Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori

Gastroenterology

Volumn 115, Issue 1, 1998, Pages 58-66

  Van Doorn, L J ^a   Figueiredo, C ^a   Sanna, R ^a   Plaisier, A ^a   Schneeberger, P ^a   De Boer, W ^a   Quint, W ^a  

^a Delft Diagnostic Laboratory   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BACTERIAL GENE; BACTERIAL GENETICS; BACTERIAL VIRULENCE; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GENOTYPE; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; HYBRIDIZATION; MAJOR CLINICAL STUDY; MALE; NETHERLANDS; NUCLEOTIDE SEQUENCE; PEPTIC ULCER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STOMACH BIOPSY;

EID: 0031750247     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(98)70365-8     Document Type: Article

References (51)

1. MJ Blaser Ecology of Helicobacter pylori in the human stomach J Clin Invest 100 1997 759 762
2. BE Dunn H Cohen MJ Blaser Helicobacter pylori Clin Microbiol Rev 10 1997 720 741
3. MF Go V Kapur DY Graham JM Musser Population genetic analysis of Helicobacter pylori by multilocus enzyme electrophoresis: extensive allelic diversity and recombinational population structure J Bacteriol 178 1996 3934 3938
4. DG Marshall DC Coleman DJ Sullivan H Xia CA O'Morain CJ Smyth Genomic DNA fingerprinting of clinical isolates of Helicobacter pylori using short oligonucleotide probes containing repetitive sequences J Appl Bacteriol 81 1996 509 517
5. A van der Ende EA Rauws M Feller CJ Mulder GN Tytgat J. Dankert Heterogeneous Helicobacter pylori isolates from members of a family with a history of peptic ulcer disease Gastroenterology 111 1996 638 647
6. MJ Blaser Intrastrain differences in Helicobacter pylori : a key question in mucosal damage? Ann Med 27 1995 559 563
7. HL Mobley Defining Helicobacter pylori as a pathogen: strain heterogeneity and virulence Am J Med 100 1997 2S 11S
8. JC Atherton The clinical relevance of strain types of Helicobacter pylori Gut 40 1997 701 703
9. RD Leunk PT Johnson BS David WG Kraft DR Morgan Cytotoxic activity in broth culture filtrates of Campylobacter pylori J Med Microbiol 26 1988 93 99
10. JL Telford P Ghiara M Dell'Orco M Comanducci D Burroni M Bugnoli MF Tecce S Censini A Covacci Z. Xiang Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease J Exp Med 179 1994 1653 1658
11. TL Cover The vacuolating cytotoxin of Helicobacter pylori Mol Microbiol 20 1996 241 246
12. TL Cover MK Tummuru P Cao SA Thompson MJ Blaser Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains J Biol Chem 269 1994 10566 10573
13. JC Atherton P Cao RMJ Peek MK Tummuru MJ Blaser TL Cover Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori . Association of specific vac A types with cytotoxin production and peptic ulceration J Biol Chem 270 1995 17771 17777
14. LJ van Doorn C Figueiredo R Sanna AS Pena P Midolo EK Ng JC Atherton MJ Blaser W. Quint Expanding allelic diversity of Helicobacter pylori vacA 1998 (submitted for publication)
15. JC Atherton RMJ Peek KT Tham TL Cover MJ Blaser Clinical and pathological importance of heterogeneity in vac A, the vacuolating cytotoxin gene of Helicobacter pylori Gastroenterology 112 1997 92 99
16. S Censini C Lange Z Xiang JE Crabtree P Ghiara M Borodovsky R Rappuoli A. Covacci cag , a pathogenicity island of Helicobacter pylori , encodes type I–specific and disease-associated virulence factors Proc Natl Acad Sci USA 93 1996 14648 14653
17. MK Tummuru SA Sharma MJ Blaser Helicobacter pylori picB , a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells Mol Microbiol 18 1995 867 876
18. T Shimoyama JE Crabtree Mucosal chemokines in Helicobacter pylori infection J Physiol Pharmacol 48 1997 315 323
19. F. Megraud Pathogenic diversity of Helicobacter pylori J Gastroenterol 32 1997 278 281
20. RMJ Peek SA Thompson JC Atherton MJ Blaser GG Miller Expression of a novel ulcer-associated H. pylori gene, iceA , following adherence to gastric epithelial cells (abstr) Gastroenterology 110 Suppl 1996 A225
21. J Sambrook IF Fritsch T. Maniatis Molecular cloning, a laboratory manual 2nd ed 1989 Cold Spring Harbor Laboratory Cold Spring Harbor, NY
22. L Stuyver R Rossau A Wyseur M Duhamel B Vandenborght H van Heuverswyn G. Maertens Typing of HCV isolates and characterization of new (sub)types using a line probe assay J Gen Virol 74 1993 1093 1102
23. AC Wotherspoon Gastric MALT lymphoma and Helicobacter pylori Yale J Biol Med 69 1997 61 68
24. DY Graham HM Malaty MF Go Are there susceptible hosts to Helicobacter pylori infection? Scand J Gastroenterol Suppl 205 1994 6 10
25. HM Malaty DY Graham Importance of childhood socioeconomic status on the current prevalence of Helicobacter pylori infection Gut 35 1994 742 745
26. HM Malaty V Paykov O Bykova A Ross DP Graham JF Anneger DY Graham Helicobacter pylori and socioeconomic factors in Russia Helicobacter 1 1996 82 87
27. A Covacci S Censini M Bugnoli R Petracca D Burroni G Macchia A Massone E Papini Z Xiang N. Figura Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer Proc Natl Acad Sci USA 90 1993 5791 5795
28. Z Xiang S Censini PF Bayeli JL Telford N Figura R Rappuoli A. Covacci Analysis of expression of cagA and vacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that cagA is not necessary for expression of the vacuolating cytotoxin Infect Immun 63 1995 94 98
29. A Labigne H. de Reuse Determinants of Helicobacter pylori pathogenicity Infect Agents Dis 5 1996 191 202
30. IL Beales JE Crabtree D Scunes A Covacci J. Calam Antibodies to cagA protein are associated with gastric atrophy in Helicobacter pylori infection Eur J Gastroenterol Hepatol 8 1996 645 649
31. TL Cover Y Glupczynski AP Lage A Burette MK Tummuru GI Perez-Perez MJ Blaser Serologic detection of infection with cagA + Helicobacter pylori strains J Clin Microbiol 33 1995 1496 1500
32. + strains and dissociation of gastric epithelial cell proliferation from apoptosis J Natl Cancer Inst 89 1997 863 868
33. MJ Blaser GI Perez-Perez H Kleanthous TL Cover RM Peek PH Chyou GN Stemmermann A. Nomura Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach Cancer Res 55 1995 2111 2115
34. EJ Kuipers GI Perez-Perez SG Meuwissen MJ Blaser Helicobacter pylori and atrophic gastritis: importance of the cagA status J Natl Cancer Inst 87 1995 1777 1780
35. LJ van Doorn WGV Quint PM Schneeberger GNJ Tytgat WA de Boer Association between vacA and cagA status of Helicobacter pylori and the efficacy of a 1-day quadruple therapy Lancet 350 1997 71 72
36. RMJ Peek SF Moss KT Tham GI Perez-Perez S Wang GG Miller JC Atherton PR Holt MJ Blaser Helicobacter pylori cagA + strains and dissociation of gastric epithelial cell proliferation from apoptosis J Natl Cancer Inst 89 1997 863 868
37. NS Taylor JG Fox NS Akopyantz DE Berg N Thompson B Shames L Yan E Fontham F Janney FM Hunter P. Correa Long-term colonization with single and multiple strains of Helicobacter pylori assessed by DNA fingerprinting J Clin Microbiol 33 1995 918 923
38. M Jorgensen G Daskalopoulos V Warburton HM Mitchell SL Hazell Multiple strain colonization and metronidazole resistance in Helicobacter pylori– infected patients: identification from sequential and multiple biopsy specimens J Infect Dis 174 1996 631 635
39. MF Go DY Graham Presence of the cagA gene in the majority of Helicobacter pylori strains is independent of whether the individual has duodenal ulcer or asymptomatic gastritis Helicobacter 1 1996 107 111
40. S Maeda F Kanai K Ogura H Yoshida T Ikenoue M Takahashi T Kawabe Y Shiratori M. Omata High seropositivity of anti- cagA antibody in Helicobacter pylori– infected patients irrelevant to peptic ulcers and normal mucosa in Japan Dig Dis Sci 42 1997 1841 1847
41. Y Ito T Azuma S Ito H Miyaji M Hirai Y Yamazaki F Sato T Kato Y Kohli M. Kuriyama Analysis and typing of the vacA gene from cagA -positive strains of Helicobacter pylori isolated in Japan J Clin Microbiol 35 1997 1710 1714
42. J Rudi C Kolb M Maiwald I Zuna A von Herbay PR Galle W. Stremmel Serum antibodies against Helicobacter pylori proteins VacA and CagA are associated with increased risk for gastric adenocarcinoma Dig Dis Sci 42 1997 1652 1659
43. K Ogura F Kanai S Maeda H Yoshida M Ogura KH Lan K Hirota T Kawabe Y Shiratori M. Omata High prevalence of cytotoxin positive Helicobacter pylori in patients unrelated to the presence of peptic ulcers in Japan Gut 41 1997 463 468
44. M Donati S Moreno E Storni A Tucci L Poli C Mazzoni O Varoli V Sambri A Farencena R. Cevenini Detection of serum antibodies to CagA and VacA and of serum neutralizing activity for vacuolating cytotoxin in patients with Helicobacter pylori– induced gastritis Clin Diagn Lab Immunol 4 1997 478 482
45. S Maeda K Ogura M Ishitobi F Kanai H Yoshida S Ota Y Shiratory M. Omata Diversity of Helicobacter pylori vacA gene in Japanese strains—high activity type s1 is dominant in Japan (abstr) Gastroenterology 100 Suppl 1996 A182
46. N Matsukura M Onda S Kato H Hasegawa K Okawa T Shirakawa A Tokunaga K Yamashita A. Hayashi Cytotoxin genes of Helicobacter pylori in chronic gastritis, gastroduodenal ulcer and gastric cancer: an age and gender matched case-control study Jpn J Cancer Res 88 1997 532 536
47. S Campbell A Fraser B Holliss J Schmid PW O'Toole Evidence for ethnic tropism of Helicobacter pylori Infect Immun 65 1997 3708 3712
48. JC Yang TH Wang HJ Wang CH Kuo JT Wang WC Wang Genetic analysis of the cytotoxin-associated gene and the vacuolating toxin gene in Helicobacter pylori strains isolated from Taiwanese patients Am J Gastroenterol 92 1997 1316 1321
49. RM Genta IE Gurer DY Graham Geographical pathology of Helicobacter pylori infection: is there more than one gastritis? Ann Med 27 1995 595 599
50. LJ van Doorn C Figueiredo F Carneiro R Sanna AS Peña P Midolo MJ Blaser WGV Quint Worldwide heterogeneity of the Helicobacter pylori vacA gene (abstr) Gut 41 Suppl 1 1997 A34
51. D Ilver A Arnqvist J Ogren IM Frick D Kersulyte ET Incecik DE Berg A Covacci L Engstrand T. Boren Helicobacter pylori adhesion binding fucosylated histo-blood group antigens revealed by retagging Science 279 1998 373 377