-
1
-
-
0031046296
-
-
(a) McHugh, M. M.; Beerman, T. A.; Burhans, W. C. Biochemistry 1997, 36, 1003-1009.
-
(1997)
Biochemistry
, vol.36
, pp. 1003-1009
-
-
McHugh, M.M.1
Beerman, T.A.2
Burhans, W.C.3
-
2
-
-
0023767790
-
-
(b) Hu, J.; Xue, Y.-C.; Xie, M.-Y.; Zhang, R.; Otani, T.; Yamada, Y.; Marunaka, T. J. Antibiot. (Tokyo) 1988, 41, 1575-1579.
-
(1988)
J. Antibiot. (Tokyo)
, vol.41
, pp. 1575-1579
-
-
Hu, J.1
Xue, Y.-C.2
Xie, M.-Y.3
Zhang, R.4
Otani, T.5
Yamada, Y.6
Marunaka, T.7
-
3
-
-
0024315075
-
-
(c) Zhen, Y.-S.; Ming, X.-Y.; Yu, B.; Otani, T.; Saito, H.; Yamada, Y. J. Antibiot. (Tokyo) 1989, 42, 1294-1298.
-
(1989)
J. Antibiot. (Tokyo)
, vol.42
, pp. 1294-1298
-
-
Zhen, Y.-S.1
Ming, X.-Y.2
Yu, B.3
Otani, T.4
Saito, H.5
Yamada, Y.6
-
4
-
-
0027964508
-
-
(a) Okuno, Y.; Otsuka, M.; Sugiura, Y. J. Med. Client. 1994, 37, 2266-2273.
-
(1994)
J. Med. Client.
, vol.37
, pp. 2266-2273
-
-
Okuno, Y.1
Otsuka, M.2
Sugiura, Y.3
-
5
-
-
0023698081
-
-
(b) Otani, T.; Minami, Y.; Marunaka, T.; Zhang, R.; Xie, M.Y. ]. Antibiot. (Tokyo) 1988, 4l, 1580-1585.
-
(1988)
. Antibiot. (Tokyo)
, vol.4
, pp. 1580-1585
-
-
Otani, T.1
Minami, Y.2
Marunaka, T.3
Zhang, R.4
Xie, M.Y.5
-
6
-
-
0027327230
-
-
Matsumoto, T.; Okuno, Y.; Sugiura, Y. Biochem. Biophys. Res. Commun. 1993, 795, 659-666.
-
(1993)
Biochem. Biophys. Res. Commun.
, vol.795
, pp. 659-666
-
-
Matsumoto, T.1
Okuno, Y.2
Sugiura, Y.3
-
9
-
-
0031575397
-
-
(b) Kumar, R. A.; Ikemoto, N.; Patel, D. J. J. Mol. Biol. 1997, 265, 173186.
-
(1997)
J. Mol. Biol.
, vol.265
, pp. 173
-
-
Kumar, R.A.1
Ikemoto, N.2
Patel, D.J.3
-
10
-
-
0031575419
-
-
Kumar, R. A.; Ikemoto, N.; Patel, D. J. J. Mol. Biol. 1997, 265, 187201.
-
(1997)
J. Mol. Biol.
, vol.265
, pp. 187
-
-
Kumar, R.A.1
Ikemoto, N.2
Patel, D.J.3
-
11
-
-
0027398948
-
-
Zein, N.; Colson, K. L.; Leet, J. E.; Schroeder, D. R.; Solomon, W.; Doyle, T. W.; Casazza, A. M. Proc. Natl. Acad. Sci. U.SA. 1993, 90, 28222826.
-
(1993)
Proc. Natl. Acad. Sci. U.SA.
, vol.90
, pp. 2822
-
-
Zein, N.1
Colson, K.L.2
Leet, J.E.3
Schroeder, D.R.4
Solomon, W.5
Doyle, T.W.6
Casazza, A.M.7
-
12
-
-
0029951453
-
-
Okuno, Y.; Iwashita, T.; Otani, T.; Sugiura, Y. J. Am. Chem. Soc. 1996, 118, 4729-4730.
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 4729-4730
-
-
Okuno, Y.1
Iwashita, T.2
Otani, T.3
Sugiura, Y.4
-
14
-
-
0028970342
-
-
(a) McHugh, M. M.; Woynarowski, J. M.; Gawron, L. S.; Otani, T.; Beerman, T. A. Biochemistry 1995, 34, 1805-1814.
-
(1995)
Biochemistry
, vol.34
, pp. 1805-1814
-
-
McHugh, M.M.1
Woynarowski, J.M.2
Gawron, L.S.3
Otani, T.4
Beerman, T.A.5
-
15
-
-
0028965941
-
-
(b) Cobuzzi, R. J.; Kotsopoulos, S. K.; Otani, T.; Beerman, T. A. Biochemistry 1995, 34, 583592.
-
(1995)
Biochemistry
, vol.34
, pp. 583
-
-
Cobuzzi, R.J.1
Kotsopoulos, S.K.2
Otani, T.3
Beerman, T.A.4
-
16
-
-
0028240985
-
-
Xu, Y. J.; Zhen, Y. S.; Goldberg, I. H. Biochemistry 1994, 33, 59475954.
-
(1994)
Biochemistry
, vol.33
, pp. 5947
-
-
Xu, Y.J.1
Zhen, Y.S.2
Goldberg, I.H.3
-
18
-
-
0030575361
-
-
lida, K.; Fukuda, S.; Tanaka, T.; Hirama, M.; Imajo, S.; Ishiguro, M.; Yoshida, K.; Otani, T. Tetrahedron Lett. 1996, 37, 4997-5000.
-
(1996)
Tetrahedron Lett.
, vol.37
, pp. 4997-5000
-
-
Lida, K.1
Fukuda, S.2
Tanaka, T.3
Hirama, M.4
Imajo, S.5
Ishiguro, M.6
Yoshida, K.7
Otani, T.8
-
19
-
-
0026951903
-
-
Piotto, M.; Sandek, V.; Sklenar, V. J. Biomol. NMR 1992, 2, 661665.
-
(1992)
J. Biomol. NMR
, vol.2
, pp. 661
-
-
Piotto, M.1
Sandek, V.2
Sklenar, V.3
-
21
-
-
0023841714
-
-
Kessler, H.; Bats, J. W.; Griesinger, C.; Roll, S.; Will, M.; Wagner, K. J. Am. Chem. Soc. 1988, 110, 1033-1049.
-
(1988)
J. Am. Chem. Soc.
, vol.110
, pp. 1033-1049
-
-
Kessler, H.1
Bats, J.W.2
Griesinger, C.3
Roll, S.4
Will, M.5
Wagner, K.6
-
22
-
-
0029097415
-
-
Yu, L.; Mah, S.; Otani, T.; Dedon, P. J. Am. Chem. Soc. 1995, 117, 8877-8878.
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 8877-8878
-
-
Yu, L.1
Mah, S.2
Otani, T.3
Dedon, P.4
-
23
-
-
0343101273
-
-
note
-
We used the structure coordinates of the Chr-Apo complex supplied by Dr. Ishiguro. The coodinates were derived for the aromatized Chr-Apo complex.
-
-
-
-
24
-
-
0028557126
-
-
Matsumoto, T.; Sugiura, Y. Biochem. Biophys. Res. Commun. 1994, 205, 1533-1538. In preliminary experiments of DNA-Chr titration, we tried various kinds of DNA oligomers containing GTTAT/ATAAC, CTTTT/ AAAAG, ATAAT/ATTAT, CTTTA/TAAAG, and CTCJT/AAGAG. However, the imino proton-spectral region of complexes of Chrs with most oligomers except for d(TGCCATC)/d(GATGGCA) exhibited nonstoichiometric or broadening resonaces, indicating formation of multiple conformations of complex in each case. Namely, other duplexes except for d(TGCCATC)/d(GATGGCA) contain multiple binding sites despite single cleavage site by the Chr. The drug bound to a DNA sequence cannot always abstract the hydrogen atoms of the DNA nucleotides. Therefore, the 2-amino group of the central G is important to enhance specificity of DNA target recognition (not cleavage) by C1027-Chr.
-
(1994)
Biochem. Biophys. Res. Commun.
, vol.205
, pp. 1533-1538
-
-
Matsumoto, T.1
Sugiura, Y.2
-
25
-
-
0343101271
-
-
note
-
lida and Hirama reported that the constraint of the nine-membered ring of C1027-Chr may contribute to lowering the barrier for interconversion between the enediyne and biradical forms, and consequently the reaction process becomes reversible at ambient temperature. The hydrogen abstraction step by a biradical form is kinetically significant in the cycloaromatization of C1027-Chr. Therefore, the reactivity of C-1027 is affected more directly by conformation of aromatized form analogous to the biradical intermediate rather than by that of enediyne form.
-
-
-
-
27
-
-
0031563676
-
-
(b) Cramer, C. J.; Nash, J. J.; Squires, R. R. Chem. Pliys. Lett. 1997, 277, 311-320.
-
(1997)
Chem. Pliys. Lett.
, vol.277
, pp. 311-320
-
-
Cramer, C.J.1
Nash, J.J.2
Squires, R.R.3
-
29
-
-
0342666963
-
-
note
-
We used the benzene ring as a group adjcent to p-benzyne biradical for the purpose of the simplicity of ab initio calculation. If chlorophenol ring is employed instead of benzen ring, the functional substituent groups (chloro- and hydroxyl-group) may influence the magnitude of S-T splitting difference for the two C1027-Chr form. Therefore, the calculated S-T gap difference (~0.04) can indicate qualitative tendency of the C1027reactivity. More accurate calculations will lead to these quantitative interpretations.
-
-
-
-
30
-
-
0030017851
-
-
(a) Stassinopoulos, A.; Ji, J.; Gao, X.; Goldberg, I. H. Science 1996, 272, 1943-1946.
-
(1996)
Science
, vol.272
, pp. 1943-1946
-
-
Stassinopoulos, A.1
Ji, J.2
Gao, X.3
Goldberg, I.H.4
-
31
-
-
0028915755
-
-
(b) Gao, X.; Stassinopoulos, A.; Rice, J. S.; Goldberg, I. H. Biochemistry 1995, 34, 40-49.
-
(1995)
Biochemistry
, vol.34
, pp. 40-49
-
-
Gao, X.1
Stassinopoulos, A.2
Rice, J.S.3
Goldberg, I.H.4
-
32
-
-
33847555804
-
-
(c) Kirn, K.-H.; Kwon, B.-H.; Myers, A. G.; Rees, D. C. Science 1993, 262, 1042-1046.
-
(1993)
Science
, vol.262
, pp. 1042-1046
-
-
Kirn, K.-H.1
Kwon, B.-H.2
Myers, A.G.3
Rees, D.C.4
|