Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway

Cancer Biology and Therapy

Volumn 6, Issue 9, 2007, Pages 1457-1464

  Cusimano, Antonella ^a,b   Foderà, Daniela ^a   D'Alessandro, Natale ^b   Lampiasi, Nadia ^a   Azzolina, Antonina ^a   Montalto, Giuseppe ^b   Cervello, Melchiorre ^a  

^a CNR   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

Apoptosis; COX 1; COX 2; Hepatic cancer; NSAIDs; Survivin; catenin

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; BETA CATENIN; CASPASE 3; CASPASE 9; CAY 10404; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; SURVIVIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIVER CANCER; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

EID: 42549167500     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.6.9.4629     Document Type: Article

References (63)