Structure analysis reveals the flexibility of the ADAMTS-5 active site

Protein Science

Volumn 20, Issue 4, 2011, Pages 735-744

  Shieh, Huey Sheng ^a   Tomasselli, Alfredo G ^a,d   Mathis, Karl J ^a   Schnute, Mark E ^a   Woodard, Scott S ^a   Caspers, Nicole ^a   Williams, Jennifer M ^a   Kiefer, James R ^a   Munie, Grace ^a   Wittwer, Arthur ^a   Malfait, Anne Marie ^a,b   Tortorella, Micky D ^a,c  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

^c GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^d NONE   (United States)

Author keywords

ADAMTS; Aggrecanase; Metalloprotease; Osteoarthritis

Indexed keywords

(2 HYDROXY 2,3 DIHYDRO 1H INDEN 1 YL)SUCCINAMIDE DERIVATIVE; AGGRECANASE 1; AGGRECANASE 2; COLLAGENASE 3; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; MATRILYSIN; MATRIX METALLOPROTEINASE 14; METALLOPROTEINASE INHIBITOR; NEUTROPHIL COLLAGENASE; STROMELYSIN; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SELECTIVITY; ENZYME ACTIVE SITE; ENZYME BINDING; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; STRUCTURE ANALYSIS;

ADAM PROTEINS; AMIDES; ANIMALS; CATALYTIC DOMAIN; CATTLE; DRUG DESIGN; HUMANS; MATRIX METALLOPROTEINASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PROTEIN CONFORMATION;

EID: 79953188347     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.606     Document Type: Article

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