Reaction of human hemoglobin with peroxynitrite. Isomerization to nitrate and secondary formation of protein radicals

Journal of Biological Chemistry

Volumn 278, Issue 45, 2003, Pages 44049-44057

  Romero, Natalia ^a   Radi, Rafael ^a   Linares, Edlaine ^b   Augusto, Ohara ^b   Detweiler, Charles D ^c   Mason, Ronald P ^c   Denicola, Ana ^a,d,e  

^a DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^e FACULTAD DE CIENCIAS   (Uruguay)

Author keywords

[No Author keywords available]

Indexed keywords

DIFFUSION; DIMERIZATION; FREE RADICALS; HEMOGLOBIN; ISOMERIZATION; OXIDATION; REACTION KINETICS; STOICHIOMETRY;

OXYHEMOGLOBIN;

BIOCHEMISTRY;

2 METHYL 2 NITROSOPROPANE; 5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; CHEMICAL AGENT; CYSTEINE; FERRYLHEMOGLOBIN; GLOBIN; HEME; HEMOGLOBIN; HEMOGLOBIN DERIVATIVE; HYDROGEN PEROXIDE; IRON; METHEMOGLOBIN; NITRATE; NITRITE; NITROGEN DIOXIDE; OXIDIZING AGENT; OXYHEMOGLOBIN; PEROXYNITRITE; SUPEROXIDE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; COVALENT BOND; DIMERIZATION; ELECTRON; ERYTHROCYTE; HUMAN; HUMAN CELL; IN VIVO STUDY; ISOMERISM; KINETICS; OXIDATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; REACTION ANALYSIS; SPIN TRAPPING; STOICHIOMETRY;

BLOTTING, WESTERN; CYCLIC N-OXIDES; DIMERIZATION; ELECTRON SPIN RESONANCE SPECTROSCOPY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLOBINS; HUMANS; HYDROGEN PEROXIDE; IMMUNOHISTOCHEMISTRY; IRON; ISOMERISM; METHEMOGLOBIN; NITRATES; NITRITES; OXYGEN; OXYHEMOGLOBINS; PEROXYNITROUS ACID; SPECTROPHOTOMETRY; SPIN LABELS; SUPEROXIDES; TYROSINE;

EID: 0242666822     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M305895200     Document Type: Article

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