Effective electrophoretic mobilities and charges of anti-VEGF proteins determined by capillary zone electrophoresis

Journal of Pharmaceutical and Biomedical Analysis

Volumn 55, Issue 3, 2011, Pages 603-607

  Li, S Kevin ^a   Liddell, Mark R ^a   Wen, He ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Anti VEGF protein; Capillary zone electrophoresis; Effective charge; Electrophoresis; Electrophoretic mobility

Indexed keywords

BEVACIZUMAB; BOVINE SERUM ALBUMIN; LIDOCAINE; PHOSPHATE BUFFERED SALINE; POLYSTYRENESULFONIC ACID; RANIBIZUMAB; SALICYLIC ACID;

ARTICLE; CAPILLARY ZONE ELECTROPHORESIS; DIFFUSION COEFFICIENT; ELECTRICITY; ELECTROPHORETIC MOBILITY; HYDRODYNAMICS; IONIC STRENGTH; LIGHT SCATTERING; PH; PRIORITY JOURNAL; VALIDATION PROCESS;

ANTIBODIES, MONOCLONAL; BUFFERS; DRUG DELIVERY SYSTEMS; ELECTROPHORESIS, CAPILLARY; HUMANS; HYDRODYNAMICS; HYDROGEN-ION CONCENTRATION; IONTOPHORESIS; MACULAR DEGENERATION; MODELS, CHEMICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79953211477     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.12.027     Document Type: Article

References (40)

1. Ludwig D.L., Pereira D.S., Zhu Z., Hicklin D.J., Bohlen P. Monoclonal antibody therapeutics and apoptosis. Oncogene 2003, 22:9097-9106.
2. Wu A.M., Senter P.D. Arming antibodies: prospects and challenges for immunoconjugates. Nat. Biotechnol. 2005, 23:1137-1146.
3. Michels S., Rosenfeld P.J., Puliafito C.A., Marcus E.N., Venkatraman A.S. Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration twelve-week results of an uncontrolled open-label clinical study. Ophthalmology 2005, 112:1035-1047.
4. Mordenti J., Cuthbertson R.A., Ferrara N., Thomsen K., Berleau L., Licko V., Allen P.C., Valverde C.R., Meng Y.G., Fei D.T., Fourre K.M., Ryan A.M. Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration. Toxicol. Pathol. 1999, 27:536-544.
5. Kalia Y.N., Naik A., Garrison J., Guy R.H. Iontophoretic drug delivery. Adv. Drug Deliv. Rev. 2004, 56:619-658.
6. Peck K.D., Srinivasan V., Li S.K., Higuchi W.I., Ghanem A.H. Quantitative description of the effect of molecular size upon electroosmotic flux enhancement during iontophoresis for a synthetic membrane and human epidermal membrane. J. Pharm. Sci. 1996, 85:781-788.
7. Pikal M.J. The role of electroosmotic flow in transdermal iontophoresis. Adv. Drug Deliv. Rev. 2001, 46:281-305.
8. Eljarrat-Binstock E., Domb A.J. Iontophoresis: a non-invasive ocular drug delivery. J. Control. Release 2006, 110:479-489.
9. Halhal M., Renard G., Courtois Y., BenEzra D., Behar-Cohen F. Iontophoresis: from the lab to the bed side. Exp. Eye Res. 2004, 78:751-757.
10. Behar-Cohen F.F., El Aouni A., Gautier S., David G., Davis J., Chapon P., Parel J.M. Transscleral coulomb-controlled iontophoresis of methylprednisolone into the rabbit eye: influence of duration of treatment, current intensity and drug concentration on ocular tissue and fluid levels. Exp. Eye Res. 2002, 74:51-59.
11. Parkinson T.M., Ferguson E., Febbraro S., Bakhtyari A., King M., Mundasad M. Tolerance of ocular iontophoresis in healthy volunteers. J. Ocul. Pharmacol. Ther. 2003, 19:145-151.
12. Chopra P., Hao J., Li S.K. Iontophoretic transport of charged macromolecules across human sclera. Int. J. Pharm. 2010, 388:107-113.
13. Altria K., Marsh A., Sanger-van de Griend C. Capillary electrophoresis for the analysis of small-molecule pharmaceuticals. Electrophoresis 2006, 27:2263-2282.
14. Flurer C.L. Analysis of antibiotics by capillary electrophoresis. Electrophoresis 2003, 24:4116-4127.
15. Hempel G. Biomedical applications of capillary electrophoresis. Clin. Chem. Lab. Med. 2003, 41:720-723.
16. Menon M.K., Zydney A.L. Measurement of protein charge and ion binding using capillary electrophoresis. Anal. Chem. 1998, 70:1581-1584.
17. Sitaram B.R., Keah H.H., Hearn M.T. Studies on the relationship between structure and electrophoretic mobility of alpha-helical and beta-sheet peptides using capillary zone electrophoresis. J. Chromatogr. A 1999, 857:263-273.
18. Schmitt-Kopplin P., Junkers J. Capillary zone electrophoresis of natural organic matter. J. Chromatogr. A 2003, 998:1-20.
19. Li S.K., Ghanem A.H., Teng C.L., Hardee G.E., Higuchi W.I. Iontophoretic transport of oligonucleotides across human epidermal membrane: a study of the Nernst-Planck model. J. Pharm. Sci. 2001, 90:915-931.
20. Ornskov E., Linusson A., Folestad S. Determination of dissociation constants of labile drug compounds by capillary electrophoresis. J. Pharm. Biomed. Anal. 2003, 33:379-391.
21. a values of pharmaceuticals by pressure-assisted capillary electrophoresis combined with short-end injection. J. Chromatogr. A 2002, 979:369-377.
22. Herbert B.J., Dorsey J.G. n-Octanol water partition-coefficient estimation by micellar electrokinetic capillary chromatography. Anal. Chem. 1995, 67:744-749.
23. Abla N., Geiser L., Mirgaldi M., Naik A., Veuthey J.L., Guy R.H., Kalia Y.N. Capillary zone electrophoresis for the estimation of transdermal iontophoretic mobility. J. Pharm. Sci. 2005, 94:2667-2675.
24. Mudry B., Carrupt P.A., Guy R.H., Delgado-Charro M.B. Quantitative structure-permeation relationship for iontophoretic transport across the skin. J. Control. Release 2007, 122:165-172.
25. Hiemenz P.C. Principles of Colloid and Surface Chemistry 1986, Marcel Dekker, New York. 2nd ed.
26. Lide D.R. CRC Handbook of Chemistry and Physics 2008, CRC Press, Boca Raton, FL.
27. Olivera B., Baine P., Davidson N. Electrophoresis of the nucleic acids. Biopolymers 1964, 2:245-257.
28. Nagasawa M., Noda I., Takahashi T., Shimamoto N. Transport phenomena of polyelectrolytes in solution under electric field. J. Phys. Chem. 1972, 76:2286-2294.
29. Cottet H., Gareil P., Theodoly O., Williams C.E. A semi-empirical approach to the modeling of the electrophoretic mobility in free solution: application to polystyrenesulfonates of various sulfonation rates. Electrophoresis 2000, 21:3529-3540.
30. Berk D.A., Yuan F., Leunig M., Jain R.K. Direct in vivo measurement of targeted binding in a human tumor xenograft. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:1785-1790.
31. Kaufman E.N., Jain R.K. In vitro measurement and screening of monoclonal antibody affinity using fluorescence photobleaching. J. Immunol. Methods 1992, 155:1-17.
32. Molokhia S.A., Sant H., Simonis J., Bishop C.J., Burr R.M., Gale B.K., Ambati B.K. The capsule drug device: novel approach for drug delivery to the eye. Vision Res. 2010, 50:680-685.
33. Pescina S., Ferrari G., Govoni P., Macaluso C., Padula C., Santi P., Nicoli S. In-vitro permeation of bevacizumab through human sclera: effect of iontophoresis application. J. Pharm. Pharmacol. 2010, 62:1189-1194.
34. Gao Y., Sherman P.M., Sun Y., Li D. Multiplexed high-throughput electrokinetically-controlled immunoassay for the detection of specific bacterial antibodies in human serum. Anal. Chim. Acta 2008, 606:98-107.
35. Bohme U., Scheler U. Effective charge of bovine serum albumin determined by electrophoresis NMR. Chem. Phys. Lett. 2007, 435:342-345.
36. Sanzgiri R.D., McKinnon T.A., Cooper B.T. Intrinsic charge ladders of a monoclonal antibody in hydroxypropylcellulose-coated capillaries. Analyst 2006, 131:1034-1043.
37. Yadav S., Liu J., Shire S.J., Kalonia D.S. Specific interactions in high concentration antibody solutions resulting in high viscosity. J. Pharm. Sci. 2010, 99:1152-1168.
38. Singh R.P., Mathews M.E., Kaufman M., Riga A. Transcleral delivery of triamcinolone acetonide and ranibizumab to retinal tissues using macroesis. Br. J. Ophthalmol. 2010, 94:170-173.
39. Andrew J.S., Anglin E.J., Wu E.C., Chen M.Y., Cheng L., Freeman W.R., Sailor M.J. Sustained release of a monoclonal antibody from electrochemically prepared mesoporous silicon oxide. Adv. Funct. Mater. 2010, 20:4168-4174.
40. Li S.K., Ghanem A.H., Peck K.D., Higuchi W.I. Iontophoretic transport across a synthetic membrane and human epidermal membrane: a study of the effects of permeant charge. J. Pharm. Sci. 1997, 86:680-689.