Helicobacter pylori heat-shock protein 60 induces interleukin-8 via a Toll-like receptor (TLR)2 and mitogen-activated protein (MAP) kinase pathway in human monocytes

Journal of Medical Microbiology

Volumn 56, Issue PART 2, 2007, Pages 154-164

  Zhao, Ying ^a   Yokota, Kenji ^a   Ayada, Kiyoshi ^a   Yamamoto, Yumiko ^a   Okada, Tomayuki ^a   Shen, Lianhua ^a   Oguma, Keiji ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; EPITOPE; HEAT SHOCK PROTEIN 60; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; RECEPTOR ANTIBODY; RECOMBINANT ANTIGEN; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 2 ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; GASTRITIS; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

BACTERIAL PROTEINS; BUTADIENES; CELL LINE; CHAPERONIN 60; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; GENE EXPRESSION REGULATION; HELICOBACTER PYLORI; HUMANS; IMIDAZOLES; INTERLEUKIN-8; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; MONOCYTES; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; RNA, MESSENGER; RNA, SMALL INTERFERING; TOLL-LIKE RECEPTOR 2; TRANSCRIPTION, GENETIC;

EID: 33847226673     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.46882-0     Document Type: Article

References (49)

1. Aihara, M., Tsuchimoto, D., Takizawa, H., Azuma, A., Wakebe, H., Ohmoto, Y., Imagawa, K., Kikuchi, M., Mukaida, N. & Matsushima, K. (1997). Mechanisms involved in Helicobacter pylori-induced interleukin-8 production by a gastric cancer cell line, MKN45. Infect Immun 65, 3218-3224.
2. Asea, A., Rehli, M., Kabingu, E., Boch, J. A., Bare, O., Auron, P. E., Stevenson, M. A. & Calderwood, S. K. (2002). Novel signal transduction pathway utilized by extracellular HSP70: role of Toll-like receptor (TLR) 2 and TLR4. J Biol Chem 277, 15028-15034.
3. Basak, C., Pathak, S. K., Bhattacharyya, A., Mandal, D., Pathak, S. & Kundu, M. (2005). NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide- stimulated macrophages. J Biol Chem 280, 4279-4288.
4. Bhattacharyya, A., Pathak, S., Datta, S., Chattopadhyay, S., Basu, J. & Kundu, M. (2002). Mitogen-activated protein kinases and nuclear factor-kappaB regulate Helicobacter pylori-mediated interleukin-8 release from macrophages. Biochem J 368, 121-129.
5. Binder, R. J., Vatner, R. & Srivastava, P. (2004). The heat-shock protein receptors: some answers and more questions. Tissue Antigens 64, 442-451.
6. Bliss, C. M., Jr, Golenbock, D. T., Keates, S., Linevsky, J. K. & Kelly, C. P. (1998). Helicobacter pylori lipopolysaccharide binds to CD14 and stimulates release of interleukin-8, epithelial neutrophil-activating peptide 78, and monocyte chemotactic protein 1 by human monocytes. Infect Immun 66, 5357-5363.
7. Brisslert, M., Enarsson, K., Lundin, S., Karlsson, A., Kusters, J. G., Svennerholm, A. M., Backert, S. & Quiding-Jarbrink, M. (2005). Helicobacter pylori induce neutrophil transendothelial migration: role of the bacterial HP-NAP. FEMS Microbiol Lett 249, 95-103.
8. Bulut, Y., Faure, E., Thomas, L, Karahashi, H., Michelsen, K. S., Equils, O., Morrison, S. G., Morrison, R. P. & Arditi, M. (2002). Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway. J Immunol 168, 1435-1440.
9. Cabral, E. S., Gelderblom, H., Hornung, R. L., Munson, P. J., Martin, R. & Marques, A. R. (2006). Borrelia burgdorferi lipoprotein-mediated TLR2 stimulation causes the down-regulation of TLR5 in human monocytes. J Infect Dis 193, 849-859.
10. Chen, K., Iribarren, P., Hu, J, Chen, J., Gong, W., Cho, E. H., Lockett, S., Dunlop, N. M. & Wang, J. M. (2006). Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide. J Biol Chem 281, 3651-3659.
11. Crabtree, J. E., Covacci, A., Farmery, S. M., Xiang, Z., Tompkins, D. S., Perry, S., Lindley, I. J. & Rappuoli, R. (1995). Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype. J Clin Pathol 48, 41-45.
12. Cunningham, M. D., Seachord, C., Ratcliffe, K., Bainbridge, B., Aruffo, A. & Darveau, R. P. (1996). Helicobacter pylori and Porphyromonas gingivalis lipopolysaccharides are poorly transferred to recombinant soluble CD14. Infect Immun 64, 3601-3608.
13. Cunningham, M. D., Shapiro, R. A., Seachord, C., Ratcliffe, K., Cassiano, L. & Darveau, R. P. (2000). CD14 employs hydrophilic regions to 'capture' lipopolysaccharides. J Immunol 164, 3255-3263.
14. Ellis, R. J. (1990). The molecular chaperone concept. Semin Cell Biol 1, 1-9.
15. Evans, D. J., Jr, Evans, D. G., Takemura, T., Nakano, H., Lampert, H. C., Graham, D. Y., Granger, D. N. & Kvietys, P. R. (1995). Characterization of a Helicobacter pylori neutrophil-activating protein. Infect Immun 63, 2213-2220.
16. Friedland, J. S., Shattock, R., Remick, D. G. & Griffin, G. E. (1993). Mycobacterial 65-kD heat shock protein induces release of proinflammatory cytokines from human monocytes. Curr Exp Immunol 91, 58-62.
17. Galdiero, M., de l'Ero, G. C. & Marcatili, A. (1997). Cytokine and adhesion molecule expression in human monocytes and endothelial cells stimulated with bacterial heat shock proteins. Infect Immun 65, 699-707.
18. Gewirtz, A. T., Yu, Y., Krishna, U. S., Israel, D. A., Lyons, S. L. & Peek, R. M., Jr (2004). Helicobacter pylori flagellin evades Toll-like receptor 5-mediated innate immunity. J Infect Dis 189, 1914-1920.
19. Gobert, A. P., Bambou, J. C., Werts, C., Balloy, V., Chignard, M., Moran, A. P. & Ferrero, R. L. (2004). Helicobacter pylori heat shock protein 60 mediates interleukin-6 production by macrophages via a Toll-like receptor (TLR)-2-, TLR-4-, and myeloid differentiation factor 88-independent mechanism. J Biol Chem 279, 245-250.
20. Harris, P. R., Smythies, L. E., Smith, P. D. & Dubois, A. (2000). Inflammatory cytokine mRNA expression during early and persistent Helicobacter pylori infection in nonhuman primates. J Infect Dis 181, 783-786.
21. Ishihara, S., Rumi, M. A., Kadowaki, Y., Ortega-Cava, C. F., Yuki, T., Yoshino, N., Miyaoka, Y., Kazumori, H., Ishimura, N. & other authors (2004). Essential role of MD-2 in TLR4-dependent signaling during Helicobacter pylori-associated gastritis. J Immunol 173, 1406-1416.
22. Ishii, E., Yokota, K., Sugiyama, T., Fujinaga, Y., Ayada, K., Hokari, I., Hayashi, S., Hirai, Y., Asaka, M., Oguma, K. & other authors (2001). Immunoglobulin G1 antibody response to Helicobacter pylori heat shock protein 60 is closely associated with low-grade gastric mucosa-associated lymphoid tissue lymphoma. Clin Diagn Lab Immunol 8, 1056-1059.
23. Iwao, E., Hirayama, F., Takagi, S., Yokoyama, Y. & lkeda, Y. (1999). Virulence factors of Helicobacter pylori affecting its gastric colonization in Mongolian gerbils. J Gastroenterol 34 (Suppl. 11), 47-54.
24. Juttner, S., Cramer, T., Wessler, S., Walduck, A., Gao, F., Schmitz, F., Wunder, C., Weber, M., Fischer, S. M. & other authors (2003). Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors. Cell Microbiol 5, 821-834.
25. Kawahara, T., Kuwano, Y., Teshima-Kondo, S., Kawai, T., Nikawa, T., Kishi, K. & Rokutan, K. (2001). Toll-like receptor 4 regulates gastric pit cell responses to Helicobacter pylori infection. J Med Invest 48, 190-197.
26. Keates, S., Keates, A. C., Warny, M., Peek, R. M., Jr, Murray, P. G. & Kelly, C. P. (1999). Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag-Helicobacter pylori. J Immunol 163, 5552-5559.
27. Kol, A., Sukhova, G. K., Lichtman, A. H. & Libby, P. (1998). Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression. Circulation 98, 300-307.
28. Kol, A., Bourcier, T., Lichtman, A. H. & Libby, P. (1999). Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages. J Clin Invest 103, 571-577.
29. Kyriakis, J. M. & Avruch, J. (2001). Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 81, 807-869.
30. Lin, S. N., Ayada, K., Zhao, Y., Yokota, K., Takenaka, R., Okada, H., Kan, R., Hayashi, S., Mizuno, M. & other authors (2005). Helicobacter pylori heat-shock protein 60 induces production of the pro-inflammatory cytokine IL8 in monocytes. J Med Microbiol 54, 225-233.
31. Maeda, S., Akanuma, M., Mitsuno, Y., Hirata, Y., Ogura, K., Yoshida, H., Shiratori, Y. & Omata, M. (2001). Distinct mechanism of Helicobacter pylori-mediated NF-kappa B activation between gastric cancer cells and monocytes. J Biol Chem 276, 44856-44864.
32. Maguire, M., Poole, S., Coates, A. R., Tormay, P., Wheeler-Jones, C. & Henderson, B. (2005). Comparative cell signaling activity of ultrapure recombinant chaperonin 60 proteins from prokaryotes and eukaryotes. Immunology 115, 231-238.
33. Mann, N. S. & Westblom, T. U. (1999). Helicobacter pylori and the future: an afterword. Curr Top Microbiol Immunol 241, 301-308.
34. O'Neill, L. (2000). The Toll/interleukin-1 receptor domain: a molecular switch for inflammation and host defence. Biochem Soc Trans 28, 557-563.
35. Peetermans, W. E., Raats, C. J., Langermans, J. A. & van Furth, R. (1994). Mycobacterial heat-shock protein 65 induces proinflammatory cytokines but does not activate human mononuclear phagocytes. Scand J Immunol 39, 613-617.
36. Peetermans, W. E., Raats, C. J., van Furth, R. & Langermans, J. A. (1995). Mycobacterial 65-kilodalton heat shock protein induces tumor necrosis factor alpha and interleukin 6, reactive nitrogen intermediates, and toxoplasmastatic activity in murine peritoneal macrophages. Infect Immun 63, 3454-3458.
37. Retzlaff, C., Yamamoto, Y., Hoffman, P. S., Friedman, H. & Klein, T. W. (1994). Bacterial heat shock proteins directly induce cytokine mRNA and interleukin-1 secretion in macrophage cultures. Infect Immun 62, 5689-5693.
38. Sarsfield, P., Jones, D. B., Wotherspoon, A. C., Harvard, T. & Wright, D. H. (1996). A study of accessory cells in the acquired lymphoid tissue of helicobacter gastritis. J Pathol 180, 18-25.
39. Shibata, W., Hirata, Y., Yoshida, H., Otsuka, M., Hoshida, Y., Ogura, K., Maeda, S., Ohmae, T., Yanai, A. & other authors (2005). NF-kappaB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection. World J Gastroenterol 11, 6134-6143.
40. Smith, M. F., Jr, Mitchell, A., Li, G., Ding, S., Fitzmaurice, A. M., Ryan, K., Crowe, S. & Goldberg, J. B. (2003). Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells. J Biol Chem 278, 32552-32560.
41. Suzuki, T., Kato, K., Ohara, S., Noguchi, K., Sekine, H., Nagura, H. & Shimosegawa, T. (2002). Localization of antigen-presenting cells in Helicobacter pylori-infected gastric mucosa. Pathol Int 52, 265-271.
42. Takenaka, R., Yokota, K., Ayada, K., Mizuno, M., Zhao, Y., Fujinami, Y., Lin, S.-N., Toyokawa, T., Okada, H. & other authors (2004). Helicobacter pylori heat-shock protein 60 induces inflammatory responses through the Toll-like receptor-triggered pathway in cultured human gastric epithelial cells. Microbiology 150, 3913-3922.
43. Torok, A. M., Bouton, A. H. & Goldberg, J. B. (2005). Helicobacter pylori induces interleukin-8 secretion by Toll-like receptor 2- and Toll-like receptor 5-dependent and -independent pathways. Infect Immun 73, 1523-1531.
44. Vabulas, R. M., Ahmad-Nejad, P., Ghose, S., Kirschning, C. J., Issels, R. D. & Wagner, H. (2002). HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway. J Biol Chem 277, 15107-15112.
45. Wang, J. P., Kurt-Jones, E. A., Shin, O. S., Manchak, M. D., Levin, M. J. & Finberg, R. W. (2005). Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2. J Virol 79, 12658-12666.
46. r 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pylori. Proc Natl Acad Sci U S A 97, 7533-7538.
47. Yokota, K., Kurebayashi, Y., Takayama, Y., Hayashi, S., Isogai, H., Isogai, E., Imai, K., Yabana, T., Yachi, A. & Oguma, K. (1991). Colonization of Helicobacter pylori in the gastric mucosa of Mongolian gerbils. Microbiol Immunol 35, 475-480.
48. Young, D. B. (1990). Chaperonins and immune response. Semin Cell Biol 1, 27-35.
49. Zhang, D., Zhang, G., Hayden, M. S., Greenblatt, M. B., Bussey, C., Flavell, R. A. & Ghosh, S. (2004). A Toll-like receptor that prevents infection by uropathogenic bacteria. Science 303, 1522-1526.