The strain-encoded relationship between PrPSc replication, stability and processing in neurons is predictive of the incubation period of disease

PLoS Pathogens

Volumn 7, Issue 3, 2011, Pages

  Ayers, Jacob I ^a   Schutt, Charles R ^a   Shikiya, Ronald A ^a   Aguzzi, Adriano ^b   Kincaid, Anthony E ^c   Bartz, Jason C ^a  

^a CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c CREIGHTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; GLIA CELL; HAMSTER; MOLECULAR WEIGHT; NERVE CELL; NERVE DEGENERATION; NONHUMAN; PRION; PRION DISEASE; PROTEIN CONFORMATION; PROTEIN STABILITY; VIRUS REPLICATION; VIRUS STRAIN; ANIMAL; BRAIN; CHEMISTRY; ENZYME IMMUNOASSAY; HOST PATHOGEN INTERACTION; INCUBATION TIME; MALE; METABOLISM; MICROGLIA; PATHOLOGY; PHYSIOLOGY; SCIATIC NERVE; SPECIES DIFFERENCE; SYRIAN HAMSTER;

CRICETINAE;

ANIMALS; ASTROCYTES; BRAIN; CRICETINAE; HOST-PATHOGEN INTERACTIONS; IMMUNOENZYME TECHNIQUES; INFECTIOUS DISEASE INCUBATION PERIOD; MALE; MESOCRICETUS; MICROGLIA; NEURONS; PRIONS; SCIATIC NERVE; SPECIES SPECIFICITY;

EID: 79953286302     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1001317     Document Type: Article

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