Citrus flavonoids luteolin, apigenin, and quercetin inhibit glycogen synthase kinase-3β enzymatic activity by lowering the interaction energy within the binding cavity

Journal of Medicinal Food

Volumn 14, Issue 4, 2011, Pages 325-333

  Johnson, Jodee L ^a   Rupasinghe, Sanjeewa G ^b   Stefani, Felicia ^a   Schuler, Mary A ^b   Gonzalez De Mejia, Elvira ^a,c  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^c Department of Animal Sciences   (United States)

Author keywords

citrus compounds; flavonoids; Glycogen synthase kinase 3 ; GSK 3 ; luminescence assay; molecular docking

Indexed keywords

2 (3 CHLORO 4 HYDROXYANILINO) 3 (2 NITROPHENYL)MALEIMIDE; APIGENIN; AURANTIIN; FLAVONE; GLYCOGEN SYNTHASE KINASE 3BETA; HESPERETIN; HESPERIDIN; KAEMPFEROL; LUTEOLIN; NARINGENIN; NARIRUTIN; NEOHESPERIDIN; NOBILETIN; QUERCETIN; RUTOSIDE; TANGERETIN;

ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG EFFECT; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; MOLECULAR DOCKING; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; APIGENIN; BINDING SITES; CITRUS; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LUTEOLIN; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PANCREATIC NEOPLASMS; PROTEIN STRUCTURE, TERTIARY; QUERCETIN; SEQUENCE ALIGNMENT;

CITRUS;

EID: 79953173629     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2010.0310     Document Type: Article

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