Differential effects of multiplicity of infection on Helicobacter pylori-induced signaling pathways and interleukin-8 gene transcription

Journal of Clinical Immunology

Volumn 31, Issue 1, 2011, Pages 60-68

  Ritter, Birgit ^a   Kilian, Petra ^a   Reboll, Marc Rene ^b   Resch, Klaus ^a   DiStefano, Johanna Kay ^c   Frank, Ronald ^b   Beil, Winfried ^a   Nourbakhsh, Mahtab ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

Author keywords

duodenal ulcer; gastritis; Helicobacter pylori; interleukin 8; signal transduction; transcription

Indexed keywords

BACTERIAL PROTEIN; CAGA PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN DUPA; UNCLASSIFIED DRUG; VACUOLATING TOXIN;

ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; BINDING SITE; CAGA GENE; CONTROLLED STUDY; DUPA GENE; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC TRANSCRIPTION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; VACA GENE;

BACTERIAL LOAD; BACTERIAL PROTEINS; CELL LINE; DUODENAL ULCER; EPITHELIAL CELLS; GASTRITIS; GENE EXPRESSION REGULATION; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; INTERLEUKIN-8; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NF-KAPPA B; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; STOMACH; TRANSCRIPTION, GENETIC; VIRULENCE FACTORS;

EID: 79953893283     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-010-9467-5     Document Type: Article

References (42)

1. Peek RM Jr, Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer. 2002;2:28-37. (Pubitemid 37328805)
2. Gerhard M, Lehn N, Neumayer N, Boren T, Rad R, Schepp W, et al. Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin. Proc Natl Acad Sci U S A. 1999;96:12778-83. (Pubitemid 29513579)
3. van Doorn LJ, Figueiredo C, Sanna R, Plaisier A, Schneeberger P, De Boer W, et al. Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori. Gastroenterology. 1998;115:58-66. (Pubitemid 28307288)
4. Atherton JC, Cao P, Peek Jr RM, Tummuru MK, Blaser MJ, Cover TL. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem. 1995;270:17771-7.
5. Hussein NR, Argent RH, Marx CK, Patel SR, Robinson K, Atherton JC. Helicobacter pylori dupA is polymorphic, and its active form induces proinflammatory cytokine secretion by mononuclear cells. J Infect Dis. 2010;202:261-9.
6. Lu H, Hsu PI, Graham DY, Yamaoka Y. Duodenal ulcer promoting gene of Helicobacter pylori. Gastroenterology. 2005;128:833-48. (Pubitemid 40523536)
7. Crabtree JE, Wyatt JI, Trejdosiewicz LK, Peichl P, Nichols PH, Ramsay N, et al. Interleukin-8 expression in Helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa. J Clin Pathol. 1994;47:61-6. (Pubitemid 24057752)
8. Bartels M, Schweda AT, Dreikhausen U, Frank R, Resch K, Beil W, et al. Peptide-mediated disruption of NFkappaB/NRF interaction inhibits IL-8 gene activation by IL-1 or Helicobacter pylori. J Immunol. 2007;179:7605-13.
9. Luecke HF, Yamamoto KR. The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression. Genes Dev. 2005;19:1116-27. (Pubitemid 40632456)
10. Nourbakhsh M, Kalble S, Dorrie A, Hauser H, Resch K, Kracht M. The NF-kappa b repressing factor is involved in basal repression and interleukin (IL)-1-induced activation of IL-8 transcription by binding to a conserved NF-kappa b-flanking sequence element. J Biol Chem. 2001;276:4501-8.
11. Williams LM, Lali F, Willetts K, Balague C, Godessart N, Brennan F, et al. Rac mediates TNF-induced cytokine production via modulation of NF-kappaB. Mol Immunol. 2008;45:2446-54.
12. Mukaida N, Murayama T. Molecular mechanism of interleukin-8 gene expression. Rinsho Byori. 1998;46:821-8.
13. Winzen R, Kracht M, Ritter B, Wilhelm A, Chen CY, Shyu AB, et al. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. EMBO J. 1999;18:4969-80. (Pubitemid 29443799)
14. Winzen R, Gowrishankar G, Bollig F, Redich N, Resch K, Holtmann H. Distinct domains of AU-rich elements exert different functions in mRNA destabilization and stabilization by p38 mitogen-activated protein kinase or HuR. Mol Cell Biol. 2004;24:4835-47. (Pubitemid 38668049)
15. Chen CY, Shyu AB. AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem Sci. 1995;20:465-70.
16. Hirata Y, Maeda S, Ohmae T, Shibata W, Yanai A, Ogura K, et al. Helicobacter pylori induces IkappaB kinase alpha nuclear translocation and chemokine production in gastric epithelial cells. Infect Immun. 2006;74:1452-61. (Pubitemid 43346777)
17. Keates S, Keates AC, Warny M, Peek Jr RM, Murray PG, Kelly CP. Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag- Helicobacter pylori. J Immunol. 1999;163:5552-9.
18. Sharma SA, Tummuru MK, Blaser MJ, Kerr LD. Activation of IL-8 gene expression by Helicobacter pylori is regulated by transcription factor nuclear factor-kappa B in gastric epithelial cells. J Immunol. 1998;160:2401-7. (Pubitemid 28119924)
19. Su B, Ceponis PJ, Lebel S, Huynh H, Sherman PM. Helicobacter pylori activates Toll-like receptor 4 expression in gastrointestinal epithelial cells. Infect Immun. 2003;71:3496-502. (Pubitemid 36637578)
20. Torok AM, Bouton AH, Goldberg JB. Helicobacter pylori induces interleukin-8 secretion by Toll-like receptor 2- and Toll-like receptor 5-dependent and -independent pathways. Infect Immun. 2005;73:1523-31. (Pubitemid 40470738)
21. Zhao Y, Yokota K, Ayada K, Yamamoto Y, Okada T, Shen L, et al. Helicobacter pylori heat-shock protein 60 induces interleukin-8 via a Toll-like receptor (TLR)2 and mitogen-activated protein (MAP) kinase pathway in human monocytes. J Med Microbiol. 2007;56:154-64.
22. Brandt S, Kwok T, Hartig R, Konig W, Backert S. NF-kappaB activation and potentiation of proinflammatory responses by the Helicobacter pylori CagA protein. Proc Natl Acad Sci U S A. 2005;102:9300-5. (Pubitemid 40923558)
23. Kim SY, Lee YC, Kim HK, Blaser MJ. Helicobacter pylori CagA transfection of gastric epithelial cells induces interleukin-8. Cell Microbiol. 2006;8:97-106. (Pubitemid 43355524)
24. Glocker E, Lange C, Covacci A, Bereswill S, Kist M, Pahl HL. Proteins encoded by the cag pathogenicity island of Helicobacter pylori are required for NF-kappaB activation. Infect Immun. 1998;66:2346-8. (Pubitemid 28194141)
25. Owen RJ, Sharp S, Lawson AJ, Durrani Z, Rijpkema S, Kidd M. Investigation of the biological relevance of Helicobacter pylori cagE locus diversity, presence of CagA tyrosine phosphorylation motifs and vacuolating cytotoxin genotype on IL-8 induction in gastric epithelial cells. FEMS Immunol Med Microbiol. 2003;36:135-40. (Pubitemid 36556030)
26. Sharma SA, Tummuru MK, Miller GG, Blaser MJ. Interleukin-8 response of gastric epithelial cell lines to Helicobacter pylori stimulation in vitro. Infect Immun. 1995;63:1681-7.
27. Tummuru MK, Sharma SA, Blaser MJ. Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells. Mol Microbiol. 1995;18:867-76.
28. Hisatsune J, Nakayama M, Isomoto H, Kurazono H, Mukaida N, Mukhopadhyay AK, et al. Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation. J Immunol. 2008;180:5017-27.
29. Lamb A, Yang XD, Tsang YH, Li JD, Higashi H, Hatakeyama M, et al. Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination. EMBO Rep. 2009;10:1242-9.
30. Elitsur Y, Lawrence Z, Triest WE. Distribution of Helicobacter pylori organisms in the stomachs of children with H. pylori infection. Hum Pathol. 2002;33:1133-5. (Pubitemid 35416712)
31. Thomsen LL, Gavin JB, Tasman-Jones C. Relation of Helicobacter pylori to the human gastric mucosa in chronic gastritis of the antrum. Gut. 1990;31:1230-6.
32. Censini S, Lange C, Xiang Z, Crabtree JE, Ghiara P, Borodovsky M, et al. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci U S A. 1996;93:14648-53.
33. Stein M, Bagnoli F, Halenbeck R, Rappuoli R, Fantl WJ, Covacci A. c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs. Mol Microbiol. 2002;43:971-80. (Pubitemid 34415720)
34. Chattopadhyay S, Patra R, Ramamurthy T, Chowdhury A, Santra A, Dhali GK, et al. Multiplex PCR assay for rapid detection and genotyping of Helicobacter pylori directly from biopsy specimens. J Clin Microbiol. 2004;42:2821-4. (Pubitemid 38750217)
35. Reboll MR, Oumard A, Gazdag AC, Renger I, Ritter B, Schwarzer M, et al. NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt RNA element. RNA. 2007;13:1328-40. (Pubitemid 47080477)
36. Dreikhausen U, Hiebenthal-Millow K, Bartels M, Resch K, Nourbakhsh M. NF-kappaB-repressing factor inhibits elongation of human immunodeficiency virus type 1 transcription by DRB sensitivity-inducing factor. Mol Cell Biol. 2005;25:7473-83. (Pubitemid 41170111)
37. Kirschner DE, Blaser MJ. The dynamics of Helicobacter pylori infection of the human stomach. J Theor Biol. 1995;176:281-90.
38. Blaser MJ, Berg DE. Helicobacter pylori genetic diversity and risk of human disease. J Clin Invest. 2001;107:767-73. (Pubitemid 32274024)
39. Hirata Y, Ohmae T, Shibata W, Maeda S, Ogura K, Yoshida H, et al. MyD88 and TNF receptor-associated factor 6 are critical signal transducers in Helicobacter pylori-infected human epithelial cells. J Immunol. 2006;176:3796-803. (Pubitemid 43364028)
40. Figura N, Trabalzini L, Mini R, Bernardini G, Scaloni A, Talamo F, et al. Inactivation of Helicobacter pylori cagA gene affects motility. Helicobacter. 2004;9:185-93. (Pubitemid 38724753)
41. Huang ZG, Duan GC, Fan QT, Zhang WD, Song CH, Huang XY, et al. Mutation of cytotoxin-associated gene A affects expressions of antioxidant proteins of Helicobacter pylori. World J Gastroenterol. 2009;15:599-606.
42. Bussiere FI, Chaturvedi R, Asim M, Hoek KL, Cheng Y, Gainor J, et al. Low multiplicity of infection of Helicobacter pylori suppresses apoptosis of B lymphocytes. Cancer Res. 2006;66:6834-42. (Pubitemid 44085644)