-
2
-
-
0016342403
-
The nature and metabolism of the carbohydrate-peptide linkages of glycoproteins
-
Marshall, R. D., The nature and metabolism of the carbohydrate-peptide linkages of glycoproteins. Biochem. Soc. Symp., 40, 17-26 (1974).
-
(1974)
Biochem. Soc. Symp.
, vol.40
, pp. 17-26
-
-
Marshall, R.D.1
-
3
-
-
0017114288
-
Studies on the attachment of carbohydrate to ovalbumin nascent chains in hen oviduct
-
Kiely, M. L., McNight, G. S., and Schimke, R. T., Studies on the attachment of carbohydrate to ovalbumin nascent chains in hen oviduct. J. Biol. Chem., 251, 5490-5495 (1976).
-
(1976)
J. Biol. Chem.
, vol.251
, pp. 5490-5495
-
-
Kiely, M.L.1
McNight, G.S.2
Schimke, R.T.3
-
4
-
-
0017753965
-
Synchronised transmembrane insertion and glycosylation of a nascent membrane protein
-
Rothman, J. E., and Lodish, H. F., Synchronised transmembrane insertion and glycosylation of a nascent membrane protein. Nature, 269, 775-780 (1977).
-
(1977)
Nature
, vol.269
, pp. 775-780
-
-
Rothman, J.E.1
Lodish, H.F.2
-
5
-
-
0021199126
-
Structural comparison of protein sequences around potential N-glycosylation sites
-
Mononen, I., and Karjalainen, E., Structural comparison of protein sequences around potential N-glycosylation sites. Biochim. Biophys. Acta, 788, 364-367 (1984).
-
(1984)
Biochim. Biophys. Acta
, vol.788
, pp. 364-367
-
-
Mononen, I.1
Karjalainen, E.2
-
6
-
-
0027295871
-
Association of folding intermediates of glycoproteins with calnexin during protein maturation
-
Ou, W.-J., Cameron, P. H., Thomas, D. Y., and Bergeron, J. J. M., Association of folding intermediates of glycoproteins with calnexin during protein maturation. Nature, 364, 771-776 (1993).
-
(1993)
Nature
, vol.364
, pp. 771-776
-
-
Ou, W.-J.1
Cameron, P.H.2
Thomas, D.Y.3
Bergeron, J.J.M.4
-
7
-
-
0028103695
-
Role of N-linked oligosaccharide recognition, glucose trimming, and calnexin in glycoprotein folding and quality control
-
Hammond, C., Braakman, I., and Helenius, A., Role of N-linked oligosaccharide recognition, glucose trimming, and calnexin in glycoprotein folding and quality control. Proc. Natl. Acad. Sci. U.S.A., 91, 913-917 (1994).
-
(1994)
Proc. Natl. Acad. Sci. U.S.A.
, vol.91
, pp. 913-917
-
-
Hammond, C.1
Braakman, I.2
Helenius, A.3
-
8
-
-
0033197741
-
Calnexin discriminates between protein conformational states and functions as a molecular chaperone in vitro
-
Ihara, Y., Cohen-Doyle, M. F., Saito, Y., and Williams, D. B., Calnexin discriminates between protein conformational states and functions as a molecular chaperone in vitro. Mol. Cell, 4, 331-341 (1999).
-
(1999)
Mol. Cell
, vol.4
, pp. 331-341
-
-
Ihara, Y.1
Cohen-Doyle, M.F.2
Saito, Y.3
Williams, D.B.4
-
9
-
-
0027519943
-
Protein glycosylation: Structural and functional aspects
-
Lis, H., and Sharon, N., Protein glycosylation: Structural and functional aspects. Eur. J. Biochem., 218, 1-27 (1993).
-
(1993)
Eur. J. Biochem.
, vol.218
, pp. 1-27
-
-
Lis, H.1
Sharon, N.2
-
10
-
-
0001212535
-
Improvement of the functional properties of insoluble gluten by pronase digestion followed by dextran conjugation
-
Kato, A., Shimokawa, K., and Kobayashi, K., Improvement of the functional properties of insoluble gluten by pronase digestion followed by dextran conjugation. J. Agric. Food Chem., 39, 1053-1056 (1991).
-
(1991)
J. Agric. Food Chem.
, vol.39
, pp. 1053-1056
-
-
Kato, A.1
Shimokawa, K.2
Kobayashi, K.3
-
11
-
-
0027316833
-
Novel surface functional properties of polymannosyl lysozyme constructed by genetic modification
-
Nakamura, S., Kobayashi, K., and Kato, A., Novel surface functional properties of polymannosyl lysozyme constructed by genetic modification. FEBS Lett., 328, 259-262 (1993).
-
(1993)
FEBS Lett.
, vol.328
, pp. 259-262
-
-
Nakamura, S.1
Kobayashi, K.2
Kato, A.3
-
12
-
-
0018786653
-
The nonglycosylated glycoprotein of vesicular stomatitis virus is temperature-sensitive and undergoes intracellular aggregation at elevated temperatures
-
Gibson, R., Schlesinger, S., and Kornfeld, S., The nonglycosylated glycoprotein of vesicular stomatitis virus is temperature-sensitive and undergoes intracellular aggregation at elevated temperatures. J. Biol. Chem., 254, 3600-3607 (1979).
-
(1979)
J. Biol. Chem.
, vol.254
, pp. 3600-3607
-
-
Gibson, R.1
Schlesinger, S.2
Kornfeld, S.3
-
13
-
-
0026781044
-
Glycosylation inhibits the interaction of invertase with the chaperone GroEL
-
Kern, G., Schmidt, M., Buchner, J., and Jaenicke, R., Glycosylation inhibits the interaction of invertase with the chaperone GroEL. FEBS Lett., 305, 203-205 (1992).
-
(1992)
FEBS Lett.
, vol.305
, pp. 203-205
-
-
Kern, G.1
Schmidt, M.2
Buchner, J.3
Jaenicke, R.4
-
15
-
-
0020956688
-
Enhanced thermal stability of chemically deglycosylated human choriogonadotropin
-
Manjunath, P., and Sairam, M. R., Enhanced thermal stability of chemically deglycosylated human choriogonadotropin. J. Biol. Chem., 258, 3554-3558 (1983).
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 3554-3558
-
-
Manjunath, P.1
Sairam, M.R.2
-
16
-
-
0029904281
-
Influence of the carbohydrate moiety on the stability of glycoproteins
-
Wang, C., Eufemi, M., Turano, C., and Giartosio, A., Influence of the carbohydrate moiety on the stability of glycoproteins. Biochemistry, 35, 7299-7307 (1996).
-
(1996)
Biochemistry
, vol.35
, pp. 7299-7307
-
-
Wang, C.1
Eufemi, M.2
Turano, C.3
Giartosio, A.4
-
17
-
-
0031008063
-
1- antitrypsin toward urea denaturation and thermal deactivation
-
1-antitrypsin toward urea denaturation and thermal deactivation. Biochim. Biophys. Acta, 1335, 265-272 (1997).
-
(1997)
Biochim. Biophys. Acta
, vol.1335
, pp. 265-272
-
-
Kwon, K.-S.1
Yu, M.-H.2
-
18
-
-
0023876427
-
The L2/HNK-1 carbohydrate of neural cell adhesion molecules is involved in cell interactions
-
Kunemund, V., Jungalwala, F. B., Fischer, G., Chou, D. K. H., Keilhauer, G., and Schachner, M., The L2/HNK-1 carbohydrate of neural cell adhesion molecules is involved in cell interactions. J. Cell. Biol., 106, 213-223 (1988).
-
(1988)
J. Cell. Biol.
, vol.106
, pp. 213-223
-
-
Kunemund, V.1
Jungalwala, F.B.2
Fischer, G.3
Chou, D.K.H.4
Keilhauer, G.5
Schachner, M.6
-
19
-
-
0024340857
-
Role of carbohydrates in glycoprotein hormone signal transduction
-
Sairam, M. R., Role of carbohydrates in glycoprotein hormone signal transduction. FASEB J., 3, 1915-1926 (1989).
-
(1989)
FASEB J.
, vol.3
, pp. 1915-1926
-
-
Sairam, M.R.1
-
20
-
-
0025230490
-
Glycosylation at Asn-184 inhibits the conversion of single-chain to two-chain tissue-type plasminogen activator by plasmin
-
Wittwer, A. J., and Howard, S. C., Glycosylation at Asn-184 inhibits the conversion of single-chain to two-chain tissue-type plasminogen activator by plasmin. Biochemistry, 29, 4175-4180 (1990).
-
(1990)
Biochemistry
, vol.29
, pp. 4175-4180
-
-
Wittwer, A.J.1
Howard, S.C.2
-
21
-
-
0025111615
-
Secretory immunoglobulin A carries oligosaccharide receptors for Escherichia coli type 1 fimbrial lectin
-
Wold, A. E., Mestecky, J., Tomana, M., Kobata, A., Ohbayashi, H., Endo, T., and Svanborg-Eden, C., Secretory immunoglobulin A carries oligosaccharide receptors for Escherichia coli type 1 fimbrial lectin. Infect. Immun., 58, 3073-3077 (1990).
-
(1990)
Infect. Immun.
, vol.58
, pp. 3073-3077
-
-
Wold, A.E.1
Mestecky, J.2
Tomana, M.3
Kobata, A.4
Ohbayashi, H.5
Endo, T.6
Svanborg-Eden, C.7
-
22
-
-
0026095033
-
Diversification of the IgG molecule by oligosaccharides
-
Rudd, P. M., Leatherbarrow, R. J., Rademacher, T. W., and Dwek, R. A., Diversification of the IgG molecule by oligosaccharides. Mol. Immunol., 28, 1369-1378 (1991).
-
(1991)
Mol. Immunol.
, vol.28
, pp. 1369-1378
-
-
Rudd, P.M.1
Leatherbarrow, R.J.2
Rademacher, T.W.3
Dwek, R.A.4
-
23
-
-
0026611050
-
Complementarity between sperm surface β-1,4-galactosyltransferase and egg-coat ZP3 mediates sperm-egg binding
-
Miller, D. J., Macek, M. B., and Shur, B. D., Complementarity between sperm surface β-1,4-galactosyltransferase and egg-coat ZP3 mediates sperm-egg binding. Nature, 357, 589-593 (1992).
-
(1992)
Nature
, vol.357
, pp. 589-593
-
-
Miller, D.J.1
Macek, M.B.2
Shur, B.D.3
-
24
-
-
0024423930
-
1- antitrypsin for structure and function of serpins
-
1-antitrypsin for structure and function of serpins. Biochemistry, 28, 8951-8966 (1989).
-
(1989)
Biochemistry
, vol.28
, pp. 8951-8966
-
-
Huber, R.1
Carrell, R.W.2
-
25
-
-
0025949027
-
Crystal structure of uncleaved ovalbumin at 1.95 Å resolution
-
Stein, P. E., Leslie, A. G., Finch, J. T., and Carrell, R. W., Crystal structure of uncleaved ovalbumin at 1.95 Å resolution. J. Mol. Biol., 221, 941-959 (1991).
-
(1991)
J. Mol. Biol.
, vol.221
, pp. 941-959
-
-
Stein, P.E.1
Leslie, A.G.2
Finch, J.T.3
Carrell, R.W.4
-
26
-
-
0021711639
-
Ovalbumin is an elastase substrate
-
Wright, H. T., Ovalbumin is an elastase substrate. J. Biol. Chem., 259, 14335-14336 (1984).
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 14335-14336
-
-
Wright, H.T.1
-
27
-
-
0016776678
-
Structural studies of two ovalbumin glycopeptides in relation to endo-β-N-acetylglucosaminidase specificity
-
Tai, T., Yamashita, K., Ogata-Arakawa, M., Koide, N., Muramatsu, T., Iwashita, S., Inoue, Y., and Kobata, A., Structural studies of two ovalbumin glycopeptides in relation to endo-β-N-acetylglucosaminidase specificity. J. Biol. Chem., 250, 8569-8575 (1975).
-
(1975)
J. Biol. Chem.
, vol.250
, pp. 8569-8575
-
-
Tai, T.1
Yamashita, K.2
Ogata-Arakawa, M.3
Koide, N.4
Muramatsu, T.5
Iwashita, S.6
Inoue, Y.7
Kobata, A.8
-
28
-
-
0017899973
-
The structures of the galactose-containing sugar chains of ovalbumin
-
Yamashita, K., Tachibana, Y., and Kobata, A., The structures of the galactose-containing sugar chains of ovalbumin. J. Biol. Chem., 253, 3862-3869 (1978).
-
(1978)
J. Biol. Chem.
, vol.253
, pp. 3862-3869
-
-
Yamashita, K.1
Tachibana, Y.2
Kobata, A.3
-
29
-
-
0025615004
-
Analysis of the oligosaccharides in ovalbumin by high-performance capillary electrophoresis
-
Honda, S., Makino, A., Suzuki, S., and Kakehi, K., Analysis of the oligosaccharides in ovalbumin by high-performance capillary electrophoresis. Anal. Biochem., 191, 228-234 (1990).
-
(1990)
Anal. Biochem.
, vol.191
, pp. 228-234
-
-
Honda, S.1
Makino, A.2
Suzuki, S.3
Kakehi, K.4
-
30
-
-
0019555768
-
The complete amino acid sequence of hen ovalbumin
-
Nisbet, A. D., Saundry, R. H., Moir, A. J. G., Fothergill, L. A., and Fothergill, J. E., The complete amino acid sequence of hen ovalbumin. Eur. J. Biochem., 115, 335-345 (1981).
-
(1981)
Eur. J. Biochem.
, vol.115
, pp. 335-345
-
-
Nisbet, A.D.1
Saundry, R.H.2
Moir, A.J.G.3
Fothergill, L.A.4
Fothergill, J.E.5
-
31
-
-
33751154874
-
Molten globule state of protein molecules in heat-induced transparent food gels
-
Tani, F., Murata, M., Higasa, T., Goto, M., Kitabatake, N., and Doi, E., Molten globule state of protein molecules in heat-induced transparent food gels. J. Agric. Food Chem., 43, 2325-2331 (1993).
-
(1993)
J. Agric. Food Chem.
, vol.43
, pp. 2325-2331
-
-
Tani, F.1
Murata, M.2
Higasa, T.3
Goto, M.4
Kitabatake, N.5
Doi, E.6
-
32
-
-
0030947918
-
Linear polymerization caused by the defective folding of a non-inhibitory serpin ovalbumin
-
Shirai, N., Tani, F., Higasa, T., and Yasumoto, K., Linear polymerization caused by the defective folding of a non-inhibitory serpin ovalbumin. J. Biochem., 121, 787-797 (1997).
-
(1997)
J. Biochem.
, vol.121
, pp. 787-797
-
-
Shirai, N.1
Tani, F.2
Higasa, T.3
Yasumoto, K.4
-
33
-
-
0030743517
-
Temperature control for kinetic refolding of heat-denatured ovalbumin
-
Tani, F., Shirai, N., Onishi, T., Venelle, F., Yasumoto, K., and Doi, E., Temperature control for kinetic refolding of heat-denatured ovalbumin. Protein Sci., 6, 1491-1502 (1997).
-
(1997)
Protein Sci.
, vol.6
, pp. 1491-1502
-
-
Tani, F.1
Shirai, N.2
Onishi, T.3
Venelle, F.4
Yasumoto, K.5
Doi, E.6
-
34
-
-
0042852414
-
Studies on proteins. I. On the preparation of egg-albumin solutions of well-defined composition, and on the analytical methods used
-
Sörensen, S. P. L., and Höyrup, M., Studies on proteins. I. On the preparation of egg-albumin solutions of well-defined composition, and on the analytical methods used. Compt. Rend. Trav. Lab. Carlsberg., 12, 12-67 (1915).
-
(1915)
Compt. Rend. Trav. Lab. Carlsberg.
, vol.12
, pp. 12-67
-
-
Sörensen, S.P.L.1
Höyrup, M.2
-
35
-
-
0025812217
-
In vivo analysis of integration of membrane proteins in Escherichia coli
-
Ito, K., and Akiyama, Y., In vivo analysis of integration of membrane proteins in Escherichia coli. Mol. Microbiol., 5, 2243-2253 (1991).
-
(1991)
Mol. Microbiol.
, vol.5
, pp. 2243-2253
-
-
Ito, K.1
Akiyama, Y.2
-
36
-
-
0020959710
-
Studies on transformation of Escherichia coli with plasmids
-
Hanahan, D., Studies on transformation of Escherichia coli with plasmids. J. Mol. Biol., 166, 557-580 (1983).
-
(1983)
J. Mol. Biol.
, vol.166
, pp. 557-580
-
-
Hanahan, D.1
-
37
-
-
0026736742
-
Reversible denaturation of disulfide-reduced ovalbumin and its reoxidation generating the native cystine cross-link
-
Takahashi, N., and Hirose, M., Reversible denaturation of disulfide-reduced ovalbumin and its reoxidation generating the native cystine cross-link. J. Biol. Chem., 267, 11565-11572 (1992).
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 11565-11572
-
-
Takahashi, N.1
Hirose, M.2
-
38
-
-
0014949207
-
Cleavage of structural proteins during the assembly of the head of bacteriophage T4
-
Laemmli, U. K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685 (1970).
-
(1970)
Nature
, vol.227
, pp. 680-685
-
-
Laemmli, U.K.1
-
39
-
-
85004367709
-
Physicochemical and functional properties of hen ovalbumin dephosphorylated by acid phosphatase
-
Kitabatake, N., Ishida, A., and Doi, E., Physicochemical and functional properties of hen ovalbumin dephosphorylated by acid phosphatase. Agric. Biol. Chem., 52, 967-973 (1988).
-
(1988)
Agric. Biol. Chem.
, vol.52
, pp. 967-973
-
-
Kitabatake, N.1
Ishida, A.2
Doi, E.3
-
40
-
-
0027968024
-
Denatured state of ovalbumin in high concentrations of urea as evaluated by disulfide rearrangement analysis
-
Tatsumi, E., Takahashi, N., and Hirose, M., Denatured state of ovalbumin in high concentrations of urea as evaluated by disulfide rearrangement analysis. J. Biol. Chem., 269, 28062-28067 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 28062-28067
-
-
Tatsumi, E.1
Takahashi, N.2
Hirose, M.3
-
41
-
-
0037154980
-
Protein folding and unfolding at atomic resolution
-
Fersht, A. R., and Daggett, V., Protein folding and unfolding at atomic resolution. Cell, 108, 573-582 (2002).
-
(2002)
Cell
, vol.108
, pp. 573-582
-
-
Fersht, A.R.1
Daggett, V.2
-
42
-
-
0037221599
-
Is there a unifying mechanism for protein folding?
-
Daggett, V., and Fersht, A. R., Is there a unifying mechanism for protein folding? Trends Biochem. Sci., 28, 18-25 (2003).
-
(2003)
Trends Biochem. Sci.
, vol.28
, pp. 18-25
-
-
Daggett, V.1
Fersht, A.R.2
-
43
-
-
0037181484
-
The chicken-egg scenario of protein folding revisited
-
Uversky, V. N., and Fink, A. L., The chicken-egg scenario of protein folding revisited. FEBS Lett., 515, 79-83 (2002).
-
(2002)
FEBS Lett.
, vol.515
, pp. 79-83
-
-
Uversky, V.N.1
Fink, A.L.2
-
44
-
-
0021114569
-
'Molten-globule state': A compact form of globular proteins with mobile side chains
-
Ohgushi, M., and Wada, A., 'Molten-globule state': a compact form of globular proteins with mobile side chains. FEBS Lett., 164, 21-24 (1983).
-
(1983)
FEBS Lett.
, vol.164
, pp. 21-24
-
-
Ohgushi, M.1
Wada, A.2
-
45
-
-
0023626273
-
Protein folding: Hypotheses and experiments
-
Ptitsyn, O. B., Protein folding: hypotheses and experiments. J. Protein Chem., 6, 273-293 (1987).
-
(1987)
J. Protein Chem.
, vol.6
, pp. 273-293
-
-
Ptitsyn, O.B.1
-
46
-
-
0024417964
-
The molten globule state as a clue for understanding the folding and cooperativity of globular protein structure
-
Kuwajima, K., The molten globule state as a clue for understanding the folding and cooperativity of globular protein structure. Proteins: Struct. Funct. Genet., 6, 87-103 (1989).
-
(1989)
Proteins: Struct. Funct. Genet.
, vol.6
, pp. 87-103
-
-
Kuwajima, K.1
-
47
-
-
0027313673
-
Pathways of protein folding
-
Matthews, C. R., Pathways of protein folding. Annu. Rev. Biochem., 62, 653-683 (1993).
-
(1993)
Annu. Rev. Biochem.
, vol.62
, pp. 653-683
-
-
Matthews, C.R.1
-
48
-
-
0028947257
-
Funnels, pathways and the energy landscape of protein folding: A synthesis
-
Bryngelson, J. D., Onuchic, J. N., Socci, N. D., and Wolynes, P. G., Funnels, pathways and the energy landscape of protein folding: A synthesis. Proteins: Struct. Funct. Genet., 21, 167-195 (1995).
-
(1995)
Proteins: Struct. Funct. Genet.
, vol.21
, pp. 167-195
-
-
Bryngelson, J.D.1
Onuchic, J.N.2
Socci, N.D.3
Wolynes, P.G.4
-
49
-
-
0028929556
-
Principles of protein folding - A perspective from simple exact models
-
Dill, K. A., Bromberg, S., Yue, K., Fiebig, K. M., Yee, D. P., Thomas, P. D., and Chan, H. S., Principles of protein folding - A perspective from simple exact models. Protein Sci., 4, 561-602 (1995).
-
(1995)
Protein Sci.
, vol.4
, pp. 561-602
-
-
Dill, K.A.1
Bromberg, S.2
Yue, K.3
Fiebig, K.M.4
Yee, D.P.5
Thomas, P.D.6
Chan, H.S.7
-
50
-
-
0028924552
-
Navigating the folding routes
-
Wolynes, P. G., Onuchic, J. N., and Thirumalai, D., Navigating the folding routes. Science, 267, 1619-1620 (1995).
-
(1995)
Science
, vol.267
, pp. 1619-1620
-
-
Wolynes, P.G.1
Onuchic, J.N.2
Thirumalai, D.3
-
51
-
-
0003166498
-
Protein folding in the landscape perspective: Chevron plots and non-Arrhenius kinetics
-
Chan, H. S., and Dill, K. A., Protein folding in the landscape perspective: chevron plots and non-Arrhenius kinetics. Proteins: Struct. Funct. Genet., 30, 2-33 (1998).
-
(1998)
Proteins: Struct. Funct. Genet.
, vol.30
, pp. 2-33
-
-
Chan, H.S.1
Dill, K.A.2
-
52
-
-
0029249945
-
The nature of protein folding pathways: The classical versus the new view
-
Baldwin, R. L., The nature of protein folding pathways: The classical versus the new view. J. Biomol. NMR, 5, 103-109 (1995).
-
(1995)
J. Biomol. NMR
, vol.5
, pp. 103-109
-
-
Baldwin, R.L.1
-
53
-
-
0029653893
-
Insights into protein folding using physical techniques: Studies of lysozyme and α-lactalbumin
-
Radford, S. E., and Dobson, C. M., Insights into protein folding using physical techniques: studies of lysozyme and α-lactalbumin. Phil. Trans. R. Soc. Lond. B, 348, 17-25 (1995).
-
(1995)
Phil. Trans. R. Soc. Lond. B
, vol.348
, pp. 17-25
-
-
Radford, S.E.1
Dobson, C.M.2
-
54
-
-
0029783697
-
A chaperone-like function of intramolecular high-mannose chains in the oxidative refolding of bovine pancreatic RNase B
-
Yamaguchi, H., and Uchida, M., A chaperone-like function of intramolecular high-mannose chains in the oxidative refolding of bovine pancreatic RNase B. J. Biochem., 120, 474-477 (1996).
-
(1996)
J. Biochem.
, vol.120
, pp. 474-477
-
-
Yamaguchi, H.1
Uchida, M.2
-
55
-
-
0027050823
-
Stability, quaternary structure, and folding of internal, external, and core-glycosylated invertase from yeast
-
Kern, G., Schülke, N., Schmid, F. X., and Jaenicke, R., Stability, quaternary structure, and folding of internal, external, and core-glycosylated invertase from yeast. Protein Sci., 1, 120-131 (1992).
-
(1992)
Protein Sci.
, vol.1
, pp. 120-131
-
-
Kern, G.1
Schülke, N.2
Schmid, F.X.3
Jaenicke, R.4
|