Escape from p21-mediated oncogene-induced senescence leads to cell dedifferentiation and dependence on anti-apoptotic Bcl-xL and MCL1 proteins

Journal of Biological Chemistry

Volumn 286, Issue 15, 2011, Pages 12825-12838

  Carné Trécesson, Sophie De ^a   Guillemin, Yannis ^b   Bélanger, Audrey ^a   Bernard, Anne Charlotte ^a   Preisser, Laurence ^a   Ravon, Elisa ^a   Gamelin, Erick ^a   Juin, Philippe ^b   Barré, Benjamin ^a   Coqueret, Olivier ^b  

^a CENTRE PAUL PAPIN   (France)

^b Team 12   (France)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOTIC; CELL DEDIFFERENTIATION; CELL LINES; CELL-CYCLE ARREST; DNA DAMAGES; DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; MALIGNANT CELLS; PRIMARY CELLS; TRANSCRIPTIONAL FUNCTIONS; TRANSCRIPTIONAL REPRESSION; TUMOR PROGRESSIONS; TUMOR SUPPRESSORS;

CELL CULTURE; GENE EXPRESSION; PLANTS (BOTANY); RUBIDIUM; SIGNALING;

TUMORS;

CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; HERMES ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE P38; POLO LIKE KINASE 1; PROTEIN BCL X; PROTEIN CDC25A; PROTEIN MCL 1; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL DEDIFFERENTIATION; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA DAMAGE; EPITHELIAL MESENCHYMAL TRANSITION; HETEROCHROMATIN; HUMAN; HUMAN CELL; ONCOGENE INDUCED SENESCENCE; ONCOGENE RAS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION;

BCL-X PROTEIN; CDC25 PHOSPHATASES; CELL AGING; CELL CYCLE PROTEINS; CELL DEDIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR PROTEINS; HETEROCHROMATIN; HUMANS; MUTATION, MISSENSE; ONCOGENE PROTEIN P21(RAS); PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 79953877268     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.186437     Document Type: Article

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