Protective effects of diosgenin in the hyperlipidemic rat model and in human vascular endothelial cells against hydrogen peroxide-induced apoptosis

Chemico-Biological Interactions

Volumn 184, Issue 3, 2010, Pages 366-375

  Gong, Guohua ^a   Qin, Yuan ^a   Huang, Wen ^a   Zhou, Shu ^b   Wu, Xiaohua ^a   Yang, Xiaohua ^b   Zhao, Yinlan ^a   Li, Dan ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Apoptosis; Diosgenin; Human umbilical vein endothelial cells; Hyperlipidemia; Mitochondria; Oxidative stress

Indexed keywords

DIOSGENIN; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG STRUCTURE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HYPERLIPIDEMIA; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; RAT; TREATMENT RESPONSE; TRIACYLGLYCEROL BLOOD LEVEL; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELLS, CULTURED; CHOLESTEROL; CHOLESTEROL, LDL; DIOSGENIN; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HUMANS; HYDROGEN PEROXIDE; HYPERLIPIDEMIAS; LIPASE; LIPOPROTEIN LIPASE; MEMBRANE POTENTIAL, MITOCHONDRIAL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; TRIGLYCERIDES;

RATTUS;

EID: 77949912798     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.02.005     Document Type: Article

References (58)

1. Jain K.S., Kathiravan M.K., Somani R.S., Shishoo C.J. The biology and chemistry of hyperlipidemia. Bioorgan. Med. Chem. 2007, 15:4674-4699.
2. Sharma S.K., Mishra H.K., Sharma H., Goel A., Sreenivas V., Gulati V., Tahir M. Obesity, and not obstructive sleep apnea, is responsible for increased serum hs-CRP levels in patients with sleep-disordered breathing in Delhi. Sleep Med. 2008, 9:149-156.
3. Saravanan R., Pugalendi V. Impact of ursolic acid on chronic ethanol-induced oxidative stress in the rat heart. Pharmacol. Rep. 2006, 58:41-47.
4. Bitar M.S., Al-Saleh E., Al-Mulla F. Oxidative stress-mediated alterations in glucose dynamics in a genetic animal model of type II diabetes. Life Sci. 2005, 77:2552-2573.
5. Yan M.X., Li Y.Q., Meng M., Ren H.B., Kou Y. Long-term high-fat diet induces pancreatic injuries via pancreatic microcirculatory disturbances and oxidative stress in rats with hyperlipidemia. Biochem. Biophys. Res. Commun. 2006, 347:192-199.
6. Scheuer H., Gwinner W., Hohbach J., Grone E.F., Brandes R.P., Malle E., Olbricht C.J., Walli A.K., Grone H.-J. Oxidant stress in hyperlipidemia-induced renal damage. Am. J. Physiol. Renal Physiol. 2000, 278:F63-74.
7. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 1993, 362:801-809.
8. Stemerman M.B., Spaet T.H. The subendothelium and thrombogenesis. Bull. N. Y. Acad. Med. 1972, 48:289-301.
9. Jaffe E.A., Nachman R.L., Becker C.G., Minick C.R. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 1973, 52:2745-2756.
10. Cines D.B., Pollak E.S., Buck C.A., Loscalzo J., Zimmerman G.A., McEver R.P., Pober J.S., Wick T.M., Konkle B.A., Schwartz B.S., Barnathan E.S., McCrae K.R., Hug B.A., Schmidt A.-M., Stern D.M. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 1998, 91:3527-3561.
11. Larsson L.I., Bourne W.M., Pach J.M., Brubaker R.F. Structure and function of the corneal endothelium in diabetes mellitus type I and type II. Arch. Ophthalmol. 1996, 114:9-14.
12. Haaber A., Eidemak I., Jensen T., Feldt-Rasmussen B., Strandgaard S. Vascular endothelial cell function and cardiovascular risk factors in patients with chronic renal failure. J. Am. Soc. Nephrol. 1995, 5:1581-1584.
13. Liu C.-L., Xie L.-X., Li M., Durairajan S.S.K., Goto S., Huang J.-D. Salvianolic acid b inhibits hydrogen peroxide-induced endothelial cell apoptosis through regulating PI3K/Akt signaling. PLoS ONE 2007, 2:e1321.
14. Karsan A., Harlan J.M. Modulation of endothelial cell apoptosis: mechanisms and pathophysiological roles. J. Atheroscler. Thromb. 1996, 3:75-80.
15. Li J.M., Shah A.M. Endothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004, 287:R1014-1030.
16. Boots A.W., Haenen G.R., Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur. J. Pharmacol. 2008, 585:325-337.
17. Sautour M., Mitaine-Offer A.C., Miyamoto T., Dongmo A., Lacaille Dubois M.A Antifungal steroid saponins from Dioscorea cayenensis. Plant Medica 2004, 70:90-92.
18. Son I.K., kim J.H., Shon H.Y., Son K.H., Kim J.S., Kwon C.S. Antioxidative and hypolipidemic effects of diosgenin, a steroidal saponin of yam (Dioscorea spp.), on high-cholesterol fed rats. Biosci. Biotechnol. Biochem. 2007, 71:3063-3071.
19. Sun Q., Ju Y., Zhao Y. Steroid saponins with biological activities. Chin. Tradit. Herb. Drug 2002, 33:276-280.
20. Cayen M., Dvornik D. Effect of diosgenin on lipid metabolism in rats. J. Lipid Res. 1979, 20:162-174.
21. Liu L.j., Liu Y.Q., Chang Y.R., Li Q., Wang J.B.X. GC/MS determination of diosgenin in rats plasma. Chin. J. Pharm. Anal. 2006, 26:177-180.
22. Corbiere C., Liager B., Terro F., Beneytout J.L. Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-dnducing factor and modulation of caspase-3 activity in different human cancer cells. Cell Res. 2004, 14:188-196.
23. Huo R., Zhou Q.L., Wang B.X., Tashiro S.I., Onodera S., Ikejima T. Diosgenin induces apoptosis in HeLa cells via activation of caspase pathway. Acta Pharmacol. Sin. 2004, 25:1077-1082.
24. Flohé L., Günzler W.A. Assays of glutathione peroxidase. Methods Enzymol. 1984, 105:114-121.
25. 2+-independent nitric oxide synthases. FEBS Lett. 1991, 291:145-149.
26. Morenoa D.A., Nebojsa I., Alexander P., Ilya R. Effects of Arachis hypogaea nutshell extract on lipid metabolic enzymes and obesity parameters. Life Sci. 2006, 78:2797-2803.
27. Sun Y., Oberley L., Li Y. A simple method for clinical assay of superoxide dismutase. Clin. Chem. 1988, 34:497-500.
28. Maruyama Y. The human endothelial cell in tissue culture. Cell Tissue Res. 1963, 60:69-79.
29. 2. Free Radic. Biol. Med. 2002, 33:691-702.
30. Zorov D.B., Filburn C.R., Klotz L.O., Zweier J.L., Sollott S.J. Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J. Exp. Med. 2000, 192:1001-1014.
31. Kaur P., Aschner M., Syversen T. Glutathione modulation influences methyl mercury induced neurotoxicity in primary cell cultures of neurons and astrocytes. Neurotoxicology 2006, 27:492-500.
32. Gonda K., Tsuchiya H., Sakabe T., Akechi Y., Ikeda R., Nishio R., Terabayashi K., Ishii K., Matsumi Y., Ashla A.A., Okamoto H., Takubo K., Matsuoka S., Watanabe Y., Hoshikawa Y., Kurimasa A., Shiota G. Synthetic retinoid CD437 induces mitochondria-mediated apoptosis in hepatocellular carcinoma cells. Biochem. Biophys. Res. Commun. 2008, 370:629-933.
33. Carreras M.C., Schopfer F., Lisdero C., Riobo N., Poderoso J.J. Mitochondrial function and nitric oxide utilization. Biol. Res. 2000, 33:177-183.
34. Compton M.M. A biochemical hallmark of apoptosis: internucleosomal degradation of the genome. Cancer Metastasis Rev. 1992, 11:105-119.
35. Kumari C.S., Govindasamy S., Sukumar E. Lipid lowering activity of Eclipta prostrata in experimental hyperlipidemia. J. Ethnopharmacol. 2006, 105:332-335.
36. Bos G., Snijder M.B., Nijpels G., Dekker J.M., Stehouwer C.D., Bouter L.M. Opposite contributions of trunk and leg fat mass with plasma lipase activities: the hoorn study. Obes. Res. 2005, 13:1817-1823.
37. Argani H., Ghorbani A., Rashtchizade N., Rahbaninobar M. Effect of Lovastatin on lipid peroxidation and total antioxidant concentrations in hemodialysis patients. Lipids Health Dis. 2004, 6-10.
38. Bok S., Jag M. Antioxidative activity of naringin and Lovastatin in high cholesterol fed rabbits. Life Sci. 2001, 69:2855-2866.
39. Honga J.H., Lee I.S. Effects of Artemisia capillaris ethyl acetate fraction on oxidative stress and antioxidant enzyme in high-fat diet induced obese mice. Chem. Biol. Interact. 2009, 179:88-93.
40. Stroes E., de Bruin T., de Valk H., Erkelens W., Banga J.D., van Rijn H., Koomans H., Rabelink T. NO activity in familial combined hyperlipidemia: potential role of cholesterol remnants. Cardiovasc. Res. 1997, 36:445-452.
41. Ricciardolo F.L., Nijkamp F.P., Folkerts G. Nitric oxide synthase (NOS) as therapeutic target for asthma and chronic obstructive pulmonary disease. Curr. Drug Targets 2006, 7:721-735.
42. Czako L., Szabolcs A., Vajda A., Csati S., Venglovecz V., Rakonczay Z., Hegyi P., Tiszlavicz L., Csont T., Posa A., Berko A., Varga C., Varga Ilona S., Boros I., Lonovics J. Hyperlipidemia induced by a cholesterol-rich diet aggravates necrotizing pancreatitis in rats. Eur. J. Pharmacol. 2007, 572:74-81.
43. Kobayashi N., DeLano F.A., Schmid-Schonbein G.W. Oxidative stress promotes endothelial cell apoptosis and loss of microvessels in the spontaneously hypertensive rats. Arterioscler. Thromb. Vasc. Biol. 2005, 25:2114-2121.
44. Malek A.M., Izumo S. Molecular aspects of signal transduction of shear stress in the endothelial cell. J. Hypertens. 1994, 12:989-999.
45. 2 or products of activated neutrophils. Am. J. Med. 1991, 91:89S-94S.
46. Liu Y.M., Jiang B., Bao Y.M., An L.J. Protocatechuic acid inhibits apoptosis by mitochondrial dysfunction in rotenone-induced PC12 cells. Toxicol. In Vitro 2008, 22:430-437.
47. Zhanga R., Kanga K.A., Piaoa M.J., Maenga Y.H., Leea K.H., Changa W.Y., Youb H.J., Kimc J.S., Kangc S.S., Hyuna J.W. Cellular protection of morin against the oxidative stress induced by hydrogen peroxide. Chem. Biol. Interact. 2009, 177:21-27.
48. Ma E., Kim J. Epoxidation of Diosgenin, 25(R)-1,4,6-Spirostatrien-3-one and 25(R)-4,6-Spirostadien-3β-ol. Molecules 2003, 8:886-893.
49. Bhunia A.K., Schwarzmann G., Chatterjee S. GD3 recruits reactive oxygen species to induce cell proliferation and apoptosis in human aortic smooth muscle cells. J. Biol. Chem. 2002, 277:16396-16402.
50. Silva A., Gomes O., Coutinho Oxidative DNA damage protection and repair by polyphenolic compounds in PC12 cells. Eur. J. Pharmacol. 2008, 601:50-60.
51. Yu D.Y., Cringle S.J., Alder V.A., Su E.N. Intraretinal oxygen distribution in rats as a function of systemic blood pressure. Am. J. Physiol. Heart Circ. Physiol. 1994, 267:H2498-2507.
52. Fico A., Manganelli G., Cigliano L., Bergamo P., Abrescia P., Franceschi C., Martini G., Filosa S. 2-Deoxy-d-ribose induces apoptosis by inhibiting the synthesis and increasing the efflux of glutathione. Free Radic. Biol. Med. 2008, 45:211-217.
53. Elbekai R.H., El-Kadi A.O.S. The role of oxidative stress in the modulation of aryl hydrocarbon receptor-regulated genes by As3+, Cd2+, and Cr6+. Free Radic. Biol. Med. 2005, 39:1499-1511.
54. Schnelldorfer T., Gansauge S., Gansauge F., Schlosser S., Beger H.G., Nussler A.K. Glutathione depletion causes cell growth inhibition and enhanced apoptosis in pancreatic cancer cells. Cancer Metastasis Rev. 2000, 89:1440-1447.
55. Bernuzzia F., Recalcatia S., Alberghinia A., Cairo G. Reactive oxygen species-independent apoptosis in doxorubicin-treated H9c2 cardiomyocytes: role for heme oxygenase-1 down-modulation. Chem. Biol. Interact. 2009, 177:12-20.
56. Ishikawa K., Takenaga K., Akimoto M., Koshikawa N., Yamaguchi A., Imanishi H., Nakada K., Honma Y., Hayashi J.-I. ROS-generating mitochondrial DNA Mutations can regulate tumor cell metastasis. Science 2008, 320:661-664.
57. Dimmeler S., Zeiher A.M. Nitric oxide-an endothelial cell survival factor. Cell Death Differ. 1999, 6:964-968.
58. Loscalzo J. Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circ. Res. 2001, 88:756-762.