Transscleral Coulomb-controlled iontophoresis of methylprednisolone into the rabbit eye: Influence of duration of treatment, current intensity and drug concentration on ocular tissue and fluid levels

Experimental Eye Research

Volumn 74, Issue 1, 2002, Pages 51-59

  Behar Cohen, F F ^a   El Aouni, A ^a,b   Gautier, S ^c   David, G ^d   Davis, J ^c   Chapon, P ^c   Parel, J M ^c  

^a HÔTEL DIEU   (France)

^b MILITARY HOSPITAL MOHAMMED V   (Morocco)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d OPTIS   (France)

Author keywords

Corticosteroids; Drug delivery; Iontophoresis; Pharmacokinetic; Rabbit

Indexed keywords

METHYLPREDNISOLONE; METHYLPREDNISOLONE SODIUM SUCCINATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR EYE SEGMENT; AQUEOUS HUMOR; ARTICLE; CHOROID; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG SAFETY; ELECTRIC CURRENT; EYE; EYE TOXICITY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; IONTOPHORESIS; NONHUMAN; PRIORITY JOURNAL; RABBIT; RETINA; SCLERA;

EID: 0036346995     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1006/exer.2001.1098     Document Type: Article

References (36)

1. La place de la corticothérapie dans l'endophtalmie post-opératoire
2. The penetration of steroids into the rabbit's vitreous, choroid and retina following retrobulbar injection, Part 1
3. Intraocular penetration of carbenicillin in the rabbit
4. Transscleral iontophoresis of cefazolin, ticarcillin, and gentamicin in the rabbit
5. Transscleral iontophoresis of gentamicin in monkeys
6. Methylprednisolone concentrations in the vitreous and serum after pulse therapy
7. Iontophoresis of dexamethasone in the treatment of endotoxin-induced-uveitis in rats
8. Reduction of corneal edema in endotoxin-induced-uveitis after application of L-NAME as nitric oxide synthase inhibitor in rats by iontophoresis
9. Topical formulations of novel angiostatic steroids inhibit rabbit corneal neovascularization
10. Permeability of the cornea to topically applied drugs
11. Intraocular dexamethasone penetration via subconjunctival or retrobulbar injections in rabbits
12. Transscleral and transcorneal iontophoresis of vancomycin in the rabbit eye
13. High dose intravitreal dexamethasone for infections endophthalmitis
14. The eye and cortisone
15. Transscleral and transcorneal iontophoresis of ketoconazole in the rabbit eye
16. A fesh look at iontophoresis
17. Consideration of the use of corticosteroids by ionization in certain ocular diseases
18. Transscleral iontophoresis of dexamethasone
19. A histopathological study of retinal lesions inflicted by transscleral iontophoresis
20. Rapid method for the measurement of methylprednisolone and its hemisuccinate in plasma and urine following 'pulse therapy' by high-performance liquid chromatography
21. Periocular injection of corticosteroids. An experimental evaluation of its role in the treatment of corneal inflammation
22. Orbital infusion of steroids in the rabbit
23. Iontophoresis of fluorescein into the posterior segment of the rabbit eye
24. An autoradiographic study of the penetration of subconjunctivaly injected hydrocortisone into the normal and inflamed rabbit eye
25. Intravitreal corticosteroids as an adjunct in the treatment of bacterial and fungal endophthalmitis
26. Transscleral iontophoresis of foscarnet
27. High performance liquid chromatography assay for methylprednisolone and methylprednisolone 21-[8-(methyl-(2-sulfoethyl) amino 8-oxoctanoate] sodium salt in human plasma
28. Systemic corticosteroid therapy-side effects and their management
29. Hydrolysis of prednisolone succinate by esterase in rabbit ocular tissues
30. Intraocular penetration kinetics of prednisolone after subconjunctival injection in rabbits
31. In vitro iontophoretic studies using a synthetic membrane
32. Intravenous pulse methylprednisolone therapy in severe inflammatory eye disease
33. Dexamethasone concentration in the vitreous and the serum after oral administration
34. Peribulbar corticosteroids injection: Vitreal and serum concentrations after dexamethasone disodium phosphate injection
35. Determination of ocular toxicity in multiple applications of foscarnet iontophoresis