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Volumn 15, Issue 12, 2011, Pages 2664-2674

Palmitoylethanolamide counteracts reactive astrogliosis induced by β-amyloid peptide

Author keywords

amyloid; Astrocyte; Neuroinflammation; Palmitoylethanolamide; PPAR

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); MESSENGER RNA; NONSTEROID ANTIINFLAMMATORY AGENT; PALMIDROL; PALMITIC ACID DERIVATIVE; PEPTIDE FRAGMENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

EID: 79953662512     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2011.01267.x     Document Type: Article
Times cited : (95)

References (51)
  • 1
    • 33645420706 scopus 로고    scopus 로고
    • Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration
    • Craft JM, Watterson DM, Van Eldik LJ. Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration. Glia. 2006; 53: 484-90.
    • (2006) Glia , vol.53 , pp. 484-490
    • Craft, J.M.1    Watterson, D.M.2    Van Eldik, L.J.3
  • 2
    • 77950363010 scopus 로고    scopus 로고
    • Mechanisms underlying inflammation in neurodegeneration
    • Glass CK, Saijo K, Winner B, et al. Mechanisms underlying inflammation in neurodegeneration. Cell. 2010; 140: 918-34.
    • (2010) Cell , vol.140 , pp. 918-934
    • Glass, C.K.1    Saijo, K.2    Winner, B.3
  • 3
    • 0036685522 scopus 로고    scopus 로고
    • Inflammation in neurodegenerative disease-a double-edged sword
    • Wyss-Coray T, Mucke L. Inflammation in neurodegenerative disease-a double-edged sword. Neuron. 2002; 35: 419-32.
    • (2002) Neuron , vol.35 , pp. 419-432
    • Wyss-Coray, T.1    Mucke, L.2
  • 4
    • 41149125146 scopus 로고    scopus 로고
    • Neurodegeneration and inflammation
    • DeLegge MH, Smoke A. Neurodegeneration and inflammation. Nutr Clin Pract. 2008; 23: 35-41.
    • (2008) Nutr Clin Pract , vol.23 , pp. 35-41
    • DeLegge, M.H.1    Smoke, A.2
  • 5
    • 37049020205 scopus 로고    scopus 로고
    • The brain as a target for inflammatory processes and neuroprotective strategies
    • Skaper SD. The brain as a target for inflammatory processes and neuroprotective strategies. Ann NY Acad Sci. 2007; 1122: 23-34.
    • (2007) Ann NY Acad Sci , vol.1122 , pp. 23-34
    • Skaper, S.D.1
  • 6
    • 0035690976 scopus 로고    scopus 로고
    • Interleukin-1, neuroinflammation, and Alzheimer's disease
    • Mrak RE, Griffin WS. Interleukin-1, neuroinflammation, and Alzheimer's disease. Neurobiol Aging. 2001; 22: 903-8.
    • (2001) Neurobiol Aging , vol.22 , pp. 903-908
    • Mrak, R.E.1    Griffin, W.S.2
  • 7
    • 77955091036 scopus 로고    scopus 로고
    • Astrogliosis in CNS pathologies: is there a role for microglia
    • Zhang D, Hu X, Qian L, et al. Astrogliosis in CNS pathologies: is there a role for microglia Mol Neurobiol. 2010; 41: 232-41.
    • (2010) Mol Neurobiol , vol.41 , pp. 232-241
    • Zhang, D.1    Hu, X.2    Qian, L.3
  • 8
    • 0036850023 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimer's disease and prion disease
    • Eikelenboom P, Bate C, Van Gool WA, et al. Neuroinflammation in Alzheimer's disease and prion disease. Glia. 2002; 40: 232-9.
    • (2002) Glia , vol.40 , pp. 232-239
    • Eikelenboom, P.1    Bate, C.2    Van Gool, W.A.3
  • 9
    • 60349132064 scopus 로고    scopus 로고
    • The role of neuroimmunomodulation in Alzheimer's disease
    • Maccioni RB, Rojo LE, Fernández JA, et al. The role of neuroimmunomodulation in Alzheimer's disease. Ann NY Acad Sci. 2009; 1153: 240-6.
    • (2009) Ann NY Acad Sci , vol.1153 , pp. 240-246
    • Maccioni, R.B.1    Rojo, L.E.2    Fernández, J.A.3
  • 10
    • 0036849021 scopus 로고    scopus 로고
    • Microglia and inflammatory mechanisms in the clearance of amyloid b peptide
    • Rogers J, Strohmeyer R, Koveleowski CJ, et al. Microglia and inflammatory mechanisms in the clearance of amyloid b peptide. Glia. 2002; 40: 260-9.
    • (2002) Glia , vol.40 , pp. 260-269
    • Rogers, J.1    Strohmeyer, R.2    Koveleowski, C.J.3
  • 11
    • 36549083642 scopus 로고    scopus 로고
    • Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease
    • Rojo LE, Fernández JA, Maccioni AA, et al. Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease. Arch Med Res. 2008; 39: 1-16.
    • (2008) Arch Med Res , vol.39 , pp. 1-16
    • Rojo, L.E.1    Fernández, J.A.2    Maccioni, A.A.3
  • 12
    • 78650820931 scopus 로고    scopus 로고
    • Amyloid-β induces cyclooxygenase-2 and PGE2 release in human astrocytes in NF-κ B dependent manner
    • Blanco A, Alvarez S, Fresno M, et al. Amyloid-β induces cyclooxygenase-2 and PGE2 release in human astrocytes in NF-κ B dependent manner. J Alzheimers Dis. 2010; 22.
    • (2010) J Alzheimers Dis. , vol.22
    • Blanco, A.1    Alvarez, S.2    Fresno, M.3
  • 13
    • 69249100372 scopus 로고    scopus 로고
    • RAGE: therapeutic target and biomarker of the inflammatory response-the evidence mounts
    • Ramasamy R, Yan SF, Schmidt AM. RAGE: therapeutic target and biomarker of the inflammatory response-the evidence mounts. J Leukoc Biol. 2009; 86: 505-12.
    • (2009) J Leukoc Biol , vol.86 , pp. 505-512
    • Ramasamy, R.1    Yan, S.F.2    Schmidt, A.M.3
  • 14
    • 10344238086 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway
    • Liao YF, Wang BJ, Cheng HT, et al. Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway. J Biol Chem. 2004; 279: 49523-32.
    • (2004) J Biol Chem , vol.279 , pp. 49523-49532
    • Liao, Y.F.1    Wang, B.J.2    Cheng, H.T.3
  • 15
    • 39749177650 scopus 로고    scopus 로고
    • Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in Abeta production
    • Tachida Y, Nakagawa K, Saito T, et al. Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in Abeta production. J Neurochem. 2008; 104: 1387-93.
    • (2008) J Neurochem , vol.104 , pp. 1387-1393
    • Tachida, Y.1    Nakagawa, K.2    Saito, T.3
  • 17
    • 74349084448 scopus 로고    scopus 로고
    • The neuroprotective properties of palmitoylethanolamine against oxidative stress in a neuronal cell line
    • Duncan RS, Chapman KD, Koulen P. The neuroprotective properties of palmitoylethanolamine against oxidative stress in a neuronal cell line. Mol Neurodegener. 2009; 4: 50.
    • (2009) Mol Neurodegener. , vol.4 , pp. 50
    • Duncan, R.S.1    Chapman, K.D.2    Koulen, P.3
  • 18
    • 23044438547 scopus 로고    scopus 로고
    • The search for the palmitoylethanolamide receptor
    • LoVerme J, La Rana G, Russo R, et al. The search for the palmitoylethanolamide receptor. Life Sci. 2005; 77: 1685-98.
    • (2005) Life Sci , vol.77 , pp. 1685-1698
    • LoVerme, J.1    La Rana, G.2    Russo, R.3
  • 19
    • 33646814424 scopus 로고    scopus 로고
    • Cannabinoid receptors and endocannabinoids: evidence for new players.AAPS J.
    • Mackie K, Stella N. Cannabinoid receptors and endocannabinoids: evidence for new players.AAPS J. 2006; 8: E298-306.
    • (2006) , vol.8
    • Mackie, K.1    Stella, N.2
  • 20
    • 0032537734 scopus 로고    scopus 로고
    • Control of pain initiation by endogenous cannabinoids
    • Calignano A, La Rana G, Giuffrida A, et al. Control of pain initiation by endogenous cannabinoids. Nature. 1998; 394: 277-81.
    • (1998) Nature , vol.394 , pp. 277-281
    • Calignano, A.1    La Rana, G.2    Giuffrida, A.3
  • 21
    • 0035843772 scopus 로고    scopus 로고
    • Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide
    • Calignano A, La Rana G, Piomelli D. Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide. Eur J Pharmacol. 2001; 419: 191-8.
    • (2001) Eur J Pharmacol , vol.419 , pp. 191-198
    • Calignano, A.1    La Rana, G.2    Piomelli, D.3
  • 22
    • 0042320663 scopus 로고    scopus 로고
    • Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility
    • Franklin A, Parmentier-Batteur S, Walter L, et al. Palmitoylethanolamide increases after focal cerebral ischemia and potentiates microglial cell motility. J Neurosci. 2003; 23: 7767-75.
    • (2003) J Neurosci , vol.23 , pp. 7767-7775
    • Franklin, A.1    Parmentier-Batteur, S.2    Walter, L.3
  • 23
    • 0031776783 scopus 로고    scopus 로고
    • The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain
    • Jaggar SI, Hasnie FS, Sellaturay S, et al. The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain. Pain. 1998; 76: 189-99.
    • (1998) Pain , vol.76 , pp. 189-199
    • Jaggar, S.I.1    Hasnie, F.S.2    Sellaturay, S.3
  • 24
    • 0035060264 scopus 로고    scopus 로고
    • Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice
    • Lambert DM, Vandevoorde S, Diependaele G, et al. Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice. Epilepsia. 2001; 42: 321-7.
    • (2001) Epilepsia , vol.42 , pp. 321-327
    • Lambert, D.M.1    Vandevoorde, S.2    Diependaele, G.3
  • 25
    • 0029865544 scopus 로고    scopus 로고
    • N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation
    • Mazzari S, Canella R, Petrelli L, et al. N-(2-hydroxyethyl)hexadecanamide is orally active in reducing edema formation and inflammatory hyperalgesia by down-modulating mast cell activation. Eur J Pharmacol. 1996; 300: 227-36.
    • (1996) Eur J Pharmacol , vol.300 , pp. 227-236
    • Mazzari, S.1    Canella, R.2    Petrelli, L.3
  • 26
    • 5344277612 scopus 로고    scopus 로고
    • Selective antiepileptic effects of N-palmitoylethanolamide, a putative endocannabinoid
    • Sheerin AH, Zhang X, Saucier DM, et al. Selective antiepileptic effects of N-palmitoylethanolamide, a putative endocannabinoid. Epilepsia. 2004; 45: 1184-8.
    • (2004) Epilepsia , vol.45 , pp. 1184-1188
    • Sheerin, A.H.1    Zhang, X.2    Saucier, D.M.3
  • 27
    • 0029870716 scopus 로고    scopus 로고
    • The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons
    • Skaper SD, Buriani A, Dal Toso R, et al. The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebellar granule neurons. Proc Natl Acad Sci USA. 1996; 93: 3984-9.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3984-3989
    • Skaper, S.D.1    Buriani, A.2    Dal Toso, R.3
  • 28
    • 67651146366 scopus 로고    scopus 로고
    • N-acylethanolamines, anandamide and food intake
    • Hansen HS, Diep TA. N-acylethanolamines, anandamide and food intake. Biochem Pharmacol. 2009; 78: 553-60.
    • (2009) Biochem Pharmacol , vol.78 , pp. 553-560
    • Hansen, H.S.1    Diep, T.A.2
  • 29
    • 0035159492 scopus 로고    scopus 로고
    • Inhibitory effect of palmitoylethanolamide on gastrointestinal motility in mice
    • Capasso R, Izzo AA, Fezza F, et al. Inhibitory effect of palmitoylethanolamide on gastrointestinal motility in mice. Br J Pharmacol. 2001; 134: 945-50.
    • (2001) Br J Pharmacol , vol.134 , pp. 945-950
    • Capasso, R.1    Izzo, A.A.2    Fezza, F.3
  • 30
    • 0036399326 scopus 로고    scopus 로고
    • Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems
    • De Petrocellis L, Bisogno T, Ligresti A, et al. Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems. Fundam Clin Pharmacol. 2002; 16: 297-302.
    • (2002) Fundam Clin Pharmacol , vol.16 , pp. 297-302
    • De Petrocellis, L.1    Bisogno, T.2    Ligresti, A.3
  • 31
    • 0035881542 scopus 로고    scopus 로고
    • Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells
    • Di Marzo V, Melck D, Orlando P, et al. Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells. Biochem J. 2001; 358: 249-55.
    • (2001) Biochem J , vol.358 , pp. 249-255
    • Di Marzo, V.1    Melck, D.2    Orlando, P.3
  • 32
    • 0037424211 scopus 로고    scopus 로고
    • Contribution of endocannabinoids in the endothelial protection afforded by ischemic preconditioning in the isolated rat heart
    • Bouchard JF, LÈpicier P, Lamontagne D. Contribution of endocannabinoids in the endothelial protection afforded by ischemic preconditioning in the isolated rat heart. Life Sci. 2003; 72: 1859-70.
    • (2003) Life Sci , vol.72 , pp. 1859-1870
    • Bouchard, J.F.1    Lèpicier, P.2    Lamontagne, D.3
  • 33
    • 33751166817 scopus 로고    scopus 로고
    • Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha
    • LoVerme J, Russo R, La Rana G, et al. Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha. J Pharmacol Exp Ther. 2006; 319: 1051-61.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 1051-1061
    • LoVerme, J.1    Russo, R.2    La Rana, G.3
  • 34
    • 33846378110 scopus 로고    scopus 로고
    • Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals
    • Re G, Barbero R, Miolo A, et al. Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals. Vet J. 2007; 173: 21-30.
    • (2007) Vet J , vol.173 , pp. 21-30
    • Re, G.1    Barbero, R.2    Miolo, A.3
  • 35
    • 0031033841 scopus 로고    scopus 로고
    • Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain
    • Cadas H, di Tomaso E, Piomelli D. Occurrence and biosynthesis of endogenous cannabinoid precursor, N-arachidonoyl phosphatidylethanolamine, in rat brain. J Neurosci. 1997; 17: 1226-42.
    • (1997) J Neurosci , vol.17 , pp. 1226-1242
    • Cadas, H.1    di Tomaso, E.2    Piomelli, D.3
  • 36
    • 33646521012 scopus 로고    scopus 로고
    • Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the rat
    • Murillo-Rodriguez E, Désarnaud F, Prospéro-Garcìa O. Diurnal variation of arachidonoylethanolamine, palmitoylethanolamide and oleoylethanolamide in the brain of the rat. Life Sci. 2006; 79: 30-7.
    • (2006) Life Sci , vol.79 , pp. 30-37
    • Murillo-Rodriguez, E.1    Désarnaud, F.2    Prospéro-Garcìa, O.3
  • 37
    • 0036690130 scopus 로고    scopus 로고
    • Erythropoietin exerts anti-apoptotic effects on rat microglial cellsin vitro
    • Vairano M, Dello Russo C, Pozzoli G, et al. Erythropoietin exerts anti-apoptotic effects on rat microglial cellsin vitro. Eur J Neurosci. 2002; 16: 584-92.
    • (2002) Eur J Neurosci , vol.16 , pp. 584-592
    • Vairano, M.1    Dello Russo, C.2    Pozzoli, G.3
  • 38
    • 0025221099 scopus 로고
    • Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages
    • Di Rosa M, Radomski M, Carnuccio R, et al. Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages. Biochem Biophys Res Commun. 1990; 172: 1246-52.
    • (1990) Biochem Biophys Res Commun , vol.172 , pp. 1246-1252
    • Di Rosa, M.1    Radomski, M.2    Carnuccio, R.3
  • 39
    • 77953291080 scopus 로고    scopus 로고
    • N-palmitoyl-ethanolamine: biochemistry and new therapeutic opportunities
    • Petrosino S, Iuvone T, Di Marzo V. N-palmitoyl-ethanolamine: biochemistry and new therapeutic opportunities. Biochimie. 2010; 92: 724-7.
    • (2010) Biochimie , vol.92 , pp. 724-727
    • Petrosino, S.1    Iuvone, T.2    Di Marzo, V.3
  • 40
    • 59049100727 scopus 로고    scopus 로고
    • Targeted activation of astrocytes: a potential neuroprotective strategy
    • Escartin C, Bonvento G. Targeted activation of astrocytes: a potential neuroprotective strategy. Mol Neurobiol. 2008; 38: 231-41.
    • (2008) Mol Neurobiol , vol.38 , pp. 231-241
    • Escartin, C.1    Bonvento, G.2
  • 41
    • 10044235332 scopus 로고    scopus 로고
    • Secreted beta-amyloid precursor protein activates microgliaviaJNK and p38-MAPK
    • Bodles AM, Barger SW. Secreted beta-amyloid precursor protein activates microgliaviaJNK and p38-MAPK. Neurobiol Aging. 2005; 26: 9-16.
    • (2005) Neurobiol Aging , vol.26 , pp. 9-16
    • Bodles, A.M.1    Barger, S.W.2
  • 42
    • 21044448540 scopus 로고    scopus 로고
    • Mechanisms of cell signaling and inflammation in Alzheimer's disease
    • Ho GJ, Drego R, Hakimian E, et al. Mechanisms of cell signaling and inflammation in Alzheimer's disease. Curr Drug Targets Inflamm Allergy. 2005; 4: 247-56.
    • (2005) Curr Drug Targets Inflamm Allergy , vol.4 , pp. 247-256
    • Ho, G.J.1    Drego, R.2    Hakimian, E.3
  • 43
    • 0034678024 scopus 로고    scopus 로고
    • B-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1β- and tumor necrosis factor-α (TNF-α)-dependent, and involves a TNF-α receptor-associated factor- and NF-κB-inducing kinase-dependent signaling mechanism
    • Akama KT, Van Eldik LJ. B-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1β- and tumor necrosis factor-α (TNF-α)-dependent, and involves a TNF-α receptor-associated factor- and NF-κB-inducing kinase-dependent signaling mechanism. J Biol Chem. 2000; 275: 7918-24.
    • (2000) J Biol Chem , vol.275 , pp. 7918-7924
    • Akama, K.T.1    Van Eldik, L.J.2
  • 44
    • 0033043939 scopus 로고    scopus 로고
    • p38 kinase is activated in the Alzheimer's disease brain
    • Hensley RA, Floyd RA, Zheng NY, et al. p38 kinase is activated in the Alzheimer's disease brain. J. Neurochem. 1999; 72: 2053-8.
    • (1999) J. Neurochem , vol.72 , pp. 2053-2058
    • Hensley, R.A.1    Floyd, R.A.2    Zheng, N.Y.3
  • 45
    • 0031172065 scopus 로고    scopus 로고
    • NF-κB: a crucial transcription factor for glial and neuronal cell function
    • O'Neill LAJ, Kaltschmidt C. NF-κB: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci. 1997; 20: 252-8.
    • (1997) Trends Neurosci , vol.20 , pp. 252-258
    • O'Neill, L.A.J.1    Kaltschmidt, C.2
  • 46
    • 25444505871 scopus 로고    scopus 로고
    • Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases
    • Walker DG, Lue LF. Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases. J Neurosci Res. 2005; 81: 412-25.
    • (2005) J Neurosci Res , vol.81 , pp. 412-425
    • Walker, D.G.1    Lue, L.F.2
  • 47
    • 0035142804 scopus 로고    scopus 로고
    • Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease
    • Zhu X, Raina AK, Rottkamp CA, et al. Activation and redistribution of c-jun N-terminal kinase/stress activated protein kinase in degenerating neurons in Alzheimer's disease. J Neurochem. 2001; 76: 435-41.
    • (2001) J Neurochem , vol.76 , pp. 435-441
    • Zhu, X.1    Raina, A.K.2    Rottkamp, C.A.3
  • 48
    • 0034797352 scopus 로고    scopus 로고
    • Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis
    • Zhu X, Castellani RJ, Takeda A, et al. Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis. Mech Ageing Dev. 2001; 123: 39-46.
    • (2001) Mech Ageing Dev , vol.123 , pp. 39-46
    • Zhu, X.1    Castellani, R.J.2    Takeda, A.3
  • 49
    • 77954175115 scopus 로고    scopus 로고
    • Cannabinoid activation of peroxisome proliferator-activated receptors: potential for modulation of inflammatory disease
    • O'Sullivan SE, Kendall DA. Cannabinoid activation of peroxisome proliferator-activated receptors: potential for modulation of inflammatory disease. Immunobiology. 2010; 215: 611-6.
    • (2010) Immunobiology , vol.215 , pp. 611-616
    • O'Sullivan, S.E.1    Kendall, D.A.2
  • 50
    • 0032766027 scopus 로고    scopus 로고
    • The palmitoylethanolamide and oleamide enigmas: are these two fatty acid amides cannabimimetic
    • Lambert DM, Di Marzo V. The palmitoylethanolamide and oleamide enigmas: are these two fatty acid amides cannabimimetic Curr Med Chem. 1999; 6: 757-73.
    • (1999) Curr Med Chem , vol.6 , pp. 757-773
    • Lambert, D.M.1    Di Marzo, V.2
  • 51
    • 34548069374 scopus 로고    scopus 로고
    • Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis:in vitroandin vivoevidence
    • Esposito G, Iuvone T, Savani C, et al. Opposing control of cannabinoid receptor stimulation on amyloid-beta-induced reactive gliosis:in vitroandin vivoevidence. J Pharmacol Exp Ther. 2007; 322: 1144-52.
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 1144-1152
    • Esposito, G.1    Iuvone, T.2    Savani, C.3


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