Effect of PEG molecular weight and linking chemistry on the biological activity and thermal stability of PEGylated trypsin

International Journal of Pharmaceutics

Volumn 357, Issue 1-2, 2008, Pages 252-259

  Treetharnmathurot, Benjaporn ^a   Ovartlarnporn, Chitchamai ^a   Wungsintaweekul, Juraithip ^a   Duncan, Ruth ^b   Wiwattanapatapee, Ruedeekorn ^a  

^a PRINCE OF SONGKLA UNIVERSITY   (Thailand)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Monomethoxypolyethylene glycol (mPEG); PEG conjugates; Thermal stability; Trypsin

Indexed keywords

AMIDASE; BENZOYLARGININE 4 NITROANILIDE; BENZOYLARGININE ETHYL ESTER; CYANURIC ACID; CYANURIC CHLORIDE; ESTERASE; MACROGOL; MONOMETHOXYPOLYETHYLENE GLYCOL; SUCCINIC ANHYDRIDE; TOLUENESULFONIC ACID DERIVATIVE; TOLUENESULFONYL CHLORIDE; TRYPSIN;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN DEGRADATION; THERMOSTABILITY;

ARGININE; BENZOYLARGININE NITROANILIDE; DRUG STABILITY; EXCIPIENTS; HALF-LIFE; HEAT; KINETICS; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; SUCCINATES; TEMPERATURE; TRYPSIN;

EID: 42949093817     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2008.01.016     Document Type: Article

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