) Intercellular communication of cellular stress monitored by gamma-H2AX induction. Carcinogenesis 30:1686-1695
9. Durner J, Kreppel H, Zaspel J, Schweikl H, Hickel R, Reichl FX (2009) The toxicokinetics and distribution of 2-hydroxyethyl methacrylate in mice. Biomaterials 30:2066-2071
10. Durner J, Spahl W, Zaspel J, Schweikl H, Hickel R, Reichl FX (2010) Eluted substances from unpolymerized and polymerized dental restorative materials and their Nernst partition coefficient. Dent Mater 26:91-99
11. Elliott A (2009) Issues in medical exposures. J Radiol Prot 29: A107-A121
12. Fliedner TM, Graessle D, Paulsen C, Reimers K (2002) Structure and function of bone marrow hemopoiesis: mechanisms of response to ionizing radiation exposure. Cancer Biother Radiopharm 17:405-426
13. Forst HT (1985) Problems of multiple tests and evaluations in drug research. Arzneim Forsch/Drug Res 35:563-569
14. Geurtsen W, Lehmann F, Spahl W, Leyhausen G (1998) Cytotoxicity of 35 dental resin composite monomers/additives in permanent 3T3 and three human primary fibroblast cultures. J Biomed Mater Res 41:474-480 (Pubitemid 28300113)
15. Goon AT, Bruze M, Zimerson E, Goh CL, Soo-Quee Koh D, Isaksson M (2008) Screening for acrylate/methacrylate allergy in the baseline series: our experience in Sweden and Singapore. Contact Dermatitis 59:307-313
16. Issa Y, Watts DC, Brunton PA, Waters CM, Duxbury AJ (2004) Resin composite monomers alter MTT and LDH activity of human gingival fibroblasts in vitro. Dent Mater 20:12-20
17. Klaassen C (1998) Heavy metals and heavy-metal antagonists. In: Hardman J, Limbird L, Molinoff P, Ruddon R (eds) Goodman and Gilman's. The pharmacological basis of therapeutics. McGraw-Hill, New York, pp 1649-1671
18. Kleinsasser NH, Wallner BC, Harreus UA et al (2004) Genotoxicity and cytotoxicity of dental materials in human lymphocytes as assessed by the single cell microgel electrophoresis (comet) assay. J Dent 32:229-234 (Pubitemid 38328465)
19. Kleinsasser NH, Schmid K, Sassen AW et al (2006) Cytotoxic and genotoxic effects of resin monomers in human salivary gland tissue and lymphocytes as assessed by the single cell microgel electrophoresis (Comet) assay. Biomaterials 27:1762-1770 (Pubitemid 41759470)
20. Mahaney BL, Meek K, Lees-Miller SP (2009) Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem J 417:639-650
21. Menke M, Angelis KJ, Schubert I (2000) Detection of specific DNA lesions by a combination of comet assay and FISH in plants. Environ Mol Mutagen 35:132-138 (Pubitemid 30171822)
22. Miletic VJ, Santini A (2008) Remaining unreacted methacrylate groups in resin-based composite with respect to sample preparation and storing conditions using micro-Raman spectroscopy. J Biomed Mater Res B Appl Biomater 87:468-474
23. Mitzel-Landbeck L, Schutz G, Hagen U (1976) In vitro repair of radiation-induced strand breaks in DNA. Biochim Biophys Acta 432:145-153
24. Moreno-Villanueva M, Pfeiffer R, Sindlinger T et al (2009) A modified and automated version of the 'Fluorimetric Detection of Alkaline DNA Unwinding' method to quantify formation and repair of DNA strand breaks. BMC Biotechnol 9:39-45
25. Nakamura AJ, Rao VA, Pommier Y, Bonner WM (2010) The complexity of phosphorylated H2AX foci formation and DNA repair assembly at DNA double-strand breaks. Cell Cycle 9:389-397
26. Polydorou O, Trittler R, Hellwig E, Kummerer K (2007) Elution of monomers from two conventional dental composite materials. Dent Mater 23:1535-1541 (Pubitemid 350018865)
27. Povirk LF (2006) Biochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaks. DNA Repair (Amst) 5:1199-1212 (Pubitemid 44291610)
28. Redon CE, Dickey JS, Bonner WM, Sedelnikova OA (2009) Gamma-H2AX as a biomarker of DNA damage induced by ionizing radiation in human peripheral blood lymphocytes and artificial skin. Adv Space Res 43:1171-1178
29. Reichl FX, Seiss M, Kleinsasser N et al (2008a) Distribution and excretion of BisGMA in guinea pigs. J Dent Res 87:378-380
30. Reichl FX, Seiss M, Marquardt W et al (2008b) Toxicity potentiation by H2O2 with components of dental restorative materials on human oral cells. Arch Toxicol 82:21-28
31. Schweikl H, Schmalz G, Rackebrandt K (1998) The mutagenic activity of unpolymerized resin monomers in Salmonella typhimurium and V79 cells. Mutat Res 415:119-130 (Pubitemid 28377252)
32. Schweikl H, Spagnuolo G, Schmalz G (2006) Genetic and cellular toxicology of dental resin monomers. J Dent Res 85:870-877 (Pubitemid 44578595)
33. Schwengberg S, Bohlen H, Kleinsasser N et al (2005) In vitro embryotoxicity assessment with dental restorative materials. J Dent 33:49-55 (Pubitemid 40093562)
34. Seiss M, Nitz S, Kleinsasser N et al (2007) Identification of 2, 3-epoxymethacrylic acid as an intermediate in the metabolism of dental materials in human liver microsomes. Dent Mater 23:9-16 (Pubitemid 44880060)
35. Singh NP (2000) Microgels for estimation of DNA strand breaks, DNA protein crosslinks and apoptosis. Mutat Res 455:111-127
36. Spahl W, Budzikiewicz H, Geurtsen W (1998) Determination of leachable components from four commercial dental composites by gas and liquid chromatography/mass spectrometry. J Dent 26:137-145 (Pubitemid 128392124)
37. Tehrany EA, Desobry S (2004) Partition coefficients in food/packaging systems: a review. Food Addit Contam 21:1186-1202 (Pubitemid 40124801)
38. Urcan E, Scherthan H, Styllou M, Haertel U, Hickel R, Reichl FX (2010) Induction of DNA double-strand breaks in primary gingival fibroblasts by exposure to dental resin composites. Biomaterials 31:2010-2014
39. Uzunova Y, Lukanov L, Filipov I, Vladimirov S (2008) Highperformance liquid chromatographic determination of unreacted monomers and other residues contained in dental composites. J Biochem Biophys Meth 70:883-888