Prohepcidin and iron metabolism parameters in the obese elderly patients with anemia

Journal of Nutrition, Health and Aging

Volumn 15, Issue 4, 2011, Pages 259-264

  Przybyszewska, Justyna ^a   Zekanowska, E ^a   Kedziora Kornatowska, K ^a   Boinska, J ^a   Cichon, R ^a   Porzych, K ^a  

^a NICOLAUS COPERNICUS UNIVERSITY   (Poland)

Author keywords

anemia; elderly; iron metabolism; obesity; Prohepcidin

Indexed keywords

C REACTIVE PROTEIN; ERYTHROPOIETIN; FERRITIN; INTERLEUKIN 6; PROHEPCIDIN; TRANSFERRIN;

AGED; ANTHROPOMETRIC PARAMETERS; ANTHROPOMETRY; ARTICLE; BICEPS BRACHII MUSCLE; BLOOD CELL COUNT; BODY FAT; BODY FAT DISTRIBUTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FAT CONTENT; FEMALE; HUMAN; IRON METABOLISM; MAJOR CLINICAL STUDY; MALE; MICROCYTIC ANEMIA; OBESITY; PRIORITY JOURNAL; PROTEIN INTAKE; SKINFOLD THICKNESS;

EID: 79954417476     PISSN: 12797707     EISSN: 17604788     Source Type: Journal    
DOI: 10.1007/s12603-010-0320-6     Document Type: Article

References (39)

1. J.M. Guralnik W.B. Ershler S.L. Schrier, et al. 2005 Anemia in the Elderly: A Public Health Crisis in Hematology Hematology 1 528 532 10.1182/asheducation-2005.1.528
2. L. Balducci 2003 Epidemiology of Anemia in the Elderly: Information on Diagnostic Evaluation J Am Geriatr Soc 51 2 9 10.1046/j.1532-5415.51.3s.4.x
3. S. Bekri P. Gual R. Anty, et al. 2006 Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH Gastroenterol 131 691 693 10.1053/j.gastro.2006.07.007 (Pubitemid 44316823)
4. B. Chung P. Matak A.T. McKie, et al. 2007 Leptin Increases the Expression of the Iron Regulatory Hormone Hepcidin in HuH7 Human Hepatoma Cells J Nutr 137 2366 2370 1:CAS:528:DC%2BD2sXht1ynsb3M (Pubitemid 350058702)
5. P. Farahani S. Chiu C.L. Bowlus, et al. 2004 Obesity in BSB mice is correlated with expression of genes for iron homeostasis and leptin Obes Res 12 191 204 14981211 10.1038/oby.2004.26 1:CAS:528:DC%2BD2cXislarur4%3D (Pubitemid 41132542)
6. A. Lecube A. Carrera E. Losada, et al. 2006 Iron deficiency in obese postmenopausal women Obesity 14 1724 1730 17062801 10.1038/oby.2006.198 1:CAS:528:DC%2BD28Xht1ehtbnK (Pubitemid 46214794)
7. K.G. Nead J.S. Halterman J.M. Kaczorowski, et al. 2004 Overweight children and adolescents: a risk group for iron deficiency Pediatrics 114 104 108 15231915 10.1542/peds.114.1.104 (Pubitemid 38857573)
8. O. Pinhas-Hamiel R.S. Newfield I. Koren, et al. 2003 Greater prevalence of iron deficiency in overweight and obese children and adolescents Int J Obes Relat Metab Disord 27 416 418 12629572 10.1038/sj.ijo.0802224 1:CAS:528:DC%2BD3sXhslKqtr4%3D (Pubitemid 36384882)
9. L.B. Yanoff C.M. Menzie B. Denkinger, et al. 2007 Inflammation and iron deficiency in the hypoferremia of obesity Int J Obes (Lond) 9 1412 1419 10.1038/sj.ijo.0803625 (Pubitemid 47339930)
10. M. Olivares E. Hertrampf M.T. Capurro, et al. 2000 Prevalence of anemia in elderly subjects living at home: role of micronutrient deficiency and inflammation Eur J Clin Nutr. 54 834 839 11114677 10.1038/sj.ejcn.1601099 1:STN:280:DC%2BD3M3jtFOqsA%3D%3D
11. F. Lago C. Dieguez J. Gómez-Reino, et al. 2007 Adipokines as emerging mediators of immune response and inflammation Nat Clin Pract Rheumatol 3 716 724 18037931 10.1038/ncprheum0674 1:CAS:528:DC%2BD2sXhtlCqsr%2FF (Pubitemid 350187017)
12. F. Lago C. Dieguez J. Gomez-Reino, et al. 2007 The emerging role of adipokines as mediators of inflammation and immune responses Cytokine Growth Factor Rev 18 313 325 17507280 10.1016/j.cytogfr.2007.04.007 1:CAS:528:DC%2BD2sXmsFCms7w%3D (Pubitemid 46891288)
13. E.D. Rosen B.M. Spiegelman 2006 Adipocytes as regulators of energy balance and glucose homeostasis Nature 444 847 853 17167472 10.1038/nature05483 1:CAS:528:DC%2BD28XhtlShtrzI (Pubitemid 46024991)
14. G. Nicolas C. Chauvet L. Viatte, et al. 2002 The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation J Clin Invest 110 1037 1044 12370282 1:CAS:528:DC%2BD38XnslSktrs%3D
15. C.H. Park E.V. Valore A.J. Waring, et al. 2001 Hepcidin, a urinary antimicrobial peptide synthesized in the liver J Biol Chem 276 7806 7810 11113131 10.1074/jbc.M008922200 1:CAS:528:DC%2BD3MXitFKhtbo%3D
16. A. Krause S. Neitz H.J. Magert, et al. 2000 LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity FEBS Lett 480 147 150 11034317 10.1016/S0014-5793(00)01920-7 1:CAS:528:DC%2BD3cXmt1Sju78%3D
17. H.N. Hunter D.B. Fulton T. Ganz, et al. 2002 The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis J Biol Chem 277 37597 37603 12138110 10.1074/jbc.M205305200 1:CAS:528:DC%2BD38XnsVejsLY%3D
18. C. Benedict A.J. Ghio H. Gehring, et al. 2007 Transient hypoxia and downregulation of circulating prohepcidin concentrations in healthy young men Haematologica 92 125 126 17229646 10.3324/haematol.10637 1:CAS:528: DC%2BD2sXitlOrtbs%3D (Pubitemid 46232667)
19. P.S. Leung S.K. Srai M. Mascarenhas, et al. 2005 Increased duodenal iron uptake and transfer in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression Gut 54 1391 1395 15914574 10.1136/gut.2004.062083 1:CAS:528:DC%2BD2MXhtFCksrfP (Pubitemid 41375194)
20. K.B. Hadley L.K. Johnson J.R. Hunt 2006 Iron absorption by healthy women is not associated with either serum or urinary prohepcidin Am J Clin Nutr 84 150 155 16825689 1:CAS:528:DC%2BD28XntVerur0%3D (Pubitemid 44699179)
21. M.D. Knutson M. Oukka L.M. Koss, et al. 2005 Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin Proc Natl Acad Sci U S A 102 1324 1328 15665091 10.1073/pnas.0409409102 1:CAS:528:DC%2BD2MXhs1KlsLo%3D (Pubitemid 40209169)
22. A.H. Laftah B. Ramesh R.J. Simpson, et al. 2004 Effect of hepcidin on intestinal iron absorption in mice Blood 103 3940 3944 14751922 10.1182/blood-2003-03-0953 1:CAS:528:DC%2BD2cXjvF2hsrg%3D (Pubitemid 38596316)
23. S. Rivera L. Liu E. Nemeth, et al. 2005 Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia Blood 105 1797 1802 15479721 10.1182/blood-2004-08-3375 1:CAS:528:DC%2BD2MXhsVGjsbw%3D (Pubitemid 40223704)
24. S. Rivera E. Nemeth V. Gabayan, et al. 2005 Synthetic hepcidin causes rapid dosedependent hypoferremia and is concentrated in ferroportin-containing organs Blood 106 2196 2199 15933050 10.1182/blood-2005-04-1766 1:CAS:528:DC%2BD2MXhtVWksLjJ (Pubitemid 41291740)
25. D.A. Weinstein C.N. Roy M.D. Fleming, et al. 2002 Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease Blood 100 3776 3781 12393428 10.1182/blood-2002-04-1260 1:CAS:528:DC%2BD38XoslKlsrs%3D (Pubitemid 35303951)
26. S. Yamaji P. Sharp B. Ramesh, et al. 2004 Inhibition of iron transport across human intestinal epithelial cells by hepcidin Blood 104 2178 2180 15178582 10.1182/blood-2004-03-0829 1:CAS:528:DC%2BD2cXotVOqu7k%3D (Pubitemid 39297875)
27. F. Lainé A. Jouannolle J. Morcet, et al. 2005 Phenotypic expression in detected C282Y homozygous women depends on body mass index J Hepatol 43 1055 1059 16139917 10.1016/j.jhep.2005.05.027 (Pubitemid 41627992)
28. L.M. Tussing-Humphreys E. Nemeth G. Fantuzzi, et al. 2010 Elevated systemic hepcidin and iron depletion in obese premenopausal females Obesity 18 1449 1456 19816411 10.1038/oby.2009.319 1:CAS:528:DC%2BC3cXnvFymtb4%3D
29. L.B. Yanoff C.M. Menzie B. Denkinger, et al. 2007 Inflammation and iron deficiency in the hypoferremia of obesity Int J Obes 31 1412 1419 10.1038/sj.ijo.0803625 1:CAS:528:DC%2BD2sXpsF2qur4%3D (Pubitemid 47339930)
30. E. Miraglia del Giudice N. Santoro A. Amato, et al. 2009 Hepcidin in obese children as a potential mediator of the association between obesity and iron deficiency J Clin Endocrinol Metab 94 5102 5107 10.1210/jc.2009-1361 1:CAS:528:DC%2BD1MXhsFyltbzE
31. M.W. Richardson L. Ang P.F. Visintainer, et al. 2009 The Abnormal Measures of Iron Homeostasis in Pediatric Obesity Are Associated with the Inflammation of Obesity Int J Pediatr Endocrinol 2009 713269 19956746
32. World Health Organization (1972) Nutritional anaemias: report of a WHO group of experts. WHO, Geneva
33. Malinowski A, Boiow W (1997) Podstawy antropometrii. Metody, techniki, normy. PWN, Warszawa - ód
34. World Health Organization (1995) Physical status: the use and interpretation of anthropometry. Technical Report Series 854. WHO, Genewa,.
35. Gibson RS (2003) Principles of nutritional assessment. Oxford University Press, New York
36. Heymsfield SB, Williams PJ (1998) Nutritional assessment by clinical and biochemical methods. In: Shils ME, Young V R Lea Febiger (eds) Modern nutrition in health and disease, Ed. 7th; Ch. 45. Philadelfia, pp 817-860
37. Szczygie B (2001) Metody oceny stanu odywienia chorych w szpitalach. In: Dzieniszewski J, Szponar L, Szczygie B, Socha J (eds) Podstawy naukowe ywienia w szpitalach, I, Warszawa, pp 324-339
38. G. Nicolas M. Bennoun A. Porteu, et al. 2002 Severe iron deficiency anemia in transgenic mice expressing liver hepcidin Proc Natl Acad Sci USA 99 4596 4601 11930010 10.1073/pnas.072632499 1:CAS:528:DC%2BD38XivFShu7o%3D (Pubitemid 34286030)
39. U. Merle E. Fein S.G. Gehrke, et al. 2007 The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation Endocrinology 148 2663 2668 17363462 10.1210/en.2006-1331 1:CAS:528: DC%2BD2sXmt1ajt7w%3D (Pubitemid 46984791)