Combined x-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335

Journal of Biological Chemistry

Volumn 286, Issue 13, 2011, Pages 11434-11443

  Lemke, Christopher T ^a   Goudreau, Nathalie ^a   Zhao, Songping ^a   Hucke, Oliver ^a   Thibeault, Diane ^a   Llinàs Brunet, Montse ^a   White, Peter W ^a  

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ANTIVIRAL AGENTS; BINDING CHARACTERISTICS; BINDING MECHANISMS; CATALYTIC TRIAD; DISSOCIATION RATES; DISTINCTIVE FEATURES; HALOGEN BONDS; HEPATITIS C VIRUS; INFECTED PATIENTS; KINETIC ANALYSIS; LIVER DISEASE; PROLINE RESIDUES; PROTEASE INHIBITOR; SIDE CHAIN REARRANGEMENTS; SINGLE-STEP; STOPPED-FLOW KINETICS; WATER MOLECULE;

AMINO ACIDS; BROMINE; CARBOXYLIC ACIDS; DISEASE CONTROL; DISSOCIATION; ENZYME INHIBITION; HYDROLASES; OXYGEN; VIRUSES;

X RAY CRYSTALLOGRAPHY;

ANTIVIRUS AGENT; BI 201335; BROMINE; HYDROGEN; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 4A; OXYGEN; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; WATER;

ARTICLE; CHEMICAL BOND; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG DETERMINATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; FLOW KINETICS; HALOGEN BOND; HEPATITIS C VIRUS; HYDROGEN BOND; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; VIRUS INHIBITION; X RAY CRYSTALLOGRAPHY;

CARRIER PROTEINS; CATALYTIC DOMAIN; CLINICAL TRIALS, PHASE I AS TOPIC; CRYSTALLOGRAPHY, X-RAY; HEPACIVIRUS; HEPATITIS C; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGOPEPTIDES; PROTEASE INHIBITORS; PROTEIN BINDING; THIAZOLES; VIRAL NONSTRUCTURAL PROTEINS;

HEPATITIS C VIRUS;

EID: 79953184315     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.211417     Document Type: Article

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