메뉴 건너뛰기




Volumn 3, Issue 1, 2011, Pages 621-635

Treatment resistance mechanisms of malignant glioma tumor stem cells

Author keywords

Chemotherapy; Glioblastoma; Glioma stem cell; Malignant glioma; Radiation therapy; Treatment resistance; Tumor stem cell

Indexed keywords

BEVACIZUMAB; BMI1 PROTEIN; BORTEZOMIB; BREAST CANCER RESISTANCE PROTEIN; DNA; MULTIDRUG RESISTANCE PROTEIN 1; NOTCH RECEPTOR; SONIC HEDGEHOG PROTEIN; TEMOZOLOMIDE; TRANSCRIPTION FACTOR EZH2; VASCULOTROPIN;

EID: 79953675086     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers3010621     Document Type: Review
Times cited : (24)

References (101)
  • 3
    • 78651423627 scopus 로고    scopus 로고
    • Experimental approaches for the treatment of malignant gliomas
    • Arko, L.; Katsyv, I.; Park, G.E.; Luan, W.P.; Park, J.K. Experimental approaches for the treatment of malignant gliomas. Pharmacol. Ther. 2010, 28, 1-36.
    • (2010) Pharmacol. Ther. , vol.28 , pp. 1-36
    • Arko, L.1    Katsyv, I.2    Park, G.E.3    Luan, W.P.4    Park, J.K.5
  • 5
    • 48249125791 scopus 로고    scopus 로고
    • Malignant gliomas in adults
    • Wen, P.Y.; Kesari, S. Malignant gliomas in adults. N. Engl. J. Med. 2008, 359, 492-507.
    • (2008) N. Engl. J. Med. , vol.359 , pp. 492-507
    • Wen, P.Y.1    Kesari, S.2
  • 10
    • 33646358694 scopus 로고    scopus 로고
    • Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
    • Lee, J.; Kotliarova, S.; Kotliarov, Y.; Li, A.; Su, Q.; Donin, N.M.; Pastorino, S.; Purow, B.W.; Christopher, N.; Zhang, W.; et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 2006, 9, 391-403.
    • (2006) Cancer Cell , vol.9 , pp. 391-403
    • Lee, J.1    Kotliarova, S.2    Kotliarov, Y.3    Li, A.4    Su, Q.5    Donin, N.M.6    Pastorino, S.7    Purow, B.W.8    Christopher, N.9    Zhang, W.10
  • 11
    • 0025190642 scopus 로고
    • CNS stem cells express a new class of intermediate filament protein
    • Lendahl, U.; Zimmerman, L.B.; McKay, R.D. CNS stem cells express a new class of intermediate filament protein. Cell 1990, 60, 585-595.
    • (1990) Cell , vol.60 , pp. 585-595
    • Lendahl, U.1    Zimmerman, L.B.2    McKay, R.D.3
  • 13
    • 65349115320 scopus 로고    scopus 로고
    • SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma
    • Son, M.J.; Woolard, K.; Nam, D.H.; Lee, J.; Fine, H.A. SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma. Cell Stem Cell 2009, 4, 440-452.
    • (2009) Cell Stem Cell , vol.4 , pp. 440-452
    • Son, M.J.1    Woolard, K.2    Nam, D.H.3    Lee, J.4    Fine, H.A.5
  • 14
    • 0037194887 scopus 로고    scopus 로고
    • LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal
    • Capela, A.; Temple, S. LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal. Neuron 2002, 35, 865-875.
    • (2002) Neuron , vol.35 , pp. 865-875
    • Capela, A.1    Temple, S.2
  • 17
    • 36248961179 scopus 로고    scopus 로고
    • Tumorigenesis of chemotherapeutic drug-resistant cancer stem-like cells in brain glioma
    • Kang, M.K.; Kang, S.K. Tumorigenesis of chemotherapeutic drug-resistant cancer stem-like cells in brain glioma. Stem Cells Dev. 2007, 16, 837-847.
    • (2007) Stem Cells Dev. , vol.16 , pp. 837-847
    • Kang, M.K.1    Kang, S.K.2
  • 19
    • 0034044574 scopus 로고    scopus 로고
    • Sox2 regulatory sequences direct expression of a E-geo transgene to telencephalic neural stem cells and precursors of the mouse embryo, revealing regionalization of gene expression in CNS stem cells
    • Zappone, M.V.; Galli, R.; Catena, R.; Meani, N.; De Biasi, S.; Mattei, E.; Tiveron, C.; Vescovi, A.L.; Lovell-Badge, R.; Ottolenghi, S.; Nicolis, S.K. Sox2 regulatory sequences direct expression of a E-geo transgene to telencephalic neural stem cells and precursors of the mouse embryo, revealing regionalization of gene expression in CNS stem cells. Development 2000, 127, 2367-2382.
    • (2000) Development , vol.127 , pp. 2367-2382
    • Zappone, M.V.1    Galli, R.2    Catena, R.3    Meani, N.4    De Biasi, S.5    Mattei, E.6    Tiveron, C.7    Vescovi, A.L.8    Lovell-Badge, R.9    Ottolenghi, S.10    Nicolis, S.K.11
  • 26
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean, M.; Fojo, T.; Bates, S. Tumour stem cells and drug resistance. Nat. Rev. Cancer 2005, 5, 275-284.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 27
    • 0036792874 scopus 로고    scopus 로고
    • Multidrug resistance and cancer: The role of the human ABC transporter ABCG2
    • Ejendal, K.F.; Hrycyna, C.A. Multidrug resistance and cancer: The role of the human ABC transporter ABCG2. Curr. Protein Pept. Sci. 2002, 3, 503-511.
    • (2002) Curr. Protein Pept. Sci. , vol.3 , pp. 503-511
    • Ejendal, K.F.1    Hrycyna, C.A.2
  • 29
    • 0037125973 scopus 로고    scopus 로고
    • Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo
    • Zhou, S.; Morris, J.J.; Barnes, Y.; Lan, L.; Schuetz, J.D.; Sorrentino, B.P. Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Proc. Natl. Acad. Sci. USA 2002, 99, 12339-12344.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 12339-12344
    • Zhou, S.1    Morris, J.J.2    Barnes, Y.3    Lan, L.4    Schuetz, J.D.5    Sorrentino, B.P.6
  • 34
    • 0028816350 scopus 로고
    • A phase III randomized study of oral verapamil as a chemosensitizer to reverse drug resistance in patients with refractory myeloma. a southwest oncology group study
    • Dalton, W.S.; Crowley, J.J.; Salmon, S.S.; Grogan, T.M.; Laufman, L.R.; Weiss, G.R.; Bonnet, J.D. A phase III randomized study of oral verapamil as a chemosensitizer to reverse drug resistance in patients with refractory myeloma. a southwest oncology group study. Cancer 1995, 75, 815-820.
    • (1995) Cancer , vol.75 , pp. 815-820
    • Dalton, W.S.1    Crowley, J.J.2    Salmon, S.S.3    Grogan, T.M.4    Laufman, L.R.5    Weiss, G.R.6    Bonnet, J.D.7
  • 41
    • 23044514578 scopus 로고    scopus 로고
    • Multiple drug resistance in cancer revisited: The cancer stem cell hypothesis
    • Donnenberg, A.D.; Donnenberg, V. Multiple drug resistance in cancer revisited: The cancer stem cell hypothesis. J. Clin. Pharmacol. 2005, 45, 872-877.
    • (2005) J. Clin. Pharmacol. , vol.45 , pp. 872-877
    • Donnenberg, A.D.1    Donnenberg, V.2
  • 42
    • 0026711242 scopus 로고
    • Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody
    • Mechetner, E.B.; Roninson, I.B. Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody. Proc. Natl. Acad. Sci. USA 1992, 89, 5824-5828.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5824-5828
    • Mechetner, E.B.1    Roninson, I.B.2
  • 43
    • 0025224853 scopus 로고
    • Monoclonal anti-P-glycoprotein antibody-dependent killing of multidrug-resistant tumor cells by human mononuclear cells
    • Heike, Y.; Hamada, H.; Inamura, N.; Sone, S.; Ogura, T.; Tsuruo, T. Monoclonal anti-P-glycoprotein antibody-dependent killing of multidrug-resistant tumor cells by human mononuclear cells. Jpn. J. Cancer Res. 1990, 81, 1155-1161.
    • (1990) Jpn. J. Cancer Res. , vol.81 , pp. 1155-1161
    • Heike, Y.1    Hamada, H.2    Inamura, N.3    Sone, S.4    Ogura, T.5    Tsuruo, T.6
  • 46
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • Sancar, A.; Lindsey-Boltz, L.A.; Unsal-Kacmaz, K.; Linn, S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem. 2004, 73, 39-85.
    • (2004) Annu. Rev. Biochem. , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kacmaz, K.3    Linn, S.4
  • 48
    • 0028133013 scopus 로고
    • NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA
    • Denny, B.J.; Wheelhouse, R.T.; Stevens, M.F.; Tsang, L.L.; Slack, J.A. NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA. Biochemistry 1994, 33, 9045-9051.
    • (1994) Biochemistry , vol.33 , pp. 9045-9051
    • Denny, B.J.1    Wheelhouse, R.T.2    Stevens, M.F.3    Tsang, L.L.4    Slack, J.A.5
  • 49
    • 0026750738 scopus 로고
    • Self-destruction and tolerance in resistance of mammalian cells to alkylation damage
    • Karran, P.; Bignami, M. Self-destruction and tolerance in resistance of mammalian cells to alkylation damage. Nucleic Acids Res. 1992, 20, 2933-2940.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 2933-2940
    • Karran, P.1    Bignami, M.2
  • 50
    • 0025105041 scopus 로고
    • Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine
    • Tano, K.; Shiota, S.; Collier, J.; Foote, R.S.; Mitra, S. Isolation and structural characterization of a cDNA clone encoding the human DNA repair protein for O6-alkylguanine. Proc. Natl. Acad. Sci. USA 1990, 87, 686-690.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 686-690
    • Tano, K.1    Shiota, S.2    Collier, J.3    Foote, R.S.4    Mitra, S.5
  • 55
    • 0028883850 scopus 로고
    • Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
    • Kischkel, F.C.; Hellbardt, S.; Behrmann, I.; Germer, M.; Pawlita, M.; Krammer, P.H.; Peter, M.E. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 1995, 14, 5579-5588.
    • (1995) EMBO J. , vol.14 , pp. 5579-5588
    • Kischkel, F.C.1    Hellbardt, S.2    Behrmann, I.3    Germer, M.4    Pawlita, M.5    Krammer, P.H.6    Peter, M.E.7
  • 56
    • 0033662433 scopus 로고    scopus 로고
    • Apo2L/TRAIL-Dependent Recruitment of Endogenous FADD and Caspase-8 to Death Receptors 4 and 5
    • Kischkel, F.C.; Lawrence, D.A.; Chuntharapai, A.; Schow, P.; Kim, J.K.; Ashkenazi, A. Apo2L/TRAIL-Dependent Recruitment of Endogenous FADD and Caspase-8 to Death Receptors 4 and 5. Immunity 2000, 12, 611-620.
    • (2000) Immunity , vol.12 , pp. 611-620
    • Kischkel, F.C.1    Lawrence, D.A.2    Chuntharapai, A.3    Schow, P.4    Kim, J.K.5    Ashkenazi, A.6
  • 61
    • 41949117754 scopus 로고    scopus 로고
    • Potential identity of multi-potential cancer stem-like subpopulation after radiation of cultured brain glioma
    • Kang, M.K.; Hur, B.I.; Ko, M.H.; Kim, C.H.; Cha, S.H.; Kang, S.K. Potential identity of multi-potential cancer stem-like subpopulation after radiation of cultured brain glioma. BMC Neurosci. 2008, 9, 15.
    • (2008) BMC Neurosci. , vol.9 , pp. 15
    • Kang, M.K.1    Hur, B.I.2    Ko, M.H.3    Kim, C.H.4    Cha, S.H.5    Kang, S.K.6
  • 65
    • 34250645768 scopus 로고    scopus 로고
    • Bortezomib sensitizes primary human astrocytoma cells of WHO grades I to IV for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis
    • Koschny, R.; Holland, H.; Sykora, J.; Haas, T.L.; Sprick, M.R.; Ganten, T.M.; Krupp, W.; Bauer, M.; Ahnert, P.; Meixensberger, J.; et al. Bortezomib sensitizes primary human astrocytoma cells of WHO grades I to IV for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Clin. Cancer Res. 2007, 13, 3403-3412.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 3403-3412
    • Koschny, R.1    Holland, H.2    Sykora, J.3    Haas, T.L.4    Sprick, M.R.5    Ganten, T.M.6    Krupp, W.7    Bauer, M.8    Ahnert, P.9    Meixensberger, J.10
  • 66
    • 33846558132 scopus 로고    scopus 로고
    • L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells
    • Stoeck, A.; Gast, D.; Sanderson, M.P.; Issa, Y.; Gutwein, P.; Altevogt, P. L1-CAM in a membrane-bound or soluble form augments protection from apoptosis in ovarian carcinoma cells. Gynecol. Oncol. 2007, 104, 461-469.
    • (2007) Gynecol. Oncol. , vol.104 , pp. 461-469
    • Stoeck, A.1    Gast, D.2    Sanderson, M.P.3    Issa, Y.4    Gutwein, P.5    Altevogt, P.6
  • 67
    • 34247483148 scopus 로고    scopus 로고
    • Drug-induced expression of the cellular adhesion molecule L1CAM confers anti-apoptotic protection and chemoresistance in pancreatic ductal adenocarcinoma cells
    • Sebens Muerkoster, S.; Werbing, V.; Sipos, B.; Debus, M.A.; Witt, M.; Grossmann, M.; Leisner, D.; Kotteritzsch, J.; Kappes, H.; Kloppel, G.; et al. Drug-induced expression of the cellular adhesion molecule L1CAM confers anti-apoptotic protection and chemoresistance in pancreatic ductal adenocarcinoma cells. Oncogene 2007, 26, 2759-2768.
    • (2007) Oncogene , vol.26 , pp. 2759-2768
    • Sebens Muerkoster, S.1    Werbing, V.2    Sipos, B.3    Debus, M.A.4    Witt, M.5    Grossmann, M.6    Leisner, D.7    Kotteritzsch, J.8    Kappes, H.9    Kloppel, G.10
  • 68
    • 0034730713 scopus 로고    scopus 로고
    • Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice
    • Lee, E.G.; Boone, D.L.; Chai, S.; Libby, S.L.; Chien, M.; Lodolce, J.P.; Ma, A. Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 2000, 289, 2350-2354.
    • (2000) Science , vol.289 , pp. 2350-2354
    • Lee, E.G.1    Boone, D.L.2    Chai, S.3    Libby, S.L.4    Chien, M.5    Lodolce, J.P.6    Ma, A.7
  • 69
    • 0030026698 scopus 로고    scopus 로고
    • A20 zinc finger protein inhibits TNF and IL-1 signaling
    • Jaattela, M.; Mouritzen, H.; Elling, F.; Bastholm, L. A20 zinc finger protein inhibits TNF and IL-1 signaling. J. Immunol. 1996, 156, 1166-1173.
    • (1996) J. Immunol. , vol.156 , pp. 1166-1173
    • Jaattela, M.1    Mouritzen, H.2    Elling, F.3    Bastholm, L.4
  • 70
    • 0026691240 scopus 로고
    • The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity
    • Opipari, A.W. Jr.; Hu, H.M.; Yabkowitz, R.; Dixit, V.M. The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. J. Biol. Chem. 1992, 267, 12424-12427.
    • (1992) J. Biol. Chem. , vol.267 , pp. 12424-12427
    • Opipari Jr., A.W.1    Hu, H.M.2    Yabkowitz, R.3    Dixit, V.M.4
  • 71
    • 34447507710 scopus 로고    scopus 로고
    • A20/TNFAIP3, a new estrogen-regulated gene that confers tamoxifen resistance in breast cancer cells
    • Vendrell, J.A.; Ghayad, S.; Ben-Larbi, S.; Dumontet, C.; Mechti, N.; Cohen, P.A. A20/TNFAIP3, a new estrogen-regulated gene that confers tamoxifen resistance in breast cancer cells. Oncogene 2007, 26, 4656-4667.
    • (2007) Oncogene , vol.26 , pp. 4656-4667
    • Vendrell, J.A.1    Ghayad, S.2    Ben-Larbi, S.3    Dumontet, C.4    Mechti, N.5    Cohen, P.A.6
  • 74
    • 33644822862 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas
    • Bredel, M.; Bredel, C.; Juric, D.; Duran, G.E.; Yu, R.X.; Harsh, G.R.; Vogel, H.; Recht, L.D.; Scheck, A.C.; Sikic, B.I. Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J. Clin. Oncol. 2006, 24, 274-287.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 274-287
    • Bredel, M.1    Bredel, C.2    Juric, D.3    Duran, G.E.4    Yu, R.X.5    Harsh, G.R.6    Vogel, H.7    Recht, L.D.8    Scheck, A.C.9    Sikic, B.I.10
  • 75
    • 0028798251 scopus 로고
    • Expression of endothelial cell-specific receptor tyrosine kinases and growth factors in human brain tumors
    • Hatva, E.; Kaipainen, A.; Mentula, P.; Jaaskelainen, J.; Paetau, A.; Haltia, M.; Alitalo, K. Expression of endothelial cell-specific receptor tyrosine kinases and growth factors in human brain tumors. Am. J. Pathol. 1995, 146, 368-378.
    • (1995) Am. J. Pathol. , vol.146 , pp. 368-378
    • Hatva, E.1    Kaipainen, A.2    Mentula, P.3    Jaaskelainen, J.4    Paetau, A.5    Haltia, M.6    Alitalo, K.7
  • 77
    • 0036559186 scopus 로고    scopus 로고
    • Gli and hedgehog in cancer: Tumours, embryos and stem cells
    • Ruiz i Altaba, A.; Sanchez, P.; Dahmane, N. Gli and hedgehog in cancer: Tumours, embryos and stem cells. Nat. Rev. Cancer 2002, 2, 361-372.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 361-372
    • Ruiz i Altaba, A.1    Sanchez, P.2    Dahmane, N.3
  • 78
    • 0028410349 scopus 로고
    • Pattern formation. Hedgehog points the way
    • Ingham, P.W. Pattern formation. Hedgehog points the way. Curr. Biol. 1994, 4, 347-350.
    • (1994) Curr. Biol. , vol.4 , pp. 347-350
    • Ingham, P.W.1
  • 81
    • 33846237601 scopus 로고    scopus 로고
    • HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity
    • Clement, V.; Sanchez, P.; de Tribolet, N.; Radovanovic, I.; Ruiz i Altaba, A. HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity. Curr. Biol. 2007, 17, 165-172.
    • (2007) Curr. Biol. , vol.17 , pp. 165-172
    • Clement, V.1    Sanchez, P.2    de Tribolet, N.3    Radovanovic, I.4    Ruiz i Altaba, A.5
  • 83
    • 58049193929 scopus 로고    scopus 로고
    • Hedgehog signaling regulates brain tumor-initiating cell proliferation and portends shorter survival for patients with PTEN-coexpressing glioblastomas
    • Xu, Q.; Yuan, X.; Liu, G.; Black, K.L.; Yu, J.S. Hedgehog signaling regulates brain tumor-initiating cell proliferation and portends shorter survival for patients with PTEN-coexpressing glioblastomas. Stem Cells 2008, 26, 3018-3026.
    • (2008) Stem Cells , vol.26 , pp. 3018-3026
    • Xu, Q.1    Yuan, X.2    Liu, G.3    Black, K.L.4    Yu, J.S.5
  • 84
    • 79953684136 scopus 로고    scopus 로고
    • The Hedgehog signalling pathway and its prognostic impact in human gliomas
    • doi:10.1111/j.1445-2197.2010.05585.x
    • Li, Q.; Zhang, Y.; Zhan, H.; Yuan, Z.; Lu, P.; Zhan, L.; Xu, W. The Hedgehog signalling pathway and its prognostic impact in human gliomas. ANZ J. Surg. 2010, doi:10.1111/j.1445-2197.2010.05585.x.
    • (2010) ANZ J. Surg.
    • Li, Q.1    Zhang, Y.2    Zhan, H.3    Yuan, Z.4    Lu, P.5    Zhan, L.6    Xu, W.7
  • 85
    • 0033617522 scopus 로고    scopus 로고
    • Notch signaling: Cell fate control and signal integration in development
    • Artavanis-Tsakonas, S.; Rand, M.D.; Lake, R.J. Notch signaling: Cell fate control and signal integration in development. Science 1999, 284, 770-776.
    • (1999) Science , vol.284 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 87
    • 0022780155 scopus 로고
    • Sequence of the notch locus of Drosophila melanogaster: Relationship of the encoded protein to mammalian clotting and growth factors
    • Kidd, S.; Kelley, M.R.; Young, M.W. Sequence of the notch locus of Drosophila melanogaster: Relationship of the encoded protein to mammalian clotting and growth factors. Mol. Cell Biol. 1986, 6, 3094-3108.
    • (1986) Mol. Cell Biol. , vol.6 , pp. 3094-3108
    • Kidd, S.1    Kelley, M.R.2    Young, M.W.3
  • 89
    • 18844414504 scopus 로고    scopus 로고
    • The roles of receptor and ligand endocytosis in regulating Notch signaling
    • Le Borgne, R.; Bardin, A.; Schweisguth, F. The roles of receptor and ligand endocytosis in regulating Notch signaling. Development 2005, 132, 1751-1762.
    • (2005) Development , vol.132 , pp. 1751-1762
    • le Borgne, R.1    Bardin, A.2    Schweisguth, F.3
  • 90
    • 0033867521 scopus 로고    scopus 로고
    • A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch 1
    • Mumm, J.; Schroeter, E.; Saxena, M.; Griesemer, A.; Tian, X.; Pan, D.J.; Ray, W.; Kopan, R. A Ligand-Induced Extracellular Cleavage Regulates γ-Secretase-like Proteolytic Activation of Notch 1. Mol. Cell 2000, 5, 197-206.
    • (2000) Mol. Cell , vol.5 , pp. 197-206
    • Mumm, J.1    Schroeter, E.2    Saxena, M.3    Griesemer, A.4    Tian, X.5    Pan, D.J.6    Ray, W.7    Kopan, R.8
  • 91
    • 0037648484 scopus 로고    scopus 로고
    • Notch-induced proteolysis and nuclear localization of the Delta ligand
    • Bland, C.E.; Kimberly, P.; Rand, M.D. Notch-induced proteolysis and nuclear localization of the Delta ligand. J. Biol. Chem. 2003, 278, 13607-13610.
    • (2003) J. Biol. Chem. , vol.278 , pp. 13607-13610
    • Bland, C.E.1    Kimberly, P.2    Rand, M.D.3
  • 92
    • 34547922380 scopus 로고    scopus 로고
    • Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors
    • Fischer, A.; Gessler, M. Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Nucleic Acids Res. 2007, 35, 4583-4596.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 4583-4596
    • Fischer, A.1    Gessler, M.2
  • 93
    • 34250645690 scopus 로고    scopus 로고
    • Oscillator mechanism of Notch pathway in the segmentation clock
    • Kageyama, R.; Masamizu, Y.; Niwa, Y. Oscillator mechanism of Notch pathway in the segmentation clock. Dev. Dyn. 2007, 236, 1403-1409.
    • (2007) Dev. Dyn. , vol.236 , pp. 1403-1409
    • Kageyama, R.1    Masamizu, Y.2    Niwa, Y.3
  • 94
    • 0042286558 scopus 로고    scopus 로고
    • Notch and cancer: Best to avoid the ups and downs
    • Maillard, I.; Pear, W.S. Notch and cancer: Best to avoid the ups and downs. Cancer Cell 2003, 3, 203-205.
    • (2003) Cancer Cell , vol.3 , pp. 203-205
    • Maillard, I.1    Pear, W.S.2
  • 96
    • 36949031706 scopus 로고    scopus 로고
    • Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells
    • Zhang, X.P.; Zheng, G.; Zou, L.; Liu, H.L.; Hou, L.H.; Zhou, P.; Yin, D.D.; Zheng, Q.J.; Liang, L.; Zhang, S.Z.; et al. Notch activation promotes cell proliferation and the formation of neural stem cell-like colonies in human glioma cells. Mol. Cell. Biochem. 2008, 307, 101-108.
    • (2008) Mol. Cell. Biochem. , vol.307 , pp. 101-108
    • Zhang, X.P.1    Zheng, G.2    Zou, L.3    Liu, H.L.4    Hou, L.H.5    Zhou, P.6    Yin, D.D.7    Zheng, Q.J.8    Liang, L.9    Zhang, S.Z.10
  • 97
    • 33747874155 scopus 로고    scopus 로고
    • Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors
    • Fan, X.; Matsui, W.; Khaki, L.; Stearns, D.; Chun, J.; Li, Y.M.; Eberhart, C.G. Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. Cancer Res. 2006, 66, 7445-7452.
    • (2006) Cancer Res. , vol.66 , pp. 7445-7452
    • Fan, X.1    Matsui, W.2    Khaki, L.3    Stearns, D.4    Chun, J.5    Li, Y.M.6    Eberhart, C.G.7
  • 99
    • 1342289563 scopus 로고    scopus 로고
    • Bmi1, stem cells, and senescence regulation
    • Park, I.K.; Morrison, S.J.; Clarke, M.F. Bmi1, stem cells, and senescence regulation. J. Clin. Invest. 2004, 113, 175-179.
    • (2004) J. Clin. Invest. , vol.113 , pp. 175-179
    • Park, I.K.1    Morrison, S.J.2    Clarke, M.F.3
  • 101
    • 77957193274 scopus 로고    scopus 로고
    • Clinical significance of Polycomb gene expression in brain tumors
    • Crea, F.; Hurt, E.; Farrar, W. Clinical significance of Polycomb gene expression in brain tumors. Mol. Cancer 2010, 9, 265-270.
    • (2010) Mol. Cancer , vol.9 , pp. 265-270


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.