The mechanism of fibril formation of a non-inhibitory serpin ovalbumin revealed by the identification of amyloidogenic core regions

Journal of Biological Chemistry

Volumn 286, Issue 7, 2011, Pages 5884-5894

  Tanaka, Naoki ^a   Morimoto, Yumi ^a   Noguchi, Yurika ^a   Tada, Tomoko ^a   Waku, Tomonori ^a   Kunugi, Shigeru ^a   Morii, Takashi ^b   Lee, Yin Fai ^c   Konno, Takashi ^d   Takahashi, Nobuyuki ^b  

^a KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

^d UNIVERSITY OF FUKUI   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID FIBRIL; AMYLOID FIBRIL FORMATION; COMPUTER PREDICTIONS; CORE REGION; DISULFIDE BONDS; FIBRIL FORMATION; FIBRILLAR AGGREGATES; LIMITED PROTEOLYSIS; N-TERMINALS; OVALBUMINS; POLYMERIZATION MECHANISMS; SERPINS; SITE DIRECTED MUTAGENESIS; SOLUBLE PEPTIDES; SYNTHETIC PEPTIDE;

COVALENT BONDS; FORECASTING; GLYCOPROTEINS; MUTAGENESIS; POLYPEPTIDES;

PEPTIDES;

AMYLOID; CYSTEINE; OVALBUMIN; SERINE PROTEINASE INHIBITOR;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; AMYLOIDOSIS; ARTICLE; BETA SHEET; CONTROLLED STUDY; DISULFIDE BOND; HEAT TREATMENT; MOLECULAR MECHANICS; MUTATIONAL ANALYSIS; PREDICTION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; TURBIDITY;

AMYLOID; ANIMALS; CHICKENS; CYSTEINE; DISULFIDES; MUTAGENESIS, SITE-DIRECTED; OVALBUMIN; PEPTIDES; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY;

EID: 79953152845     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.176396     Document Type: Article

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