메뉴 건너뛰기




Volumn 145, Issue 3, 1997, Pages 605-614

Hyperactivation of the silencing proteins, Sir2p and Sir3p, causes chromosome loss

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; FUNGAL PROTEIN; HISTONE H4; SILENCING PROTEIN; UNCLASSIFIED DRUG;

EID: 0031019155     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (67)

References (45)
  • 1
    • 0025900189 scopus 로고
    • Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae
    • APARICIO, O. M., B. L. BILLINGTON and D. E. GOTTSCHLING, 1991 Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae. Cell 66: 1279-1287.
    • (1991) Cell , vol.66 , pp. 1279-1287
    • Aparicio, O.M.1    Billington, B.L.2    Gottschling, D.E.3
  • 2
    • 0024406531 scopus 로고
    • Propagation and expression of genes in yeast using 2-micron circle vectors
    • edited by P. J. BARR, A. J. BRACK and P. Valenzuela. Butterworths, Stoneham, MA
    • ARMSTRONG, K. A., T. SOM, F. C. VOLKERT, A. B. ROSE and J. R. BROACH, 1990 Propagation and expression of genes in yeast using 2-micron circle vectors, pp. 165-192 in Yeast Genetic Engineering, edited by P. J. BARR, A. J. BRACK and P. Valenzuela. Butterworths, Stoneham, MA.
    • (1990) Yeast Genetic Engineering , pp. 165-192
    • Armstrong, K.A.1    Som, T.2    Volkert, F.C.3    Rose, A.B.4    Broach, J.R.5
  • 3
    • 0028832366 scopus 로고
    • The multidomain structure of Orclp reveals similarity to regulators of DNA replication and transcriptional silencing
    • BELL, S. P., J. MITCHELL, J. LEBER, R. KOBAYASHI and B. STILLMAN, 1995 The multidomain structure of Orclp reveals similarity to regulators of DNA replication and transcriptional silencing. Cell 83: 563-568.
    • (1995) Cell , vol.83 , pp. 563-568
    • Bell, S.P.1    Mitchell, J.2    Leber, J.3    Kobayashi, R.4    Stillman, B.5
  • 4
    • 0028841317 scopus 로고
    • The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability
    • BRACHMANN, C. B., J. M. SHERMAN, S. E. DEVINE, E. E. CAMERON, L. PILLUS et al., 1995 The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev. 9: 2888-2902.
    • (1995) Genes Dev. , vol.9 , pp. 2888-2902
    • Brachmann, C.B.1    Sherman, J.M.2    Devine, S.E.3    Cameron, E.E.4    Pillus, L.5
  • 5
    • 0027192267 scopus 로고
    • Transcriptional silencing in yeast is associated with reduced nucleosome acetylation
    • BRAUNSTEIN, M., A. B. ROSE, S. G. HOLMES, C. D. ALLIS and J. R. BROACH, 1993 Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes Dev. 7: 592-604.
    • (1993) Genes Dev. , vol.7 , pp. 592-604
    • Braunstein, M.1    Rose, A.B.2    Holmes, S.G.3    Allis, C.D.4    Broach, J.R.5
  • 6
    • 0029953722 scopus 로고    scopus 로고
    • Efficient transcriptional silencing in yeast requires a heterochromatin histone acetylation pattern
    • BRAUNSTEIN, M., R. E. SOBEL, C. D. ALLIS, B. M. TURNER and J. R. BROACH, 1996a Efficient transcriptional silencing in yeast requires a heterochromatin histone acetylation pattern. Mol. Cell Biol. 16: 4349-4356.
    • (1996) Mol. Cell Biol. , vol.16 , pp. 4349-4356
    • Braunstein, M.1    Sobel, R.E.2    Allis, C.D.3    Turner, B.M.4    Broach, J.R.5
  • 7
    • 0345545046 scopus 로고    scopus 로고
    • Heterochromatin and regulation of gene expression in Saccharomyces cerevisiae
    • edited by R. VAN DRIEL and A. P. OTTE. Oxford University Press, Oxford (in press)
    • BRAUNSTEIN, M., S. G. HOLMES and J. R. BROACH, 1996b Heterochromatin and regulation of gene expression in Saccharomyces cerevisiae, pp. in Nuclear Organization, Chromatin Structure and Gene Expresssion, edited by R. VAN DRIEL and A. P. OTTE. Oxford University Press, Oxford (in press).
    • (1996) Nuclear Organization, Chromatin Structure and Gene Expresssion
    • Braunstein, M.1    Holmes, S.G.2    Broach, J.R.3
  • 8
    • 0002830667 scopus 로고
    • Vectors for high-level, inducible expression of cloned genes in yeast
    • edited by M. INOUYE. Academic Press, New York, NY
    • BROACH, J. R., Y. Y. LI, L. C. C. Wu and M. JAYARAM, 1983 Vectors for high-level, inducible expression of cloned genes in yeast, pp. 83-117 in Experimental Manipulation of Gene Expression, edited by M. INOUYE. Academic Press, New York, NY.
    • (1983) Experimental Manipulation of Gene Expression , pp. 83-117
    • Broach, J.R.1    Li, Y.Y.2    Wu, L.C.C.3    Jayaram, M.4
  • 9
    • 0027443405 scopus 로고
    • Targeting of SIRI protein establishes transcriptional silencing at HM loci and telomeres in yeast
    • CHIEN, C. T., S. BUCK, R. STERNGLANZ and D. SHORE, 1993 Targeting of SIRI protein establishes transcriptional silencing at HM loci and telomeres in yeast. Cell 75: 531-541.
    • (1993) Cell , vol.75 , pp. 531-541
    • Chien, C.T.1    Buck, S.2    Sternglanz, R.3    Shore, D.4
  • 10
    • 0029048189 scopus 로고
    • The carboxy termini of Sir4 and Rap 1 affect Sir3 localization: Evidence for a multicomponent complex required for yeast telomeric silencing
    • COCKELL, M., F. PALLADINO, T. LAROCHE, G. KYRION, C. LIU et al., 1995 The carboxy termini of Sir4 and Rap 1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing. J. Cell Biol. 129: 909-924.
    • (1995) J. Cell Biol. , vol.129 , pp. 909-924
    • Cockell, M.1    Palladino, F.2    Laroche, T.3    Kyrion, G.4    Liu, C.5
  • 11
    • 0024959918 scopus 로고
    • Transcriptional silencing and lamins
    • DIFFLEY, J. F. X., and B. STILLMAN, 1989 Transcriptional silencing and lamins. Nature 342: 24.
    • (1989) Nature , vol.342 , pp. 24
    • Diffley, J.F.X.1    Stillman, B.2
  • 12
    • 0029820640 scopus 로고    scopus 로고
    • The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae
    • GOLTA, M., T. LAROCHE, A. FORMENTON, L. MAILLET, H. SCHERTHAN et al., 1996 The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae. J. Cell Biol. 134: 1349-1364.
    • (1996) J. Cell Biol. , vol.134 , pp. 1349-1364
    • Golta, M.1    Laroche, T.2    Formenton, A.3    Maillet, L.4    Scherthan, H.5
  • 13
    • 0024536650 scopus 로고
    • A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA
    • GOTTLIEB, S., and R. E. ESPOSITO, 1989 A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA. Cell 56: 771-776.
    • (1989) Cell , vol.56 , pp. 771-776
    • Gottlieb, S.1    Esposito, R.E.2
  • 14
    • 0025201982 scopus 로고
    • Position effect at S. cerevisiae telomeres: Reversible repression of pol II transcription
    • GOTTSCHLING, D. E., O. M. APARICIO, B. L. BILLINGTON and V. A. ZAKIAN, 1990 Position effect at S. cerevisiae telomeres: reversible repression of pol II transcription. Cell 63: 751-762.
    • (1990) Cell , vol.63 , pp. 751-762
    • Gottschling, D.E.1    Aparicio, O.M.2    Billington, B.L.3    Zakian, V.A.4
  • 15
    • 0018614960 scopus 로고
    • A mutation that permits the expression of normally silent copies of mating-type infromation in Saccharomyces cerevisiae
    • HABER, J. E., and J. R. GEORGE, 1979 A mutation that permits the expression of normally silent copies of mating-type infromation in Saccharomyces cerevisiae. Genetics 93: 13-35.
    • (1979) Genetics , vol.93 , pp. 13-35
    • Haber, J.E.1    George, J.R.2
  • 16
    • 0021796842 scopus 로고
    • Altered fidelity of mitotic chromosome transmission in cell cycle mutants of S. cerevisiae
    • HARTWELL, L. H., and D. SMITH, 1985 Altered fidelity of mitotic chromosome transmission in cell cycle mutants of S. cerevisiae. Genetics 110: 381-395.
    • (1985) Genetics , vol.110 , pp. 381-395
    • Hartwell, L.H.1    Smith, D.2
  • 17
    • 0024425887 scopus 로고
    • Checkpoints: Controls that ensure the order of cell cycle events
    • HARTWELL, L. H., and T. A. WEINERT, 1989 Checkpoints: controls that ensure the order of cell cycle events. Science 246: 629-634.
    • (1989) Science , vol.246 , pp. 629-634
    • Hartwell, L.H.1    Weinert, T.A.2
  • 18
    • 0028919756 scopus 로고
    • Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast
    • HECHT, A., T. LAROCHE, S. STRAHL-BOLSINGER, S. M. GASSER and M. GRUNSTEIN, 1995 Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast. Cell 80: 583-592.
    • (1995) Cell , vol.80 , pp. 583-592
    • Hecht, A.1    Laroche, T.2    Strahl-Bolsinger, S.3    Gasser, S.M.4    Grunstein, M.5
  • 19
    • 0001225813 scopus 로고
    • Mating-type determination and mating type interconversion in Saccharomyces cerevisiae
    • edited by E. W. JONES, J. R. PRINGLE and J. R. BROACH. Cold Spring Harbor Press, Cold Spring Harbor, NY
    • HERSKOWITZ, I., J. RINE and J. STRATHERN, 1992 Mating-type determination and mating type interconversion in Saccharomyces cerevisiae, pp. 583-656 in The Molecular and Cellular Biology of the Yeast Saccharomyces, edited by E. W. JONES, J. R. PRINGLE and J. R. BROACH. Cold Spring Harbor Press, Cold Spring Harbor, NY.
    • (1992) The Molecular and Cellular Biology of the Yeast Saccharomyces , pp. 583-656
    • Herskowitz, I.1    Rine, J.2    Strathern, J.3
  • 20
    • 0000385792 scopus 로고    scopus 로고
    • Transcriptional silencing of the yeast mating-type genes
    • edited by V. E. A. RUSSO, R. MARTIENSSEN and A. RIGGS. Cold Spring Harbor Press, Cold Spring Harbor, NY
    • HOLMES, S. G., M. BRAUNSTEIN and J. R. BROACH, 1996 Transcriptional silencing of the yeast mating-type genes, pp. 467-487 in Epigenetic Mechanisms of Gene Regulation, edited by V. E. A. RUSSO, R. MARTIENSSEN and A. RIGGS. Cold Spring Harbor Press, Cold Spring Harbor, NY.
    • (1996) Epigenetic Mechanisms of Gene Regulation , pp. 467-487
    • Holmes, S.G.1    Braunstein, M.2    Broach, J.R.3
  • 21
    • 0022625954 scopus 로고
    • Cloning and characterization of four SIR genes of Saccharomyces cerevisiae
    • IVY, J. M., A. J. S. KLAR and J. B. HICKS, 1986 Cloning and characterization of four SIR genes of Saccharomyces cerevisiae. Mol. Cell. Biol. 6: 688-702.
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 688-702
    • Ivy, J.M.1    Klar, A.J.S.2    Hicks, J.B.3
  • 22
    • 0025002966 scopus 로고
    • Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae
    • JOHNSON, L. M., P. S. KAYNE, E. S. KAHN and M. GRUNSTEIN, 1990 Genetic evidence for an interaction between SIR3 and histone H4 in the repression of the silent mating loci in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 87: 6286-6290.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 6286-6290
    • Johnson, L.M.1    Kayne, P.S.2    Kahn, E.S.3    Grunstein, M.4
  • 23
    • 0024280881 scopus 로고
    • Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast
    • KAYNE, P. S., U.-J. KIM, M. HAN, J. R. MULLEN, F. YOSHIZAKI et al., 1988 Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast. Cell 55: 27-39.
    • (1988) Cell , vol.55 , pp. 27-39
    • Kayne, P.S.1    Kim, U.-J.2    Han, M.3    Mullen, J.R.4    Yoshizaki, F.5
  • 24
    • 0018644035 scopus 로고
    • MAR1 - A regulator of HMa and HMa loci in Saccharomyces cerevisiae
    • KLAR, A. J. S., S. FOGEL and K. MACLEOD, 1979 MAR1 - a regulator of HMa and HMa loci in Saccharomyces cerevisiae. Genetics 93: 37-50.
    • (1979) Genetics , vol.93 , pp. 37-50
    • Klar, A.J.S.1    Fogel, S.2    Macleod, K.3
  • 25
    • 0026443594 scopus 로고
    • Silencers, silencing, and heritable transcriptional states
    • LAURENSON, P., and J. RINE, 1992 Silencers, silencing, and heritable transcriptional states. Microbiol. Rev. 56: 543-560.
    • (1992) Microbiol. Rev. , vol.56 , pp. 543-560
    • Laurenson, P.1    Rine, J.2
  • 26
    • 0027465862 scopus 로고
    • A positive role for histone acetylation in transcription factor access to nucleosomal DNA
    • LEE, D. Y., J. J. HAYES, D. PRUSS and A. P. WOLFFE, 1993 A positive role for histone acetylation in transcription factor access to nucleosomal DNA. Cell 72: 73-84.
    • (1993) Cell , vol.72 , pp. 73-84
    • Lee, D.Y.1    Hayes, J.J.2    Pruss, D.3    Wolffe, A.P.4
  • 27
    • 0030009208 scopus 로고    scopus 로고
    • Genetic analysis of Rap1p/Sir3p interactions in telomeric and HML silencing in Saccharomyces cerevisiae
    • LIU, C., and A. J. LUSTIG, 1996 Genetic analysis of Rap1p/Sir3p interactions in telomeric and HML silencing in Saccharomyces cerevisiae. Genetics 143: 81-93.
    • (1996) Genetics , vol.143 , pp. 81-93
    • Liu, C.1    Lustig, A.J.2
  • 28
    • 0023515404 scopus 로고
    • Functional domains of SIR4, a gene required for position effect regulation in Saccharomyces cerevisiae
    • MARSHALL, M., S. MAHONEY, A. ROSE, J. B. HICKS and J. R. BROACH, 1987 Functional domains of SIR4, a gene required for position effect regulation in Saccharomyces cerevisiae. Mol. Cell. Biol. 7: 4441-4452.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 4441-4452
    • Marshall, M.1    Mahoney, S.2    Rose, A.3    Hicks, J.B.4    Broach, J.R.5
  • 29
    • 0025093599 scopus 로고
    • Genetic analysis of histone H4: Essential role of lysines subject to reversible acetylation
    • MEGEE, P. C., B. A. MORGAN, B. A. MITTMAN and M. M. SMITH, 1990 Genetic analysis of histone H4: essential role of lysines subject to reversible acetylation. Science 247: 841-845.
    • (1990) Science , vol.247 , pp. 841-845
    • Megee, P.C.1    Morgan, B.A.2    Mittman, B.A.3    Smith, M.M.4
  • 30
    • 0029123092 scopus 로고
    • Histone H4 and the maintenance of genome integrity
    • MEGEE, P. C., B. A. MORGAN and M. M. SMITH, 1995 Histone H4 and the maintenance of genome integrity. Genes Dev. 9: 1716-1727.
    • (1995) Genes Dev. , vol.9 , pp. 1716-1727
    • Megee, P.C.1    Morgan, B.A.2    Smith, M.M.3
  • 31
    • 0030598895 scopus 로고    scopus 로고
    • A deubiquitinating enzyme interacts with SIR4 and regulates silencing in S. cerevisiae
    • MOAZED, D., and A. D. JOHNSON, 1996 A deubiquitinating enzyme interacts with SIR4 and regulates silencing in S. cerevisiae. Cell 86: 667-677.
    • (1996) Cell , vol.86 , pp. 667-677
    • Moazed, D.1    Johnson, A.D.2
  • 32
    • 0028004378 scopus 로고
    • Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1
    • MORETTI, P., K. FREEMAN, L. GOODLY and D. SHORE, 1994 Evidence that a complex of SIR proteins interacts with the silencer and telomere-binding protein RAP1. Genes Dev. 8: 2257-2269.
    • (1994) Genes Dev. , vol.8 , pp. 2257-2269
    • Moretti, P.1    Freeman, K.2    Goodly, L.3    Shore, D.4
  • 33
    • 0026703325 scopus 로고
    • Creative blocks: Cell-cycle checkppoints and feedback controls
    • MURRAY, A. W., 1992 Creative blocks: cell-cycle checkppoints and feedback controls. Nature 359: 599-604.
    • (1992) Nature , vol.359 , pp. 599-604
    • Murray, A.W.1
  • 34
    • 0027423154 scopus 로고
    • SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres
    • PALLADINO, F., T. LAROCHE, E. GILSON, A. AXELROD, L. PILLUS et al., 1993 SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres. Cell 75: 543-555.
    • (1993) Cell , vol.75 , pp. 543-555
    • Palladino, F.1    Laroche, T.2    Gilson, E.3    Axelrod, A.4    Pillus, L.5
  • 35
    • 0025110835 scopus 로고
    • Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML
    • PARK, E.-C., and J. W. SZOSTAK, 1990 Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML. Mol. Cell. Biol. 10: 4932-4934.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 4932-4934
    • Park, E.-C.1    Szostak, J.W.2
  • 36
    • 0024424452 scopus 로고
    • Epigenetic inheritance of transcription states in S. cerevisiae
    • PILLUS, L., and J. RINE, 1989 Epigenetic inheritance of transcription states in S. cerevisiae. Cell 59: 637-647.
    • (1989) Cell , vol.59 , pp. 637-647
    • Pillus, L.1    Rine, J.2
  • 37
    • 0027184524 scopus 로고
    • Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage
    • RENAULD, H., O. M. APARICIO, P. D. ZIERATH, B. L. BILLINGTON, S. K. CHHABLANI et al., 1993 Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage. Genes Dev. 7: 1133-1145.
    • (1993) Genes Dev. , vol.7 , pp. 1133-1145
    • Renauld, H.1    Aparicio, O.M.2    Zierath, P.D.3    Billington, B.L.4    Chhablani, S.K.5
  • 38
    • 0023340731 scopus 로고
    • Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae
    • RINE, J., and I. HERSKOWITZ, 1987 Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116: 9-22.
    • (1987) Genetics , vol.116 , pp. 9-22
    • Rine, J.1    Herskowitz, I.2
  • 39
    • 0018564390 scopus 로고
    • A suppressor of mating-type locus mutation in Saccharomyces cerevisiae: Evidence for and identification of cryptic mating type loci
    • RINE, J. D., J. N. STRATHERN, J. B. HICKS and I. HERSKOWTTZ, 1979 A suppressor of mating-type locus mutation in Saccharomyces cerevisiae: evidence for and identification of cryptic mating type loci. Genetics 93: 877-901.
    • (1979) Genetics , vol.93 , pp. 877-901
    • Rine, J.D.1    Strathern, J.N.2    Hicks, J.B.3    Herskowttz, I.4
  • 40
    • 0027472324 scopus 로고
    • Saccharomyces cerevisiae linear chromosome stability mutants increase the loss rate of artificial and natural linear chromosomes
    • RUNGE, K. W., and V. A. ZAKIAN, 1993 Saccharomyces cerevisiae linear chromosome stability mutants increase the loss rate of artificial and natural linear chromosomes. Chromosoma 102: 207-217.
    • (1993) Chromosoma , vol.102 , pp. 207-217
    • Runge, K.W.1    Zakian, V.A.2
  • 41
  • 42
    • 0021734287 scopus 로고
    • Characterization of two genes required for the position-effect control of yeast mating-type genes
    • SHORE, D., M. SQUIRE and K. A. NASMYTH, 1984 Characterization of two genes required for the position-effect control of yeast mating-type genes. EMBO J. 3: 2817-2823.
    • (1984) EMBO J. , vol.3 , pp. 2817-2823
    • Shore, D.1    Squire, M.2    Nasmyth, K.A.3
  • 43
    • 0026061252 scopus 로고
    • The SIR1 gene of Saccharomyces cerevisiae and its role as an extragenic suppressor of several mating-defective mutants
    • STONE, E. M., M. J. SWANSON, A. M. ROMEO, J. B. HICKS and R. STERNGLANZ, 1991 The SIR1 gene of Saccharomyces cerevisiae and its role as an extragenic suppressor of several mating-defective mutants. Mol. Cell. Biol. 11: 2253-2262.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 2253-2262
    • Stone, E.M.1    Swanson, M.J.2    Romeo, A.M.3    Hicks, J.B.4    Sternglanz, R.5
  • 45
    • 0029922959 scopus 로고    scopus 로고
    • Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing
    • TRIOLO, T., and R. STERNGLANZ, 1996 Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing. Nature 381: 252-253.
    • (1996) Nature , vol.381 , pp. 252-253
    • Triolo, T.1    Sternglanz, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.