Pyrrolidine-pyrazole ureas as potent and selective inhibitors of 11β-hydroxysteroid-dehydrogenase type 1

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 8, 2011, Pages 2244-2251

  Venier, Olivier ^a   Pascal, Cécile ^a   Braun, Alain ^a   Namane, Claudie ^a   Mougenot, Patrick ^a   Crespin, Olivier ^a   Pacquet, Franois ^a   Mougenot, Cécile ^a   Monseau, Catherine ^a   Onofri, Bénédicte ^a   Dadji Faïhun, Rommel ^a   Leger, Céline ^a   Ben Hassine, Majdi ^a   Van Pham, Thao ^a   Ragot, Jean Luc ^a   Philippo, Christophe ^a   Güssregen, Stefan ^b   Engel, Christian ^b   Farjot, Géraldine ^a   Noah, Lionel ^a   Maniani, Karima ^a   Nicolaï, Eric ^a   more..

^a SANOFI   (France)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

11 HSD 1 inhibitors; 11 Hydroxysteroid dehydrogenase type 1; Metabolic syndrome; Pharmacodynamic ex vivo assay; Pyrrolidine pyrazole; Urea

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE INHIBITOR; PYRAZOLE DERIVATIVE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; DRUG ACTIVITY; DRUG DETERMINATION; DRUG POTENCY; DRUG SELECTIVITY; HIGH THROUGHPUT SCREENING; HUMAN; NONHUMAN;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADMINISTRATION, ORAL; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICE; PYRAZOLES; PYRROLIDINES; UREA;

MURINAE;

EID: 79953276995     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.02.111     Document Type: Article

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