Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells

Journal of Biological Chemistry

Volumn 286, Issue 8, 2011, Pages 5956-5966

  Chaix, Amandine ^a,b,c   Lopez, Sophie ^a,b,c   Voisset, Edwige ^a,b,c   Gros, Laurent ^d   Dubreuil, Patrice ^a,b,c   De Sepulveda, Paulo ^a,b,c  

^a AIX MARSEILLE UNIVERSITY   (France)

^b INSTITUT PAOLI CALMETTES   (France)

^c AIX MARSEILLE UNIVERSITY   (France)

^d AB Science   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT PATIENTS; CELL LINES; IN-VITRO; KINASE DOMAINS; MAST CELLS; MUTANT PROTEINS; SERINE PHOSPHORYLATION; SERINE RESIDUES; SRC-FAMILY KINASE; STAT PROTEINS; TRANSCRIPTIONALLY ACTIVE; TYROSINE PHOSPHORYLATION; TYROSINE RESIDUES;

CELL CULTURE; CELL PROLIFERATION; ENZYMES; GENES; PHOSPHORYLATION; TRANSCRIPTION; TRANSCRIPTION FACTORS;

AMINO ACIDS;

ASPARTIC ACID; JANUS KINASE; PROTEIN TYROSINE KINASE; SERINE; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN; STEM CELL FACTOR RECEPTOR;

ANIMAL CELL; ARTICLE; CELL LINE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; MAST CELL; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TUMOR CELL;

ADULT; ANIMALS; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; MAST CELLS; MASTOCYTOSIS; MICE; MUTATION; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-KIT; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 79953215678     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.182642     Document Type: Article

References (58)

1. Lennartsson, J., Jelacic, T., Linnekin, D., and Shivakrupa, R. (2005) Stem Cells 23, 16-43
2. Liu, H., Chen, X., Focia, P. J., and He, X. (2007) EMBO J. 26, 891-901
3. Hirota, S., Isozaki, K., Moriyama, Y., Hashimoto, K., Nishida, T., Ishiguro, S., Kawano, K., Hanada, M., Kurata, A., Takeda, M., Muhammad Tunio, G., Matsuzawa, Y., Kanakura, Y., Shinomura, Y., and Kitamura, Y. (1998) Science 279, 577-580
4. Curtin, J. A., Busam, K., Pinkel, D., and Bastian, B. C. (2006) J. Clin. Oncol. 24, 4340-4346
5. Longley, B. J., Jr., Metcalfe, D. D., Tharp, M., Wang, X., Tyrrell, L., Lu, S. Z., Heitjan, D., and Ma, Y. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 1609-1614
6. Valent, P., Akin, C., Sperr, W. R., Mayerhofer, M., Födinger, M., Fritsche-Polanz, R., Sotlar, K., Escribano, L., Arock, M., Horny, H. P., and Metcalfe, D. D. (2005) Leuk. Lymphoma 46, 35-48
7. Beghini, A., Ripamonti, C. B., Cairoli, R., Cazzaniga, G., Colapietro, P., Elice, F., Nadali, G., Grillo, G., Haas, O. A., Biondi, A., Morra, E., and Larizza, L. (2004) Haematologica 89, 920-925
8. Cairoli, R., Beghini, A., Grillo, G., Nadali, G., Elice, F., Ripamonti, C. B., Colapietro, P., Nichelatti, M., Pezzetti, L., Lunghi, M., Cuneo, A., Viola, A., Ferrara, F., Lazzarino, M., Rodeghiero, F., Pizzolo, G., Larizza, L., and Morra, E. (2006) Blood 107, 3463-3468
9. Tian, Q., Frierson, H. F., Jr., Krystal, G. W., and Moskaluk, C. A. (1999) Am. J. Pathol. 154, 1643-1647
10. Looijenga, L. H., de Leeuw, H., van Oorschot, M., van Gurp, R. J., Stoop, H., Gillis, A. J., de Gouveia Brazao, C. A., Weber, R. F., Kirkels, W. J., van Dijk, T., von Lindern, M., Valk, P., Lajos, G., Olah, E., Nesland, J. M., Fosså, S. D., and Oosterhuis, J. W. (2003) Cancer Res. 63, 7674-7678
11. Kemmer, K., Corless, C. L., Fletcher, J. A., McGreevey, L., Haley, A., Griffith, D., Cummings, O. W., Wait, C., Town, A., and Heinrich, M. C. (2004) Am. J. Pathol. 164, 305-313
12. Rönnstrand, L. (2004) Cell. Mol. Life Sci. 61, 2535-2548
13. Levy, D. E., and Darnell, J. E., Jr. (2002) Nat. Rev. Mol. Cell Biol. 3, 651-662
14. Bowman, T., Garcia, R., Turkson, J., and Jove, R. (2000) Oncogene 19, 2474-2488
15. Benekli, M., Baer, M. R., Baumann, H., and Wetzler, M. (2003) Blood 101, 2940-2954
16. Bromberg, J. F., Horvath, C. M., Besser, D., Lathem, W. W., and Darnell, J. E., Jr. (1998) Mol. Cell. Biol. 18, 2553-2558
17. Carlesso, N., Frank, D. A., and Griffin, J. D. (1996) J. Exp. Med. 183, 811-820
18. Ning, Z. Q., Li, J., and Arceci, R. J. (2001) Blood 97, 3559-3567
19. Harir, N., Boudot, C., Friedbichler, K., Sonneck, K., Kondo, R., Martin- Lannerée, S., Kenner, L., Kerenyi, M., Yahiaoui, S., Gouilleux-Gruart, V., Gondry, J., Bénit, L., Dusanter-Fourt, I., Lassoued, K., Valent, P., Moriggl, R., and Gouilleux, F. (2008) Blood 112, 2463-2473
20. Baumgartner, C., Cerny-Reiterer, S., Sonneck, K., Mayerhofer, M., Gleixner, K. V., Fritz, R., Kerenyi, M., Boudot, C., Gouilleux, F., Kornfeld, J. W., Sillaber, C., Moriggl, R., and Valent, P. (2009) Am. J. Pathol. 175, 2416-2429
21. Furitsu, T., Tsujimura, T., Tono, T., Ikeda, H., Kitayama, H., Koshimizu, U., Sugahara, H., Butterfield, J. H., Ashman, L. K., Kanayama, Y., et al. (1993) J. Clin. Invest. 92, 1736-1744
22. Zappulla, J. P., Dubreuil, P., Desbois, S., Létard, S., Hamouda, N. B., Daëron, M., Delsol, G., Arock, M., and Liblau, R. S. (2005) J. Exp. Med. 202, 1635-1641
23. Ali, M. S., Sayeski, P. P., and Bernstein, K. E. (2000) J. Biol. Chem. 275, 15586-15593
24. Cao, X., Tay, A., Guy, G. R., and Tan, Y. H. (1996) Mol. Cell. Biol. 16, 1595-1603
25. Maki, K., and Ikuta, K. (2008) J. Immunol. 181, 494-502
26. Hocke, G. M., Cui, M. Z., and Fey, G. H. (1995) Cytokine 7, 491-502
27. Aman, M. J., Migone, T. S., Sasaki, A., Ascherman, D. P., Zhu, M., Soldaini, E., Imada, K., Miyajima, A., Yoshimura, A., and Leonard, W. J. (1999) J. Biol. Chem. 274, 30266-30272
28. Dubreuil, P., Letard, S., Ciufolini, M., Gros, L., Humbert, M., Castéran, N., Borge, L., Hajem, B., Lermet, A., Sippl, W., Voisset, E., Arock, M., Auclair, C., Leventhal, P. S., Mansfield, C. D., Moussy, A., and Hermine, O. (2009) PLoS One 4, e7258
29. Casteran, N., De Sepulveda, P., Beslu, N., Aoubala, M., Letard, S., Lecocq, E., Rottapel, R., and Dubreuil, P. (2003) Oncogene 22, 4710-4722
30. Growney, J. D., Clark, J. J., Adelsperger, J., Stone, R., Fabbro, D., Griffin, J. D., and Gilliland, D. G. (2005) Blood 106, 721-724
31. Pan, J., Quintás-Cardama, A., Kantarjian, H. M., Akin, C., Manshouri, T., Lamb, P., Cortes, J. E., Tefferi, A., Giles, F. J., and Verstovsek, S. (2007) Blood 109, 315-322
32. Voisset, E., Lopez, S., Dubreuil, P., and De Sepulveda, P. (2007) Blood 110, 2593-2599
33. Zermati, Y., De Sepulveda, P., Féger, F., Létard, S., Kersual, J., Castéran, N., Gorochov, G., Dy, M., Ribadeau Dumas, A., Dorgham, K., Parizot, C., Bieche, Y., Vidaud, M., Lortholary, O., Arock, M., Hermine, O., and Dubreuil, P. (2003) Oncogene 22, 660-664
34. Schittenhelm, M. M., Shiraga, S., Schroeder, A., Corbin, A. S., Griffith, D., Lee, F. Y., Bokemeyer, C., Deininger, M. W., Druker, B. J., and Heinrich, M. C. (2006) Cancer Res. 66, 473-481
35. Krejci, P., Salazar, L., Goodridge, H. S., Kashiwada, T. A., Schibler, M. J., Jelinkova, P., Thompson, L. M., and Wilcox, W. R. (2008) J. Cell Sci. 121, 272-281
36. Vignais, M. L., and Gilman, M. (1999) Mol. Cell. Biol. 19, 3727-3735
37. Paukku, K., Valgeirsdóttir, S., Saharinen, P., Bergman, M., Heldin, C. H., and Silvennoinen, O. (2000) Biochem. J. 345, 759-766
38. Choudhary, C., Brandts, C., Schwable, J., Tickenbrock, L., Sargin, B., Ueker, A., Böhmer, F. D., Berdel, W. E., Müller-Tidow, C., and Serve, H. (2007) Blood 110, 370-374
39. Tyner, J. W., Walters, D. K., Willis, S. G., Luttropp, M., Oost, J., Loriaux, M., Erickson, H., Corbin, A. S., O'Hare, T., Heinrich, M. C., Deininger, M. W., and Druker, B. J. (2008) Blood 111, 2238-2245
40. Rocnik, J. L., Okabe, R., Yu, J. C., Lee, B. H., Giese, N., Schenkein, D. P., and Gilliland, D. G. (2006) Blood 108, 1339-1345
41. Lennartsson, J., Blume-Jensen, P., Hermanson, M., Pontén, E., Carlberg, M., and Rönnstrand, L. (1999) Oncogene 18, 5546-5553
42. Wen, Z., Zhong, Z., and Darnell, J. E., Jr. (1995) Cell 82, 241-250
43. Bain, J., Plater, L., Elliott, M., Shpiro, N., Hastie, C. J., McLauchlan, H., Klevernic, I., Arthur, J. S., Alessi, D. R., and Cohen, P. (2007) Biochem. J. 408, 297-315
44. Jelacic, T., and Linnekin, D. (2005) Blood 105, 1923-1929
45. Yu, H., and Jove, R. (2004) Nat. Rev. Cancer 4, 97-105
46. Benekli, M., Baumann, H., and Wetzler, M. (2009) J. Clin. Oncol. 27, 4422-4432
47. Schindler, C., Levy, D. E., and Decker, T. (2007) J. Biol. Chem. 282, 20059-20063
48. Storz, P., Döppler, H., Pfizenmaier, K., and Müller, G. (1999) FEBS Lett. 464, 159-163
49. Chaturvedi, P., Reddy, M. V., and Reddy, E. P. (1998) Oncogene 16, 1749-1758
50. Turkson, J., Bowman, T., Garcia, R., Caldenhoven, E., De Groot, R. P., and Jove, R. (1998) Mol. Cell. Biol. 18, 2545-2552
51. Deberry, C., Mou, S., and Linnekin, D. (1997) Biochem. J. 327, 73-80
52. Kozlowski, M., Larose, L., Lee, F., Le, D. M., Rottapel, R., and Siminovitch, K. A. (1998) Mol. Cell. Biol. 18, 2089-2099
53. Tomasson, M. H., Sternberg, D. W., Williams, I. R., Carroll, M., Cain, D., Aster, J. C., Ilaria, R. L., Jr., Van Etten, R. A., and Gilliland, D. G. (2000) J. Clin. Invest. 105, 423-432
54. Decker, T., and Kovarik, P. (2000) Oncogene 19, 2628-2637
55. Uddin, S., Sassano, A., Deb, D. K., Verma, A., Majchrzak, B., Rahman, A., Malik, A. B., Fish, E. N., and Platanias, L. C. (2002) J. Biol. Chem. 277, 14408-14416
56. Gartsbein, M., Alt, A., Hashimoto, K., Nakajima, K., Kuroki, T., and Tennenbaum, T. (2006) J. Cell Sci. 119, 470-481
57. Gough, D. J., Corlett, A., Schlessinger, K., Wegrzyn, J., Larner, A. C., and Levy, D. E. (2009) Science 324, 1713-1716
58. Wegrzyn, J., Potla, R., Chwae, Y. J., Sepuri, N. B., Zhang, Q., Koeck, T., Derecka, M., Szczepanek, K., Szelag, M., Gornicka, A., Moh, A., Moghaddas, S., Chen, Q., Bobbili, S., Cichy, J., Dulak, J., Baker, D. P., Wolfman, A., Stuehr, D., Hassan, M. O., Fu, X. Y., Avadhani, N., Drake, J. I., Fawcett, P., Lesnefsky, E. J., and Larner, A. C. (2009) Science 323, 793-797