P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells

British Journal of Pharmacology

Volumn 151, Issue 1, 2007, Pages 96-108

  Wilson, H L ^a   Varcoe, R W ^b   Stokes, L ^b   Holland, K L ^a   Francis, S E ^a   Dower, S K ^a   Surprenant, A ^b   Crossman, D C ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Cytokines; Endothelial cells; IL 1; IL 1Ra; Inflammation; P2X receptors

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 8; LIGAND; LUCIFERASE; PURINE P2X4 RECEPTOR; PURINE P2X7 RECEPTOR; INTERLEUKIN 1BETA; MESSENGER RNA; PURINE P2 RECEPTOR;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INFLAMMATION; MOLECULAR BIOLOGY; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UMBILICAL VEIN; WHOLE CELL; CELL MEMBRANE POTENTIAL; CHEMISTRY; GENETICS; METABOLISM; PHYSIOLOGY; SECRETION;

ENDOTHELIAL CELLS; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1BETA; MEMBRANE POTENTIALS; RECEPTORS, PURINERGIC P2; RNA, MESSENGER;

EID: 34247630017     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707213     Document Type: Article

References (56)

1. Arend WP (2002). The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Factor Rev 13: 323-340.
2. Bevilacqua MP, Pober JS, Majeau GR, Cotran RS, Gimbrone Jr MA (1984). Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells. J Exp Med 160: 618-623.
3. Bowler JW, Bailey RJ, North RA, Surprenant A (2003). P2X4, P2Y1 and P2Y2 receptors on rat alveolar macrophages. Br J Pharmacol 140: 567-575.
4. Buell G, Chessell IP, Michel AD, Collo G, Salazzo M, Herren S et al. (1998). Blockade of human P2X7 receptor function with a monoclonal antibody. Blood 92: 3521-3528.
5. Cabrini G, Falzoni S, Forchap SL, Pellegatti P, Balboni A, Agostini P et al. (2005). A His-155 to Tyr polymorphism confers gain-of-function to the human P2X7 receptor of human leukemic lymphocytes. J Immunol 175: 82-89.
6. Chamberlain J, Evans D, King A, Dewberry R, Dower S, Crossman D et al. (2006). Interleukin-1beta and signaling of interleukin-1 in vascular wall and circulating cells modulates the extent of neointima formation in mice. Am J Pathol 168: 1396-1403.
7. Chamberlain J, Gunn J, Francis S, Holt C, Crossman D (1999). Temporal and spatial distribution of interleukin-1 beta in balloon injured porcine coronary arteries. Cardiovasc Res 44: 156-165.
8. Dewberry R, Holden H, Crossman D, Francis S (2000). Interleukin-1 receptor antagonist expression in human endothelial cells and atherosclerosis. Arterioscler Thromb Vasc Biol 20: 2394-2400.
9. Di Virgilio F, Chiozzi P, Falzoni S, Ferrari D, Sanz JM, Venketaraman V et al. (1998). Cytolytic P2X purinoceptors. Cell Death Differ 5: 191-199.
10. Dinarello CA (1996). Biologic basis for interleukin-1 in disease. Blood 87: 2095-2147.
11. Dower SK, Call SM, Gillis S, Urdal DL (1986). Similarity between the interleukin 1 receptors on a murine T-lymphoma cell line and on a murine fibroblast cell line. Proc Natl Acad Sci USA 83: 1060-1064.
12. Ennion SJ, Evans RJ (2001). Agonist-stimulated internalisation of the ligand-gated ion channel P2X(1) in rat vas deferens. FEBS Lett 489: 154-158.
13. Evans I, Dower SK, Francis SE, Crossman DC, Wilson HL (2006). Action of intracellular IL-1Ra (Type 1) is independent of the IL-1 intracellular signalling pathway. Cytokine 33: 274-280.
14. Ferrari D, Chiozzi P, Falzoni S, Dal Susino M, Melchiorri L, Baricordi OR et al. (1997a). Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages. J Immunol 159: 1451-1458.
15. Ferrari D, Chiozzi P, Falzoni S, Hanau S, Di Virgilio F (1997b). Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin. J Exp Med 185: 579-582.
16. Ferrari D, Pizzirani C, Adinolfi E, Lemoli RM, Curti A, Idzko M et al. (2006). The P2X7 Receptor: a key player in IL-1 processing and release. J Immunol 176: 3877-3883.
17. Galea J, Armstrong J, Gadsdon P, Holden H, Francis SE, Holt CM (1996). Interleukin-1 beta in coronary arteries of patients with ischemic heart disease. Arterioscler Thromb Vasc Biol 16: 1000-1006.
18. Griffiths RJ, Stam EJ, Downs JT, Otterness IG (1995). ATP induces the release of IL-1 from LPS-primed cells in vivo. J Immunol 154: 2821-2828.
19. Gu BJ, Sluyter R, Skarratt KK, Shemon AN, Dao-Ung LP, Fuller SJ et al. (2004). An Arg307 to Gln polymorphism within the ATP-binding site causes loss of function of the human P2X7 receptor. J Biol Chem 279: 31287-31295.
20. Hazuda DJ, Lee JC, Young PR (1988). The kinetics of interleukin 1 secretion from activated monocytes. Differences between interleukin 1 alpha and interleukin 1 beta. J Biol Chem 263: 8473-8479.
21. Hogquist KA, Nett MA, Unanue ER, Chaplin DD (1991). Interleukin 1 is processed and released during apoptosis. Proc Natl Acad Sci USA 88: 8485-8489.
22. Imai M, Goepfert C, Kaczmarek E, Robson SC (2000). CD39 modulates IL-1 release from activated endothelial cells. Biochem Biophys Res Commun 270: 272-278.
23. Jaffe EA, Nachman RL, Becker CG, Minick CR (1973). Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J Clin Invest 52: 2745-2756.
24. Khakh BS, Proctor WR, Dunwiddie TV, Labarca C, Lester HA (1999). Allosteric control of gating and kinetics at P2X(4) receptor channels. J Neurosci 19: 7289-7299.
25. Kiss-Toth E, Guesdon FM, Wyllie DH, Qwarnstrom EE, Dower SK (2000). A novel mammalian expression screen exploiting green fluorescent protein-based transcription detection in single cells. J Immunol Methods 239: 125-135.
26. Labasi JM, Petrushova N, Donovan C, Mccurdy S, Lira P, Payette MM et al. (2002). Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response. J Immunol 168: 6436-6445.
27. Lammas DA, Stober C, Harvey CJ, Kendrick N, Panchalingam S, Kumararatne DS (1997). ATP-induced killing of mycobacteria by human macrophages is mediated by purinergic P2Z(P2X7) receptors. Immunity 7: 433-444.
28. Le Feuvre R, Brough D, Rothwell N (2002). Extracellular ATP and P2X7 receptors in neurodegeneration. Eur J Pharmacol 447: 261-269.
29. Li CM, Campbell SJ, Kumararatne DS, Bellamy R, Ruwende C, Mcadam KP et al. (2002). Association of a polymorphism in the P2X7 gene with tuberculosis in a Gambian population. J Infect Dis 186: 1458-1462.
30. Mackenzie A, Wilson HL, Kiss-Toth E, Dower SK, North RA, Surprenant A (2001). Rapid secretion of interleukin-1beta by microvesicle shedding. Immunity 15: 825-835.
31. Marceau F, Grassi J, Frobert Y, Bergeron C, Poubelle PE (1992). Effects of experimental conditions on the production of interleukin-1 alpha and -1 beta by human endothelial cells cultured in vitro. Int J Immunopharmacol 14: 525-534.
32. Mason JC, Yarwood H, Sugars K, Morgan BP, Davies KA, Haskard DO (1999). Induction of decay-accelerating factor by cytokines or the membrane-attack complex protects vascular endothelial cells against complement deposition. Blood 94: 1673-1682.
33. Mehta VB, Hart J, Wewers MD (2001). ATP-stimulated release of interleukin (IL)-1beta and IL-18 requires priming by lipopolysaccharide and is independent of caspase-1 cleavage. J Biol Chem 276: 3820-3826.
34. Morton AC, Arnold ND, Gunn J, Varcoe R, Francis SE, Dower SK et al. (2005). Interleukin-1 receptor antagonist alters the response to vessel wall injury in a porcine coronary artery model. Cardiovasc Res 68: 493-501.
35. North RA, Surprenant A (2000). Pharmacology of cloned P2X receptors. Annu Rev Pharmacol Toxicol 40: 563-580.
36. North RA (2002). Molecular physiology of P2X receptors. Physiol Rev 82: 1013-1067.
37. Perregaux D, Gabel CA (1994). Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. J Biol Chem 269: 15195-15203.
38. Perregaux DG, Bhavsar K, Contillo L, Shi J, Gabel CA (2002). Antimicrobial peptides initiate IL-1 beta posttranslational processing: a novel role beyond innate immunity. J Immunol 168: 3024-3032.
39. Perregaux DG, McNiff P, Laliberte R, Conklyn M, Gabel CA (2000). ATP acts as an agonist to promote stimulus-induced secretion of IL-1 beta and IL-18 in human blood. J Immunol 165: 4615-4623.
40. Rasmussen R (2001). Quantification on the LightCycler. In: Rapid Cycle Real-Time PCR, Methods and Applications. Springer Press: Heidelberg, pp. 21-34.
41. Sanz JM, Di Virgilio F (2000). Kinetics and mechanism of ATP-dependent IL-1 beta release from microglial cells. J Immunol 164: 4893-4898.
42. Saunders BM, Fernando SL, Sluyter R, Britton WJ, Wiley JS (2003). A loss-of-function polymorphism in the human P2X7 rece ptor abolishes ATP-mediated killing of mycobacteria. J Immunol 171: 5442-5446.
43. Schonbeck U, Mach F, Bonnefoy JY, Loppnow H, Flad HD, Libby P (1997). Ligation of CD40 activates interleukin 1beta-converting enzyme (caspase-1) activity in vascular smooth muscle and endothelial cells and promotes elaboration of active interleukin 1beta. J Biol Chem 272: 19569-19574.
44. Schumann RR, Belka C, Reuter D, Lamping N, Kirschning CJ, Weber JR et al. (1998). Lipopolysaccharide activates caspase-1 (interleukin-1-converting enzyme) in cultured monocytic and endothelial cells. Blood 91: 577-584.
45. Shemon AN, Sluyter R, Fernando SL, Clarke AL, Dao-Ung LP, Skarratt KK et al. (2006). A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages. J Biol Chem 281: 2079-2086.
46. Skarratt KK, Fuller SJ, Sluyter R, Dao-Ung LP, Gu BJ, Wiley JS (2005). A 5′ intronic splice site polymorphism leads to a null allele of the P2X7 gene in 1-2% of the Caucasian population. FEBS Lett 579: 2675-2678.
47. Sluyter R, Dalitz JG, Wiley JS (2004a). P2X7 receptor polymorphism impairs extracellular adenosine 5′-triphosphate-induced interleukin-18 release from human monocytes. Genes Immun 5: 588-591.
48. Sluyter R, Shemon AN, Wiley JS (2004b). Glu496 to Ala polymorphism in the P2X7 receptor impairs ATP-induced IL-1 beta release from human monocytes. J Immunol 172: 3399-3405.
49. Solle M, Labasi J, Perregaux DG, Stam E, Petrushova N, Koller BH et al. (2001). Altered cytokine production in mice lacking P2X(7) receptors. J Biol Chem 276: 125-132.
50. Stokes L, Jiang LH, Alcaraz L, Bent J, Bowers K, Fagura M et al. (2006). Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373. Br J Pharmacol 149: 880-887.
51. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A et al. (2002). Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3 RESEARCH0034.
52. Virginio C, Mackenzie A, North RA, Surprenant A (1999). Kinetics of cell lysis, dye uptake and permeability changes in cells expressing the rat P2X7 receptor. J Physiol 519 (Part 2): 335-346.
53. Warner SJ, Auger KR, Libby P (1987). Interleukin 1 induces interleukin 1. II. Recombinant human interleukin 1 induces interleukin 1 production by adult human vascular endothelial cells. J Immunol 139: 1911-1917.
54. Wiley JS, Dao-Ung LP, Li C, Shemon AN, Gu BJ, Smart ML et al. (2003). An Ile-568 to Asn polymorphism prevents normal trafficking and function of the human P2X7 receptor. J Biol Chem 278: 17108-17113.
55. Wilson HL, Francis SE, Dower SK, Crossman DC (2004). Secretion of intracellular IL-1 receptor antagonist (type 1) is dependent on P2X7 receptor activation. J Immunol 173: 1202-1208.
56. Zocchi MR, Rubartelli A (2001). Nonclassical mechanisms of secretion in the physiopathology of the immune system. In: Baltimore D, Dulbecco R, Jacob F, Levi-Montalcini R (eds). Frontiers of Life. Academic Press, MA, USA, pp. 477-488.