Cytotoxicity of 35 dental resin composite monomers/additives in permanent 3T3 and three human primary fibroblast cultures

Journal of Biomedical Materials Research

Volumn 41, Issue 3, 1998, Pages 474-480

  Geurtsen, W ^a   Lehmann, F ^a   Spahl, W ^b   Leyhausen, G ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Additives; Composites; Cytocompatibility; Monomers; Oral fibroblasts; Permanent cells

Indexed keywords

ADDITIVES; BIOCOMPATIBILITY; INITIATORS (CHEMICAL); MONOMERS; TISSUE CULTURE; TOXICITY;

CYTOTOXICITY; FIBROBLASTS;

DENTAL COMPOSITES;

ALCOHOL DERIVATIVE; AMINE; ANILINE DERIVATIVE; BENZOIC ACID DERIVATIVE; BENZOIN; BENZOPHENONE; BENZOYL PEROXIDE; BUTYLCRESOL; CAMPHORQUINONE; DECYLAMINE; HEXANE; HEXYLAMINE; METHACRYLIC ACID DERIVATIVE; MONOMER; PHOSPHINE DERIVATIVE; PHTHALIC ACID DERIVATIVE; RESIN; TOLUIDINE DERIVATIVE; TRIETHYLENE GLYCOL;

ANIMAL CELL; ARTICLE; CYTOTOXICITY; FIBROBLAST; GINGIVA; HUMAN; HUMAN CELL; LIGAMENT; MONOLAYER CULTURE; NONHUMAN; SCREENING; TOOTH FILLING; TOOTH PULP;

3T3 CELLS; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; COMPOSITE RESINS; FIBROBLASTS; HUMANS; MICE; MICE, INBRED BALB C;

EID: 0032487113     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4636(19980905)41:3<474::AID-JBM18>3.0.CO;2-I     Document Type: Article

References (37)

1. W. Spahl and H. Budzikiewicz, "Qualitative analysis by gas and liquid chromatography/mass spectrometry of dental resin composites," Fresenius J. Anal. Chem., 350, 684-691 (1994).
2. W. Spahl, H. Budzikiewic, and W. Geurtsen, "Determination of leachable components from four commercial dental composites by gas and liquid chromatography/mass spectrometry," J. Dent., 26, 137-145 (1998).
3. J. L. Ferracane and J. U. R. Condon, "Rate of elution of leachable components from composite," Dent. Mater., 6, 282-287 (1990).
4. K.-J. Söderholm, M. Zigan, M. Ragan, W. Fischlschweiger, and M. Bergman, "Hydrolytic degradation of dental composites," J. Dent. Res., 63, 1248-1254 (1984).
5. H. Oysaed, I. E. Ruyter, and I. J. Sjovik Kleven, "Release of formaldehyde from dental composites," J. Dent. Res., 67, 1289-1294 (1988).
6. J. L Ferracane, "Elution of leachable components from composites," J. Oral Rehabil., 21, 441-452 (1994).
7. H. R. Stanley, "Local and systemic responses to dental composites and glass ionomers," Adv. Dent. Res., 6, 55-64 (1992).
8. H. R. Stanley, R. L. Bowen, and J. Folio, "Compatibility of various materials with oral tissues. II. Pulp responses to composite ingredients," J. Dent. Res., 58, 1507-1517 (1979).
9. H. Schweikl, G. Schmalz, and B. Bey, "Mutagenicity of dentin bonding agents," J. Biomed. Mater. Res., 28, 1061-1067 (1994).
10. J. Heil, G. Reifferscheid, P. Waldmann, G. Leyhausen, and W. Geurtsen, "Genotoxicity of dental materials," Mut. Res. Genet. Toxicol. Test., 368, 181-194 (1996).
11. N. Olea, R. Pulgar, P. Perez, F. Olea-Serrano, A. Rivas, A. Novillo-Fertrell, V. Pedraza, A. M. Soto, and C. Sonnenschein, "Estrogenicity of resin-based composites and sealants used in dentistry," Environ. Health Perspect., 104, 298-305 (1996).
12. C. Hansel, G. Leyhausen, U. E. H. Mai, and W. Geurtsen, "Effects of various composite resin (co)monomers and extracts on two caries-associated microorganisms in vitro," J. Dent. Res., 77, 60-67 (1998).
13. M. Brännström and O. Vojinovic, "Response of the dental pulp to invasion of bacteria around three filling materials," ASDC J. Dent. Child., 43, 83-89 (1976).
14. J. C. Wataha, C. T. Hanks, S. E. Strawn, and J. C. Fat, "Cytotoxicity of components of resins and other dental restorative materials," J. Oral Rehabil., 21, 453-462 (1994).
15. A. Hensten-Petersen and K. Hegeland, "Sensitivity of different human cell lines in the biological evaluation of dental resinbased restorative materials," Scand. J. Dent. Res., 89, 102-107 (1981).
16. F. Lehmann, G. Leyhausen, W. Spahl, and W. Geurtsen, "Comparative cell culture studies of the cytotoxicity of composite resin components," Dtsch. Zahnärztl. Z., 48, 651-653 (1993).
17. F. Lehmann, G. Leyhausen, and W. Geurtsen, "Cytotoxic alterations in different fibroblast cultures caused by matrix monomers," J. Dent. Res., 72, 219 (abstr. 929) (1993).
18. G. Schmalz, "Use of cell cultures for toxicity testing of dental materials - advantages and limitations," J. Dent., 22 (Suppl. 2), S6-S11 (1994).
19. F. Lehmann, G. Leyhausen, and W. Geurtsen, "Usefulness of primary gingival fibroblast cultures for cytotoxicity tests," J. Dent. Res., 75, 254 (abstr. 1896) (1996).
20. C. T. Hanks, R. G. Craig, M. L. Diehl, and D. H. Pashley, "Cytotoxicity of dental composites and other materials in a new in vitro device," J. Oral Pathol., 17, 396-403 (1988).
21. Nakamura, H. Koda, and H. Kawahara, "A proposition for long-term biocompatibility test of dental materials in vitro," Dent. Mater. J., 2, 113-123 (1983).
22. W. Geurtsen, "Investigations into the duration of the toxicity of a composite," Dtsch. Zahnärztl. Z., 41, 496-498 (1986).
23. W. Geurtsen, "Long-term effects of a composite on cultured human gingiva cells," J. Dent. Res., 68, 330 (abstr. 1789) (1987).
24. M. A. Rathbun, R. G. Craig, C. T. Hanks, and F. E. Filisko, "Cytotoxicity of a Bis-GMA dental composite before and after leaching in organic solvents," J. Biomed. Mater. Res., 25, 443-457 (1991).
25. C. T. Hanks, S. E. Strawn, J. C. Wataha, and R. G. Craig, "Cytotoxic effects of resin components on cultured mammalian fibroblasts," J. Dent. Res., 70, 1450-1455 (1991).
26. M. R. Nassiri, C. T. Hanks, M. J. Cameron, S. E. Strawn, and R. G. Craig, "Application of flow cytometry to determine the cytotoxicity of urethane dimethacrylate in human cells," J. Biomed. Mater. Res., 28, 153-158 (1994).
27. G. Leyhausen, M. Abtahi, M. Karbakhsch, A. Sapotnik, and W. Geurtsen, "The biocompatibility of various resin-modified and one conventional glass-ionomer cement," Biomaterials (to appear).
28. K. Langeland, "Correlation of screening tests to usage tests," J. Endodomol., 4, 300-303 (1978).
29. 51Cr release assay for cytotoxicity determination of dental biomaterials," Dent. Mater., 11, 327-331 (1995).
30. M. Terakado, M. Yamazaki, Y. Tsujimoto, T. Kawashima, K. Nagashima, J. Ogawa, Y. Fujita, H. Sugiya, T. Sakai, and S. Furuyama, "Lipid peroxidation as a possible cause of benzoyl peroxide toxicity in rabbit dental pulp - a microsomal lipid peroxidation in vitro," J. Dent. Res., 63, 901-905 (1984).
31. S. Fujisawa, Y. Kadoma, and E. Masuhara, "A calorimetric study of the interaction of synthetic phospholipid liposomes with vinyl monomers, acrylates and methacrylates," J. Biomed. Mater. Res., 18, 1105-1114 (1984).
32. W. H. Lawrence, G. E. Bass, W. P. Purcell, and J. Autian, "Use of mathematical models in the study of structure-toxicity relationships of dental compounds: I. Esters of acrylic and methacrylic acids," J. Dent. Res., 51, 526-535 (1972).
33. S. Fujisawa, Y. Imai, K. Kojima, and E. Masuhara, "Studies on the hemolytic activity of bisphenol A diglycidyl methacrylate (BIS-GMA)," J. Dent. Res., 57, 98-102 (1978).
34. 13C NMR studies of the interaction of eugenol, phenol, and triethylenglycol dimethacrylate with phospholipid liposomes as a model system for odontoblast membranes," J. Dent. Res., 67, 1438-1441 (1988).
35. W. Spahl, "Analyse zahnmedizinischer Komposite auf extrahierbare Restmonomere und Additive mit Hilfe der Gaschromatographie/Massenspektrometrie und der Hochleistungs-flüssigkeitschromatographie/Massenspektrometrie," Chemistry thesis, Cologne, 1995.
36. W. Geurtsen, "Substances released from dental resin composites and glass-ionomer cements," Eur. J. Oral Sci. (to appear).
37. J. F. Glenn, "Comments on Dr. Bowen's presentation," J. Dent. Res., 58, 1493 (1979).