Role of the single disulphide bond of β2-microglobulin in amyloidosis in vitro

Protein Science

Volumn 10, Issue 9, 2001, Pages 1775-1784

  Smith, D P ^a   Radford, S E ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

2 Microgobulin; Amyloidosis; Disulphide bond; Protein fibril

Indexed keywords

AMYLOID; BETA 2 MICROGLOBULIN; CYSTEINE; DISULFIDE; IMMUNOGLOBULIN; PROTEIN; SODIUM CHLORIDE;

AMYLOIDOSIS; ARTICLE; CIRCULAR DICHROISM; DISULFIDE BOND; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IONIC STRENGTH; NONHUMAN; OLIGOMERIZATION; PH; PRIORITY JOURNAL; PROTEIN FOLDING;

AMYLOID; AMYLOIDOSIS; BETA 2-MICROGLOBULIN; CIRCULAR DICHROISM; DISULFIDES; HUMANS; HYDROGEN-ION CONCENTRATION; MICROSCOPY, ELECTRON; MODELS, MOLECULAR; OSMOLAR CONCENTRATION; OXIDATION-REDUCTION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET; THIAZOLES;

EID: 0034846252     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.4901     Document Type: Article

References (52)

1. Enzymatic reduction of disulphide bonds in lysosomes: Characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT)
2. Dialysis arthropathy of the hip
3. Beta-2-microglobulin can be refolded into a native state from ex vivo amyloid fibrils
4. 2-globulin occurring in human biological fluids
5. Structure of the human class I histocompatibity antigen, HLA-A2
6. Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis
7. Formation of insulin amyloid fibrils followed by FTIR simultaneosly with CD and electron microscopy
8. Molecule-mimetic chemistry and mesoscale self-assembly
9. Deposition of kappa-light-chains and lambda-light-chains in amyloid filaments of dialysis-related amyloidosis
10. Polymerization of normal and intact beta 2-microglobulin as the amyloidogenic protein in dialysis-amyloidosis
11. Designing conditions for in vitro formation of amyloid protofilaments and fibrils
12. Homodimeric and expanded behavior of trimethylamine dehydrogenase in solution at different temperatures
13. In vitro formation of amyloid fibrils from intact beta 2-microglobulin
14. Removal of the N-terminal hexapeptide from human beta-2- microglobulin facilitates protein aggregation and fibril formation
15. Beta 2-microglobulin associated amyloidosis
16. Contribution of the intramolecular disulfide bridge to the folding stability of REI(v), the variable domain of a human immunoglobulin kappa light chain
17. Serum levels of beta-2-microglobulin as a new form of amyloid protein in patients undergoing long-term hemodialysis
18. 131I-beta-2-microglobulin scintigraphy in patients with dialysis amyloidosis
19. Amyloid deposits and amyloidosis. The beta-fibrilloses
20. Polymorphic fibrillar assembly of human amylin
21. Swiss-Model and the Swiss-Pdb P(lb Viewer: An enviroment for comparative protien modeling
22. Amyloid fibril formation by an SH3 domain
23. Specificity of abnormal assembly in immunoglobulin light chain deposition disease and amyloidosis
24. Beta-2-microglobulin modified with advanced glycation end products delays monocyte apoptosis
25. Pathogenesis of beta-2-microglobulin amyloidosis: Role of monocytes/macrophages
26. Ultra-structural organization of hemodialysis-associated beta-2-microglobulin amyloid fibrils
27. The structure and function of immunoglobulin domains: Studies with beta-2-microglobulin on the role of the intrachain disulfide bond
28. Cryo-electron microscopy structure of an SH3 amyloid fibril and model of the molecular packing
29. Reduction of disulphide bonds in an amyloidogenic Bence Jones protein leads to formation of amyloid-like fibrils in-vitro
30. Quantifying amyloid beta-peptide (Ab) aggregation using the Congo red Ab (CR-Ab) spectrophotometric assay
31. Partial unfolding and refolding of scrapie-associated prion protein: Evidence for a critical 16-kDa C-terminal domain
32. The acid-mediated denaturation pathway of transthyrelin yields a conformational intermediate that can selfassemble into amyloid
33. Evolution of amyloid: What normal protein folding may tell us about fibrillogenesis and disease
34. Partially unfolded states of beta-2-microglobulin and amyloid formation in vitro
35. Kidney dialysis-associated amyloidosis: A molecular role for copper in fiber formation
36. Fluorometric-determination of amyloid fibrils in vitro using the fluorescent dye, Thioflavin-T
37. Establishment of a kinetic model of dialysis-related amyloid fibril extension in vitro
38. Electron-microscopic and immunohistochemical study of beta-2-microglobulin-related amyloidosis
39. Cervical disks are most susceptible to beta-2-microglobulin amyloid deposition in the vertebral column
40. 1H-NMR assignments and secondary structure of human beta-2-microglobulin in solution
41. Formation of amyloid-like substance from beta2-microglobulin in vitro
42. Evidence that amyloidogenic light chains undergo antigen-driven selection
43. Physicochemical consequences of amino acid variations that contribute to fibril formation by immunoglobulin light chains
44. Beta-2-microglobulin associated amyloidosis
45. Protein conformations and disease: Pathological consequences of analogous mutations in homologous proteins
46. The structure of amyloid fibrils by electron microscopy and X-ray diffraction
47. Common core structure of amyloid fibrils by synchrotron X-ray diffraction
48. pH-dependent stability and conformation of the recombinant human prion protein PrP(90-231)
49. Aggregation and fibrillisation of the recombinant human prion protein huPrP90-231
50. Chapter two: Various clinical types of amyloidosis
51. Molecular self-assembly and nanochemistry: A chemical strategy for the synthesis of nanostructures
52. Circular-dichroism