The Role of the Hyaluronan Receptor RHAMM in Wound Repair and Tumorigenesis

Chemistry and Biology of Hyaluronan

Volumn , Issue , 2004, Pages 125-151

  Tölg, Cornelia ^a   Hamilton, Sara R ^b   Turley, Eva A ^b  

^a LONDON REGIONAL CANCER PROGRAM   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CELL SIGNALING; CYTOLOGY; HYALURONIC ACID;

ACTIN-BINDING PROTEINS; ADAPTER PROTEINS; CELLULAR LOCALIZATION; COILED-COIL PROTEINS; DIRECT INTERACTIONS; MUTUAL BINDING; PROTEIN STRUCTURES; SIGNALING PATHWAYS;

PROTEINS;

EID: 79953655427     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-008044382-9/50037-6     Document Type: Chapter

References (146)

1. Spicer AP, Tien JL, Joo A, Bowling RA Investigation of hyaluronan function in the mouse through targeted mutagenesis. Glycoconj J 2002, 19:341-345.
2. McDonald JA, Camenisch TD Hyaluronan: Genetic insights into the complex biology of a simple polysaccharide. Glycoconj J 2002, 19:331-339.
3. DeAngelis PL Evolution of glycosaminoglycans and their glycosyltransferases: implications for the extracellular matrices of animals and the capsules of pathogenic bacteria. Anat Rec 2002, 268:317-326.
4. Tammi MI, Day AJ, Turley EA Hyaluronan and homeostasis: a balancing act. J Biol Chem 2002, 277:4581-4584.
5. McCourt PA How does the hyaluronan scrap-yard operate?. Matrix Biol 1999, 18:427-432.
6. Itano N, Kimata K Mammalian hyaluronan synthases. IUBMB Life 2002, 54:195-199.
7. Weigel PH, Hascall VC, Tammi M Hyaluronan synthases. J Biol Chem 1997, 272:13997-14000.
8. DeAngelis PL Hyaluronan synthases: fascinating glycosyltransferases from vertebrates, bacterial pathogens, and algal viruses. Cell Mol Life Sci 1999, 56:670-682.
9. Bissell MJ, Radisky D Putting tumours in context. Nat Rev Cancer 2001, 1:46-54.
10. Cox R The multi-step nature of carcinogenesis and the implications for risk analysis. Int J Radiat Biol 1998, 73:373-376.
11. Toole BP, Wight TN, Tammi MI Hyaluronan-cell interactions in cancer and vascular disease. J Biol Chem 2002, 277:4593-4596.
12. Turino GM, Cantor JO Hyaluronan in respiratory injury and repair. Am J Respir Crit Care Med 2003, 167:1169-1175.
13. Juhlin L Hyaluronan in skin. J Intern Med 1997, 242:61-66.
14. Casey G Wound repair: advanced dressing materials. Nurs Stand 2002, 17:49-53. (quiz 54,56).
15. Saika S, Ohnishi Y, Ooshima A, Liu CY, Kao WW Epithelial repair: roles of extracellular matrix. Cornea 2002, 21:S23-S29.
16. Turley EA, Noble PW, Bourguignon LY Signaling properties of hyaluronan receptors. J Biol Chem 2002, 277:4589-4592.
17. Cichy J, Pure E The liberation of CD44. J Cell Biol 2003, 161:839-843.
18. Christofori G Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression. EMBO J 2003, 22:2318-2323.
19. Jothy S. CD44 and its partners in metastasis. Clin Exp Metastasis 2003, 20:195-201.
20. Jackson DG The lymphatics revisited: new perspectives from the hyaluronan receptor LYVE-1. Trends Cardiovasc Med 2003, 13:1-7.
21. Ponta H, Sherman L, Herrlich PA CD44: from adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol 2003, 4:33-45.
22. Naor D, Nedvetzki S, Golan I, Melnik L, Faitelson Y CD44 in cancer. Crit Rev Clin Lab Sci 2002, 39:527-579.
23. Bullard KM, Longaker MT, Lorenz HP Fetal wound healing: current biology. World J Surg 2003, 27:54-61.
24. Anderson I The properties of hyaluronan and its role in wound healing. Prof Nurs 2001, 17:232-235.
25. Moseley R, Waddington RJ, Embery G Hyaluronan and its potential role in periodontal healing. Dent Update 2002, 29:144-148.
26. Chen WY, Abatangelo G Functions of hyaluronan in wound repair. Wound Repair Regen 1999, 7:79-89.
27. Tuxhorn JA, Ayala GE, Rowley DR Reactive stroma in prostate cancer progression. J Urol 2001, 166:2472-2483.
28. Wiesen JF, Werb Z The role of stromelysin-1 in stromal-epithelial interactions and cancer. Enzyme Protein 1996, 49:174-181.
29. Triffitt JT, Oreffo RO, Virdi AS, Xia Z Osteogenic stem-cell characterization and development: potentials for cytotherapy. Cytotherapy 2001, 3:413-416.
30. Huber MA, Kraut N, Park JE, Schubert RD, Rettig WJ, Peter RU, Garin-Chesa P Fibroblast activation protein: differential expression and serine protease activity in reactive stromal fibroblasts of melanocytic skin tumors. J Investig Dermatol 2003, 120:182-188.
31. Thomasset N, Lochter A, Sympson CJ, Lund LR, Williams DR, Behrendtsen O, Werb Z, Bissell MJ Expression of autoactivated stromelysin-1 in mammary glands of transgenic mice leads to a reactive stroma during early development. Am J Pathol 1998, 153:457-467.
32. Rossler A, Hinghofer-Szalkay H Hyaluronan fragments: an information-carrying system?. Horm Metab Res 2003, 35:67-68.
33. Rooney P, Kumar S, Ponting J, Wang M The role of hyaluronan in tumour neovascularization (review). Int J Cancer 1995, 60:632-636.
34. Colwell AS, Longaker MT, Lorenz HP Fetal wound healing. Front Biosci 2003, 8:S1240-S1248.
35. Croce MA, Dyne K, Boraldi F, Quaglino D, Cetta G, Tiozzo R, Pasquali Ronchetti I Hyaluronan affects protein and collagen synthesis by in vitro human skin fibroblasts. Tissue Cell 2001, 33:326-331.
36. Iocono JA, Ehrlich HP, Keefer KA, Krummel TM Hyaluronan induces scarless repair in mouse limb organ culture. J Pediatr Surg 1998, 33:564-567.
37. Iocono JA, Krummel TM, Keefer KA, Allison GM, Paul H Repeated additions of hyaluronan alters granulation tissue deposition in sponge implants in mice. Wound Repair Regen 1998, 6:442-448.
38. Jia C, Chen B, Arnold F The effect of ultrapure hyaluronic acid with different molecular weights on the healing of porcine full thickness skin wound. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 1998, 12:197-200.
39. West DC, Shaw DM, Lorenz P, Adzick NS, Longaker MT Fibrotic healing of adult and late gestation fetal wounds correlates with increased hyaluronidase activity and removal of hyaluronan. Int J Biochem Cell Biol 1997, 29:201-210.
40. Bourguignon LY, Singleton PA, Zhu H, Zhou B Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor beta receptor I in metastatic breast tumor cells. J Biol Chem 2002, 277:39703-39712.
41. Huang SS, Tang FM, Huang YH, Liu IH, Hsu SC, Chen ST, Huang JS Cloning, expression, characterization and role in autocrine cell growth of cell surface retention sequence binding protein-1. J Biol Chem 2003, 278:43855-43869.
42. Zhang S, Chang MC, Zylka D, Turley S, Harrison R, Turley EA The hyaluronan receptor RHAMM regulates extracellular-regulated kinase. J Biol Chem 1998, 273:11342-11348.
43. Vincent T, Molina L, Espert L, Mechti N Hyaluronan, a major non-protein glycosaminoglycan component of the extracellular matrix in human bone marrow, mediates dexamethasone resistance in multiple myeloma. Br J Haematol 2003, 121:259-269.
44. Sato H, Takahashi T, Ide H, Fukushima T, Tabata M, Sekine F, Kobayashi K, Negishi M, Niwa Y Antioxidant activity of synovial fluid, hyaluronic acid, and two subcomponents of hyaluronic acid. Synovial fluid scavenging effect is enhanced in rheumatoid arthritis patients. Arthritis Rheum 1988, 31:63-71.
45. Moseley R, Walker M, Waddington RJ, Chen WY Comparison of the antioxidant properties of wound dressing materials-carboxymethylcellulose, hyaluronan benzyl ester and hyaluronan, towards polymorphonuclear leukocyte-derived reactive oxygen species. Biomaterials 2003, 24:1549-1557.
46. Moseley R, Leaver M, Walker M, Waddington RJ, Parsons D, Chen WY, Embery G Comparison of the antioxidant properties of HYAFF-11p75, AQUACEL and hyaluronan towards reactive oxygen species in vitro. Biomaterials 2002, 23:2255-2264.
47. Campo GM, Avenoso A, Campo S, Ferlazzo A, Altavilla D, Micali C, Calatroni A Aromatic trap analysis of free radicals production in experimental collagen-induced arthritis in the rat: protective effect of glycosaminoglycans treatment. Free Radic Res 2003, 37:257-268.
48. Balogh GT, Illes J, Szekely Z, Forrai E, Gere A Effect of different metal ions on the oxidative damage and antioxidant capacity of hyaluronic acid. Arch Biochem Biophys 2003, 410:76-82.
49. Debbasch C, De La Salle SB, Brignole F, Rat P, Warnet JM, Baudouin C Cytoprotective effects of hyaluronic acid and Carbomer 934P in ocular surface epithelial cells. Investig Ophthalmol Vis Sci 2002, 43:3409-3415.
50. Itano N, Atsumi F, Sawai T, Yamada Y, Miyaishi O, Senga T, Hamaguchi M, Kimata K Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration. Proc Natl Acad Sci USA 2002, 99:3609-3614.
51. Karvinen S, Pasonen-Seppanen S, Hyttinen JM, Pienimaki JP, Torronen K, Jokela TA, Tammi MI, Tammi R Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3. J Biol Chem 2003, 278:49495-49504.
52. Rilla K, Lammi MJ, Sironen R, Torronen K, Luukkonen M, Hascall VC, Midura RJ, Hyttinen M, Pelkonen J, Tammi M, Tammi R Changed lamellipodial extension, adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan synthase 2 (Has2) genes. J Cell Sci 2002, 115:3633-3643.
53. Hall CL, Collis LA, Bo AJ, Lange L, McNicol A, Gerrard JM, Turley EA Fibroblasts require protein kinase C activation to respond to hyaluronan with increased locomotion. Matrix Biol 2001, 20:183-192.
54. Hall CL, Lange LA, Prober DA, Zhang S, Turley EA pp60(c-src) is required for cell locomotion regulated by the hyaluronanreceptor RHAMM. Oncogene 1996, 13:2213-2224.
55. Mohapatra S, Yang X, Wright JA, Turley EA, Greenberg AH Soluble hyaluronan receptor RHAMM induces mitotic arrest by suppressing Cdc2 and cyclin B1 expression. J Exp Med 1996, 183:1663-1668.
56. De Wever O, Mareel M Role of tissue stroma in cancer cell invasion. J Pathol 2003, 200:429-447.
57. Wiseman BS, Werb Z Stromal effects on mammary gland development and breast cancer. Science 2002, 296:1046-1049.
58. Stamenkovic I Extracellular matrix remodelling: the role of matrix metalloproteinses. J Pathol 2003, 200:448-464.
59. Sternlicht MD, Bissell MJ, Werb Z The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter. Oncogene 2000, 19:1102-1113.
60. Auvinen P, Tammi R, Parkkinen J, Tammi M, Agren U, Johansson R, Hirvikoski P, Eskelinen M, Kosma VM Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival. Am J Pathol 2000, 156:529-536.
61. Jacobson A, Rahmanian M, Rubin K, Heldin P Expression of hyaluronan synthase 2 or hyaluronidase 1 differentially affect the growth rate of transplantable colon carcinoma cell tumors. Int J Cancer 2002, 102:212-219.
62. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003, 100:3983-3988.
63. Ghatak S, Misra S, Toole BP Hyaluronan oligosaccharides inhibit anchorage-independent growth of tumor cells by suppressing the phosphoinositide 3-kinase/Akt cell survival pathway. J Biol Chem 2002, 277:38013-38020.
64. Zoltan-Jones A, Huang L, Ghatak S, Toole BP Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells. J Biol Chem 2003, 278:45801-45810.
65. Nehls V, Hayen W Are hyaluronan receptors involved in three-dimensional cell migration?. Histol Histopathol 2000, 15:629-636.
66. Yamada KM, Pankov R, Cukierman E Dimensions and dynamics in integrin function. Braz J Med Biol Res 2003, 36:959-966.
67. Force T, Michael A, Kilter H, Haq S Stretch-activated pathways and left ventricular remodeling. J Card Fail 2002, 8:S351-S358.
68. Turley EA Hyaluronic acid stimulates protein kinase activity in intact cells and in an isolated protein complex. J Biol Chem 1989, 264:8951-8955.
69. Okamoto I, Kawano Y, Murakami D, Sasayama T, Araki N, Miki T, Wong AJ, Saya H Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway. J Cell Biol 2001, 155:755-762.
70. Hardwick C, Hoare K, Owens R, Hohn HP, Hook M, Moore D, Cripps V, Austen L, Nance DM, Turley EA Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility. J Cell Biol 1992, 117:1343-1350.
71. Day AJ, Prestwich GD Hyaluronan-binding proteins: tying up the giant. J Biol Chem 2002, 277:4585-4588.
72. Yang B, Hall CL, Yang BL, Savani RC, Turley EA Identification of a novel heparin binding domain in RHAMM and evidence that it modifies HA mediated locomotion of ras-transformed cells. J Cell Biochem 1994, 56:455-468.
73. Yu WH, Woessner JF, McNeish JD, Stamenkovic I CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling. Genes Dev 2002, 16:307-323.
74. Orian-Rousseau V, Chen L, Sleeman JP, Herrich P, Ponta H CD44 is required for two consecutive steps in HGF/c-Met signaling. Genes Dev 2002, 16:3074-3086.
75. Kamikura DM, Khoury H, Maroun C, Naujokas MA, Park M Enhanced transformation by a plasma membrane-associated met oncoprotein: activation of a phosphoinositide 3'-kinase-dependent autocrine loop involving hyaluronic acid and CD44. Mol Cell Biol 2000, 20:3482-3496.
76. Radisky DC, Hirai Y, Bissell MJ Delivering the message: epimorphin and mammary epithelial morphogenesis. Trends Cell Biol 2003, 13:426-434.
77. Regeczy N, Kormos L, Szigetvari CM, Torbagyi E, Hajdu M, Gopcsa L, Banyai A, Paloczi K Reactivity of new adhesion molecules on lymphocytes from patients with chronic graft versus host disease. Acta Microbiol Immunol Hung 2003, 50:55-65.
78. Gares SL, Pilarski LM Balancing thymocyte adhesion and motility: a functional linkage between betal integrins and the motility receptor RHAMM. Dev Immunol 2000, 7:209-225.
79. Lynn BD, Turley EA, Nagy JI Subcellular distribution, calmodulin interaction, and mitochondrial association of the hyaluronan-binding protein RHAMM in rat brain. J Neurosci Res 2001, 65:6-16.
80. Pilarski LM, Masellis-Smith A, Belch AR, Yang B, Savani RC, Turley EA RHAMM, a receptor for hyaluronan-mediated motility, on normal human lymphocytes, thymocytes and malignant B cells: a mediator in B cell malignancy?. Leuk Lymphoma 1994, 14:363-374.
81. Assmann V, Jenkinson D, Marshall JF, Hart IR The intracellular hyaluronan receptor RHAMM/IHABP interacts with microtubules and actin filaments. J Cell Sci 1999, 112:3943-3954.
82. Maxwell CA, Keats JJ, Crainie M, Sun X, Yen T, Shibuya E, Hendzel M, Chan G, Pilarski LM RHAMM is a centrosomal protein that interacts with dynein and maintains spindle pole stability. Mol Biol Cell 2003, 14:2262-2276.
83. Lokeshwar VB, Selzer MG Differences in hyaluronic acid-mediated functions and signaling in arterial, microvessel, and vein-derived human endothelial cells. J Biol Chem 2000, 275:27641-27649.
84. Hall CL, Wang C, Lange LA, Turley EA Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity. J Cell Biol 1994, 126:575-588.
85. Savani RC, Cao G, Pooler PM, Zaman A, Zhou Z, DeLisser HM Differential involvement of the hyaluronan (HA) receptors CD44 and receptor for HA-mediated motility in endothelial cell function and angiogenesis. J Biol Chem 2001, 276:36770-36778.
86. Tölg C, Poon R, Fodde R, Turley EA, Alman BA Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor). Oncogene 2003, 22:6873-6882.
87. Yang B, Yang BL, Savani RC, Turley EA Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein. EMBO J 1994, 13:286-296.
88. Crainie M, Belch AR, Mant MJ, Pilarski LM Overexpression of the receptor for hyaluronan-mediated motility (RHAMM) characterizes the malignant clone in multiple myeloma: identification of three distinct RHAMM variants. Blood 1999, 93:1684-1696.
89. Hall CL, Yang B, Yang X, Zhang X, Turley M, Samuel S, Lange LA, Wang C, Curpen GD, Savani RC, Greenberg AH, Turley EA Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation. Cell 1995, 82:19-26.
90. Wang C, Thor AD, Moore DH, Zhao Y, Kerschmann R, Stern R, Watson PH, Turley EA The overexpression of RHAMM, a hyaluronan-binding protein that regulates ras signaling, correlates with overexpression of mitogen-activated protein kinase and is a significant parameter in breast cancer progression. Clin Cancer Res 1998, 4:567-576.
91. Li H, Guo L, Li JW, Liu N, Qi R, Liu J Expression of hyaluronan receptors CD44 and RHAMM in stomach cancers: relevance with tumor progression. Int J Oncol 2000, 17:927-932.
92. Savani RC, Wang C, Yang B, Zhang S, Kinsella MG, Wight TN, Stern R, Nance DM, Turley EA Migration of bovine aortic smooth muscle cells after wounding injury. The role of hyaluronan and RHAMM. J Clin Investig 1995, 95:1158-1168.
93. Entwistle J, Hall CL, Turley EA HA receptors: regulators of signalling to the cytoskeleton. J Cell Biochem 1996, 61:569-577.
94. Turley EA, Moore D, Hayden LJ Characterization of hyaluronate binding proteins isolated from 3T3 and murine sarcoma virus transformed 3T3 cells. Biochemistry 1987, 26:2997-3005.
95. Cassimeris L, Spittle C Regulation of microtubule-associated proteins. Int Rev Cytol 2001, 210:163-226.
96. Maccioni RB, Cambiazo V Role of microtubule-associated proteins in the control of microtubule assembly. Physiol Rev 1995, 75:835-864.
97. MacRae TH Microtubule organization by cross-linking and bundling protein. Biochim Biophys Acta 1992, 1160:145-155.
98. Mandelkow EM, Schweers O, Drewes G, Biernat J, Gustke N, Trinczek B, Mandelkow E Structure, microtubule interactions, and phosphorylation of tau protein. Ann N Y Acad Sci 1996, 777:96-106.
99. Trinczek B, Biernat J, Baumann K, Mandelkow EM, Mandelkow E Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules. Mol Biol Cell 1995, 6:1887-1902.
100. Gustke N, Trinczek B, Biernat J, Mandelkow EM, Mandelkow E Domains of tau protein and interactions with microtubules. Biochemistry 1994, 33:9511-9522.
101. Littauer UZ, Giveon D, Thierauf M, Ginzburg I, Ponstingl H Common and distinct tubulin binding sites for microtubule-associated proteins. Proc Natl Acad Sci USA 1986, 83:7162-7166.
102. Lappin TR, Mullan RN, Stewart JP, Morgan NA, Thompson A, Maxwell AP AINT/ERIC/TACC: an expanding family of proteins with C-terminal coiled coil domains. Leuk Lymphoma 2002, 43:1455-1459.
103. Steadman BT, Schmidt PH, Shanks RA, Lapierre LA, Goldenring JR Transforming acidic coiled-coil-containing protein 4 interacts with centrosomal AKAP350 and the mitotic spindle apparatus. J Biol Chem 2002, 277:30165-30176.
104. Gergely F, Karlsson C, Still I, Cowell J, Kilmartin J, Raff JW The TACC domain identifies a family of centrosomal proteins that can interact with microtubules. Proc Natl Acad Sci USA 2000, 97:14352-14357.
105. Gergely F Centrosomal TACCtics. Bioessays 2002, 24:915-925.
106. Still IH, Vince P, Cowell JK The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines. Genomics 1999, 58:165-170.
107. Still IH, Hamilton M, Vince P, Wolfman A, Cowell JK Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon. Oncogene 1999, 18:4032-4038.
108. Raff JW Centrosomes and cancer: lessons from a TACC. Trends Cell Biol 2002, 12:222-225.
109. Kull FJ Motor proteins of the kinesin superfamily: structure and mechanism. Essays Biochem 2000, 35:61-73.
110. Verhey KJ, Rapoport TA Kinesin carries the signal. Trends Biochem Sci 2001, 26:545-550.
111. Aitken K, Bagli DJ Stretch-induced bladder smooth muscle cell (SMC) proliferation is mediated by RHAMM-dependent extracellular-regulated kinase (erk) signaling. Urology 2001, 57:109.
112. Dell'Acqua ML, Scott JD Protein kinase A anchoring. J Biol Chem 1997, 272:12881-12884.
113. Michel JJ, Scott JD AKAP mediated signal transduction. Annu Rev Pharmacol Toxicol 2002, 42:235-257.
114. Feliciello A, Gottesman ME, Avvedimento EV The biological functions of A-kinase anchor proteins. J Mol Biol 2001, 308:99-114.
115. Dodge K, Scott JD AKAP79 and the evolution of the AKAP model. FEBS Lett 2000, 476:58-61.
116. Jorquera R, Tanguay RM Fumarylacetoacetate, the metabolite accumulating in hereditary tyrosinemia, activates the ERK pathway and induces mitotic abnormalities and genomic instability. Hum Mol Genet 2001, 10:1741-1752.
117. Willard FS, Crouch MF MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit. Cell Signal 2001, 13:653-664.
118. Shapiro PS, Vaisberg E, Hunt AJ, Tolwinski NS, Whalen AM, McIntosh JR, Ahn NG Activation of the MKK/ERK pathway during somatic cell mitosis: direct interactions of active ERK with kinetochores and regulation of the mitotic 3F3/2 phosphoantigen. J Cell Biol 1998, 142:1533-1545.
119. Pennisi E Nuclear transport protein does double duty in mitosis. Science 1999, 284:1260-1261.
120. Guarguaglini G, Renzi L, D'Ottavio F, Di Fiore B, Casenghi M, Cundari E, Lavia P Regulated Ran-binding protein 1 activity is required for organization and function of the mitotic spindle in mammalian cells in vivo. Cell Growth Differ 2000, 11:455-465.
121. Lewis TS, Hunt JB, Aveline LD, Johscher KR, Louie DF, Yeh JM, Nahreini TS, Resing KA, Ahn NG Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry. Mol Cell 2000, 6:1343-1354.
122. Di Fiore B, Ciciarello M, Mangiacasale R, Palena A, Tassin AM, Cundari E, Lavia P Mammalian RanBP1 regulates centrosome cohesion during mitosis. J Cell Sci 2003, 116:3399-3411.
123. Theurkauf WE, Vallee RB Molecular characterization of the cAMP-dependent protein kinase bound to microtubule-associated protein 2. J Biol Chem 1982, 257:3284-3290.
124. Sarkar D, Erlichman J, Rubin CS Identification of a calmodulin-binding protein that co-purifies with the regulatory subunit of brain protein kinase II. J Biol Chem 1984, 259:9840-9846.
125. Harrison A, Hyams JS Mapping MAP-2. J Cell Sci 1990, 96(Pt 3):347-349.
126. Nedvetzki S, Gonen E, Assayag N, Reich R, Williams RO, Neudecker BA, Stern R, Wang FS, Turley EA, Naor D. RHAMM, a motility-mediated receptor, compensates for CD44 in inflamed CD44-knockout mice: evidence for molecular redundancy. Submitted.
127. Enegd B, King JA, Stylli S, Paradiso L, Kaye AH, Novak U Overexpression of hyaluronan synthase-2 reduces the tumorigenic potential of glioma cells lacking hyaluronidase activity. Neurosurgery 2002, 50:1311-1318.
128. Akiyama Y, Jung S, Salhia B, Lee S, Hubbard S, Taylor M, Mainprize T, Akaishi K, van Furth W, Rutka JT Hyaluronate receptors mediating glioma cell migration and proliferation. J Neurooncol 2001, 53:115-127.
129. Lovvorn HN, Cass DL, Sylvester KG, Yang EY, Crombleholme TM, Adzick NS, Savani RC Hyaluronan receptor expression increases in fetal excisional skin wounds and correlates with fibroplasia. J Pediatr Surg 1998, 33:1062-1069. (discussion 1069-1070).
130. Meyer LJ, Russell SB, Russell JD, Trupin JS, Egbert BM, Shuster S, Stern R Reduced hyaluronan in keloid tissue and cultured keloid fibroblasts. J Investig Dermatol 2000, 114:953-959.
131. Capolicchio G, Aitken KJ, Gu JX, Reddy P, Bagli DJ, Extracellular matrix gene responses in a novel ex vivo model of bladder stretch injury J Urol 2001, 165:2235-2240.
132. Greiner J, Ringhoffer M, Taniguchi M, Schmitt A, Kirchner D, Krahn G, Heilmann V, Gschwend J, Bergmann L, Dohner H, Schmitt M Receptor for hyaluronan acid-mediated motility (RHAMM) is a new immunogenic leukemia-associated antigen in acute and chronic myeloid leukemia. Exp Hematol 2002, 30:1029-1035.
133. Yamada Y, Itano N, Narimatsu H, Kudo T, Hirohashi S, Ochiai A, Niimi A, Ueda M, Kimata K Receptor for hyaluronan-mediated motility and CD44 expressions in colon cancer assessed by quantitative analysis using real-time reverse transcriptase-polymerase chain reaction. Jpn J Cancer Res 1999, 90:987-992.
134. Duval A, Rolland S, Compoint A, Tubacher E, Iacopetta B, Thomas G, Hamelin R Evolution of instability at coding and non-coding repeat sequences in human MSI-H colorectal cancers. Hum Mol Genet 2001, 10:513-518.
135. Assmann V, Gillett CE, Poulsom R, Ryder K, Hart IR, Hanby AM The pattern of expression of the microtubule-binding protein RHAMM/IHABP in mammary carcinoma suggests a role in the invasive behaviour of tumour cells. J Pathol 2001, 195:191-196.
136. Chang F, Steelman LS, Shelton JG, Lee JT, Navolanic PM, Blalock WL, Franklin R, McCubrey JA Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review). Int J Oncol 2003, 22:469-480.
137. Mazzoni E, Adam A, Bal de Kier Joffe E, Aguirre-Ghiso JA Immortalized mammary epithelial cells overexpressing protein kinase C gamma acquire a malignant phenotype and become tumorigenic in vivo. Mol Cancer Res 2003, 1:776-787.
138. Reginato MJ, Mills KR, Paulus JK, Lynch DK, Sgroi DC, Debnath J, Muthuswamy SK, Brugge JS Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol 2003, 5:733-740.
139. Howe AK, Aplin AE, Julian RL Anchorage-dependent ERK signaling-mechanisms and consequences. Curr Opin Genet Dev 2002, 12:30-35.
140. Rein DT, Roehrig K, Schondorf T, Lazar A, Fleisch M, Niederacher D, Bender HG, Dall P Expression of the hyaluronan receptor RHAMM in endometrial carcinomas suggests a role in tumour progression and metastasis. J Cancer Res Clin Oncol 2003, 129:161-164.
141. Zhou R, X Wu, Skalli O The hyaluronan receptor RHAMM/IHABP in astrocytoma cells: expression of a tumor-specific variant and association with microtubules. J Neurooncol 2002, 59:15-26.
142. Line A, Slucka Z, Stengrevies A, Silina K, Li G, Rees RC Characterisation of tumour-associated antigens in colon cancer. Cancer Immunol Immunother 2002, 51:574-582.
143. Smits R, van der Houven van Oordt W, Luz A, Zurcher C, Jagmohan-Changur S, Breukel C, Khan PM, Fodde R Apc 1638N: a mouse model for familial adenomatous polyposis-associated desmoid tumors and cutaneous cysts. Gastroenterology 1998, 114:275-283.
144. Murashita T, Nakayama Y, Hirano T, Ohashi S Acceleration of granulation tissue ingrowth by hyaluronic acid in artificial skin. Br J Plast Surg 1996, 49:58-63.
145. Blaker H, Scholten M, Sutter C, Otto HF, Penzel R Somatic mutations in familial adenomatous polyps. Nuclear translocation of beta-catenin requires more than biallelic APC inactivation. Am J Clin Pathol 2003, 120:418-423.
146. Kim K, Hay ED New evidence that nuclear import of endogenous beta-catenin is LEF-1 dependent, while LEF-1 independent import of exogenous beta-catenin leads to nuclear abnormalities. Cell Biol Int 2001, 25:1149-1161.