-
1
-
-
0016261404
-
Prophylactic efficacy of N-2-hydroxyethyl palmitamide (impulsin) in acute respiratory tract infections
-
Masek K., Perlík F., Klíma J., Kahlich R. Prophylactic efficacy of N-2-hydroxyethyl palmitamide (impulsin) in acute respiratory tract infections. Eur. J. Clin. Pharmacol. 1974, 7:415-419.
-
(1974)
Eur. J. Clin. Pharmacol.
, vol.7
, pp. 415-419
-
-
Masek, K.1
Perlík, F.2
Klíma, J.3
Kahlich, R.4
-
2
-
-
11244328917
-
The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of Palmitoylethanolamide
-
Lo Verme J., Fu J., Astarita G., et al. The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of Palmitoylethanolamide. Mol. Pharmacol. 2005, 67:15-19.
-
(2005)
Mol. Pharmacol.
, vol.67
, pp. 15-19
-
-
Lo Verme, J.1
Fu, J.2
Astarita, G.3
-
3
-
-
33846378110
-
Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals
-
Re G., Barbero R., Miolo A., Di Marzo V. Palmitoylethanolamide, endocannabinoids and related cannabimimetic compounds in protection against tissue inflammation and pain: potential use in companion animals. Vet. J. 2007, 173:21-30.
-
(2007)
Vet. J.
, vol.173
, pp. 21-30
-
-
Re, G.1
Barbero, R.2
Miolo, A.3
Di Marzo, V.4
-
4
-
-
1242294480
-
Molecular characterization of a phospholipase D generating anandamide and its congeners
-
Okamoto Y., Morishita J., Tsuboi K., Tonai T., Ueda N. Molecular characterization of a phospholipase D generating anandamide and its congeners. J. Biol. Chem. 2004, 279:5298-5305.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 5298-5305
-
-
Okamoto, Y.1
Morishita, J.2
Tsuboi, K.3
Tonai, T.4
Ueda, N.5
-
5
-
-
33744962965
-
Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-beta-lactamase family
-
Wang J., Okamoto Y., Morishita J., Tsuboi K., Miyatake A., Ueda N. Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-beta-lactamase family. J. Biol. Chem. 2006, 281:12325-12335.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 12325-12335
-
-
Wang, J.1
Okamoto, Y.2
Morishita, J.3
Tsuboi, K.4
Miyatake, A.5
Ueda, N.6
-
6
-
-
67649865359
-
Endocannabinoid chemical biology: a tool for the development of novel therapies
-
Petrosino S., Ligresti A., Di Marzo V. Endocannabinoid chemical biology: a tool for the development of novel therapies. Curr. Opin. Chem. Biol. 2009, 13:309-320.
-
(2009)
Curr. Opin. Chem. Biol.
, vol.13
, pp. 309-320
-
-
Petrosino, S.1
Ligresti, A.2
Di Marzo, V.3
-
7
-
-
3042737612
-
Biosynthesis of anandamide and N-palmitoyl-ethanolamine by sequential actions of phospholipase A2 and lysophospholipase D
-
Sun Y.X., Tsuboi K., Okamoto Y., et al. Biosynthesis of anandamide and N-palmitoyl-ethanolamine by sequential actions of phospholipase A2 and lysophospholipase D. Biochem. J. 2004, 380:749-756.
-
(2004)
Biochem. J.
, vol.380
, pp. 749-756
-
-
Sun, Y.X.1
Tsuboi, K.2
Okamoto, Y.3
-
8
-
-
33748743637
-
Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway
-
Simon G.M., Cravatt B.F. Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway. J. Biol. Chem. 2006, 281:26465-26472.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 26465-26472
-
-
Simon, G.M.1
Cravatt, B.F.2
-
10
-
-
37349020974
-
Multiple pathways involved in the biosynthesis of anandamide
-
Liu J., Wang L., Harvey-White J., et al. Multiple pathways involved in the biosynthesis of anandamide. Neuropharmacology 2008, 54:1-7.
-
(2008)
Neuropharmacology
, vol.54
, pp. 1-7
-
-
Liu, J.1
Wang, L.2
Harvey-White, J.3
-
11
-
-
0029904838
-
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
-
Cravatt B.F., Giang D.K., Mayfield S.P., Boger D.L., Lerner R.A., Gilula N.B. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature 1996, 384:83-87.
-
(1996)
Nature
, vol.384
, pp. 83-87
-
-
Cravatt, B.F.1
Giang, D.K.2
Mayfield, S.P.3
Boger, D.L.4
Lerner, R.A.5
Gilula, N.B.6
-
12
-
-
0030903752
-
Molecular characterization of human and mouse fatty acid amide hydrolases
-
Giang D.K., Cravatt B.F. Molecular characterization of human and mouse fatty acid amide hydrolases. Proc. Natl. Acad. Sci. U S A 1997, 94:2238-2242.
-
(1997)
Proc. Natl. Acad. Sci. U S A
, vol.94
, pp. 2238-2242
-
-
Giang, D.K.1
Cravatt, B.F.2
-
13
-
-
0035929564
-
Purification and characterization of an acid amidase selective for N-palmitoyl-ethanolamine, a putative endogenous anti-inflammatory substance
-
Ueda N., Yamanaka K., Yamamoto S. Purification and characterization of an acid amidase selective for N-palmitoyl-ethanolamine, a putative endogenous anti-inflammatory substance. J. Biol. Chem. 2001, 276:35552-35557.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 35552-35557
-
-
Ueda, N.1
Yamanaka, K.2
Yamamoto, S.3
-
14
-
-
15744378565
-
Molecular characterization of N-acyl-ethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase
-
Tsuboi K., Sun Y.X., Okamoto Y., Araki N., Tonai T., Ueda N. Molecular characterization of N-acyl-ethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase. J. Biol. Chem. 2005, 280:11082-11092.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 11082-11092
-
-
Tsuboi, K.1
Sun, Y.X.2
Okamoto, Y.3
Araki, N.4
Tonai, T.5
Ueda, N.6
-
15
-
-
34247585700
-
Predominant expression of lysosomal N-acyl-ethanolamine-hydrolyzing acid amidase in macrophages revealed by immunochemical studies
-
Tsuboi K., Zhao L.Y., Okamoto Y., et al. Predominant expression of lysosomal N-acyl-ethanolamine-hydrolyzing acid amidase in macrophages revealed by immunochemical studies. Biochim. Biophys. Acta 2007, 1771:623-632.
-
(2007)
Biochim. Biophys. Acta
, vol.1771
, pp. 623-632
-
-
Tsuboi, K.1
Zhao, L.Y.2
Okamoto, Y.3
-
16
-
-
36749044294
-
Proteolytic activation and glycosylation of N-acylethanolamine-hydrolyzing acid amidase, a lysosomal enzyme involved in the endocannabinoid metabolism
-
Zhao L.Y., Tsuboi K., Okamoto Y., Nagahata S., Ueda N. Proteolytic activation and glycosylation of N-acylethanolamine-hydrolyzing acid amidase, a lysosomal enzyme involved in the endocannabinoid metabolism. Biochim. Biophys. Acta 2007, 1771:1397-1405.
-
(2007)
Biochim. Biophys. Acta
, vol.1771
, pp. 1397-1405
-
-
Zhao, L.Y.1
Tsuboi, K.2
Okamoto, Y.3
Nagahata, S.4
Ueda, N.5
-
17
-
-
0027313392
-
A proposed autacoid mechanism controlling mastocyte behaviour
-
Aloe L., Leon A., Levi-Montalcini R. A proposed autacoid mechanism controlling mastocyte behaviour. Agents Actions 1993, 39:145-147.
-
(1993)
Agents Actions
, vol.39
, pp. 145-147
-
-
Aloe, L.1
Leon, A.2
Levi-Montalcini, R.3
-
18
-
-
0036157693
-
Anti-inflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat
-
Conti S., Costa B., Colleoni M., Parolaro D., Giagnoni G. Anti-inflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat. Br. J. Pharmacol. 2002, 135:181-187.
-
(2002)
Br. J. Pharmacol.
, vol.135
, pp. 181-187
-
-
Conti, S.1
Costa, B.2
Colleoni, M.3
Parolaro, D.4
Giagnoni, G.5
-
19
-
-
0031830516
-
An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity
-
Ben-Shabat S., Fride E., Sheskin T., et al. An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. Eur. J. Pharmacol. 1998, 353:23-31.
-
(1998)
Eur. J. Pharmacol.
, vol.353
, pp. 23-31
-
-
Ben-Shabat, S.1
Fride, E.2
Sheskin, T.3
-
20
-
-
0032766027
-
The palmitoylethanolamide and oleamide enigmas: are these two fatty acid amides cannabimimetic?
-
Lambert D.M., Di Marzo V. The palmitoylethanolamide and oleamide enigmas: are these two fatty acid amides cannabimimetic?. Curr. Med. Chem. 1999, 9:757-773.
-
(1999)
Curr. Med. Chem.
, vol.9
, pp. 757-773
-
-
Lambert, D.M.1
Di Marzo, V.2
-
21
-
-
0035881542
-
Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells
-
Di Marzo V., Melck D., Orlando P., et al. Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells. Biochem. J. 2001, 358:249-255.
-
(2001)
Biochem. J.
, vol.358
, pp. 249-255
-
-
Di Marzo, V.1
Melck, D.2
Orlando, P.3
-
22
-
-
0035850918
-
Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors
-
De Petrocellis L., Davis J.B., Di Marzo V. Palmitoylethanolamide enhances anandamide stimulation of human vanilloid VR1 receptors. FEBS Lett. 2001, 506:253-256.
-
(2001)
FEBS Lett.
, vol.506
, pp. 253-256
-
-
De Petrocellis, L.1
Davis, J.B.2
Di Marzo, V.3
-
23
-
-
0036016117
-
'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism
-
Smart D., Jonsson K.O., Vandevoorde S., Lambert D.M., Fowler C.J. 'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism. Br. J. Pharmacol. 2002, 136:452-458.
-
(2002)
Br. J. Pharmacol.
, vol.136
, pp. 452-458
-
-
Smart, D.1
Jonsson, K.O.2
Vandevoorde, S.3
Lambert, D.M.4
Fowler, C.J.5
-
24
-
-
57349088304
-
'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors
-
Ho W.S., Barrett D.A., Randall M.D. 'Entourage' effects of N-palmitoylethanolamide and N-oleoylethanolamide on vasorelaxation to anandamide occur through TRPV1 receptors. Br. J. Pharmacol. 2008, 155:837-846.
-
(2008)
Br. J. Pharmacol.
, vol.155
, pp. 837-846
-
-
Ho, W.S.1
Barrett, D.A.2
Randall, M.D.3
-
25
-
-
53349089891
-
The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPAR gamma receptors and neurotrophic factors
-
Costa B., Comelli F., Bettoni I., Colleoni M., Giagnoni G. The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPAR gamma receptors and neurotrophic factors. Pain 2008, 139:541-550.
-
(2008)
Pain
, vol.139
, pp. 541-550
-
-
Costa, B.1
Comelli, F.2
Bettoni, I.3
Colleoni, M.4
Giagnoni, G.5
-
26
-
-
0032537734
-
Control of pain initiation by endogenous cannabinoids
-
Calignano A., La Rana G., Giuffrida A., Piomelli D. Control of pain initiation by endogenous cannabinoids. Nature 1998, 394:277-281.
-
(1998)
Nature
, vol.394
, pp. 277-281
-
-
Calignano, A.1
La Rana, G.2
Giuffrida, A.3
Piomelli, D.4
-
27
-
-
0035843772
-
Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide
-
Calignano A., La Rana G., Piomelli D. Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide. Eur. J. Pharmacol. 2001, 419:191-198.
-
(2001)
Eur. J. Pharmacol.
, vol.419
, pp. 191-198
-
-
Calignano, A.1
La Rana, G.2
Piomelli, D.3
-
28
-
-
35649015179
-
The orphan receptor GPR55 is a novel cannabinoid receptor
-
Ryberg E., Larsson N., Sjögren S., et al. The orphan receptor GPR55 is a novel cannabinoid receptor. Br. J. Pharmacol. 2007, 152:1092-1101.
-
(2007)
Br. J. Pharmacol.
, vol.152
, pp. 1092-1101
-
-
Ryberg, E.1
Larsson, N.2
Sjögren, S.3
-
29
-
-
70350376735
-
Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands
-
Kapur A., Zhao P., Sharir H., et al. Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands. J. Biol. Chem. 2009, 284:29817-29827.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 29817-29827
-
-
Kapur, A.1
Zhao, P.2
Sharir, H.3
-
30
-
-
19444386886
-
Involvement of the cannabimimetic compound, N-palmitoyl-ethanolamine, in inflammatory and neuropathic conditions: review of the available pre-clinical data, and first human studies
-
Darmani N.A., Izzo A.A., Degenhardt B., et al. Involvement of the cannabimimetic compound, N-palmitoyl-ethanolamine, in inflammatory and neuropathic conditions: review of the available pre-clinical data, and first human studies. Neuropharmacology 2005, 48:1154-1163.
-
(2005)
Neuropharmacology
, vol.48
, pp. 1154-1163
-
-
Darmani, N.A.1
Izzo, A.A.2
Degenhardt, B.3
-
31
-
-
0141923653
-
Esters, retroesters, and a retroamide of palmitic acid: pool for the first selective inhibitors of N-palmitoyl-ethanolamine-selective acid amidase
-
Vandevoorde S., Tsuboi K., Ueda N., Jonsson K.O., Fowler C.J., Lambert D.M. Esters, retroesters, and a retroamide of palmitic acid: pool for the first selective inhibitors of N-palmitoyl-ethanolamine-selective acid amidase. J. Med. Chem. 2003, 46:4373-4376.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 4373-4376
-
-
Vandevoorde, S.1
Tsuboi, K.2
Ueda, N.3
Jonsson, K.O.4
Fowler, C.J.5
Lambert, D.M.6
-
32
-
-
1842833388
-
N-cyclohexanecarbonylpentadecylamine: a selective inhibitor of the acid amidase hydrolyzing N-acyl-ethanolamines, as a tool to distinguish acid amidase from fatty acid amide hydrolase
-
Tsuboi K., Hilligsmann C., Vandevoorde S., Lambert D.M., Ueda N. N-cyclohexanecarbonylpentadecylamine: a selective inhibitor of the acid amidase hydrolyzing N-acyl-ethanolamines, as a tool to distinguish acid amidase from fatty acid amide hydrolase. Biochem. J. 2004, 379:99-106.
-
(2004)
Biochem. J.
, vol.379
, pp. 99-106
-
-
Tsuboi, K.1
Hilligsmann, C.2
Vandevoorde, S.3
Lambert, D.M.4
Ueda, N.5
-
33
-
-
74049085872
-
Synthesis and biological evaluation of new analogues of palmitic acid as inhibitors of N-acyl-ethanolamine-hydrolyzing acid amidase
-
Saturnino C., Petrosino S., Ligresti A., et al. Synthesis and biological evaluation of new analogues of palmitic acid as inhibitors of N-acyl-ethanolamine-hydrolyzing acid amidase. Bioorg. Med. Chem. Lett. 2010, 20:1210-1213.
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 1210-1213
-
-
Saturnino, C.1
Petrosino, S.2
Ligresti, A.3
-
34
-
-
19444371229
-
A second N-acylethanolamine hydrolase in mammalian tissues
-
Ueda N., Tsuboi K., Lambert D.M. A second N-acylethanolamine hydrolase in mammalian tissues. Neuropharmacology 2005, 48:1079-1085.
-
(2005)
Neuropharmacology
, vol.48
, pp. 1079-1085
-
-
Ueda, N.1
Tsuboi, K.2
Lambert, D.M.3
-
35
-
-
77953287268
-
Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats
-
[Epub ahead of print]
-
De Filippis D., D'Amico A., Cipriano M., et al. Levels of endocannabinoids and palmitoylethanolamide and their pharmacological manipulation in chronic granulomatous inflammation in rats. Pharmacol. Res. 2009, [Epub ahead of print].
-
(2009)
Pharmacol. Res.
-
-
De Filippis, D.1
D'Amico, A.2
Cipriano, M.3
-
36
-
-
73949084238
-
Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation
-
Solorzano C., Zhu C., Battista N., et al. Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation. Proc. Natl. Acad. Sci. U S A 2009, 106:20966-20971.
-
(2009)
Proc. Natl. Acad. Sci. U S A
, vol.106
, pp. 20966-20971
-
-
Solorzano, C.1
Zhu, C.2
Battista, N.3
-
37
-
-
45749149121
-
Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury
-
Genovese T., Esposito E., Mazzon E., et al. Effects of palmitoylethanolamide on signaling pathways implicated in the development of spinal cord injury. J. Pharmacol. Exp. Ther. 2008, 326:12-23.
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.326
, pp. 12-23
-
-
Genovese, T.1
Esposito, E.2
Mazzon, E.3
-
38
-
-
65749102097
-
Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia
-
D'Agostino G., La Rana G., Russo R., et al. Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia. Eur. J. Pharmacol. 2009, 613:54-59.
-
(2009)
Eur. J. Pharmacol.
, vol.613
, pp. 54-59
-
-
D'Agostino, G.1
La Rana, G.2
Russo, R.3
-
39
-
-
49249094482
-
Study of the regulation of the endocannabinoid system in a virus model of multiple sclerosis reveals a therapeutic effect of Palmitoylethanolamide
-
Loría F., Petrosino S., Mestre L., et al. Study of the regulation of the endocannabinoid system in a virus model of multiple sclerosis reveals a therapeutic effect of Palmitoylethanolamide. Eur. J. Neurosci. 2008, 28:633-641.
-
(2008)
Eur. J. Neurosci.
, vol.28
, pp. 633-641
-
-
Loría, F.1
Petrosino, S.2
Mestre, L.3
-
40
-
-
65049090530
-
Enhancement of the hypotensive effects of intrathecally injected endocannabinoids by the entourage compound Palmitoylethanolamide
-
García Mdel C., Adler-Graschinsky E., Celuch S.M. Enhancement of the hypotensive effects of intrathecally injected endocannabinoids by the entourage compound Palmitoylethanolamide. Eur. J. Pharmacol. 2009, 610:75-80.
-
(2009)
Eur. J. Pharmacol.
, vol.610
, pp. 75-80
-
-
García Mdel, C.1
Adler-Graschinsky, E.2
Celuch, S.M.3
-
41
-
-
77953294059
-
-
Intracellular mechanisms of N-acylethanolamine-mediated neuroprotection in a rat model of stroke. Neuroscience 2009 Dec 3 [Epub ahead of print].
-
P. Garg, R.S. Duncan, S. Kaja, P. Koulen, Intracellular mechanisms of N-acylethanolamine-mediated neuroprotection in a rat model of stroke. Neuroscience 2009 Dec 3 [Epub ahead of print].
-
-
-
Garg, P.1
Duncan, R.S.2
Kaja, S.3
Koulen, P.4
-
42
-
-
77953289514
-
Protective role of palmitoylethanolamide in contact allergic dermatitis
-
[Epub ahead of print]
-
Petrosino S., Cristino L., Karsak M., et al. Protective role of palmitoylethanolamide in contact allergic dermatitis. Allergy 2009, [Epub ahead of print].
-
(2009)
Allergy
-
-
Petrosino, S.1
Cristino, L.2
Karsak, M.3
|