Iontophoretic transport of charged macromolecules across human sclera

International Journal of Pharmaceutics

Volumn 388, Issue 1-2, 2010, Pages 107-113

  Chopra, Poonam ^a   Hao, Jinsong ^a   Li, S Kevin ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

Author keywords

Charged macromolecules; Electroosmosis; Electrophoresis; Human sclera

Indexed keywords

BEVACIZUMAB; BOVINE SERUM ALBUMIN; POLYSTYRENESULFONIC ACID; SALICYLIC ACID; TETRYLAMMONIUM;

ARTICLE; CONTROLLED STUDY; DIFFUSION; DRUG TRANSPORT; ELECTROOSMOSIS; ELECTROPHORESIS; HUMAN; HUMAN TISSUE; IONTOPHORESIS; MACROMOLECULE; PARTICLE SIZE; PRIORITY JOURNAL; SCLERA; SURFACE CHARGE;

ADMINISTRATION, TOPICAL; ANIMALS; ANTIBODIES, MONOCLONAL; BIOLOGICAL TRANSPORT; CATTLE; ELECTROOSMOSIS; ELECTROPHORESIS; HUMANS; IONTOPHORESIS; POLYSTYRENES; RABBITS; SALICYLIC ACID; SCLERA; SERUM ALBUMIN, BOVINE; TETRAETHYLAMMONIUM;

EID: 76549113537     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.12.046     Document Type: Article

References (30)

1. Ambati J., Canakis C.S., Miller J.W., Gragoudas E.S., Edwards A., Weissgold D.J., Kim I., Delori F.C., and Adamis A.P. Diffusion of high molecular weight compounds through sclera. Invest. Ophthalmol. Vis. Sci. 41 (2000) 1181-1185
2. Behar-Cohen F., El Aouni A., Gautier S., David G., Davis J., Chapon P., and Parel J.M. Transscleral coulomb-controlled iontophoresis of methylprednisolone into the rabbit eye: influence of duration of treatment, current intensity and drug concentration on ocular tissue and fluid levels. Exp. Eye Res. 74 (2002) 51-59
3. Behar-Cohen F., Parel J.M., Pouliquen Y., Thillaye-Goldenberg B., Goureau O., Heydolph S., Courtois Y., and deKozak Y. Iontophoresis of dexamethasone in the treatment of endotoxin-induced-uveitis in rats. Exp. Eye Res. 65 (1997) 533-545
4. Bockris J.O.M., and Reddy A.K.N. Modern Electrochemistry. 2nd ed. (1998), Kluwer Academic/Plenum Publishers, New York
5. Cruysberg L.P.J., Nuijts R.M.M.A., Geroski D.H., Koole L.H., Hendrikse F., and Edelhauser H.F. In vitro human scleral permeability of fluorescein, dexamethasone-fluorescein, methotrexate-fluorescein and rhodamine 6G and the use of a coated coil as a new drug delivery system. J. Ocul. Pharmacol. Ther. 18 (2002) 559-569
6. Davies J.B., Ciavatta V.T., Boatright J.H., and Nickerson J.M. Delivery of several forms of DNA, DNA-RNA hybrids, and dyes across human sclera by electrical fields. Mol. Vis. 9 (2003) 569-578
7. Deen W.M. Hindered transport of large molecules in liquid-filled pores. AIChE J. 33 (1987) 1409-1425
8. Edwards D.A., and Langer R. A linear-theory of transdermal transport phenomena. J. Pharm. Sci. 83 (1994) 1315-1334
9. Eljarrat-Binstock E., and Domb A.J. Iontophoresis: a non-invasive ocular drug delivery. J. Control. Release 110 (2006) 479-489
10. Eljarrat-Binstock E., Domb A.J., Orucov F., Dagan A., Frucht-Pery J., and Pe'er J. In vitro and in vivo evaluation of carboplatin delivery to the eye using hydrogel-iontophoresis. Curr. Eye Res. 33 (2008) 269-275
11. Eljarrat-Binstock E., Domb A.J., Orucov F., Frucht-Pery J., and Pe'er J. Methotrexate delivery to the eye using transscleral hydrogel iontophoresis. Curr. Eye Res. 32 (2007) 639-646
12. Eljarrat-Binstock E., Orucov F., Frucht-Pery J., Pe'er J., and Domb A.J. Methylprednisolone delivery to the back of the eye using hydrogel iontophoresis. J. Ocul. Pharmacol. Ther. 24 (2008) 344-350
13. Frucht-Pery J., Raiskup F., Mechoulam H., Shapiro M., Eljarrat-Binstock E., and Domb A. Iontophoretic treatment of experimental pseudomonas keratitis in rabbit eyes using gentamicin-loaded hydrogels. Cornea 25 (2006) 1182-1186
14. Hofman P., Blaauwgeers H.G.T., Tolentino M.J., Adamis A.P., Cardozo B.J.N., Vrensen G.F.J.M., and Schlingemann R.O. VEGF-A induced hyperpermeability of blood-retinal barrier endothelium in vivo is predominantly associated with pinocytotic vesicular transport and not with formation of fenestrations. Curr. Eye Res. 21 (2000) 637-645
15. Jager R.D., Aiello L.P., Patel S.C., and Cunningham E.T. Risks of intravitreous injection: a comprehensive review. Retina 24 (2004) 676-698
16. Kasting G.B. Theoretical models for iontophoretic delivery. Adv. Drug Deliv. Rev. 9 (1992) 177-199
17. Krohne T.U., Eter N., Holz F.G., and Meyer C.H. Intraocular pharmacokinetics of bevacizumab after a single intravitreal injection in humans. Am. J. Ophthalmol. 146 (2008) 508-512
18. Li S.K., Zhang Y.H., Zhu H.G., Higuchi W.I., and White H.S. Influence of asymmetric donor-receiver ion concentration upon transscleral iontophoretic transport. J. Pharm. Sci. 94 (2005) 847-860
19. Maurice D.M. Drug delivery to the posterior segment from drops. Surv. Ophthalmol. 47 (2002) S41-S52
20. Michels S., Rosenfeld P.J., Puliafito C.A., Marcus E.N., and Venkatraman A.S. Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration-twelve-week results of an uncontrolled open-label clinical study. Ophthalmology 112 (2005) 1035-1047
21. Mordenti J., Cuthbertson R.A., Ferrara N., Thomsen K., Berleau L., Licko V., Allen P.C., Valverde C.R., Meng Y.G., Fei D.T., Fourre K.M., and Ryan A.M. Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration. Toxicol. Pathol. 27 (1999) 536-544
22. Myles M.E., Neumann D.M., and Hill J.M. Recent progress in ocular drug delivery for posterior segment disease: emphasis on transscleral iontophoresis. Adv. Drug Deliv. Rev. 57 (2005) 2063-2079
23. Nicoli S., Ferrari G., Quarta M., Macaluso C., and Santi P. In vitro transscleral iontophoresis of high molecular weight neutral compounds. Eur. J. Pharm. Sci. 36 (2009) 486-492
24. Olsen T.W., Edelhauser H.F., Lim J.I., and Geroski D.H. Human scleral permeability-effects of age, cryotherapy, transscleral diode-laser, and surgical thinning. Invest. Ophthalmol. Vis. Sci. 36 (1995) 1893-1903
25. Pikal M.J. The role of electroosmotic flow in transdermal iontophoresis. Adv. Drug Deliv. Rev. 9 (1992) 201-237
26. Prausnitz M.R., and Noonan J.S. Permeability of cornea, sclera, and conjunctiva: a literature analysis for drug delivery to the eye. J. Pharm. Sci. 87 (1998) 1479-1488
27. Ranta V.P., and Urtti A. Transscleral drug delivery to the posterior eye: prospects of pharmacokinetic modeling. Adv. Drug Deliv. Rev. 58 (2006) 1164-1181
28. Sims S.M., Higuchi W.I., and Srinivasan V. Interaction of electric-field and electroosmotic effects in determining iontophoretic enhancement of anions and cations. Int. J. Pharm. 77 (1991) 107-118
29. Srinivasan V., Higuchi W.I., Sims S.M., Ghanem A.H., and Behl C.R. Transdermal iontophoretic drug delivery: mechanistic analysis and application to polypeptide delivery. J. Pharm. Sci. 78 (1989) 370-375
30. Urtti A. Challenges and obstacles of ocular pharmacokinetics and drug delivery. Adv. Drug Deliv. Rev. 58 (2006) 1131-1135