Differential effects of PPARγ ligands on oxidative stress-induced death of retinal pigmented epithelial cells

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 2, 2011, Pages 890-903

  Rodrigues, Gerard A ^a   Maurier Mahé, Florence ^b   Shurland, Dixie Lee ^a   McLaughlin, Anne ^a   Luhrs, Keith ^a   Throo, Emeline ^b   Delalonde Delaunay, Laurence ^b   Pallares, Diego ^b   Schweighoffer, Fabien ^b   Donello, John ^a  

^a ALLERGAN INC   (United States)

^b ExonHit Therapeutics SA   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PIOGLITAZONE; REACTIVE OXYGEN METABOLITE; ROSIGLITAZONE; SMALL INTERFERING RNA; TERT BUTYL HYDROPEROXIDE; TROGLITAZONE; CASPASE 3; LIGAND;

APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; GENE EXPRESSION; GENE MUTATION; GENETIC REGULATION; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; CELL LINE; DRUG POTENTIATION; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CELL LINE; CELL SURVIVAL; DRUG SYNERGISM; GENE SILENCING; HUMANS; LIGANDS; MICROARRAY ANALYSIS; OXIDATIVE STRESS; PPAR GAMMA; REACTIVE OXYGEN SPECIES; RETINAL PIGMENT EPITHELIUM; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TERT-BUTYLHYDROPEROXIDE; THIAZOLIDINEDIONES; TRANSFECTION;

EID: 79953276843     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-5715     Document Type: Article

References (63)

1. Willson TM, Brown PJ, Sternbach DD, Henke BR. The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000;43:527-550.
2. Rosen ED, Spiegelman BM. PPAR7: a nuclear regulator of metabolism, differentiation, and cell growth. J Biol Chem. 2001;276: 37731-37734.
3. Yamamoto K, Itoh T, Abe D, et al. Identification of putative metabolites of docosahexaenoic acid as potent PPAR7 agonists and antidiabetic agents. Bioorg Med Chem Lett. 2005;15:517-522.
4. Nagy L, Tontonoz P, Alvarez JG, Chen H, Evans RM. Oxidized LDL regulates macrophage gene expression through ligand activation of PPAR7. Cell. 1998;93:229-240.
5. Walczak R, Tontonoz P. PPARadigms and PPARadoxes: expanding roles for PPAR7 in the control of lipid metabolism. J Lipid Res. 2002;43:177-186.
6. Lee CH, Evans RM. Peroxisome proliferator-activated receptor-7 in macrophage lipid homeostasis. Trends Endocrinol Metab. 2002; 13:331-335
7. Tontonoz P, Nagy L, Alvarez JG, Thomazy VA, Evans RM. PPAR7 promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell. 1998;93:241-252.
8. Chawla A, Barak Y, Nagy L, Liao D, Tontonoz P, Evans RM. PPAR-7 dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation. Nat Med. 2001; 7:48-52.
9. Chawla A, Boisvert WA, Lee CH, et al. A PPAR 7-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell. 2001;7:161-171.
10. Feng J, Han J, Pearce SF, et al. Induction of CD36 expression by oxidized LDL and IL-4 by a common signaling pathway dependent on protein kinase C and PPAR-7. JLipid Res. 2000;41:688-696.
11. Moore KJ, Rosen ED, Fitzgerald ML, et al. The role of PPAR-7 in macrophage differentiation and cholesterol uptake. Nat Med. 2001;7:41-47.
12. Chinetti G, Lestavel S, Bocher V, et al. PPAR-alpha and PPAR-7 activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat Med. 2001;7:53-58.
13. Strauss O. The retinal pigment epithelium in visual function. Physiol Rev. 2005;85:845-881.
14. McBee JK, Palczewski K, Baehr W, Pepperberg DR. Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina. Prog Retin Eye Res. 2001;20: 469-529
15. Thompson DA, Gal A. Vitamin A metabolism in the retinal pigment epithelium: genes, mutations, and diseases. Prog Retin Eye Res. 2003;22:683-703.
16. Nguyen-Legros J, Hicks D. Renewal of photoreceptor outer segments and their phagocytosis by the retinal pigment epithelium. Int Rev Cytol. 2000;196:245-313
17. Ryeom SW, Sparrow JR, Silverstein RL. CD36 participates in the phagocytosis of rod outer segments by retinal pigment epithelium. J Cell Sci. 1996;109):387-395
18. Donoso LA, Kim D, Frost A, Callahan A, Hageman G. The role of inflammation in the pathogenesis of age-related macular degeneration. Surv Ophthalmol. 2006;51:137-152.
19. Zarbin MA. Current concepts in the pathogenesis of age-related macular degeneration. Arch Ophthalmol. 2004;122:598-614.
20. Cai J, Nelson KC, Wu M, Sternberg P Jr, Jones DP. Oxidative damage and protection of the RPE. Prog Retin Eye Res. 2000;19: 205-221.
21. Beatty S, Koh H, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol. 2000;45:115-134.
22. Curcio CA, Millican CL, Bailey T, Kruth HS. Accumulation of cholesterol with age in human Bruch's membrane. Invest Ophthalmol Vis Sci. 2001;42:265-274.
23. Joffre C, Leclere L, Buteau B, et al. Oxysterols induced inflammation and oxidation in primary porcine retinal pigment epithelial cells. Curr Eye Res. 2007;32:271-280.
24. Yamada Y, Tian J, Yang Y, et al. Oxidized low density lipoproteins induce a pathologic response by retinal pigmented epithelial cells. JNeurochem. 2008;105:1187-1197.
25. Gordiyenko N, Campos M, Lee JW, Fariss RN, Sztein J, Rodriguez IR. RPE cells internalize low-density lipoprotein (LDL) and oxidized LDL (oxLDL) in large quantities in vitro and in vivo. Invest Ophthalmol Vis Sci. 2004;45:2822-2829
26. Hoppe G, ONeil J, Hoff HF, Sears J. Accumulation of oxidized lipid-protein complexes alters phagosome maturation in retinal pigment epithelium. Cell Mol Life Sci. 2004;61:1664-1674.
27. Hoppe G, Marmorstein AD, Pennock EA, Hoff HF. Oxidized low density lipoprotein-induced inhibition of processing of photoreceptor outer segments by RPE. Invest Ophthalmol Vis Sci. 2001; 42:2714-2720.
28. Rodriguez IR, Alam S, Lee JW. Cytotoxicity of oxidized low-density lipoprotein in cultured RPE cells is dependent on the formation of 7-ketocholesterol. Invest Ophthalmol VisSci. 2004;45:2830-2837.
29. Murata T, He S, Hangai M, et al. Peroxisome proliferator-activated receptor-7 ligands inhibit choroidal neovascularization. Invest Ophthalmol VisSci. 2000;41:2309-2317.
30. Ershov AV, Bazan NG. Photoreceptor phagocytosis selectively activates PPAR7 expression in retinal pigment epithelial cells. J Neu-rosci Res. 2000;60:328-337.
31. Rosenkranz AR, Schmaldienst S, Stuhlmeier KM, Chen W, Knapp W, Zlabinger GJ. A microplate assay for the detection of oxidative products using 2',7'-dichlorofluorescein-diacetate. J Immunol Methods. 1992;156:39-45.
32. Cartharius K, Frech K, Grote K, et al. MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics. 2005;21:2933-2942.
33. Tachibana K, Kobayashi Y, Tanaka T, et al. Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms. Nucl Recept. 2005;3:3
34. Sternberg P Jr, Davidson PC, Jones DP, Hagen TM, Reed RL, Drews-Botsch C. Protection of retinal pigment epithelium from oxidative injury by glutathione and precursors. Invest Ophthalmol Vis Sci. 1993;34:3661-3668.
35. Nelson KC, Armstrong JS, Moriarty S, et al. Protection of retinal pigment epithelial cells from oxidative damage by oltipraz, a cancer chemopreventive agent. Invest Ophthalmol Vis Sci. 2002;43: 3550-3554.
36. Cai J, Wu M, Nelson KC, Sternberg P, Jones DP. Oxidant-induced apoptosis in cultured human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1999;40:959-966.
37. Rangwala SM, Lazar MA. The dawn of the SPPARMs? Sci STKE. 2002;2002: PE9.
38. Smith CL, O'Malley BW. Coregulator function: a key to understanding tissue specificity of selective receptor modulators. Endocr Rev. 2004;25:45-71.
39. Weigel AL, Handa JT, Hjelmeland LM. Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002;33: 1419-1432.
40. Qin S, McLaughlin AP, De Vries GW. Protection of RPE cells from oxidative injury by 15-deoxy-delta12,14-prostaglandin J2 by augmenting GSH and activating MAPK. Invest Ophthalmol Vis Sci. 2006;47:5098-5105.
41. Garg TK, Chang JY. Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2. BMC Ophthalmol. 2003;3:5
42. Dutertre M, Smith CL. Molecular mechanisms of selective estrogen receptor modulator (SERM) action. J Pharmacol Exp Ther. 2000; 295:431-437.
43. Zhang F, Lavan BE, Gregoire FM. Selective modulators of PPAR-7 activity: molecular aspects related to obesity and side-effects. PPAR Res. 2007;2007:32696.
44. Camp HS, Li O, Wise SC, et al. Differential activation of peroxisome proliferator-activated receptor-7 by troglitazone and rosigli-tazone. Diabetes. 2000;49:539-547.
45. Walker AB, Naderali EK, Chattington PD, Buckingham RE, Williams G. Differential vasoactive effects of the insulin sensitizers rosigli-tazone (BRL 49653) and troglitazone on human small arteries in vitro. Diabetes. 1998;47:810-814.
46. Ishizuka T, Itaya S, Wada H, et al. Differential effect of the antidiabetic thiazolidinediones troglitazone and pioglitazone on human platelet aggregation mechanism. Diabetes. 1998;47:1494-1500.
47. Kaspar JW, Niture SK, Jaiswal AK. Nrf2:INrf2 (Keap1) signaling in oxidative stress (review). Free Radic Biol Med. 2009;47:1304-1309
48. Niture SK, Kaspar JW, Shen J, Jaiswal AK. Nrf2 signaling and cell survival (review). Toxicol ApplPharmacol. 2010;244;37-42.
49. Cano M, Thimmalappula R, Fujihara M, et al. Cigarette smoking, oxidative stress, the antioxidant response through Nrf2 signaling, and age-related macular degeneration. Vision Res. 2010;50:652-664.
50. Qutub AA, Popel AS. Reactive oxygen species regulate hypoxia-inducible factor 1alpha differentially in cancer and ischemia. Mol Cell Biol. 2008;28:5106-5119
51. Brunelle JK, Bell EL, Quesada NM, et al. Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metab. 2005;1:409-414.
52. Gerald D, Berra E, Frapart YM, et al. JunD reduces tumor angio-genesis by protecting cells from oxidative stress. Cell. 2004;118: 781-794.
53. Yu S, Matsusue K, Kashireddy P, et al. Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor 71 (PPAR71) overex-pression. J Biol Chem. 2003;278:498-505.
54. Besson A, Dowdy SF, Roberts JM. CDK inhibitors: cell cycle regulators and beyond. Dev Cell. 2008;14:159-169.
55. Vlachos P, Nyman U, Hajji N, Joseph B. The cell cycle inhibitor p57(Kip2) promotes cell death via the mitochondrial apoptotic pathway. Cell Death Differ. 2007;14:1497-1507.
56. Watanabe H, Pan ZQ, Schreiber-Agus N, DePinho RA, Hurwitz J, Xiong Y. Suppression of cell transformation by the cyclin-depen-dent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen. Proc Natl Acad Sci USA. 1998;95:1392-1397.
57. Chen H, Liu B, Lukas TJ, Neufeld AH. The aged retinal pigment epithelium/choroid: a potential substratum for the pathogenesis of age-related macular degeneration. PLoS One. 2008;3:e2339
58. Lima e Silva R, Shen J, Hackett SF, et al. The SDF-1/CXCR4 ligand/ receptor pair is an important contributor to several types of ocular neovascularization. FASEB J. 2007;21:3219-3230.
59. Guerin E, Sheridan C, Assheton D, et al. SDF1-alpha is associated with VEGFR-2 in human choroidal neovascularisation. Microvasc Res. 2008;75:302-307.
60. Bhutto IA, McLeod DS, Merges C, Hasegawa T, Lutty GA. Localisation of SDF-1 and its receptor CXCR4 in retina and choroid of aged human eyes and in eyes with age related macular degeneration. Br J Ophthalmol. 2006;90:906-910.
61. Chan CC, Ross RJ, Shen D, et al. Ccl2/Cx3cr1-deficient mice: an animal model for age-related macular degeneration. Ophthalmic Res. 2008;40:124-128.
62. Ambati J, Anand A, Fernandez S, et al. An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Nat Med. 2003;9:1390-1397.
63. Han KH, Chang MK, Boullier A, et al. Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator-activated receptor 7. J Clin Invest. 2000;106: 793-802.