Concentrations of unmetabolized folic acid and primary folate forms in pregnant women at delivery and in umbilical cord blood

American Journal of Clinical Nutrition

Volumn 92, Issue 6, 2010, Pages 1416-1422

  Obeid, Rima ^a   Kasoha, Mariz ^a   Kirsch, Susanne H ^a   Munz, Winfried ^a   Herrmann, Wolfgang ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; FOLIC ACID; FOLIC ACID DERIVATIVE; FOLINIC ACID; TETRAHYDROFOLIC ACID;

ADULT; ARTICLE; CONTROLLED STUDY; DELIVERY; DIET SUPPLEMENTATION; DIETARY INTAKE; FEMALE; FOLIC ACID BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MATERNAL BLOOD; PREGNANCY; PREGNANT WOMAN; UMBILICAL CORD BLOOD;

ADULT; DIETARY SUPPLEMENTS; FEMALE; FETAL BLOOD; FOLIC ACID; FORMYLTETRAHYDROFOLATES; HUMANS; INFANT, NEWBORN; PREGNANCY; TETRAHYDROFOLATES; YOUNG ADULT;

EID: 78651330055     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.2010.29361     Document Type: Article

References (27)

1. Shaw GM, Schaffer D, Velie EM, Morland K, Harris JA. Periconceptional vitamin use, dietary folate, and the occurrence of neural tube defects. Epidemiology 1995;6:219-26.
2. Heseker HB, Mason JB, Selhub J, Rosenberg IH, Jacques PF. Not all cases of neural-tube defect can be prevented by increasing the intake of folic acid. Br J Nutr 2009;102:173-80.
3. Selhub J, Miller JW. The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine. Am J Clin Nutr 1992; 55:131-8.
4. Bagley PJ, Selhub J. A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proc Natl Acad Sci USA 1998;95:13217-20.
5. Malinow MR, Nieto FJ, Kruger WD, et al. The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes. Arterioscler Thromb Vasc Biol 1997;17:1157-62.
6. Kalmbach RD, Choumenkovitch SF, Troen AM, D'Agostino R, Jacques PF, Selhub J. Circulating folic acid in plasma: relation to folic acid fortification. Am J Clin Nutr 2008;88:763-8.
7. Troen AM, Mitchell B, Sorensen B, et al. Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr 2006;136:189-94.
8. Kelly P, McPartlin J, Goggins M, Weir DG, Scott JM. Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements. Am J Clin Nutr 1997;65:1790-5.
9. Wright AJ, Dainty JR, Finglas PM. Folic acid metabolism in human subjects revisited: potential implications for proposed mandatory folic acid fortification in the UK. Br J Nutr 2007;98:667-75.
10. Whitrow MJ, Moore VM, Rumbold AR, Davies MJ. Effect of supplemental folic acid in pregnancy on childhood asthma: a prospective birth cohort study. Am J Epidemiol 2009;170:1486-93.
11. Haberg SE, London SJ, Stigum H, Nafstad P, Nystad W. Folic acid supplements in pregnancy and early childhood respiratory health. Arch Dis Child 2009;94:180-4.
12. Smith AD, Kim YI, Refsum H. Is folic acid good for everyone? Am J Clin Nutr 2008;87:517-33.
13. Achón M, Reyes L, Alonso-Aperte E, Ubeda N, Varela-Moreiras G. High dietary folate supplementation affects gestational development and dietary protein utilization in rats. J Nutr 1999;129:1204-8.
14. Bailey SW, Ayling JE. The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake. Proc Natl Acad Sci USA 2009;106:15424-9.
15. Obeid R, Munz W, Jager M, Schmidt W, Herrmann W. Biochemical indexes of the B vitamins in cord serum are predicted by maternal B vitamin status. Am J Clin Nutr 2005;82:133-9.
16. Giugliani ER, Jorge SM, Goncalves AL. Serum and red blood cell folate levels in parturients, in the intervillous space of the placenta and in full-term newborns. J Perinat Med 1985;13:55-9.
17. Bisseling TM, Steegers EA, van den Heuvel JJ, et al. Placental folate transport and binding are not impaired in pregnancies complicated by fetal growth restriction. Placenta 2004;25:588-93.
18. Antony AC, Utley C, Van Horne KC, Kolhouse JF. Isolation and characterization of a folate receptor from human placenta. J Biol Chem 1981;256:9684-92.
19. Sweeney MR, McPartlin J, Weir DG, et al. Evidence of unmetabolised folic acid in cord blood of newborn and serum of 4-day-old infants. Br J Nutr 2005;94:727-30.
20. Sweeney MR, Staines A, Daly L, et al. Persistent circulating unmetabolised folic acid in a setting of liberal voluntary folic acid forti- fication. Implications for further mandatory fortification? BMC Public Health 2009;9:295.
21. Stabler SP, Marcell PD, Podell ER, Allen RH, Savage DG, Lindenbaum J. Elevation of total homocysteine in the serum of patients with cobalamin or folate deficiency detected by capillary gas chromatography-mass spectrometry. J Clin Invest 1988;81:466-74.
22. Kirsch SH, Knapp JP, Herrmann W, Obeid R. Quantification of key folate forms in serum using stable-isotope dilution ultra performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2010;878:68-75.
23. Frosst P, Blom HJ, Milos R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-3.
24. Shaw GM, Lammer EJ, Zhu H, Baker MW, Neri E, Finnell RH. Maternal periconceptional vitamin use, genetic variation of infant reduced folate carrier (A80G), and risk of spina bifida. Am J Med Genet 2002; 108:1-6.
25. Rezk BM, Haenen GR, van der Vijgh WJ, Bast A. Tetrahydrofolate and 5-methyltetrahydrofolate are folates with high antioxidant activity. Identification of the antioxidant pharmacophore. FEBS Lett 2003;555: 601-5.
26. Pfeiffer CM, Fazili Z, McCoy L, Zhang M, Gunter EW. Determination of folate vitamers in human serum by stable-isotope-dilution tandem mass spectrometry and comparison with radioassay and microbiologic assay. Clin Chem 2004;50:423-32.
27. Kalmbach RD, Choumenkovitch SF, Troen AP, Jacques PF, D'Agostino R, Selhub J. A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate. J Nutr 2008;138:2323-7.